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Protein

Alpha-1B-glycoprotein

Gene

A1BG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

MEROPSiI43.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
Gene namesi
Name:A1BG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:5. A1BG.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24356.

Polymorphism and mutation databases

BioMutaiA1BG.
DMDMi317373553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 495474Alpha-1B-glycoproteinPRO_0000014502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...) (complex)4 Publications
Disulfide bondi49 ↔ 931 Publication
Disulfide bondi139 ↔ 182PROSITE-ProRule annotation1 Publication
Glycosylationi179 – 1791N-linked (GlcNAc...)3 Publications
Disulfide bondi232 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation1 Publication
Glycosylationi363 – 3631N-linked (GlcNAc...)2 Publications
Glycosylationi371 – 3711N-linked (GlcNAc...)2 Publications
Disulfide bondi423 ↔ 4701 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04217.
PeptideAtlasiP04217.
PRIDEiP04217.

2D gel databases

DOSAC-COBS-2DPAGEP04217.
REPRODUCTION-2DPAGEIPI00022895.
SWISS-2DPAGEP04217.

PTM databases

PhosphoSiteiP04217.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP04217.
CleanExiHS_A1BG.
ExpressionAtlasiP04217. baseline.
GenevisibleiP04217. HS.

Organism-specific databases

HPAiCAB016673.
HPA044252.

Interactioni

Subunit structurei

Interacts with CRISP3.1 Publication

Protein-protein interaction databases

BioGridi106523. 25 interactions.
IntActiP04217. 9 interactions.
MINTiMINT-8247347.
STRINGi9606.ENSP00000263100.

Structurei

3D structure databases

ProteinModelPortaliP04217.
SMRiP04217. Positions 28-195, 208-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11392Ig-like V-type 1Add
BLAST
Domaini114 – 20693Ig-like V-type 2Add
BLAST
Domaini207 – 29993Ig-like V-type 3Add
BLAST
Domaini300 – 39798Ig-like V-type 4Add
BLAST
Domaini398 – 49598Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG26440.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiP04217.
OMAiYTCRYQL.
OrthoDBiEOG78SQGZ.
PhylomeDBiP04217.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ
60 70 80 90 100
AHLETPDFQL FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG
110 120 130 140 150
WTQLSKLLEL TGPKSLPAPW LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL
160 170 180 190 200
RREGDHEFLE VPEAQEDVEA TFPVHQPGNY SCSYRTDGEG ALSEPSATVT
210 220 230 240 250
IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD FQLRRGEKEL
260 270 280 290 300
LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI
310 320 330 340 350
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ
360 370 380 390 400
SPAGTEALFE LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP
410 420 430 440 450
PRPQLRATWS GAVLAGRDAV LRCEGPIPDV TFELLREGET KAVKTVRTPG
460 470 480 490
AAANLELIFV GPQHAGNYRC RYRSWVPHTF ESELSDPVEL LVAES
Length:495
Mass (Da):54,254
Last modified:January 11, 2011 - v4
Checksum:i8E611BDC3BC824C8
GO
Isoform 2 (identifier: P04217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):40,718
Checksum:i13B698EF0DEEE203
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051S → G in AAL07469 (Ref. 2) Curated
Sequence conflicti127 – 1271S → P in AAL07469 (Ref. 2) Curated
Sequence conflicti146 – 1461V → E in AAL07469 (Ref. 2) Curated
Sequence conflicti304 – 3041E → G in BAF82106 (PubMed:14702039).Curated
Sequence conflicti413 – 4131V → A in AAL07469 (Ref. 2) Curated
Sequence conflicti446 – 4472VR → IP in AAL07469 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521H → R.3 Publications
Corresponds to variant rs893184 [ dbSNP | Ensembl ].
VAR_018369
Natural varianti395 – 3951H → R.
Corresponds to variant rs2241788 [ dbSNP | Ensembl ].
VAR_018370

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 122122Missing in isoform 2. 1 PublicationVSP_040323Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073611 mRNA. Translation: BAD38648.1.
AF414429 mRNA. Translation: AAL07469.1.
AK289417 mRNA. Translation: BAF82106.1.
AC010642 Genomic DNA. No translation available.
AC012313 Genomic DNA. No translation available.
BC035719 mRNA. Translation: AAH35719.1.
CCDSiCCDS12976.1. [P04217-1]
RefSeqiNP_570602.2. NM_130786.3. [P04217-1]
UniGeneiHs.529161.
Hs.709582.

Genome annotation databases

EnsembliENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
GeneIDi1.
KEGGihsa:1.
UCSCiuc002qsd.4. human. [P04217-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073611 mRNA. Translation: BAD38648.1.
AF414429 mRNA. Translation: AAL07469.1.
AK289417 mRNA. Translation: BAF82106.1.
AC010642 Genomic DNA. No translation available.
AC012313 Genomic DNA. No translation available.
BC035719 mRNA. Translation: AAH35719.1.
CCDSiCCDS12976.1. [P04217-1]
RefSeqiNP_570602.2. NM_130786.3. [P04217-1]
UniGeneiHs.529161.
Hs.709582.

3D structure databases

ProteinModelPortaliP04217.
SMRiP04217. Positions 28-195, 208-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106523. 25 interactions.
IntActiP04217. 9 interactions.
MINTiMINT-8247347.
STRINGi9606.ENSP00000263100.

Protein family/group databases

MEROPSiI43.950.

PTM databases

PhosphoSiteiP04217.

Polymorphism and mutation databases

BioMutaiA1BG.
DMDMi317373553.

2D gel databases

DOSAC-COBS-2DPAGEP04217.
REPRODUCTION-2DPAGEIPI00022895.
SWISS-2DPAGEP04217.

Proteomic databases

PaxDbiP04217.
PeptideAtlasiP04217.
PRIDEiP04217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263100; ENSP00000263100; ENSG00000121410. [P04217-1]
GeneIDi1.
KEGGihsa:1.
UCSCiuc002qsd.4. human. [P04217-1]

Organism-specific databases

CTDi1.
GeneCardsiGC19M058858.
HGNCiHGNC:5. A1BG.
HPAiCAB016673.
HPA044252.
MIMi138670. gene.
neXtProtiNX_P04217.
PharmGKBiPA24356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG26440.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiP04217.
OMAiYTCRYQL.
OrthoDBiEOG78SQGZ.
PhylomeDBiP04217.
TreeFamiTF336644.

Miscellaneous databases

ChiTaRSiA1BG. human.
GeneWikiiA1BG_(gene).
GenomeRNAii1.
NextBioi1.
PROiP04217.
SOURCEiSearch...

Gene expression databases

BgeeiP04217.
CleanExiHS_A1BG.
ExpressionAtlasiP04217. baseline.
GenevisibleiP04217. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and characterization of the human A1BG gene."
    Zhao Y., Sun D.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-52.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-52.
    Tissue: Mammary gland.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  6. "Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family."
    Ishioka N., Takahashi N., Putnam F.W.
    Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44; ASN-179; ASN-363 AND ASN-371, VARIANT ARG-52.
  7. "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
    Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
    Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRISP3.
  8. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179.
    Tissue: Plasma.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 AND ASN-371.
    Tissue: Plasma.
  10. "Enrichment of glycopeptides for glycan structure and attachment site identification."
    Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
    Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, STRUCTURE OF CARBOHYDRATES.
    Tissue: Cerebrospinal fluid.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiA1BG_HUMAN
AccessioniPrimary (citable) accession number: P04217
Secondary accession number(s): A8K052
, Q68CK0, Q8IYJ6, Q96P39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 148 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.