P04207 (KV308_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-III region CLL Alternative name(s): Rheumatoid factor
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 129	109	Ig kappa chain V-III region CLL		PRO_0000015175
Regions
	Region	21 – 43	23	Framework-1
	Region	44 – 54	11	Complementarity-determining-1
	Region	55 – 69	15	Framework-2
	Region	70 – 76	7	Complementarity-determining-2
	Region	77 – 108	32	Framework-3
	Region	109 – 118	10	Complementarity-determining-3
	Region	119 – 129	11	JK1 segment
Amino acid modifications
	Disulfide bond	43 ↔ 108		By similarity
Experimental info
	Non-terminal residue	129	1

Sequences

	Sequence		Length	Mass (Da)
	P04207 [UniParc]. Last modified November 1, 1990. Version 2. Checksum: 5C13B411BE60CC14	FASTA	129	14,275
	10 20 30 40 50 60 MEAPAQLLFL LLLWLPDTTG EIVMTQSPAT LSVSPGERAT LSCRASQSVS NNLAWYQQKP 70 80 90 100 110 120 GQPPRLLIYG ASTRATGIPA RFSGSGSGTE FTLTISRLQS EDFAVYYCQQ YNNWPPWTFG QGTRVEIKR

References

[1]

"Cloning and sequence determination of a human rheumatoid factor light-chain gene." Jirik F.R., Sorge J., Fong S., Heitzmann J.G., Curd J.G., Chen P.P., Goldfien R., Carson D.A. Proc. Natl. Acad. Sci. U.S.A. 83:2195-2199(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M12740 Genomic DNA. Translation: AAA58992.1.
IPI	IPI00385253.
PIR	K3HUCL. A01898. A30553. I30608.
3D structure databases
ProteinModelPortal	P04207.
ModBase	Search...
Protein family/group databases
IMGT	Search...
Polymorphism databases
DMDM	125809.
Proteomic databases
PeptideAtlas	P04207.
PRIDE	P04207.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC02M089430. GC02P090154.
HPA	HPA047702.
Phylogenomic databases
HOGENOM	HOG000059537.
HOVERGEN	HBG018013.
InParanoid	P04207.
OrthoDB	EOG4ZCT62.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P04207.
GermOnline	ENSG00000172038. Homo sapiens. ENSG00000173799. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35537723.

Entry information

Entry name

KV308_HUMAN

Accession

Primary (citable) accession number: P04207

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.