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Protein

Ig mu heavy chain disease protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This protein has no V region homology or CH1 region.

GO - Molecular functioni

  • antigen binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Ig mu heavy chain disease protein
Alternative name(s):
BOT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi127506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536211 – 391Ig mu heavy chain disease proteinAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi217N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP04220.
PRIDEiP04220.

Structurei

3D structure databases

ProteinModelPortaliP04220.
SMRiP04220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 42Pre-C-part (no V region homology)Add BLAST42
Regioni43 – 155CH2Add BLAST113
Regioni156 – 261CH3Add BLAST106
Regioni262 – 391CH4Add BLAST130

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG005814.
PhylomeDBiP04220.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 3 hits.

Sequencei

Sequence statusi: Complete.

P04220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DSPLEQSGHE VGILKETEAE DRIIKEEEAR LSGRDMQVTS QPVIAELPPK
60 70 80 90 100
VSVFVPPRDG FFGNPRKSKL ICQATGFSPR QIEVSWLREG KQVGSGVTTD
110 120 130 140 150
EVEAEAKESG PTTYKVTSTL TIKESDWLGQ SMFTCRVDHR GLTFQQNASS
160 170 180 190 200
MCGPDQDTAI RVFAIPPSFA SIFLTKSTKL TCLVTDLTTY DSVTISWTRQ
210 220 230 240 250
DGEAVKTHTN ISESHPNATF SAVGEASICE DDWDSGERFT CTVTHTDLPS
260 270 280 290 300
PLKQTISRPK GVALHRPDVY LLPPAREQLN LRESATITCL VTGFSPADVF
310 320 330 340 350
VQWMQRGQPL SPEKYVTSAP MPEPQAPGRY FAHSILTVSE EEWNTGETYT
360 370 380 390
CVVAHEALPN RVTERTVDKS TGKPTLYNVS LVMSDTAGTC Y
Length:391
Mass (Da):43,057
Last modified:March 20, 1987 - v1
Checksum:i9100843AF0CF021A
GO

Sequence databases

PIRiA02163. MHHUBT.

Cross-referencesi

Sequence databases

PIRiA02163. MHHUBT.

3D structure databases

ProteinModelPortaliP04220.
SMRiP04220.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi127506.

Proteomic databases

PeptideAtlasiP04220.
PRIDEiP04220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005814.
PhylomeDBiP04220.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMUCB_HUMAN
AccessioniPrimary (citable) accession number: P04220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: May 10, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.