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P04217

- A1BG_HUMAN

UniProt

P04217 - A1BG_HUMAN

Protein

Alpha-1B-glycoprotein

Gene

A1BG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    MEROPSiI43.950.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1B-glycoprotein
    Alternative name(s):
    Alpha-1-B glycoprotein
    Gene namesi
    Name:A1BG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:5. A1BG.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProt
    4. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24356.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 495474Alpha-1B-glycoproteinPRO_0000014502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...) (complex)4 Publications
    Disulfide bondi49 ↔ 931 Publication
    Disulfide bondi139 ↔ 1821 PublicationPROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)3 Publications
    Disulfide bondi232 ↔ 2791 PublicationPROSITE-ProRule annotation
    Disulfide bondi325 ↔ 3741 PublicationPROSITE-ProRule annotation
    Glycosylationi363 – 3631N-linked (GlcNAc...)2 Publications
    Glycosylationi371 – 3711N-linked (GlcNAc...)2 Publications
    Disulfide bondi423 ↔ 4701 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP04217.
    PaxDbiP04217.
    PeptideAtlasiP04217.
    PRIDEiP04217.

    2D gel databases

    DOSAC-COBS-2DPAGEP04217.
    REPRODUCTION-2DPAGEIPI00022895.
    SWISS-2DPAGEP04217.

    PTM databases

    PhosphoSiteiP04217.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    BgeeiP04217.
    CleanExiHS_A1BG.
    GenevestigatoriP04217.

    Organism-specific databases

    HPAiCAB016673.
    HPA044252.

    Interactioni

    Subunit structurei

    Interacts with CRISP3.1 Publication

    Protein-protein interaction databases

    BioGridi106523. 11 interactions.
    IntActiP04217. 9 interactions.
    MINTiMINT-8247347.
    STRINGi9606.ENSP00000263100.

    Structurei

    3D structure databases

    ProteinModelPortaliP04217.
    SMRiP04217. Positions 28-195, 208-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 11392Ig-like V-type 1Add
    BLAST
    Domaini114 – 20693Ig-like V-type 2Add
    BLAST
    Domaini207 – 29993Ig-like V-type 3Add
    BLAST
    Domaini300 – 39798Ig-like V-type 4Add
    BLAST
    Domaini398 – 49598Ig-like V-type 5Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG26440.
    HOGENOMiHOG000152502.
    HOVERGENiHBG000037.
    InParanoidiP04217.
    OMAiATFPVHR.
    OrthoDBiEOG78SQGZ.
    PhylomeDBiP04217.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    [Graphical view]
    PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTiSM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P04217-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ    50
    AHLETPDFQL FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG 100
    WTQLSKLLEL TGPKSLPAPW LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL 150
    RREGDHEFLE VPEAQEDVEA TFPVHQPGNY SCSYRTDGEG ALSEPSATVT 200
    IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD FQLRRGEKEL 250
    LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 300
    LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ 350
    SPAGTEALFE LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP 400
    PRPQLRATWS GAVLAGRDAV LRCEGPIPDV TFELLREGET KAVKTVRTPG 450
    AAANLELIFV GPQHAGNYRC RYRSWVPHTF ESELSDPVEL LVAES 495
    Length:495
    Mass (Da):54,254
    Last modified:January 11, 2011 - v4
    Checksum:i8E611BDC3BC824C8
    GO
    Isoform 2 (identifier: P04217-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:373
    Mass (Da):40,718
    Checksum:i13B698EF0DEEE203
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051S → G in AAL07469. 1 PublicationCurated
    Sequence conflicti127 – 1271S → P in AAL07469. 1 PublicationCurated
    Sequence conflicti146 – 1461V → E in AAL07469. 1 PublicationCurated
    Sequence conflicti304 – 3041E → G in BAF82106. (PubMed:14702039)Curated
    Sequence conflicti413 – 4131V → A in AAL07469. 1 PublicationCurated
    Sequence conflicti446 – 4472VR → IP in AAL07469. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521H → R.3 Publications
    Corresponds to variant rs893184 [ dbSNP | Ensembl ].
    VAR_018369
    Natural varianti395 – 3951H → R.
    Corresponds to variant rs2241788 [ dbSNP | Ensembl ].
    VAR_018370

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 122122Missing in isoform 2. 1 PublicationVSP_040323Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073611 mRNA. Translation: BAD38648.1.
    AF414429 mRNA. Translation: AAL07469.1.
    AK289417 mRNA. Translation: BAF82106.1.
    AC010642 Genomic DNA. No translation available.
    AC012313 Genomic DNA. No translation available.
    BC035719 mRNA. Translation: AAH35719.1.
    CCDSiCCDS12976.1. [P04217-1]
    RefSeqiNP_570602.2. NM_130786.3. [P04217-1]
    UniGeneiHs.529161.
    Hs.709582.

    Genome annotation databases

    EnsembliENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
    GeneIDi1.
    KEGGihsa:1.
    UCSCiuc002qsd.4. human. [P04217-1]

    Polymorphism databases

    DMDMi317373553.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073611 mRNA. Translation: BAD38648.1 .
    AF414429 mRNA. Translation: AAL07469.1 .
    AK289417 mRNA. Translation: BAF82106.1 .
    AC010642 Genomic DNA. No translation available.
    AC012313 Genomic DNA. No translation available.
    BC035719 mRNA. Translation: AAH35719.1 .
    CCDSi CCDS12976.1. [P04217-1 ]
    RefSeqi NP_570602.2. NM_130786.3. [P04217-1 ]
    UniGenei Hs.529161.
    Hs.709582.

    3D structure databases

    ProteinModelPortali P04217.
    SMRi P04217. Positions 28-195, 208-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106523. 11 interactions.
    IntActi P04217. 9 interactions.
    MINTi MINT-8247347.
    STRINGi 9606.ENSP00000263100.

    Protein family/group databases

    MEROPSi I43.950.

    PTM databases

    PhosphoSitei P04217.

    Polymorphism databases

    DMDMi 317373553.

    2D gel databases

    DOSAC-COBS-2DPAGE P04217.
    REPRODUCTION-2DPAGE IPI00022895.
    SWISS-2DPAGE P04217.

    Proteomic databases

    MaxQBi P04217.
    PaxDbi P04217.
    PeptideAtlasi P04217.
    PRIDEi P04217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263100 ; ENSP00000263100 ; ENSG00000121410 . [P04217-1 ]
    GeneIDi 1.
    KEGGi hsa:1.
    UCSCi uc002qsd.4. human. [P04217-1 ]

    Organism-specific databases

    CTDi 1.
    GeneCardsi GC19M058858.
    HGNCi HGNC:5. A1BG.
    HPAi CAB016673.
    HPA044252.
    MIMi 138670. gene.
    neXtProti NX_P04217.
    PharmGKBi PA24356.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26440.
    HOGENOMi HOG000152502.
    HOVERGENi HBG000037.
    InParanoidi P04217.
    OMAi ATFPVHR.
    OrthoDBi EOG78SQGZ.
    PhylomeDBi P04217.
    TreeFami TF336644.

    Miscellaneous databases

    GeneWikii A1BG_(gene).
    GenomeRNAii 1.
    NextBioi 1.
    PROi P04217.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04217.
    CleanExi HS_A1BG.
    Genevestigatori P04217.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    [Graphical view ]
    PIRSFi PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTi SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and characterization of the human A1BG gene."
      Zhao Y., Sun D.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-52.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-52.
      Tissue: Mammary gland.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Ovary.
    6. "Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family."
      Ishioka N., Takahashi N., Putnam F.W.
      Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44; ASN-179; ASN-363 AND ASN-371, VARIANT ARG-52.
    7. "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
      Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
      Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRISP3.
    8. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
      Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179.
      Tissue: Plasma.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 AND ASN-371.
      Tissue: Plasma.
    10. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.

    Entry informationi

    Entry nameiA1BG_HUMAN
    AccessioniPrimary (citable) accession number: P04217
    Secondary accession number(s): A8K052
    , Q68CK0, Q8IYJ6, Q96P39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 141 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3