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P04207

- KV308_HUMAN

UniProt

P04207 - KV308_HUMAN

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Protein
Ig kappa chain V-III region CLL
Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  3. complement activation Source: Reactome
  4. complement activation, classical pathway Source: Reactome
  5. immune response Source: UniProtKB
  6. innate immune response Source: Reactome
  7. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-III region CLL
Alternative name(s):
Rheumatoid factor
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular region Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 129109Ig kappa chain V-III region CLL
PRO_0000015175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 108 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP04207.
PRIDEiP04207.

Expressioni

Gene expression databases

GenevestigatoriP04207.

Organism-specific databases

HPAiHPA047702.

Structurei

3D structure databases

ProteinModelPortaliP04207.
SMRiP04207. Positions 21-129.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 4323Framework-1
Add
BLAST
Regioni44 – 5411Complementarity-determining-1
Add
BLAST
Regioni55 – 6915Framework-2
Add
BLAST
Regioni70 – 767Complementarity-determining-2
Regioni77 – 10832Framework-3
Add
BLAST
Regioni109 – 11810Complementarity-determining-3
Regioni119 – 12911JK1 segment
Add
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP04207.
PhylomeDBiP04207.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04207-1 [UniParc]FASTAAdd to Basket

« Hide

MEAPAQLLFL LLLWLPDTTG EIVMTQSPAT LSVSPGERAT LSCRASQSVS    50
NNLAWYQQKP GQPPRLLIYG ASTRATGIPA RFSGSGSGTE FTLTISRLQS 100
EDFAVYYCQQ YNNWPPWTFG QGTRVEIKR 129
Length:129
Mass (Da):14,275
Last modified:November 1, 1990 - v2
Checksum:i5C13B411BE60CC14
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei129 – 1291

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12740 Genomic DNA. Translation: AAA58992.1.
PIRiA01898. K3HUCL.
A30553.
I30608.

Polymorphism databases

DMDMi125809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12740 Genomic DNA. Translation: AAA58992.1 .
PIRi A01898. K3HUCL.
A30553.
I30608.

3D structure databases

ProteinModelPortali P04207.
SMRi P04207. Positions 21-129.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

IMGTi Search...

Polymorphism databases

DMDMi 125809.

Proteomic databases

PeptideAtlasi P04207.
PRIDEi P04207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

HPAi HPA047702.

Phylogenomic databases

HOGENOMi HOG000059537.
HOVERGENi HBG018013.
InParanoidi P04207.
PhylomeDBi P04207.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

NextBioi 35537723.

Gene expression databases

Genevestigatori P04207.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence determination of a human rheumatoid factor light-chain gene."
    Jirik F.R., Sorge J., Fong S., Heitzmann J.G., Curd J.G., Chen P.P., Goldfien R., Carson D.A.
    Proc. Natl. Acad. Sci. U.S.A. 83:2195-2199(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKV308_HUMAN
AccessioniPrimary (citable) accession number: P04207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

External Data

Dasty 3

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