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P04216

- THY1_HUMAN

UniProt

P04216 - THY1_HUMAN

Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

    GO - Molecular functioni

    1. GPI anchor binding Source: UniProtKB
    2. integrin binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. Rho GTPase activator activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cytoskeleton organization Source: UniProtKB
    3. focal adhesion assembly Source: UniProtKB
    4. negative regulation of axonogenesis Source: UniProtKB
    5. negative regulation of cell migration Source: UniProtKB
    6. negative regulation of protein kinase activity Source: UniProtKB
    7. negative regulation of T cell receptor signaling pathway Source: UniProtKB
    8. positive regulation of GTPase activity Source: UniProtKB
    9. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    10. positive regulation of T cell activation Source: UniProtKB
    11. retinal cone cell development Source: UniProtKB
    12. single organismal cell-cell adhesion Source: UniProtKB
    13. T cell receptor signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thy-1 membrane glycoprotein
    Alternative name(s):
    CDw90
    Thy-1 antigen
    CD_antigen: CD90
    Gene namesi
    Name:THY1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11801. THY1.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: Ensembl
    2. apical plasma membrane Source: BHF-UCL
    3. cytosol Source: Ensembl
    4. dendrite Source: Ensembl
    5. endoplasmic reticulum Source: LIFEdb
    6. external side of plasma membrane Source: UniProtKB
    7. extracellular vesicular exosome Source: UniProt
    8. growth cone Source: UniProtKB
    9. integral component of plasma membrane Source: ProtInc
    10. membrane raft Source: UniProtKB
    11. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36510.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 130111Thy-1 membrane glycoproteinPRO_0000014973Add
    BLAST
    Propeptidei131 – 16131Removed in mature formBy similarityPRO_0000014974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
    Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
    Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)2 Publications
    Lipidationi130 – 1301GPI-anchor amidated cysteine; alternateBy similarity
    Glycosylationi139 – 1391N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP04216.
    PaxDbiP04216.
    PRIDEiP04216.

    PTM databases

    PhosphoSiteiP04216.

    Expressioni

    Gene expression databases

    ArrayExpressiP04216.
    BgeeiP04216.
    CleanExiHS_THY1.
    GenevestigatoriP04216.

    Organism-specific databases

    HPAiHPA003733.

    Interactioni

    Protein-protein interaction databases

    BioGridi112926. 26 interactions.
    IntActiP04216. 1 interaction.
    MINTiMINT-2878030.
    STRINGi9606.ENSP00000284240.

    Structurei

    3D structure databases

    ProteinModelPortaliP04216.
    SMRiP04216. Positions 30-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 126107Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG43439.
    HOGENOMiHOG000048719.
    HOVERGENiHBG002958.
    InParanoidiP04216.
    KOiK06514.
    OMAiIVREHED.
    OrthoDBiEOG789CCZ.
    PhylomeDBiP04216.
    TreeFamiTF336059.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY    50
    EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG 100
    TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL 150
    SLLQATDFMS L 161
    Length:161
    Mass (Da):17,935
    Last modified:May 2, 2002 - v2
    Checksum:i2B6796DA8EE7454B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 552LT → AP(PubMed:7683034)Curated
    Sequence conflicti85 – 851N → H in AAA61180. (PubMed:2864690)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11749 Genomic DNA. Translation: AAA61180.1.
    AF261093 mRNA. Translation: AAG13904.1.
    AL161958 mRNA. Translation: CAB82306.1.
    BC065559 mRNA. Translation: AAH65559.1.
    S59749 mRNA. Translation: AAB26353.2.
    CCDSiCCDS8424.1.
    PIRiA02106. TDHU.
    T47130.
    RefSeqiNP_006279.2. NM_006288.3.
    UniGeneiHs.644697.

    Genome annotation databases

    EnsembliENST00000284240; ENSP00000284240; ENSG00000154096.
    ENST00000528522; ENSP00000431301; ENSG00000154096.
    GeneIDi7070.
    KEGGihsa:7070.
    UCSCiuc001pwr.3. human.

    Polymorphism databases

    DMDMi20455514.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11749 Genomic DNA. Translation: AAA61180.1 .
    AF261093 mRNA. Translation: AAG13904.1 .
    AL161958 mRNA. Translation: CAB82306.1 .
    BC065559 mRNA. Translation: AAH65559.1 .
    S59749 mRNA. Translation: AAB26353.2 .
    CCDSi CCDS8424.1.
    PIRi A02106. TDHU.
    T47130.
    RefSeqi NP_006279.2. NM_006288.3.
    UniGenei Hs.644697.

    3D structure databases

    ProteinModelPortali P04216.
    SMRi P04216. Positions 30-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112926. 26 interactions.
    IntActi P04216. 1 interaction.
    MINTi MINT-2878030.
    STRINGi 9606.ENSP00000284240.

    PTM databases

    PhosphoSitei P04216.

    Polymorphism databases

    DMDMi 20455514.

    Proteomic databases

    MaxQBi P04216.
    PaxDbi P04216.
    PRIDEi P04216.

    Protocols and materials databases

    DNASUi 7070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284240 ; ENSP00000284240 ; ENSG00000154096 .
    ENST00000528522 ; ENSP00000431301 ; ENSG00000154096 .
    GeneIDi 7070.
    KEGGi hsa:7070.
    UCSCi uc001pwr.3. human.

    Organism-specific databases

    CTDi 7070.
    GeneCardsi GC11M119288.
    HGNCi HGNC:11801. THY1.
    HPAi HPA003733.
    MIMi 188230. gene.
    neXtProti NX_P04216.
    PharmGKBi PA36510.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43439.
    HOGENOMi HOG000048719.
    HOVERGENi HBG002958.
    InParanoidi P04216.
    KOi K06514.
    OMAi IVREHED.
    OrthoDBi EOG789CCZ.
    PhylomeDBi P04216.
    TreeFami TF336059.

    Miscellaneous databases

    GeneWikii CD90.
    GenomeRNAii 7070.
    NextBioi 27645.
    PROi P04216.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04216.
    Bgeei P04216.
    CleanExi HS_THY1.
    Genevestigatori P04216.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
      Ye Z., Connor J.R.
      Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    5. "Expression of Thy-1 on human hematopoietic progenitor cells."
      Craig W., Kay R., Cutler R.L., Lansdorp P.M.
      J. Exp. Med. 177:1331-1342(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
      Tissue: Liver.
    7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-119.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiTHY1_HUMAN
    AccessioniPrimary (citable) accession number: P04216
    Secondary accession number(s): Q16008, Q9NSP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3