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Protein

Proto-oncogene Mas

Gene

MAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.By similarity2 Publications

GO - Molecular functioni

  1. angiotensin receptor activity Source: UniProtKB
  2. angiotensin type II receptor activity Source: ProtInc
  3. G-protein coupled receptor activity Source: UniProtKB
  4. peptide binding Source: UniProtKB
  5. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  2. anatomical structure morphogenesis Source: ProtInc
  3. cell proliferation Source: ProtInc
  4. cellular response to peptide hormone stimulus Source: Ensembl
  5. G-protein coupled receptor signaling pathway Source: ProtInc
  6. hippocampus development Source: Ensembl
  7. male gonad development Source: Ensembl
  8. negative regulation of protein phosphorylation Source: Ensembl
  9. positive regulation of cell proliferation Source: Ensembl
  10. positive regulation of DNA replication Source: Ensembl
  11. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  12. protein kinase C signaling Source: UniProtKB
  13. regulation of inflammatory response Source: Ensembl
  14. response to activity Source: Ensembl
  15. response to drug Source: Ensembl
  16. response to gonadotropin Source: Ensembl
  17. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Mas
Gene namesi
Name:MAS1
Synonyms:MAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6899. MAS1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei37 – 6125Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 654CytoplasmicSequence Analysis
Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12824Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17223Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 18513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini207 – 22418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini285 – 32541CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi138 – 1381I → D: Fails to activate GNA11. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Proto-oncogene MasPRO_0000069714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP04201.
PRIDEiP04201.

PTM databases

PhosphoSiteiP04201.

Expressioni

Gene expression databases

BgeeiP04201.
CleanExiHS_MAS1.
ExpressionAtlasiP04201. baseline and differential.
GenevestigatoriP04201.

Organism-specific databases

HPAiHPA013564.

Interactioni

Subunit structurei

Interacts with AGTR1.1 Publication

Protein-protein interaction databases

BioGridi110312. 1 interaction.
STRINGi9606.ENSP00000252660.

Structurei

3D structure databases

ProteinModelPortaliP04201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG137333.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP04201.
KOiK04303.
OMAiYELSSGH.
OrthoDBiEOG79PJPH.
PhylomeDBiP04201.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN
60 70 80 90 100
GILLWFLCFR MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG
110 120 130 140 150
HYYTIVTLSV TFLFGYNTGL YLLTAISVER CLSVLYPIWY RCHRPKYQSA
160 170 180 190 200
LVCALLWALS CLVTTMEYVM CIDREEESHS RNDCRAVIIF IAILSFLVFT
210 220 230 240 250
PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF AMPMRLLYLL
260 270 280 290 300
YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT
310 320
RAFKDEMQPR RQKDNCNTVT VETVV
Length:325
Mass (Da):37,465
Last modified:March 20, 1987 - v1
Checksum:i3368E7B174744B83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13150 mRNA. Translation: AAA36199.1.
CR542261 mRNA. Translation: CAG47057.1.
AL035691 Genomic DNA. Translation: CAB72444.1.
CH471051 Genomic DNA. Translation: EAW47610.1.
CH471051 Genomic DNA. Translation: EAW47611.1.
BC069142 mRNA. Translation: AAH69142.1.
BC069581 mRNA. Translation: AAH69581.1.
BC110454 mRNA. Translation: AAI10455.1.
CCDSiCCDS5272.1.
PIRiA01375. TVHUAS.
RefSeqiNP_002368.1. NM_002377.2.
UniGeneiHs.99900.

Genome annotation databases

EnsembliENST00000252660; ENSP00000252660; ENSG00000130368.
GeneIDi4142.
KEGGihsa:4142.
UCSCiuc003qsz.3. human.

Polymorphism databases

DMDMi135920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13150 mRNA. Translation: AAA36199.1.
CR542261 mRNA. Translation: CAG47057.1.
AL035691 Genomic DNA. Translation: CAB72444.1.
CH471051 Genomic DNA. Translation: EAW47610.1.
CH471051 Genomic DNA. Translation: EAW47611.1.
BC069142 mRNA. Translation: AAH69142.1.
BC069581 mRNA. Translation: AAH69581.1.
BC110454 mRNA. Translation: AAI10455.1.
CCDSiCCDS5272.1.
PIRiA01375. TVHUAS.
RefSeqiNP_002368.1. NM_002377.2.
UniGeneiHs.99900.

3D structure databases

ProteinModelPortaliP04201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110312. 1 interaction.
STRINGi9606.ENSP00000252660.

Chemistry

GuidetoPHARMACOLOGYi150.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP04201.

Polymorphism databases

DMDMi135920.

Proteomic databases

PaxDbiP04201.
PRIDEiP04201.

Protocols and materials databases

DNASUi4142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252660; ENSP00000252660; ENSG00000130368.
GeneIDi4142.
KEGGihsa:4142.
UCSCiuc003qsz.3. human.

Organism-specific databases

CTDi4142.
GeneCardsiGC06P160327.
HGNCiHGNC:6899. MAS1.
HPAiHPA013564.
MIMi165180. gene.
neXtProtiNX_P04201.
PharmGKBiPA30643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG137333.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP04201.
KOiK04303.
OMAiYELSSGH.
OrthoDBiEOG79PJPH.
PhylomeDBiP04201.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMAS1.
GenomeRNAii4142.
NextBioi16268.
PROiP04201.
SOURCEiSearch...

Gene expression databases

BgeeiP04201.
CleanExiHS_MAS1.
ExpressionAtlasiP04201. baseline and differential.
GenevestigatoriP04201.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains."
    Young D., Waitches G., Birchmeier C., Fasano O., Wigler M.
    Cell 45:711-719(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: PRELIMINARY FUNCTION.
  7. Cited for: FUNCTION AS AGTR1 ANTAGONIST, INTERACTION WITH AGTR1.
  8. "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS."
    Canals M., Jenkins L., Kellett E., Milligan G.
    J. Biol. Chem. 281:16757-16767(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ILE-138.

Entry informationi

Entry nameiMAS_HUMAN
AccessioniPrimary (citable) accession number: P04201
Secondary accession number(s): E1P5B3, Q2TBC9, Q6FG47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: January 7, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a receptor for angiotensin II.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.