P04217 (A1BG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-1B-glycoprotein

Alternative name(s):
Alpha-1-B glycoprotein

Gene names

Name:

A1BG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CRISP3. Ref.7
Subcellular location	Secreted.
Tissue specificity	Plasma.
Sequence similarities	Contains 5 Ig-like V-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P04217-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P04217-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.6
	Chain	22 – 495	474	Alpha-1B-glycoprotein		PRO_0000014502
Regions
	Domain	22 – 113	92	Ig-like V-type 1
	Domain	114 – 206	93	Ig-like V-type 2
	Domain	207 – 299	93	Ig-like V-type 3
	Domain	300 – 397	98	Ig-like V-type 4
	Domain	398 – 495	98	Ig-like V-type 5
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) (complex) Ref.6 Ref.8 Ref.9 Ref.10
	Glycosylation	179	1	N-linked (GlcNAc...) Ref.6 Ref.8 Ref.9
	Glycosylation	363	1	N-linked (GlcNAc...) Ref.6 Ref.9
	Glycosylation	371	1	N-linked (GlcNAc...) Ref.6 Ref.9
	Disulfide bond	49 ↔ 93		Probable
	Disulfide bond	139 ↔ 182		Ref.6
	Disulfide bond	232 ↔ 279		Ref.6
	Disulfide bond	325 ↔ 374		Ref.6
	Disulfide bond	423 ↔ 470		Probable
Natural variations
	Alternative sequence	1 – 122	122	Missing in isoform 2.		VSP_040323
	Natural variant	52	1	H → R. Ref.2 Ref.3 Ref.6 Corresponds to variant rs893184 [ dbSNP | Ensembl ].		VAR_018369
	Natural variant	395	1	H → R. Corresponds to variant rs2241788 [ dbSNP | Ensembl ].		VAR_018370
Experimental info
	Sequence conflict	105	1	S → G in AAL07469. Ref.2
	Sequence conflict	127	1	S → P in AAL07469. Ref.2
	Sequence conflict	146	1	V → E in AAL07469. Ref.2
	Sequence conflict	304	1	E → G in BAF82106. Ref.3
	Sequence conflict	413	1	V → A in AAL07469. Ref.2
	Sequence conflict	446 – 447	2	VR → IP in AAL07469. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 4. Checksum: 8E611BDC3BC824C8	FASTA	495	54,254
	10 20 30 40 50 60 MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ AHLETPDFQL 70 80 90 100 110 120 FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW 130 140 150 160 170 180 LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY 190 200 210 220 230 240 SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 250 260 270 280 290 300 FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 310 320 330 340 350 360 LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 370 380 390 400 410 420 LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV 430 440 450 460 470 480 LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 490 ESELSDPVEL LVAES
	Isoform 2 [UniParc]. Checksum: 13B698EF0DEEE203	FASTA	373	40,718
	10 20 30 40 50 60 MAPVSWITPG LKTTAVCRGV LRGVTFLLRR EGDHEFLEVP EAQEDVEATF PVHQPGNYSC 70 80 90 100 110 120 SYRTDGEGAL SEPSATVTIE ELAAPPPPVL MHHGESSQVL HPGNKVTLTC VAPLSGVDFQ 130 140 150 160 170 180 LRRGEKELLV PRSSTSPDRI FFHLNAVALG DGGHYTCRYR LHDNQNGWSG DSAPVELILS 190 200 210 220 230 240 DETLPAPEFS PEPESGRALR LRCLAPLEGA RFALVREDRG GRRVHRFQSP AGTEALFELH 250 260 270 280 290 300 NISVADSANY SCVYVDLKPP FGGSAPSERL ELHVDGPPPR PQLRATWSGA VLAGRDAVLR 310 320 330 340 350 360 CEGPIPDVTF ELLREGETKA VKTVRTPGAA ANLELIFVGP QHAGNYRCRY RSWVPHTFES 370 ELSDPVELLV AES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Molecular cloning and characterization of the human A1BG gene." Zhao Y., Sun D. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-52.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-52. Tissue: Mammary gland.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Ovary.
[6]	"Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family." Ishioka N., Takahashi N., Putnam F.W. Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44; ASN-179; ASN-363 AND ASN-371, VARIANT ARG-52.
[7]	"Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma." Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L. Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CRISP3.
[8]	"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R. Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 AND ASN-371, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"Enrichment of glycopeptides for glycan structure and attachment site identification." Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G. Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, STRUCTURE OF CARBOHYDRATES, MASS SPECTROMETRY. Tissue: Cerebrospinal fluid.
+	Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073611 mRNA. Translation: BAD38648.1. AF414429 mRNA. Translation: AAL07469.1. AK289417 mRNA. Translation: BAF82106.1. AC010642 Genomic DNA. No translation available. AC012313 Genomic DNA. No translation available. BC035719 mRNA. Translation: AAH35719.1.
IPI	IPI00022895. IPI00644018.
RefSeq	NP_570602.2. NM_130786.3.
UniGene	Hs.529161. Hs.709582.
3D structure databases
ProteinModelPortal	P04217.
SMR	P04217. Positions 28-195, 208-492.
ModBase	Search...
Protein-protein interaction databases
IntAct	P04217. 3 interactions.
STRING	9606.ENSP00000263100.
Protein family/group databases
MEROPS	I43.950.
PTM databases
PhosphoSite	P04217.
Polymorphism databases
DMDM	46577680.
2D gel databases
DOSAC-COBS-2DPAGE	P04217.
REPRODUCTION-2DPAGE	IPI00022895.
SWISS-2DPAGE	P04217.
Proteomic databases
PaxDb	P04217.
PeptideAtlas	P04217.
PRIDE	P04217.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263100; ENSP00000263100; ENSG00000121410.
GeneID	1.
KEGG	hsa:1.
UCSC	uc002qsd.4. human.
Organism-specific databases
CTD	1.
GeneCards	GC19M058858.
HGNC	HGNC:5. A1BG.
HPA	CAB016673.
MIM	138670. gene.
neXtProt	NX_P04217.
PharmGKB	PA24356.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26440.
HOGENOM	HOG000152502.
HOVERGEN	HBG000037.
InParanoid	P04217.
OMA	ATFPVHR.
OrthoDB	EOG45MN53.
PhylomeDB	P04217.
Gene expression databases
ArrayExpress	P04217.
Bgee	P04217.
CleanEx	HS_A1BG.
Genevestigator	P04217.
GermOnline	ENSG00000121410. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR016332. A1B_glyco/leuk_Ig-like_rcpt. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. [Graphical view]
PIRSF	PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMART	SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1.
NextBio	1.
SOURCE	Search...

Entry information

Entry name

A1BG_HUMAN

Accession

Primary (citable) accession number: P04217
Secondary accession number(s): A8K052 , Q68CK0, Q8IYJ6, Q96P39

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 127 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.