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Protein

OX-2 membrane glycoprotein

Gene

Cd200

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
MRC OX-2 antigen
CD_antigen: CD200
Gene namesi
Name:Cd200
Synonyms:Mox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3104. Cd200.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 232ExtracellularSequence analysisAdd BLAST202
Transmembranei233 – 259HelicalSequence analysisAdd BLAST27
Topological domaini260 – 278CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001512631 – 278OX-2 membrane glycoproteinAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Expressioni

Tissue specificityi

Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04218. 1 interactor.
MINTiMINT-4996338.
STRINGi10116.ENSRNOP00000055253.

Structurei

3D structure databases

ProteinModelPortaliP04218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 141Ig-like V-typeAdd BLAST111
Domaini142 – 232Ig-like C2-typeAdd BLAST91

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWZ9. Eukaryota.
ENOG410YRD3. LUCA.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033321. CD200.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR23277:SF72. PTHR23277:SF72. 1 hit.
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR
60 70 80 90 100
CSLKTTQEPL IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG
110 120 130 140 150
LLNTSITFWN TTLDDEGCYM CLFNMFGSGK VSGTACLTLY VQPIVHLHYN
160 170 180 190 200
YFEDHLNITC SATARPAPAI SWKGTGSGIE NSTESHSHSN GTTSVTSILR
210 220 230 240 250
VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL LSIVSLVILL
260 270
VLISILLYWK RHRNQERGES SQGMQRMK
Length:278
Mass (Da):31,088
Last modified:March 20, 1987 - v1
Checksum:iB5A72DBE7B3116CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

Genome annotation databases

UCSCiRGD:3104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

3D structure databases

ProteinModelPortaliP04218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04218. 1 interactor.
MINTiMINT-4996338.
STRINGi10116.ENSRNOP00000055253.

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3104. rat.

Organism-specific databases

RGDi3104. Cd200.

Phylogenomic databases

eggNOGiENOG410IWZ9. Eukaryota.
ENOG410YRD3. LUCA.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Miscellaneous databases

PROiP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033321. CD200.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR23277:SF72. PTHR23277:SF72. 1 hit.
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOX2G_RAT
AccessioniPrimary (citable) accession number: P04218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: July 6, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.