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P04222

- 1C03_HUMAN

UniProt

P04222 - 1C03_HUMAN

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Protein

HLA class I histocompatibility antigen, Cw-3 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt
  2. TAP binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. innate immune response Source: Reactome
  7. interferon-gamma-mediated signaling pathway Source: Reactome
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
  9. regulation of immune response Source: Reactome
  10. type I interferon signaling pathway Source: Reactome
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-3 alpha chain
Alternative name(s):
MHC class I antigen Cw*3
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33325HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 36633CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 366342HLA class I histocompatibility antigen, Cw-3 alpha chainPRO_0000018870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04222.
PaxDbiP04222.
PRIDEiP04222.

Expressioni

Gene expression databases

CleanExiHS_HLA-C.
GenevestigatoriP04222.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 369Combined sources
Turni39 – 413Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Beta strandi69 – 713Combined sources
Helixi74 – 774Combined sources
Helixi81 – 10828Combined sources
Beta strandi118 – 12811Combined sources
Beta strandi131 – 15020Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2167Combined sources
Beta strandi222 – 23514Combined sources
Beta strandi238 – 2436Combined sources
Turni249 – 2513Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi268 – 2747Combined sources
Helixi277 – 2804Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EFXX-ray3.00A25-302[»]
ProteinModelPortaliP04222.
SMRiP04222. Positions 25-302.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29789Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOVERGENiHBG016709.
PhylomeDBiP04222.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04222-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV
110 120 130 140 150
SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK
210 220 230 240 250
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIACKA
Length:366
Mass (Da):40,861
Last modified:August 22, 2003 - v2
Checksum:i47E55680EA1F6D97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Y → C in CAA25190. (PubMed:6609813)Curated
Sequence conflicti64 – 652AA → DE in CAA25190. (PubMed:6609813)Curated
Sequence conflicti78 – 792QE → RK in CAA25190. (PubMed:6609813)Curated
Sequence conflicti93 – 931R → P in CAA25190. (PubMed:6609813)Curated
Sequence conflicti140 – 1401Y → H in CAA25190. (PubMed:6609813)Curated
Sequence conflicti161 – 1611D → N in CAA25190. (PubMed:6609813)Curated
Sequence conflicti205 – 2051R → G in CAA25190. (PubMed:6609813)Curated

Polymorphismi

The following alleles of Cw-3 are known: Cw*03:02 (Cw3.2), Cw*03:03, Cw*03:04 (Cw3.1), Cw*03:05, Cw*03:06, Cw*03:07, Cw*03:08, Cw*03:09 and Cw*03:13. The sequence shown is that of Cw*03:04.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731A → E.
Corresponds to variant rs1050409 [ dbSNP | Ensembl ].
VAR_056461
Natural varianti76 – 761V → M.
Corresponds to variant rs1065382 [ dbSNP | Ensembl ].
VAR_056462
Natural varianti90 – 901K → N in allele Cw*03:08.
Corresponds to variant rs28626310 [ dbSNP | Ensembl ].
VAR_016569
Natural varianti101 – 1011S → N in allele Cw*03:07.
VAR_016565
Natural varianti104 – 1041N → K in allele Cw*03:07.
VAR_016566
Natural varianti115 – 1151G → R in allele Cw*03:03 and allele Cw*03:13.
VAR_016563
Natural varianti118 – 1181I → T in allele Cw*03:05 and allele Cw*03:13.
VAR_016564
Natural varianti119 – 1191I → L in allele Cw*03:02, allele Cw*03:05 and allele Cw*03:13.
VAR_016567
Natural varianti121 – 1211R → S in allele Cw*03:05.
VAR_016617
Natural varianti127 – 1271V → L in allele Cw*03:09.
VAR_016618
Natural varianti138 – 1381D → V in allele Cw*03:06.
VAR_016619
Natural varianti140 – 1401Y → S in allele Cw*03:02.
VAR_016568
Natural varianti272 – 2721V → M.
Corresponds to variant rs1050276 [ dbSNP | Ensembl ].
VAR_056463

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00495 Genomic DNA. Translation: CAA25190.1.
M84172 mRNA. Translation: AAA59686.1.
M99389 mRNA. Translation: AAA88088.1.
M99390 mRNA. Translation: AAA88089.1.
D50853 mRNA. Translation: BAA32610.1.
U44064 Genomic DNA. Translation: AAB02773.1.
AF039198 Genomic DNA. Translation: AAD37816.1.
AH006125 Genomic DNA. Translation: AAC17715.1.
AH006126 Genomic DNA. Translation: AAC17716.1.
AH006127 Genomic DNA. Translation: AAC17717.1.
AH006128 Genomic DNA. Translation: AAC17718.1.
AJ298116 Genomic DNA. Translation: CAC18746.1.
PIRiA02190. HLHUW3.
I81231.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

EnsembliENST00000457903; ENSP00000390851; ENSG00000225691.
UCSCiuc011hpe.2. human.

