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P04218

- OX2G_RAT

UniProt

P04218 - OX2G_RAT

Protein

OX-2 membrane glycoprotein

Gene

Cd200

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (20 Mar 1987)
      Previous versions | rss
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    Functioni

    Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OX-2 membrane glycoprotein
    Alternative name(s):
    MRC OX-2 antigen
    CD_antigen: CD200
    Gene namesi
    Name:Cd200
    Synonyms:Mox2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3104. Cd200.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 278248OX-2 membrane glycoproteinPRO_0000015126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP04218.
    PRIDEiP04218.

    Expressioni

    Tissue specificityi

    Found on the surface of neurons, thymocytes, B-cells and follicular dendritic cells.

    Gene expression databases

    GenevestigatoriP04218.

    Interactioni

    Subunit structurei

    CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

    Protein-protein interaction databases

    IntActiP04218. 1 interaction.
    MINTiMINT-4996338.

    Structurei

    3D structure databases

    ProteinModelPortaliP04218.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 232202ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27819CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25927HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 141111Ig-like V-typeAdd
    BLAST
    Domaini142 – 23291Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72791.
    HOGENOMiHOG000035940.
    HOVERGENiHBG031790.
    InParanoidiP04218.
    PhylomeDBiP04218.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003596. Ig_V-set_subgr.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04218-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR    50
    CSLKTTQEPL IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG 100
    LLNTSITFWN TTLDDEGCYM CLFNMFGSGK VSGTACLTLY VQPIVHLHYN 150
    YFEDHLNITC SATARPAPAI SWKGTGSGIE NSTESHSHSN GTTSVTSILR 200
    VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL LSIVSLVILL 250
    VLISILLYWK RHRNQERGES SQGMQRMK 278
    Length:278
    Mass (Da):31,088
    Last modified:March 20, 1987 - v1
    Checksum:iB5A72DBE7B3116CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01785 mRNA. Translation: CAA25925.1.
    PIRiA02114. TDRTOX.
    UniGeneiRn.7085.

    Genome annotation databases

    UCSCiRGD:3104. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01785 mRNA. Translation: CAA25925.1 .
    PIRi A02114. TDRTOX.
    UniGenei Rn.7085.

    3D structure databases

    ProteinModelPortali P04218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04218. 1 interaction.
    MINTi MINT-4996338.

    Proteomic databases

    PaxDbi P04218.
    PRIDEi P04218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3104. rat.

    Organism-specific databases

    RGDi 3104. Cd200.

    Phylogenomic databases

    eggNOGi NOG72791.
    HOGENOMi HOG000035940.
    HOVERGENi HBG031790.
    InParanoidi P04218.
    PhylomeDBi P04218.

    Miscellaneous databases

    NextBioi 603682.
    PROi P04218.

    Gene expression databases

    Genevestigatori P04218.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003596. Ig_V-set_subgr.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain."
      Clark M.J., Gagnon J., Williams A.F., Barclay A.N.
      EMBO J. 4:113-118(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiOX2G_RAT
    AccessioniPrimary (citable) accession number: P04218
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: March 20, 1987
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3