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P04216

- THY1_HUMAN

UniProt

P04216 - THY1_HUMAN

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Protein
Thy-1 membrane glycoprotein
Gene
THY1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB
  2. Rho GTPase activator activity Source: UniProtKB
  3. integrin binding Source: UniProtKB
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. T cell receptor signaling pathway Source: UniProtKB
  2. angiogenesis Source: UniProtKB
  3. cytoskeleton organization Source: UniProtKB
  4. focal adhesion assembly Source: UniProtKB
  5. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  6. negative regulation of axonogenesis Source: UniProtKB
  7. negative regulation of cell migration Source: UniProtKB
  8. negative regulation of protein kinase activity Source: UniProtKB
  9. positive regulation of GTPase activity Source: UniProtKB
  10. positive regulation of T cell activation Source: UniProtKB
  11. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  12. retinal cone cell development Source: UniProtKB
  13. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11801. THY1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: Ensembl
  2. apical plasma membrane Source: BHF-UCL
  3. cytosol Source: Ensembl
  4. dendrite Source: Ensembl
  5. endoplasmic reticulum Source: LIFEdb
  6. external side of plasma membrane Source: UniProtKB
  7. extracellular vesicular exosome Source: UniProt
  8. growth cone Source: UniProtKB
  9. integral component of plasma membrane Source: ProtInc
  10. membrane raft Source: UniProtKB
  11. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 130111Thy-1 membrane glycoprotein
PRO_0000014973Add
BLAST
Propeptidei131 – 16131Removed in mature form By similarity
PRO_0000014974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acid By similarity
Disulfide bondi28 ↔ 130Alternate By similarity
Disulfide bondi38 ↔ 104 By similarity
Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...)2 Publications
Lipidationi130 – 1301GPI-anchor amidated cysteine; alternate By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP04216.
PaxDbiP04216.
PRIDEiP04216.

PTM databases

PhosphoSiteiP04216.

Expressioni

Gene expression databases

ArrayExpressiP04216.
BgeeiP04216.
CleanExiHS_THY1.
GenevestigatoriP04216.

Organism-specific databases

HPAiHPA003733.

Interactioni

Protein-protein interaction databases

BioGridi112926. 26 interactions.
IntActiP04216. 1 interaction.
MINTiMINT-2878030.
STRINGi9606.ENSP00000284240.

Structurei

3D structure databases

ProteinModelPortaliP04216.
SMRiP04216. Positions 30-126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 126107Ig-like V-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG43439.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP04216.
KOiK06514.
OMAiIVREHED.
OrthoDBiEOG789CCZ.
PhylomeDBiP04216.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04216-1 [UniParc]FASTAAdd to Basket

« Hide

MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY    50
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG 100
TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL 150
SLLQATDFMS L 161
Length:161
Mass (Da):17,935
Last modified:May 2, 2002 - v2
Checksum:i2B6796DA8EE7454B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552LT → AP1 Publication
Sequence conflicti85 – 851N → H in AAA61180. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1.
AF261093 mRNA. Translation: AAG13904.1.
AL161958 mRNA. Translation: CAB82306.1.
BC065559 mRNA. Translation: AAH65559.1.
S59749 mRNA. Translation: AAB26353.2.
CCDSiCCDS8424.1.
PIRiA02106. TDHU.
T47130.
RefSeqiNP_006279.2. NM_006288.3.
UniGeneiHs.644697.

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
ENST00000528522; ENSP00000431301; ENSG00000154096.
GeneIDi7070.
KEGGihsa:7070.
UCSCiuc001pwr.3. human.

Polymorphism databases

DMDMi20455514.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11749 Genomic DNA. Translation: AAA61180.1 .
AF261093 mRNA. Translation: AAG13904.1 .
AL161958 mRNA. Translation: CAB82306.1 .
BC065559 mRNA. Translation: AAH65559.1 .
S59749 mRNA. Translation: AAB26353.2 .
CCDSi CCDS8424.1.
PIRi A02106. TDHU.
T47130.
RefSeqi NP_006279.2. NM_006288.3.
UniGenei Hs.644697.

3D structure databases

ProteinModelPortali P04216.
SMRi P04216. Positions 30-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112926. 26 interactions.
IntActi P04216. 1 interaction.
MINTi MINT-2878030.
STRINGi 9606.ENSP00000284240.

PTM databases

PhosphoSitei P04216.

Polymorphism databases

DMDMi 20455514.

Proteomic databases

MaxQBi P04216.
PaxDbi P04216.
PRIDEi P04216.

Protocols and materials databases

DNASUi 7070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284240 ; ENSP00000284240 ; ENSG00000154096 .
ENST00000528522 ; ENSP00000431301 ; ENSG00000154096 .
GeneIDi 7070.
KEGGi hsa:7070.
UCSCi uc001pwr.3. human.

Organism-specific databases

CTDi 7070.
GeneCardsi GC11M119288.
HGNCi HGNC:11801. THY1.
HPAi HPA003733.
MIMi 188230. gene.
neXtProti NX_P04216.
PharmGKBi PA36510.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43439.
HOGENOMi HOG000048719.
HOVERGENi HBG002958.
InParanoidi P04216.
KOi K06514.
OMAi IVREHED.
OrthoDBi EOG789CCZ.
PhylomeDBi P04216.
TreeFami TF336059.

Miscellaneous databases

GeneWikii CD90.
GenomeRNAii 7070.
NextBioi 27645.
PROi P04216.
SOURCEi Search...

Gene expression databases

ArrayExpressi P04216.
Bgeei P04216.
CleanExi HS_THY1.
Genevestigatori P04216.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
    Ye Z., Connor J.R.
    Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Expression of Thy-1 on human hematopoietic progenitor cells."
    Craig W., Kay R., Cutler R.L., Lansdorp P.M.
    J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiTHY1_HUMAN
AccessioniPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: July 9, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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