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P04207 (KV308_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig kappa chain V-III region CLL
Alternative name(s):
Rheumatoid factor
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 129109Ig kappa chain V-III region CLL
PRO_0000015175

Regions

Region21 – 4323Framework-1
Region44 – 5411Complementarity-determining-1
Region55 – 6915Framework-2
Region70 – 767Complementarity-determining-2
Region77 – 10832Framework-3
Region109 – 11810Complementarity-determining-3
Region119 – 12911JK1 segment

Amino acid modifications

Disulfide bond43 ↔ 108 By similarity

Experimental info

Non-terminal residue1291

Sequences

Sequence LengthMass (Da)Tools
P04207 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: 5C13B411BE60CC14

FASTA12914,275
        10         20         30         40         50         60 
MEAPAQLLFL LLLWLPDTTG EIVMTQSPAT LSVSPGERAT LSCRASQSVS NNLAWYQQKP 

        70         80         90        100        110        120 
GQPPRLLIYG ASTRATGIPA RFSGSGSGTE FTLTISRLQS EDFAVYYCQQ YNNWPPWTFG 


QGTRVEIKR 

« Hide

References

[1]"Cloning and sequence determination of a human rheumatoid factor light-chain gene."
Jirik F.R., Sorge J., Fong S., Heitzmann J.G., Curd J.G., Chen P.P., Goldfien R., Carson D.A.
Proc. Natl. Acad. Sci. U.S.A. 83:2195-2199(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12740 Genomic DNA. Translation: AAA58992.1.
PIRK3HUCL. A01898.
A30553.
I30608.

3D structure databases

ProteinModelPortalP04207.
SMRP04207. Positions 21-129.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

IMGTSearch...

Polymorphism databases

DMDM125809.

Proteomic databases

PeptideAtlasP04207.
PRIDEP04207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

HPAHPA047702.

Phylogenomic databases

HOGENOMHOG000059537.
HOVERGENHBG018013.
InParanoidP04207.
PhylomeDBP04207.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Gene expression databases

GenevestigatorP04207.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35537723.

Entry information

Entry nameKV308_HUMAN
AccessionPrimary (citable) accession number: P04207
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM