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P04222

- 1C03_HUMAN

UniProt

P04222 - 1C03_HUMAN

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Protein
HLA class I histocompatibility antigen, Cw-3 alpha chain
Gene
HLA-C, HLAC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. TAP binding Source: UniProt
  2. peptide antigen binding Source: UniProt
  3. receptor binding Source: RefGenome

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. innate immune response Source: Reactome
  7. interferon-gamma-mediated signaling pathway Source: Reactome
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
  9. regulation of immune response Source: Reactome
  10. type I interferon signaling pathway Source: Reactome
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-3 alpha chain
Alternative name(s):
MHC class I antigen Cw*3
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284Extracellular Reviewed prediction
Add
BLAST
Transmembranei309 – 33325Helical; Reviewed prediction
Add
BLAST
Topological domaini334 – 36633Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. ER to Golgi transport vesicle membrane Source: Reactome
  2. Golgi apparatus Source: UniProt
  3. Golgi membrane Source: Reactome
  4. MHC class I protein complex Source: UniProt
  5. cell surface Source: UniProt
  6. early endosome membrane Source: Reactome
  7. endoplasmic reticulum Source: UniProt
  8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424
Add
BLAST
Chaini25 – 366342HLA class I histocompatibility antigen, Cw-3 alpha chain
PRO_0000018870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) By similarity
Disulfide bondi125 ↔ 1881 Publication
Disulfide bondi227 ↔ 2831 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04222.
PaxDbiP04222.
PRIDEiP04222.

Expressioni

Gene expression databases

CleanExiHS_HLA-C.
GenevestigatoriP04222.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 369
Turni39 – 413
Beta strandi45 – 528
Beta strandi55 – 617
Beta strandi64 – 663
Beta strandi69 – 713
Helixi74 – 774
Helixi81 – 10828
Beta strandi118 – 12811
Beta strandi131 – 15020
Beta strandi157 – 1615
Helixi162 – 17312
Helixi176 – 18510
Helixi187 – 19812
Helixi200 – 2034
Beta strandi210 – 2167
Beta strandi222 – 23514
Beta strandi238 – 2436
Turni249 – 2513
Beta strandi261 – 2633
Beta strandi268 – 2747
Helixi277 – 2804
Beta strandi281 – 2866
Beta strandi294 – 2963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EFXX-ray3.00A25-302[»]
ProteinModelPortaliP04222.
SMRiP04222. Positions 25-302.

Miscellaneous databases

EvolutionaryTraceiP04222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29789Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1
Add
BLAST
Regioni115 – 20692Alpha-2
Add
BLAST
Regioni207 – 29892Alpha-3
Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOVERGENiHBG016709.
PhylomeDBiP04222.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04222-1 [UniParc]FASTAAdd to Basket

« Hide

MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG    50
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV 100
SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL 150
NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK 200
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ 250
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP 300
SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS 350
SNSAQGSDES LIACKA 366
Length:366
Mass (Da):40,861
Last modified:August 22, 2003 - v2
Checksum:i47E55680EA1F6D97
GO

Polymorphismi

The following alleles of Cw-3 are known: Cw*03:02 (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05, Cw*03:06, Cw*03:07, Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of Cw*03:04.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731A → E.
Corresponds to variant rs1050409 [ dbSNP | Ensembl ].
VAR_056461
Natural varianti76 – 761V → M.
Corresponds to variant rs1065382 [ dbSNP | Ensembl ].
VAR_056462
Natural varianti90 – 901K → N in allele Cw*03:08.
Corresponds to variant rs28626310 [ dbSNP | Ensembl ].
VAR_016569
Natural varianti101 – 1011S → N in allele Cw*03:07.
VAR_016565
Natural varianti104 – 1041N → K in allele Cw*03:07.
VAR_016566
Natural varianti115 – 1151G → R in allele Cw*03:03 and allele Cw*03:13.
VAR_016563
Natural varianti118 – 1181I → T in allele Cw*03:05 and allele Cw*03:13.
VAR_016564
Natural varianti119 – 1191I → L in allele Cw*03:02, allele Cw*03:05 and allele Cw*03:13.
VAR_016567
Natural varianti121 – 1211R → S in allele Cw*03:05.
VAR_016617
Natural varianti127 – 1271V → L in allele Cw*03:09.
VAR_016618
Natural varianti138 – 1381D → V in allele Cw*03:06.
VAR_016619
Natural varianti140 – 1401Y → S in allele Cw*03:02.
VAR_016568
Natural varianti272 – 2721V → M.
Corresponds to variant rs1050276 [ dbSNP | Ensembl ].
VAR_056463

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Y → C in CAA25190. 1 Publication
Sequence conflicti64 – 652AA → DE in CAA25190. 1 Publication
Sequence conflicti78 – 792QE → RK in CAA25190. 1 Publication
Sequence conflicti93 – 931R → P in CAA25190. 1 Publication
Sequence conflicti140 – 1401Y → H in CAA25190. 1 Publication
Sequence conflicti161 – 1611D → N in CAA25190. 1 Publication
Sequence conflicti205 – 2051R → G in CAA25190. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00495 Genomic DNA. Translation: CAA25190.1.
M84172 mRNA. Translation: AAA59686.1.
M99389 mRNA. Translation: AAA88088.1.
M99390 mRNA. Translation: AAA88089.1.
D50853 mRNA. Translation: BAA32610.1.
U44064 Genomic DNA. Translation: AAB02773.1.
AF039198 Genomic DNA. Translation: AAD37816.1.
AH006125 Genomic DNA. Translation: AAC17715.1.
AH006126 Genomic DNA. Translation: AAC17716.1.
AH006127 Genomic DNA. Translation: AAC17717.1.
AH006128 Genomic DNA. Translation: AAC17718.1.
AJ298116 Genomic DNA. Translation: CAC18746.1.
PIRiA02190. HLHUW3.
I81231.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

EnsembliENST00000457903; ENSP00000390851; ENSG00000225691.
UCSCiuc011hpe.2. human.

Polymorphism databases

DMDMi34223716.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00495 Genomic DNA. Translation: CAA25190.1 .
M84172 mRNA. Translation: AAA59686.1 .
M99389 mRNA. Translation: AAA88088.1 .
M99390 mRNA. Translation: AAA88089.1 .
D50853 mRNA. Translation: BAA32610.1 .
U44064 Genomic DNA. Translation: AAB02773.1 .
AF039198 Genomic DNA. Translation: AAD37816.1 .
AH006125 Genomic DNA. Translation: AAC17715.1 .
AH006126 Genomic DNA. Translation: AAC17716.1 .
AH006127 Genomic DNA. Translation: AAC17717.1 .
AH006128 Genomic DNA. Translation: AAC17718.1 .
AJ298116 Genomic DNA. Translation: CAC18746.1 .
PIRi A02190. HLHUW3.
I81231.
UniGenei Hs.656020.
Hs.743218.
Hs.77961.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EFX X-ray 3.00 A 25-302 [» ]
ProteinModelPortali P04222.
SMRi P04222. Positions 25-302.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 34223716.

Proteomic databases

MaxQBi P04222.
PaxDbi P04222.
PRIDEi P04222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000457903 ; ENSP00000390851 ; ENSG00000225691 .
UCSCi uc011hpe.2. human.

Organism-specific databases

GeneCardsi GC06M031236.
GC06Mm31313.
HGNCi HGNC:4933. HLA-C.
MIMi 142840. gene.
neXtProti NX_P04222.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
HOVERGENi HBG016709.
PhylomeDBi P04222.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-C. human.
EvolutionaryTracei P04222.
PROi P04222.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-C.
Genevestigatori P04222.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3)."
    Sodoyer R., Damotte M., Delovitch T.L., Trucy J., Jordan B.R., Strachan T.
    EMBO J. 3:879-885(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*03:04).
  2. "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes."
    Zemmour J., Gumperz J.E., Hildebrand W.H., Ward F.E., Marsh S.G.E., Williams R.C., Parham P.
    Tissue Antigens 39:249-257(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*03:02).
  3. Domena J.D.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELES CW*03:03 AND CW*03:04).
  4. "DNA typing of HLA-C locus alleles in Japanese."
    Wang H., Tokunaga K., Kuwata S.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*03:03).
    Tissue: Peripheral blood.
  5. "Correction of the HLA-Cw3 genomic sequence tentatively identifies it as HLA-Cw*0304."
    Zarling A.L., Smith K.D., Lutz C.T., Lee D.R.
    Immunogenetics 44:82-83(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-206 (ALLELE CW*03:04).
  6. "Sequencing based typing for HLA-C. Identification of three new alleles: Cw*0307, Cw*0502 and Cw*0504."
    Santos S., Vicario J.L., Garcia-Sanchez F., Aviles M.J., Balas A.
    Tissue Antigens 58:34-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*03:07).
  7. "Sequence-based typing provides a new look at HLA-C diversity."
    Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., Fernandez-Vina M., Confer D.L., Hildebrand W.H.
    J. Immunol. 161:1406-1413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES CW*03:05; CW*03:06; CW*03:08 AND CW*03:09).
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*03:13).
  9. "Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand."
    Boyington J.C., Motyka S.A., Schuck P., Brooks A.G., Sun P.D.
    Nature 405:537-543(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-302 IN COMPLEX WITH KIR2DL2, DISULFIDE BONDS.

Entry informationi

Entry namei1C03_HUMAN
AccessioniPrimary (citable) accession number: P04222
Secondary accession number(s): O62883
, O78060, O78068, O78069, P30503, Q29743, Q29992, Q29993, Q9GIK8, Q9TQB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 22, 2003
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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