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P04216

- THY1_HUMAN

UniProt

P04216 - THY1_HUMAN

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Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB
  2. integrin binding Source: UniProtKB
  3. Rho GTPase activator activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. cytoskeleton organization Source: UniProtKB
  3. focal adhesion assembly Source: UniProtKB
  4. negative regulation of axonogenesis Source: UniProtKB
  5. negative regulation of cell migration Source: UniProtKB
  6. negative regulation of protein kinase activity Source: UniProtKB
  7. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  8. positive regulation of GTPase activity Source: UniProtKB
  9. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  10. positive regulation of T cell activation Source: UniProtKB
  11. retinal cone cell development Source: UniProtKB
  12. single organismal cell-cell adhesion Source: UniProtKB
  13. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11801. THY1.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: Ensembl
  2. apical plasma membrane Source: BHF-UCL
  3. cytosol Source: Ensembl
  4. dendrite Source: Ensembl
  5. endoplasmic reticulum Source: LIFEdb
  6. external side of plasma membrane Source: UniProtKB
  7. extracellular vesicular exosome Source: UniProtKB
  8. focal adhesion Source: UniProtKB
  9. growth cone Source: UniProtKB
  10. integral component of plasma membrane Source: ProtInc
  11. membrane raft Source: UniProtKB
  12. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 130111Thy-1 membrane glycoproteinPRO_0000014973Add
BLAST
Propeptidei131 – 16131Removed in mature formBy similarityPRO_0000014974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)2 Publications
Lipidationi130 – 1301GPI-anchor amidated cysteine; alternateBy similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP04216.
PaxDbiP04216.
PRIDEiP04216.

PTM databases

PhosphoSiteiP04216.

Expressioni

Gene expression databases

BgeeiP04216.
CleanExiHS_THY1.
ExpressionAtlasiP04216. baseline and differential.
GenevestigatoriP04216.

Organism-specific databases

HPAiHPA003733.

Interactioni

Protein-protein interaction databases

BioGridi112926. 26 interactions.
IntActiP04216. 2 interactions.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

Structurei

3D structure databases

ProteinModelPortaliP04216.
SMRiP04216. Positions 30-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 126107Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG43439.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiIVREHED.
OrthoDBiEOG789CCZ.
PhylomeDBiP04216.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04216-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY
60 70 80 90 100
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG
110 120 130 140 150
TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL
160
SLLQATDFMS L
Length:161
Mass (Da):17,935
Last modified:May 2, 2002 - v2
Checksum:i2B6796DA8EE7454B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552LT → AP(PubMed:7683034)Curated
Sequence conflicti85 – 851N → H in AAA61180. (PubMed:2864690)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_006279.2. NM_006288.3.
UniGeneiHs.644697.

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.3. human.

Polymorphism databases

DMDMi20455514.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1 .
AF261093 mRNA. Translation: AAG13904.1 .
AL161958 mRNA. Translation: CAB82306.1 .
BC065559 mRNA. Translation: AAH65559.1 .
S59749 mRNA. Translation: AAB26353.2 .
CCDSi CCDS8424.1.
PIRi A02106. TDHU.
T47130.
RefSeqi NP_006279.2. NM_006288.3.
UniGenei Hs.644697.

3D structure databases

ProteinModelPortali P04216.
SMRi P04216. Positions 30-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112926. 26 interactions.
IntActi P04216. 2 interactions.
MINTi MINT-2878030.
STRINGi 9606.ENSP00000284240.

PTM databases

PhosphoSitei P04216.

Polymorphism databases

DMDMi 20455514.

Proteomic databases

MaxQBi P04216.
PaxDbi P04216.
PRIDEi P04216.

Protocols and materials databases

DNASUi 7070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284240 ; ENSP00000284240 ; ENSG00000154096 .
ENST00000528522 ; ENSP00000431301 ; ENSG00000154096 .
GeneIDi 7070.
KEGGi hsa:7070.
UCSCi uc001pwr.3. human.

Organism-specific databases

CTDi 7070.
GeneCardsi GC11M119288.
HGNCi HGNC:11801. THY1.
HPAi HPA003733.
MIMi 188230. gene.
neXtProti NX_P04216.
PharmGKBi PA36510.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43439.
GeneTreei ENSGT00390000012352.
HOGENOMi HOG000048719.
HOVERGENi HBG002958.
InParanoidi P04216.
KOi K06514.
OMAi IVREHED.
OrthoDBi EOG789CCZ.
PhylomeDBi P04216.
TreeFami TF336059.

Miscellaneous databases

GeneWikii CD90.
GenomeRNAii 7070.
NextBioi 27645.
PROi P04216.
SOURCEi Search...

Gene expression databases

Bgeei P04216.
CleanExi HS_THY1.
ExpressionAtlasi P04216. baseline and differential.
Genevestigatori P04216.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
    Ye Z., Connor J.R.
    Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Expression of Thy-1 on human hematopoietic progenitor cells."
    Craig W., Kay R., Cutler R.L., Lansdorp P.M.
    J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiTHY1_HUMAN
AccessioniPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: November 26, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3