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P04218 (OX2G_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OX-2 membrane glycoprotein
Alternative name(s):
MRC OX-2 antigen
CD_antigen=CD200
Gene names
Name:Cd200
Synonyms:Mox2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Subunit structure

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 278248OX-2 membrane glycoprotein
PRO_0000015126

Regions

Topological domain31 – 232202Extracellular Potential
Transmembrane233 – 25927Helical; Potential
Topological domain260 – 27819Cytoplasmic Potential
Domain31 – 141111Ig-like V-type
Domain142 – 23291Ig-like C2-type

Amino acid modifications

Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 121 By similarity
Disulfide bond118 ↔ 136 By similarity
Disulfide bond160 ↔ 214 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04218 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: B5A72DBE7B3116CD

FASTA27831,088
        10         20         30         40         50         60 
MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR CSLKTTQEPL 

        70         80         90        100        110        120 
IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG LLNTSITFWN TTLDDEGCYM 

       130        140        150        160        170        180 
CLFNMFGSGK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGSGIE 

       190        200        210        220        230        240 
NSTESHSHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL 

       250        260        270 
LSIVSLVILL VLISILLYWK RHRNQERGES SQGMQRMK 

« Hide

References

[1]"MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain."
Clark M.J., Gagnon J., Williams A.F., Barclay A.N.
EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01785 mRNA. Translation: CAA25925.1.
PIRTDRTOX. A02114.
UniGeneRn.7085.

3D structure databases

ProteinModelPortalP04218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04218. 1 interaction.
MINTMINT-4996338.

Proteomic databases

PaxDbP04218.
PRIDEP04218.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3104. rat.

Organism-specific databases

RGD3104. Cd200.

Phylogenomic databases

eggNOGNOG72791.
HOGENOMHOG000035940.
HOVERGENHBG031790.
InParanoidP04218.
PhylomeDBP04218.

Gene expression databases

GenevestigatorP04218.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603682.
PROP04218.

Entry information

Entry nameOX2G_RAT
AccessionPrimary (citable) accession number: P04218
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families