Reviewed, UniProtKB/Swiss-Prot P04217 (A1BG_HUMAN)

Names and origin

Protein names

Recommended name:
    Alpha-1B-glycoprotein
Alternative name(s):
    Alpha-1-B glycoprotein

Gene names

Name:

A1BG

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Plasma.
Sequence similarities	Contains 5 Ig-like V-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Ref.4 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.4
	Chain	22 – 495	474	Alpha-1B-glycoprotein		PRO_0000014502
Regions
	Domain	22 – 113	92	Ig-like V-type 1
	Domain	114 – 206	93	Ig-like V-type 2
	Domain	207 – 299	93	Ig-like V-type 3
	Domain	300 – 397	98	Ig-like V-type 4
	Domain	398 – 495	98	Ig-like V-type 5
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Ref.4 Ref.5 Ref.6
	Glycosylation	179	1	N-linked (GlcNAc...) Ref.4 Ref.5 Ref.6
	Glycosylation	363	1	N-linked (GlcNAc...) Ref.4 Ref.6
	Glycosylation	371	1	N-linked (GlcNAc...) Ref.4 Ref.6
	Disulfide bond	49 ↔ 93		Probable
	Disulfide bond	139 ↔ 182		Ref.4
	Disulfide bond	232 ↔ 279		Ref.4
	Disulfide bond	325 ↔ 374		Ref.4
	Disulfide bond	423 ↔ 470		Probable
Natural variations
	Natural variant	52	1	R → H: dbSNP rs893184. Ref.1		VAR_018369
	Natural variant	395	1	H → R: dbSNP rs2241788.		VAR_018370
Experimental info
	Sequence conflict	105	1	S → G in AAL07469. Ref.2
	Sequence conflict	127	1	S → P in AAL07469. Ref.2
	Sequence conflict	146	1	V → E in AAL07469. Ref.2
	Sequence conflict	413	1	V → A in AAL07469. Ref.2
	Sequence conflict	446 – 447	2	VR → IP in AAL07469. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P04217-1 [UniParc]. Last modified April 26, 2004. Version 3. Checksum: FBF648A8C62BE085	FASTA	495	54,273
	10 20 30 40 50 60 MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ ARLETPDFQL 70 80 90 100 110 120 FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW 130 140 150 160 170 180 LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY 190 200 210 220 230 240 SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 250 260 270 280 290 300 FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 310 320 330 340 350 360 LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 370 380 390 400 410 420 LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV 430 440 450 460 470 480 LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 490 ESELSDPVEL LVAES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed: 15221005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-52.
[2]	"Molecular cloning and characterization of the human A1BG gene." Zhao Y., Sun D. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-495. Tissue: Ovary.
[4]	"Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family." Ishioka N., Takahashi N., Putnam F.W. Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986) [PubMed: 3458201] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44; ASN-179; ASN-363 AND ASN-371.
[5]	"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R. Proteomics 4:454-465(2004) [PubMed: 14760718] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179, MASS SPECTROMETRY. Tissue: Plasma.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 AND ASN-371, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB073611 mRNA. Translation: BAD38648.1. AF414429 mRNA. Translation: AAL07469.1. BC035719 mRNA. Translation: AAH35719.1. Different initiation.
IPI	IPI00022895.
RefSeq	NP_570602.2.
UniGene	Hs.529161
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P04217.
Protein family/group databases
MEROPS	I43.950.
2-D gel databases
SWISS-2DPAGE	P04217.
Cornea-2DPAGE	P04217.
DOSAC-COBS-2DPAGE	P04217.
REPRODUCTION-2DPAGE	IPI00022895.
Siena-2DPAGE	P04217.
Proteomic databases
PeptideAtlas	P04217.
PRIDE	P04217.
Genome annotation databases
Ensembl	ENST00000263100; ENSP00000263100; ENSG00000121410; Homo sapiens. [Genome view]
GeneID	1.
KEGG	hsa:1.
Organism-specific databases
CTD	1.
GeneCards	GC19M063548.
H-InvDB	HIX0015535.
HGNC	HGNC:5. A1BG.
HPA	CAB016673.
MIM	138670. gene.
PharmGKB	PA24356.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P04217.
HOVERGEN	P04217.
Gene expression databases
ArrayExpress	P04217.
Bgee	P04217.
CleanEx	HS_A1BG.
Genevestigator	P04217.
GermOnline	ENSG00000121410. Homo sapiens.
Family and domain databases
InterPro	IPR016332. A1B_glyco/leuk_Ig-like_rcpt. IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 5 hits.
Pfam	PF00047. ig. 3 hits. [Graphical view]
PIRSF	PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMART	SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

A1BG_HUMAN

Accession

Primary (citable) accession number: P04217
Secondary accession number(s): Q68CK0, Q8IYJ6, Q96P39

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	April 26, 2004
Last modified:	November 24, 2009
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.