SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P04218

- OX2G_RAT

UniProt

P04218 - OX2G_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
OX-2 membrane glycoprotein
Gene
Cd200, Mox2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
MRC OX-2 antigen
CD_antigen: CD200
Gene namesi
Name:Cd200
Synonyms:Mox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3104. Cd200.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 232202Extracellular Reviewed prediction
Add
BLAST
Transmembranei233 – 25927Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 27819Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 278248OX-2 membrane glycoprotein
PRO_0000015126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 121 By similarity
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 136 By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 214 By similarity
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Expressioni

Tissue specificityi

Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

Gene expression databases

GenevestigatoriP04218.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Protein-protein interaction databases

IntActiP04218. 1 interaction.
MINTiMINT-4996338.

Structurei

3D structure databases

ProteinModelPortaliP04218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 141111Ig-like V-type
Add
BLAST
Domaini142 – 23291Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72791.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04218-1 [UniParc]FASTAAdd to Basket

« Hide

MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR    50
CSLKTTQEPL IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG 100
LLNTSITFWN TTLDDEGCYM CLFNMFGSGK VSGTACLTLY VQPIVHLHYN 150
YFEDHLNITC SATARPAPAI SWKGTGSGIE NSTESHSHSN GTTSVTSILR 200
VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL LSIVSLVILL 250
VLISILLYWK RHRNQERGES SQGMQRMK 278
Length:278
Mass (Da):31,088
Last modified:March 20, 1987 - v1
Checksum:iB5A72DBE7B3116CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

Genome annotation databases

UCSCiRGD:3104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01785 mRNA. Translation: CAA25925.1 .
PIRi A02114. TDRTOX.
UniGenei Rn.7085.

3D structure databases

ProteinModelPortali P04218.
ModBasei Search...

Protein-protein interaction databases

IntActi P04218. 1 interaction.
MINTi MINT-4996338.

Proteomic databases

PaxDbi P04218.
PRIDEi P04218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3104. rat.

Organism-specific databases

RGDi 3104. Cd200.

Phylogenomic databases

eggNOGi NOG72791.
HOGENOMi HOG000035940.
HOVERGENi HBG031790.
InParanoidi P04218.
PhylomeDBi P04218.

Miscellaneous databases

NextBioi 603682.
PROi P04218.

Gene expression databases

Genevestigatori P04218.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain."
    Clark M.J., Gagnon J., Williams A.F., Barclay A.N.
    EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOX2G_RAT
AccessioniPrimary (citable) accession number: P04218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi