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Protein

OX-2 membrane glycoprotein

Gene

Cd200

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
MRC OX-2 antigen
CD_antigen: CD200
Gene namesi
Name:Cd200
Synonyms:Mox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3104. Cd200.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 232202ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25927HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 27819CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 278248OX-2 membrane glycoproteinPRO_0000015126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Expressioni

Tissue specificityi

Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

Gene expression databases

GenevestigatoriP04218.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Protein-protein interaction databases

IntActiP04218. 1 interaction.
MINTiMINT-4996338.

Structurei

3D structure databases

ProteinModelPortaliP04218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 141111Ig-like V-typeAdd
BLAST
Domaini142 – 23291Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72791.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04218-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR
60 70 80 90 100
CSLKTTQEPL IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG
110 120 130 140 150
LLNTSITFWN TTLDDEGCYM CLFNMFGSGK VSGTACLTLY VQPIVHLHYN
160 170 180 190 200
YFEDHLNITC SATARPAPAI SWKGTGSGIE NSTESHSHSN GTTSVTSILR
210 220 230 240 250
VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL LSIVSLVILL
260 270
VLISILLYWK RHRNQERGES SQGMQRMK
Length:278
Mass (Da):31,088
Last modified:March 20, 1987 - v1
Checksum:iB5A72DBE7B3116CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

Genome annotation databases

UCSCiRGD:3104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01785 mRNA. Translation: CAA25925.1.
PIRiA02114. TDRTOX.
UniGeneiRn.7085.

3D structure databases

ProteinModelPortaliP04218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04218. 1 interaction.
MINTiMINT-4996338.

Proteomic databases

PaxDbiP04218.
PRIDEiP04218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3104. rat.

Organism-specific databases

RGDi3104. Cd200.

Phylogenomic databases

eggNOGiNOG72791.
HOGENOMiHOG000035940.
HOVERGENiHBG031790.
InParanoidiP04218.
PhylomeDBiP04218.

Miscellaneous databases

NextBioi603682.
PROiP04218.

Gene expression databases

GenevestigatoriP04218.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain."
    Clark M.J., Gagnon J., Williams A.F., Barclay A.N.
    EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOX2G_RAT
AccessioniPrimary (citable) accession number: P04218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: January 7, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.