Reviewed, UniProtKB/Swiss-Prot P04216 (THY1_HUMAN)

Names and origin

Protein names

Recommended name:
    Thy-1 membrane glycoprotein
Alternative name(s):
    Thy-1 antigen
    CDw90
    CD_antigen=CD90

Gene names

Name:

THY1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB focal adhesion assembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell activation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB retinal cone cell development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: LIFEdb growth cone Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Traceable author statement. Source: ProtInc membrane raft Non-traceable author statement. Source: UniProtKB
Molecular function	GPI anchor binding Inferred from sequence or structural similarity. Source: UniProtKB Rho GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB integrin binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 130	111	Thy-1 membrane glycoprotein		PRO_0000014973
	Propeptide	131 – 161	31	Removed in mature form By similarity		PRO_0000014974
Regions
	Domain	20 – 126	107	Ig-like V-type
Amino acid modifications
	Modified residue	20	1	Pyrrolidone carboxylic acid By similarity
	Lipidation	130	1	GPI-anchor amidated cysteine By similarity
	Glycosylation	42	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Ref.7 Ref.6
	Glycosylation	139	1	N-linked (GlcNAc...)
	Disulfide bond	28 ↔ 130		By similarity
	Disulfide bond	38 ↔ 104		By similarity
Experimental info
	Sequence conflict	54 – 55	2	LT → AP Ref.5
	Sequence conflict	85	1	N → H in AAA61180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P04216-1 [UniParc]. Last modified May 2, 2002. Version 2. Checksum: 2B6796DA8EE7454B	FASTA	161	17,935
	10 20 30 40 50 60 MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY EFSLTRETKK 70 80 90 100 110 120 HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG TYTCALHHSG HSPPISSQNV 130 140 150 160 TVLRDKLVKC EGISLLAQNT SWLLLLLLSL SLLQATDFMS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human Thy-1 gene: structure and chromosomal location." Seki T., Spurr N., Obata F., Goyert S., Goodfellow P., Silver J. Proc. Natl. Acad. Sci. U.S.A. 82:6657-6661(1985) [PubMed: 2864690] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs." Ye Z., Connor J.R. Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed: 10944468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Expression of Thy-1 on human hematopoietic progenitor cells." Craig W., Kay R., Cutler R.L., Lansdorp P.M. J. Exp. Med. 177:1331-1342(1993) [PubMed: 7683034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119, MASS SPECTROMETRY. Tissue: Liver.
[7]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11749 Genomic DNA. Translation: AAA61180.1. AF261093 mRNA. Translation: AAG13904.1. AL161958 mRNA. Translation: CAB82306.1. BC065559 mRNA. Translation: AAH65559.1. S59749 mRNA. Translation: AAB26353.2.
IPI	IPI00022892.
PIR	TDHU. A02106. T47130.
RefSeq	NP_006279.2.
UniGene	Hs.644697
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P04216.
Proteomic databases
PRIDE	P04216.
Genome annotation databases
Ensembl	ENST00000284240; ENSP00000284240; ENSG00000154096; Homo sapiens. [Genome view]
GeneID	7070.
KEGG	hsa:7070.
UCSC	uc001pwq.1. human.
Organism-specific databases
CTD	7070.
GeneCards	GC11M118795.
H-InvDB	HIX0010195.
HGNC	HGNC:11801. THY1.
HPA	HPA003733.
MIM	188230. gene.
PharmGKB	PA36510.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07345.
HOGENOM	HBG279081.
HOVERGEN	P04216.
InParanoid	P04216.
OMA	LPIQYEF.
OrthoDB	EOG9NKFFB.
PhylomeDB	P04216.
Enzyme and pathway databases
Pathway_Interaction_DB	amb2_neutrophils_pathway. amb2 Integrin signaling. il4_2pathway. IL4-mediated signaling events.
Gene expression databases
ArrayExpress	P04216.
Bgee	P04216.
CleanEx	HS_THY1.
Genevestigator	P04216.
GermOnline	ENSG00000154096. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	27645.
SOURCE	Search...

Entry information

Entry name

THY1_HUMAN

Accession

Primary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	May 2, 2002
Last modified:	February 9, 2010
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.