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P04207

- KV308_HUMAN

UniProt

P04207 - KV308_HUMAN

Protein

Ig kappa chain V-III region CLL

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB

    GO - Biological processi

    1. complement activation Source: Reactome
    2. complement activation, classical pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    5. immune response Source: UniProtKB
    6. innate immune response Source: Reactome
    7. regulation of immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig kappa chain V-III region CLL
    Alternative name(s):
    Rheumatoid factor
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 129109Ig kappa chain V-III region CLLPRO_0000015175Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 108PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PeptideAtlasiP04207.
    PRIDEiP04207.

    Expressioni

    Gene expression databases

    GenevestigatoriP04207.

    Organism-specific databases

    HPAiHPA047702.

    Structurei

    3D structure databases

    ProteinModelPortaliP04207.
    SMRiP04207. Positions 21-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 4323Framework-1Add
    BLAST
    Regioni44 – 5411Complementarity-determining-1Add
    BLAST
    Regioni55 – 6915Framework-2Add
    BLAST
    Regioni70 – 767Complementarity-determining-2
    Regioni77 – 10832Framework-3Add
    BLAST
    Regioni109 – 11810Complementarity-determining-3
    Regioni119 – 12911JK1 segmentAdd
    BLAST

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region, Signal

    Phylogenomic databases

    HOGENOMiHOG000059537.
    HOVERGENiHBG018013.
    InParanoidiP04207.
    PhylomeDBiP04207.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPAQLLFL LLLWLPDTTG EIVMTQSPAT LSVSPGERAT LSCRASQSVS    50
    NNLAWYQQKP GQPPRLLIYG ASTRATGIPA RFSGSGSGTE FTLTISRLQS 100
    EDFAVYYCQQ YNNWPPWTFG QGTRVEIKR 129
    Length:129
    Mass (Da):14,275
    Last modified:November 1, 1990 - v2
    Checksum:i5C13B411BE60CC14
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei129 – 1291

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12740 Genomic DNA. Translation: AAA58992.1.
    PIRiA01898. K3HUCL.
    A30553.
    I30608.

    Polymorphism databases

    DMDMi125809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12740 Genomic DNA. Translation: AAA58992.1 .
    PIRi A01898. K3HUCL.
    A30553.
    I30608.

    3D structure databases

    ProteinModelPortali P04207.
    SMRi P04207. Positions 21-129.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    IMGTi Search...

    Polymorphism databases

    DMDMi 125809.

    Proteomic databases

    PeptideAtlasi P04207.
    PRIDEi P04207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    HPAi HPA047702.

    Phylogenomic databases

    HOGENOMi HOG000059537.
    HOVERGENi HBG018013.
    InParanoidi P04207.
    PhylomeDBi P04207.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Miscellaneous databases

    NextBioi 35537723.

    Gene expression databases

    Genevestigatori P04207.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence determination of a human rheumatoid factor light-chain gene."
      Jirik F.R., Sorge J., Fong S., Heitzmann J.G., Curd J.G., Chen P.P., Goldfien R., Carson D.A.
      Proc. Natl. Acad. Sci. U.S.A. 83:2195-2199(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKV308_HUMAN
    AccessioniPrimary (citable) accession number: P04207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM

    External Data

    Dasty 3