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Protein

Alpha-1B-glycoprotein

Gene

A1BG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121410-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI43.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
Gene namesi
Name:A1BG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:5. A1BG.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1.
OpenTargetsiENSG00000121410.
PharmGKBiPA24356.

Polymorphism and mutation databases

BioMutaiA1BG.
DMDMi317373553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001450222 – 495Alpha-1B-glycoproteinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) (complex)4 Publications1
Disulfide bondi49 ↔ 931 Publication
Disulfide bondi139 ↔ 182PROSITE-ProRule annotation1 Publication
Glycosylationi179N-linked (GlcNAc...)3 Publications1
Disulfide bondi232 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation1 Publication
Glycosylationi363N-linked (GlcNAc...)2 Publications1
Glycosylationi371N-linked (GlcNAc...)2 Publications1
Disulfide bondi423 ↔ 4701 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04217.
PeptideAtlasiP04217.
PRIDEiP04217.

2D gel databases

DOSAC-COBS-2DPAGEP04217.
REPRODUCTION-2DPAGEIPI00022895.
SWISS-2DPAGEP04217.

PTM databases

PhosphoSitePlusiP04217.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000121410.
CleanExiHS_A1BG.
ExpressionAtlasiP04217. baseline and differential.
GenevisibleiP04217. HS.

Organism-specific databases

HPAiCAB016673.
HPA044252.

Interactioni

Subunit structurei

Interacts with CRISP3.1 Publication

Protein-protein interaction databases

BioGridi106523. 22 interactors.
IntActiP04217. 9 interactors.
MINTiMINT-8247347.
STRINGi9606.ENSP00000263100.

Structurei

3D structure databases

ProteinModelPortaliP04217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 113Ig-like V-type 1Add BLAST92
Domaini114 – 206Ig-like V-type 2Add BLAST93
Domaini207 – 299Ig-like V-type 3Add BLAST93
Domaini300 – 397Ig-like V-type 4Add BLAST98
Domaini398 – 495Ig-like V-type 5Add BLAST98

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiP04217.
OMAiRCRYRSW.
OrthoDBiEOG091G020P.
PhylomeDBiP04217.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ
60 70 80 90 100
AHLETPDFQL FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG
110 120 130 140 150
WTQLSKLLEL TGPKSLPAPW LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL
160 170 180 190 200
RREGDHEFLE VPEAQEDVEA TFPVHQPGNY SCSYRTDGEG ALSEPSATVT
210 220 230 240 250
IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD FQLRRGEKEL
260 270 280 290 300
LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI
310 320 330 340 350
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ
360 370 380 390 400
SPAGTEALFE LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP
410 420 430 440 450
PRPQLRATWS GAVLAGRDAV LRCEGPIPDV TFELLREGET KAVKTVRTPG
460 470 480 490
AAANLELIFV GPQHAGNYRC RYRSWVPHTF ESELSDPVEL LVAES
Length:495
Mass (Da):54,254
Last modified:January 11, 2011 - v4
Checksum:i8E611BDC3BC824C8
GO
Isoform 2 (identifier: P04217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):40,718
Checksum:i13B698EF0DEEE203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → G in AAL07469 (Ref. 2) Curated1
Sequence conflicti127S → P in AAL07469 (Ref. 2) Curated1
Sequence conflicti146V → E in AAL07469 (Ref. 2) Curated1
Sequence conflicti304E → G in BAF82106 (PubMed:14702039).Curated1
Sequence conflicti413V → A in AAL07469 (Ref. 2) Curated1
Sequence conflicti446 – 447VR → IP in AAL07469 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01836952H → R.3 PublicationsCorresponds to variant rs893184dbSNPEnsembl.1
Natural variantiVAR_018370395H → R.Corresponds to variant rs2241788dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403231 – 122Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073611 mRNA. Translation: BAD38648.1.
AF414429 mRNA. Translation: AAL07469.1.
AK289417 mRNA. Translation: BAF82106.1.
AC010642 Genomic DNA. No translation available.
AC012313 Genomic DNA. No translation available.
BC035719 mRNA. Translation: AAH35719.1.
CCDSiCCDS12976.1. [P04217-1]
RefSeqiNP_570602.2. NM_130786.3. [P04217-1]
UniGeneiHs.529161.
Hs.709582.

Genome annotation databases

EnsembliENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
GeneIDi1.
KEGGihsa:1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073611 mRNA. Translation: BAD38648.1.
AF414429 mRNA. Translation: AAL07469.1.
AK289417 mRNA. Translation: BAF82106.1.
AC010642 Genomic DNA. No translation available.
AC012313 Genomic DNA. No translation available.
BC035719 mRNA. Translation: AAH35719.1.
CCDSiCCDS12976.1. [P04217-1]
RefSeqiNP_570602.2. NM_130786.3. [P04217-1]
UniGeneiHs.529161.
Hs.709582.

3D structure databases

ProteinModelPortaliP04217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106523. 22 interactors.
IntActiP04217. 9 interactors.
MINTiMINT-8247347.
STRINGi9606.ENSP00000263100.

Protein family/group databases

MEROPSiI43.950.

PTM databases

PhosphoSitePlusiP04217.

Polymorphism and mutation databases

BioMutaiA1BG.
DMDMi317373553.

2D gel databases

DOSAC-COBS-2DPAGEP04217.
REPRODUCTION-2DPAGEIPI00022895.
SWISS-2DPAGEP04217.

Proteomic databases

PaxDbiP04217.
PeptideAtlasiP04217.
PRIDEiP04217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
GeneIDi1.
KEGGihsa:1.

Organism-specific databases

CTDi1.
DisGeNETi1.
GeneCardsiA1BG.
HGNCiHGNC:5. A1BG.
HPAiCAB016673.
HPA044252.
MIMi138670. gene.
neXtProtiNX_P04217.
OpenTargetsiENSG00000121410.
PharmGKBiPA24356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiP04217.
OMAiRCRYRSW.
OrthoDBiEOG091G020P.
PhylomeDBiP04217.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121410-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiA1BG. human.
GeneWikiiA1BG_(gene).
GenomeRNAii1.
PROiP04217.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121410.
CleanExiHS_A1BG.
ExpressionAtlasiP04217. baseline and differential.
GenevisibleiP04217. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1BG_HUMAN
AccessioniPrimary (citable) accession number: P04217
Secondary accession number(s): A8K052
, Q68CK0, Q8IYJ6, Q96P39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 160 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.