P04218 (OX2G_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
OX-2 membrane glycoprotein

Alternative name(s):
MRC OX-2 antigen
CD_antigen=CD200

Gene names

Name:	Cd200
Synonyms:	Mox2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subunit structure	Interacts with CD200R1.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 278	248	OX-2 membrane glycoprotein		PRO_0000015126
Regions
	Topological domain	31 – 232	202	Extracellular Potential
	Transmembrane	233 – 259	27	Helical; Potential
	Topological domain	260 – 278	19	Cytoplasmic Potential
	Domain	31 – 141	111	Ig-like V-type
	Domain	142 – 232	91	Ig-like C2-type
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 121		Potential
	Disulfide bond	160 ↔ 214		Potential

Sequences

	Sequence		Length	Mass (Da)
	P04218 [UniParc]. Last modified March 20, 1987. Version 1. Checksum: B5A72DBE7B3116CD	FASTA	278	31,088
	10 20 30 40 50 60 MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR CSLKTTQEPL 70 80 90 100 110 120 IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG LLNTSITFWN TTLDDEGCYM 130 140 150 160 170 180 CLFNMFGSGK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGSGIE 190 200 210 220 230 240 NSTESHSHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL 250 260 270 LSIVSLVILL VLISILLYWK RHRNQERGES SQGMQRMK

References

[1]	"MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain." Clark M.J., Gagnon J., Williams A.F., Barclay A.N. EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01785 mRNA. Translation: CAA25925.1.
IPI	IPI00566814.
PIR	TDRTOX. A02114.
UniGene	Rn.7085.
3D structure databases
ProteinModelPortal	P04218.
ModBase	Search...
Protein-protein interaction databases
IntAct	P04218. 1 interaction.
Proteomic databases
PaxDb	P04218.
PRIDE	P04218.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:3104. rat.
Organism-specific databases
RGD	3104. Cd200.
Phylogenomic databases
eggNOG	NOG72791.
HOGENOM	HOG000035940.
HOVERGEN	HBG031790.
InParanoid	P04218.
OrthoDB	EOG40ZQZ2.
Gene expression databases
ArrayExpress	P04218.
Genevestigator	P04218.
GermOnline	ENSRNOG00000002141. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR013162. CD80_C2-set. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003596. Ig_V-set_subgr. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF08205. C2-set_2. 1 hit. PF00047. ig. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	603682.

Entry information

Entry name

OX2G_RAT

Accession

Primary (citable) accession number: P04218

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	March 20, 1987
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program