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P04217 (A1BG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
Gene names
Name:A1BG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CRISP3. Ref.7

Subcellular location

Secreted.

Tissue specificity

Plasma.

Sequence similarities

Contains 5 Ig-like V-type (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P04217-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P04217-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.6
Chain22 – 495474Alpha-1B-glycoprotein
PRO_0000014502

Regions

Domain22 – 11392Ig-like V-type 1
Domain114 – 20693Ig-like V-type 2
Domain207 – 29993Ig-like V-type 3
Domain300 – 39798Ig-like V-type 4
Domain398 – 49598Ig-like V-type 5

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) (complex) Ref.6 Ref.8 Ref.9 Ref.10
Glycosylation1791N-linked (GlcNAc...) Ref.6 Ref.8 Ref.9
Glycosylation3631N-linked (GlcNAc...) Ref.6 Ref.9
Glycosylation3711N-linked (GlcNAc...) Ref.6 Ref.9
Disulfide bond49 ↔ 93 Probable
Disulfide bond139 ↔ 182 Ref.6
Disulfide bond232 ↔ 279 Ref.6
Disulfide bond325 ↔ 374 Ref.6
Disulfide bond423 ↔ 470 Probable

Natural variations

Alternative sequence1 – 122122Missing in isoform 2.
VSP_040323
Natural variant521H → R. Ref.2 Ref.3 Ref.6
Corresponds to variant rs893184 [ dbSNP | Ensembl ].
VAR_018369
Natural variant3951H → R.
Corresponds to variant rs2241788 [ dbSNP | Ensembl ].
VAR_018370

Experimental info

Sequence conflict1051S → G in AAL07469. Ref.2
Sequence conflict1271S → P in AAL07469. Ref.2
Sequence conflict1461V → E in AAL07469. Ref.2
Sequence conflict3041E → G in BAF82106. Ref.3
Sequence conflict4131V → A in AAL07469. Ref.2
Sequence conflict446 – 4472VR → IP in AAL07469. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 4.
Checksum: 8E611BDC3BC824C8

FASTA49554,254
        10         20         30         40         50         60 
MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ AHLETPDFQL 

        70         80         90        100        110        120 
FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW 

       130        140        150        160        170        180 
LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY 

       190        200        210        220        230        240 
SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 

       250        260        270        280        290        300 
FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 

       310        320        330        340        350        360 
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 

       370        380        390        400        410        420 
LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV 

       430        440        450        460        470        480 
LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 

       490 
ESELSDPVEL LVAES 

« Hide

Isoform 2 [UniParc].

Checksum: 13B698EF0DEEE203
Show »

FASTA37340,718

References

« Hide 'large scale' references
[1]"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Molecular cloning and characterization of the human A1BG gene."
Zhao Y., Sun D.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-52.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-52.
Tissue: Mammary gland.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Ovary.
[6]"Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family."
Ishioka N., Takahashi N., Putnam F.W.
Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44; ASN-179; ASN-363 AND ASN-371, VARIANT ARG-52.
[7]"Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CRISP3.
[8]"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179.
Tissue: Plasma.
[9]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 AND ASN-371.
Tissue: Plasma.
[10]"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, STRUCTURE OF CARBOHYDRATES.
Tissue: Cerebrospinal fluid.
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB073611 mRNA. Translation: BAD38648.1.
AF414429 mRNA. Translation: AAL07469.1.
AK289417 mRNA. Translation: BAF82106.1.
AC010642 Genomic DNA. No translation available.
AC012313 Genomic DNA. No translation available.
BC035719 mRNA. Translation: AAH35719.1.
CCDSCCDS12976.1. [P04217-1]
RefSeqNP_570602.2. NM_130786.3. [P04217-1]
UniGeneHs.529161.
Hs.709582.

3D structure databases

ProteinModelPortalP04217.
SMRP04217. Positions 28-195, 208-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106523. 11 interactions.
IntActP04217. 9 interactions.
MINTMINT-8247347.
STRING9606.ENSP00000263100.

Protein family/group databases

MEROPSI43.950.

PTM databases

PhosphoSiteP04217.

Polymorphism databases

DMDM317373553.

2D gel databases

DOSAC-COBS-2DPAGEP04217.
REPRODUCTION-2DPAGEIPI00022895.
SWISS-2DPAGEP04217.

Proteomic databases

MaxQBP04217.
PaxDbP04217.
PeptideAtlasP04217.
PRIDEP04217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
GeneID1.
KEGGhsa:1.
UCSCuc002qsd.4. human. [P04217-1]

Organism-specific databases

CTD1.
GeneCardsGC19M058858.
HGNCHGNC:5. A1BG.
HPACAB016673.
HPA044252.
MIM138670. gene.
neXtProtNX_P04217.
PharmGKBPA24356.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26440.
HOGENOMHOG000152502.
HOVERGENHBG000037.
InParanoidP04217.
OMAATFPVHR.
OrthoDBEOG78SQGZ.
PhylomeDBP04217.
TreeFamTF336644.

Gene expression databases

BgeeP04217.
CleanExHS_A1BG.
GenevestigatorP04217.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
[Graphical view]
PIRSFPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiA1BG_(gene).
GenomeRNAi1.
NextBio1.
PROP04217.
SOURCESearch...

Entry information

Entry nameA1BG_HUMAN
AccessionPrimary (citable) accession number: P04217
Secondary accession number(s): A8K052 expand/collapse secondary AC list , Q68CK0, Q8IYJ6, Q96P39
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM