P04216 (THY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thy-1 membrane glycoprotein

Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen=CD90

Gene names

Name:

THY1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB focal adhesion assembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell activation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB retinal cone cell development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	anchored to external side of plasma membrane Inferred from electronic annotation. Source: Compara apical plasma membrane Inferred from direct assay PubMed 14757759. Source: BHF-UCL cytosol Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from direct assay. Source: LIFEdb external side of plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB growth cone Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Traceable author statement PubMed 2864289. Source: ProtInc membrane raft Non-traceable author statement PubMed 15093746. Source: UniProtKB
Molecular_function	GPI anchor binding Inferred from sequence or structural similarity. Source: UniProtKB Rho GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 130	111	Thy-1 membrane glycoprotein		PRO_0000014973
	Propeptide	131 – 161	31	Removed in mature form By similarity		PRO_0000014974
Regions
	Domain	20 – 126	107	Ig-like V-type
Amino acid modifications
	Modified residue	20	1	Pyrrolidone carboxylic acid By similarity
	Lipidation	130	1	GPI-anchor amidated cysteine By similarity
	Glycosylation	42	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Ref.6 Ref.7
	Glycosylation	139	1	N-linked (GlcNAc...)
	Disulfide bond	28 ↔ 130		By similarity
	Disulfide bond	38 ↔ 104		By similarity
Experimental info
	Sequence conflict	54 – 55	2	LT → AP Ref.5
	Sequence conflict	85	1	N → H in AAA61180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P04216 [UniParc]. Last modified May 2, 2002. Version 2. Checksum: 2B6796DA8EE7454B	FASTA	161	17,935
	10 20 30 40 50 60 MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY EFSLTRETKK 70 80 90 100 110 120 HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG TYTCALHHSG HSPPISSQNV 130 140 150 160 TVLRDKLVKC EGISLLAQNT SWLLLLLLSL SLLQATDFMS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human Thy-1 gene: structure and chromosomal location." Seki T., Spurr N., Obata F., Goyert S., Goodfellow P., Silver J. Proc. Natl. Acad. Sci. U.S.A. 82:6657-6661(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs." Ye Z., Connor J.R. Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Expression of Thy-1 on human hematopoietic progenitor cells." Craig W., Kay R., Cutler R.L., Lansdorp P.M. J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119, MASS SPECTROMETRY. Tissue: Liver.
[7]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11749 Genomic DNA. Translation: AAA61180.1. AF261093 mRNA. Translation: AAG13904.1. AL161958 mRNA. Translation: CAB82306.1. BC065559 mRNA. Translation: AAH65559.1. S59749 mRNA. Translation: AAB26353.2.
IPI	IPI00022892.
PIR	TDHU. A02106. T47130.
RefSeq	NP_006279.2. NM_006288.3.
UniGene	Hs.644697.
3D structure databases
ProteinModelPortal	P04216.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2878030.
STRING	9606.ENSP00000284240.
PTM databases
PhosphoSite	P04216.
Polymorphism databases
DMDM	20455514.
Proteomic databases
PaxDb	P04216.
PRIDE	P04216.
Protocols and materials databases
DNASU	7070.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284240; ENSP00000284240; ENSG00000154096. ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneID	7070.
KEGG	hsa:7070.
UCSC	uc001pwr.3. human.
Organism-specific databases
CTD	7070.
GeneCards	GC11M119288.
HGNC	HGNC:11801. THY1.
HPA	HPA003733.
MIM	188230. gene.
neXtProt	NX_P04216.
PharmGKB	PA36510.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43439.
HOGENOM	HOG000048719.
HOVERGEN	HBG002958.
InParanoid	P04216.
KO	K06514.
OrthoDB	EOG4SF977.
PhylomeDB	P04216.
Enzyme and pathway databases
Pathway_Interaction_DB	amb2_neutrophils_pathway. amb2 Integrin signaling. il4_2pathway. IL4-mediated signaling events.
Gene expression databases
ArrayExpress	P04216.
Bgee	P04216.
CleanEx	HS_THY1.
Genevestigator	P04216.
GermOnline	ENSG00000154096. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7070.
NextBio	27645.
SOURCE	Search...

Entry information

Entry name

THY1_HUMAN

Accession

Primary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	May 2, 2002
Last modified:	May 1, 2013
This is version 141 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.