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P04216 (THY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen=CD90
Gene names
Name:THY1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cytoskeleton organization

Inferred from sequence or structural similarity. Source: UniProtKB

focal adhesion assembly

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of T cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of axonogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of T cell activation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

retinal cone cell development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentanchored component of external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

apical plasma membrane

Inferred from direct assay PubMed 14757759. Source: BHF-UCL

cytosol

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

external side of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

growth cone

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of plasma membrane

Traceable author statement PubMed 2864289. Source: ProtInc

membrane raft

Non-traceable author statement PubMed 15093746. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionGPI anchor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Rho GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

integrin binding

Inferred from physical interaction PubMed 15004192. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 130111Thy-1 membrane glycoprotein
PRO_0000014973
Propeptide131 – 16131Removed in mature form By similarity
PRO_0000014974

Regions

Domain20 – 126107Ig-like V-type

Amino acid modifications

Modified residue201Pyrrolidone carboxylic acid By similarity
Lipidation1301GPI-anchor amidated cysteine; alternate By similarity
Glycosylation421N-linked (GlcNAc...) Ref.7
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation1391N-linked (GlcNAc...)
Disulfide bond28 ↔ 130Alternate By similarity
Disulfide bond38 ↔ 104 By similarity

Experimental info

Sequence conflict54 – 552LT → AP Ref.5
Sequence conflict851N → H in AAA61180. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P04216 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: 2B6796DA8EE7454B

FASTA16117,935
        10         20         30         40         50         60 
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY EFSLTRETKK 

        70         80         90        100        110        120 
HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG TYTCALHHSG HSPPISSQNV 

       130        140        150        160 
TVLRDKLVKC EGISLLAQNT SWLLLLLLSL SLLQATDFMS L 

« Hide

References

« Hide 'large scale' references
[1]"The human Thy-1 gene: structure and chromosomal location."
Seki T., Spurr N., Obata F., Goyert S., Goodfellow P., Silver J.
Proc. Natl. Acad. Sci. U.S.A. 82:6657-6661(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
Ye Z., Connor J.R.
Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]"Expression of Thy-1 on human hematopoietic progenitor cells."
Craig W., Kay R., Cutler R.L., Lansdorp P.M.
J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
Tissue: Liver.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
PIRTDHU. A02106.
T47130.
RefSeqNP_006279.2. NM_006288.3.
UniGeneHs.644697.

3D structure databases

ProteinModelPortalP04216.
SMRP04216. Positions 28-112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112926. 26 interactions.
IntActP04216. 1 interaction.
MINTMINT-2878030.
STRING9606.ENSP00000284240.

PTM databases

PhosphoSiteP04216.

Polymorphism databases

DMDM20455514.

Proteomic databases

PaxDbP04216.
PRIDEP04216.

Protocols and materials databases

DNASU7070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneID7070.
KEGGhsa:7070.
UCSCuc001pwr.3. human.

Organism-specific databases

CTD7070.
GeneCardsGC11M119288.
HGNCHGNC:11801. THY1.
HPAHPA003733.
MIM188230. gene.
neXtProtNX_P04216.
PharmGKBPA36510.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43439.
HOGENOMHOG000048719.
HOVERGENHBG002958.
InParanoidP04216.
KOK06514.
OrthoDBEOG789CCZ.
PhylomeDBP04216.
TreeFamTF336059.

Gene expression databases

ArrayExpressP04216.
BgeeP04216.
CleanExHS_THY1.
GenevestigatorP04216.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD90.
GenomeRNAi7070.
NextBio27645.
PROP04216.
SOURCESearch...

Entry information

Entry nameTHY1_HUMAN
AccessionPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: April 16, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries