Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P04218

- OX2G_RAT

UniProt

P04218 - OX2G_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

OX-2 membrane glycoprotein

Gene

Cd200

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
MRC OX-2 antigen
CD_antigen: CD200
Gene namesi
Name:Cd200
Synonyms:Mox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3104. Cd200.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 232202ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25927HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 27819CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 278248OX-2 membrane glycoproteinPRO_0000015126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Expressioni

Tissue specificityi

Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

Gene expression databases

GenevestigatoriP04218.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Protein-protein interaction databases

IntActiP04218. 1 interaction.
MINTiMINT-4996338.

Structurei

3D structure databases

ProteinModelPortaliP04218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 141111Ig-like V-typeAdd
BLAST
Domaini142 – 23291Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72791.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04218-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR
60 70 80 90 100
CSLKTTQEPL IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG
110 120 130 140 150
LLNTSITFWN TTLDDEGCYM CLFNMFGSGK VSGTACLTLY VQPIVHLHYN
160 170 180 190 200
YFEDHLNITC SATARPAPAI SWKGTGSGIE NSTESHSHSN GTTSVTSILR
210 220 230 240 250
VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL LSIVSLVILL
260 270
VLISILLYWK RHRNQERGES SQGMQRMK
Length:278
Mass (Da):31,088
Last modified:March 20, 1987 - v1
Checksum:iB5A72DBE7B3116CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

Genome annotation databases

UCSCiRGD:3104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1 .
PIRi A02114. TDRTOX.
UniGenei Rn.7085.

3D structure databases

ProteinModelPortali P04218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04218. 1 interaction.
MINTi MINT-4996338.

Proteomic databases

PaxDbi P04218.
PRIDEi P04218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3104. rat.

Organism-specific databases

RGDi 3104. Cd200.

Phylogenomic databases

eggNOGi NOG72791.
HOGENOMi HOG000035940.
HOVERGENi HBG031790.
InParanoidi P04218.
PhylomeDBi P04218.

Miscellaneous databases

NextBioi 603682.
PROi P04218.

Gene expression databases

Genevestigatori P04218.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain."
    Clark M.J., Gagnon J., Williams A.F., Barclay A.N.
    EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOX2G_RAT
AccessioniPrimary (citable) accession number: P04218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3