Polymorphism databases

DMDMi34223716.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00495 Genomic DNA. Translation: CAA25190.1 .
M84172 mRNA. Translation: AAA59686.1 .
M99389 mRNA. Translation: AAA88088.1 .
M99390 mRNA. Translation: AAA88089.1 .
D50853 mRNA. Translation: BAA32610.1 .
U44064 Genomic DNA. Translation: AAB02773.1 .
AF039198 Genomic DNA. Translation: AAD37816.1 .
AH006125 Genomic DNA. Translation: AAC17715.1 .
AH006126 Genomic DNA. Translation: AAC17716.1 .
AH006127 Genomic DNA. Translation: AAC17717.1 .
AH006128 Genomic DNA. Translation: AAC17718.1 .
AJ298116 Genomic DNA. Translation: CAC18746.1 .
PIRi A02190. HLHUW3.
I81231.
UniGenei Hs.656020.
Hs.743218.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EFX X-ray 3.00 A 25-302 [» ]
ProteinModelPortali P04222.
SMRi P04222. Positions 25-302.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 34223716.

Proteomic databases

MaxQBi P04222.
PaxDbi P04222.
PRIDEi P04222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000457903 ; ENSP00000390851 ; ENSG00000225691 .
UCSCi uc011hpe.2. human.

Organism-specific databases

GeneCardsi GC06M031236.
GC06Mm31313.
HGNCi HGNC:4933. HLA-C.
MIMi 142840. gene.
neXtProti NX_P04222.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
HOVERGENi HBG016709.
PhylomeDBi P04222.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-C. human.
EvolutionaryTracei P04222.
PROi P04222.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-C.
Genevestigatori P04222.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3)."
    Sodoyer R., Damotte M., Delovitch T.L., Trucy J., Jordan B.R., Strachan T.
    EMBO J. 3:879-885(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*03:04).
  2. "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes."
    Zemmour J., Gumperz J.E., Hildebrand W.H., Ward F.E., Marsh S.G.E., Williams R.C., Parham P.
    Tissue Antigens 39:249-257(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*03:02).
  3. Domena J.D.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELES CW*03:03 AND CW*03:04).
  4. "DNA typing of HLA-C locus alleles in Japanese."
    Wang H., Tokunaga K., Kuwata S.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*03:03).
    Tissue: Peripheral blood.
  5. "Correction of the HLA-Cw3 genomic sequence tentatively identifies it as HLA-Cw*0304."
    Zarling A.L., Smith K.D., Lutz C.T., Lee D.R.
    Immunogenetics 44:82-83(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-206 (ALLELE CW*03:04).
  6. "Sequencing based typing for HLA-C. Identification of three new alleles: Cw*0307, Cw*0502 and Cw*0504."
    Santos S., Vicario J.L., Garcia-Sanchez F., Aviles M.J., Balas A.
    Tissue Antigens 58:34-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*03:07).
  7. "Sequence-based typing provides a new look at HLA-C diversity."
    Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., Fernandez-Vina M., Confer D.L., Hildebrand W.H.
    J. Immunol. 161:1406-1413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES CW*03:05; CW*03:06; CW*03:08 AND CW*03:09).
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*03:13).
  9. "Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand."
    Boyington J.C., Motyka S.A., Schuck P., Brooks A.G., Sun P.D.
    Nature 405:537-543(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-302 IN COMPLEX WITH KIR2DL2, DISULFIDE BONDS.

Entry informationi

Entry namei1C03_HUMAN
AccessioniPrimary (citable) accession number: P04222
Secondary accession number(s): O62883
, O78060, O78068, O78069, P30503, Q29743, Q29992, Q29993, Q9GIK8, Q9TQB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 22, 2003
Last modified: November 26, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3