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Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  • GPI anchor binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11801. THY1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: GO_Central
  • apical plasma membrane Source: BHF-UCL
  • cytosol Source: Ensembl
  • dendrite Source: GO_Central
  • endoplasmic reticulum Source: LIFEdb
  • external side of plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • growth cone Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: UniProtKB
  • myelin sheath Source: GO_Central
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7070.
OpenTargetsiENSG00000154096.
PharmGKBiPA36510.

Polymorphism and mutation databases

BioMutaiTHY1.
DMDMi20455514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001497320 – 130Thy-1 membrane glycoproteinAdd BLAST111
PropeptideiPRO_0000014974131 – 161Removed in mature formBy similarityAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
Glycosylationi42N-linked (GlcNAc...)1 Publication1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Modified residuei82PhosphoserineBy similarity1
Glycosylationi119N-linked (GlcNAc...)2 Publications1
Lipidationi130GPI-anchor amidated cysteine; alternateBy similarity1
Glycosylationi139N-linked (GlcNAc...)1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP04216.
MaxQBiP04216.
PaxDbiP04216.
PeptideAtlasiP04216.
PRIDEiP04216.

PTM databases

iPTMnetiP04216.
PhosphoSitePlusiP04216.
SwissPalmiP04216.

Expressioni

Gene expression databases

BgeeiENSG00000154096.
CleanExiHS_THY1.
ExpressionAtlasiP04216. baseline and differential.
GenevisibleiP04216. HS.

Organism-specific databases

HPAiCAB068243.
CAB068244.
HPA003733.

Interactioni

GO - Molecular functioni

  • integrin binding Source: UniProtKB
  • protein kinase binding Source: GO_Central

Protein-protein interaction databases

BioGridi112926. 27 interactors.
IntActiP04216. 2 interactors.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

Structurei

3D structure databases

ProteinModelPortaliP04216.
SMRiP04216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 126Ig-like V-typeAdd BLAST107

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiTCELRLS.
PhylomeDBiP04216.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY
60 70 80 90 100
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG
110 120 130 140 150
TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL
160
SLLQATDFMS L
Length:161
Mass (Da):17,935
Last modified:May 2, 2002 - v2
Checksum:i2B6796DA8EE7454B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55LT → AP (PubMed:7683034).Curated2
Sequence conflicti85N → H in AAA61180 (PubMed:2864690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_001298089.1. NM_001311160.1.
NP_001298091.1. NM_001311162.1.
NP_006279.2. NM_006288.4.
UniGeneiHs.644697.

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_001298089.1. NM_001311160.1.
NP_001298091.1. NM_001311162.1.
NP_006279.2. NM_006288.4.
UniGeneiHs.644697.

3D structure databases

ProteinModelPortaliP04216.
SMRiP04216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112926. 27 interactors.
IntActiP04216. 2 interactors.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

PTM databases

iPTMnetiP04216.
PhosphoSitePlusiP04216.
SwissPalmiP04216.

Polymorphism and mutation databases

BioMutaiTHY1.
DMDMi20455514.

Proteomic databases

EPDiP04216.
MaxQBiP04216.
PaxDbiP04216.
PeptideAtlasiP04216.
PRIDEiP04216.

Protocols and materials databases

DNASUi7070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.4. human.

Organism-specific databases

CTDi7070.
DisGeNETi7070.
GeneCardsiTHY1.
HGNCiHGNC:11801. THY1.
HPAiCAB068243.
CAB068244.
HPA003733.
MIMi188230. gene.
neXtProtiNX_P04216.
OpenTargetsiENSG00000154096.
PharmGKBiPA36510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiTCELRLS.
PhylomeDBiP04216.
TreeFamiTF336059.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154096-MONOMER.

Miscellaneous databases

GeneWikiiCD90.
GenomeRNAii7070.
PROiP04216.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154096.
CleanExiHS_THY1.
ExpressionAtlasiP04216. baseline and differential.
GenevisibleiP04216. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHY1_HUMAN
AccessioniPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: November 2, 2016
This is version 175 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.