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Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB
  2. GTPase activator activity Source: UniProtKB
  3. integrin binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. cytoskeleton organization Source: UniProtKB
  3. focal adhesion assembly Source: UniProtKB
  4. negative regulation of axonogenesis Source: UniProtKB
  5. negative regulation of cell migration Source: UniProtKB
  6. negative regulation of protein kinase activity Source: UniProtKB
  7. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  8. positive regulation of GTPase activity Source: UniProtKB
  9. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  10. positive regulation of T cell activation Source: UniProtKB
  11. retinal cone cell development Source: UniProtKB
  12. single organismal cell-cell adhesion Source: UniProtKB
  13. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11801. THY1.

Subcellular locationi

  1. Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: Ensembl
  2. apical plasma membrane Source: BHF-UCL
  3. cytosol Source: Ensembl
  4. dendrite Source: Ensembl
  5. endoplasmic reticulum Source: LIFEdb
  6. external side of plasma membrane Source: UniProtKB
  7. extracellular vesicular exosome Source: UniProtKB
  8. focal adhesion Source: UniProtKB
  9. growth cone Source: UniProtKB
  10. integral component of plasma membrane Source: ProtInc
  11. membrane raft Source: UniProtKB
  12. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36510.

Polymorphism and mutation databases

BioMutaiTHY1.
DMDMi20455514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 130111Thy-1 membrane glycoproteinPRO_0000014973Add
BLAST
Propeptidei131 – 16131Removed in mature formBy similarityPRO_0000014974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)2 Publications
Lipidationi130 – 1301GPI-anchor amidated cysteine; alternateBy similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP04216.
PaxDbiP04216.
PRIDEiP04216.

PTM databases

PhosphoSiteiP04216.

Expressioni

Gene expression databases

BgeeiP04216.
CleanExiHS_THY1.
ExpressionAtlasiP04216. baseline and differential.
GenevestigatoriP04216.

Organism-specific databases

HPAiCAB068243.
CAB068244.
HPA003733.

Interactioni

Protein-protein interaction databases

BioGridi112926. 26 interactions.
IntActiP04216. 2 interactions.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

Structurei

3D structure databases

ProteinModelPortaliP04216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 126107Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG43439.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiGVPEHSY.
OrthoDBiEOG789CCZ.
PhylomeDBiP04216.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY
60 70 80 90 100
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG
110 120 130 140 150
TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL
160
SLLQATDFMS L
Length:161
Mass (Da):17,935
Last modified:May 2, 2002 - v2
Checksum:i2B6796DA8EE7454B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552LT → AP (PubMed:7683034).Curated
Sequence conflicti85 – 851N → H in AAA61180 (PubMed:2864690).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_006279.2. NM_006288.3.
UniGeneiHs.644697.

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.3. human.

Polymorphism and mutation databases

BioMutaiTHY1.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_006279.2. NM_006288.3.
UniGeneiHs.644697.

3D structure databases

ProteinModelPortaliP04216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112926. 26 interactions.
IntActiP04216. 2 interactions.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

PTM databases

PhosphoSiteiP04216.

Polymorphism and mutation databases

BioMutaiTHY1.
DMDMi20455514.

Proteomic databases

MaxQBiP04216.
PaxDbiP04216.
PRIDEiP04216.

Protocols and materials databases

DNASUi7070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.3. human.

Organism-specific databases

CTDi7070.
GeneCardsiGC11M119288.
HGNCiHGNC:11801. THY1.
HPAiCAB068243.
CAB068244.
HPA003733.
MIMi188230. gene.
neXtProtiNX_P04216.
PharmGKBiPA36510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43439.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiGVPEHSY.
OrthoDBiEOG789CCZ.
PhylomeDBiP04216.
TreeFamiTF336059.

Miscellaneous databases

GeneWikiiCD90.
GenomeRNAii7070.
NextBioi27645.
PROiP04216.
SOURCEiSearch...

Gene expression databases

BgeeiP04216.
CleanExiHS_THY1.
ExpressionAtlasiP04216. baseline and differential.
GenevestigatoriP04216.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
    Ye Z., Connor J.R.
    Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Expression of Thy-1 on human hematopoietic progenitor cells."
    Craig W., Kay R., Cutler R.L., Lansdorp P.M.
    J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiTHY1_HUMAN
AccessioniPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: April 29, 2015
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.