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P04201

- MAS_HUMAN

UniProt

P04201 - MAS_HUMAN

Protein

Proto-oncogene Mas

Gene

MAS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (20 Mar 1987)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin 1-7 By similarity. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.By similarity2 Publications

    GO - Molecular functioni

    1. angiotensin receptor activity Source: UniProtKB
    2. angiotensin type II receptor activity Source: ProtInc
    3. G-protein coupled receptor activity Source: UniProtKB
    4. peptide binding Source: UniProtKB
    5. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
    2. anatomical structure morphogenesis Source: ProtInc
    3. cell proliferation Source: ProtInc
    4. cellular response to peptide hormone stimulus Source: Ensembl
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. hippocampus development Source: Ensembl
    7. male gonad development Source: Ensembl
    8. negative regulation of protein phosphorylation Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of DNA replication Source: Ensembl
    11. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    12. protein kinase C signaling Source: UniProtKB
    13. regulation of inflammatory response Source: Ensembl
    14. response to activity Source: Ensembl
    15. response to drug Source: Ensembl
    16. response to gonadotropin Source: Ensembl
    17. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene Mas
    Gene namesi
    Name:MAS1
    Synonyms:MAS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6899. MAS1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi138 – 1381I → D: Fails to activate GNA11. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA30643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Proto-oncogene MasPRO_0000069714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP04201.
    PRIDEiP04201.

    PTM databases

    PhosphoSiteiP04201.

    Expressioni

    Gene expression databases

    BgeeiP04201.
    CleanExiHS_MAS1.
    GenevestigatoriP04201.

    Organism-specific databases

    HPAiHPA013564.

    Interactioni

    Subunit structurei

    Interacts with AGTR1.1 Publication

    Protein-protein interaction databases

    BioGridi110312. 1 interaction.
    STRINGi9606.ENSP00000252660.

    Structurei

    3D structure databases

    ProteinModelPortaliP04201.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 654CytoplasmicSequence Analysis
    Topological domaini87 – 10418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 18513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini207 – 22418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 32541CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 6125Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12824Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17223Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG137333.
    HOGENOMiHOG000015412.
    HOVERGENiHBG098384.
    InParanoidiP04201.
    KOiK04303.
    OMAiYELSSGH.
    OrthoDBiEOG79PJPH.
    PhylomeDBiP04201.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR000820. Proto-oncogene_Mas.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF4. PTHR11334:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00533. MASONCOGENE.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04201-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN    50
    GILLWFLCFR MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG 100
    HYYTIVTLSV TFLFGYNTGL YLLTAISVER CLSVLYPIWY RCHRPKYQSA 150
    LVCALLWALS CLVTTMEYVM CIDREEESHS RNDCRAVIIF IAILSFLVFT 200
    PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF AMPMRLLYLL 250
    YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT 300
    RAFKDEMQPR RQKDNCNTVT VETVV 325
    Length:325
    Mass (Da):37,465
    Last modified:March 20, 1987 - v1
    Checksum:i3368E7B174744B83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13150 mRNA. Translation: AAA36199.1.
    CR542261 mRNA. Translation: CAG47057.1.
    AL035691 Genomic DNA. Translation: CAB72444.1.
    CH471051 Genomic DNA. Translation: EAW47610.1.
    CH471051 Genomic DNA. Translation: EAW47611.1.
    BC069142 mRNA. Translation: AAH69142.1.
    BC069581 mRNA. Translation: AAH69581.1.
    BC110454 mRNA. Translation: AAI10455.1.
    CCDSiCCDS5272.1.
    PIRiA01375. TVHUAS.
    RefSeqiNP_002368.1. NM_002377.2.
    UniGeneiHs.99900.

    Genome annotation databases

    EnsembliENST00000252660; ENSP00000252660; ENSG00000130368.
    GeneIDi4142.
    KEGGihsa:4142.
    UCSCiuc003qsz.3. human.

    Polymorphism databases

    DMDMi135920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13150 mRNA. Translation: AAA36199.1 .
    CR542261 mRNA. Translation: CAG47057.1 .
    AL035691 Genomic DNA. Translation: CAB72444.1 .
    CH471051 Genomic DNA. Translation: EAW47610.1 .
    CH471051 Genomic DNA. Translation: EAW47611.1 .
    BC069142 mRNA. Translation: AAH69142.1 .
    BC069581 mRNA. Translation: AAH69581.1 .
    BC110454 mRNA. Translation: AAI10455.1 .
    CCDSi CCDS5272.1.
    PIRi A01375. TVHUAS.
    RefSeqi NP_002368.1. NM_002377.2.
    UniGenei Hs.99900.

    3D structure databases

    ProteinModelPortali P04201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110312. 1 interaction.
    STRINGi 9606.ENSP00000252660.

    Chemistry

    GuidetoPHARMACOLOGYi 150.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P04201.

    Polymorphism databases

    DMDMi 135920.

    Proteomic databases

    PaxDbi P04201.
    PRIDEi P04201.

    Protocols and materials databases

    DNASUi 4142.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252660 ; ENSP00000252660 ; ENSG00000130368 .
    GeneIDi 4142.
    KEGGi hsa:4142.
    UCSCi uc003qsz.3. human.

    Organism-specific databases

    CTDi 4142.
    GeneCardsi GC06P160327.
    HGNCi HGNC:6899. MAS1.
    HPAi HPA013564.
    MIMi 165180. gene.
    neXtProti NX_P04201.
    PharmGKBi PA30643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG137333.
    HOGENOMi HOG000015412.
    HOVERGENi HBG098384.
    InParanoidi P04201.
    KOi K04303.
    OMAi YELSSGH.
    OrthoDBi EOG79PJPH.
    PhylomeDBi P04201.
    TreeFami TF336336.

    Miscellaneous databases

    GeneWikii MAS1.
    GenomeRNAii 4142.
    NextBioi 16268.
    PROi P04201.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04201.
    CleanExi HS_MAS1.
    Genevestigatori P04201.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR000820. Proto-oncogene_Mas.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF4. PTHR11334:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00533. MASONCOGENE.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains."
      Young D., Waitches G., Birchmeier C., Fasano O., Wigler M.
      Cell 45:711-719(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: PRELIMINARY FUNCTION.
    7. Cited for: FUNCTION AS AGTR1 ANTAGONIST, INTERACTION WITH AGTR1.
    8. "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS."
      Canals M., Jenkins L., Kellett E., Milligan G.
      J. Biol. Chem. 281:16757-16767(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ILE-138.

    Entry informationi

    Entry nameiMAS_HUMAN
    AccessioniPrimary (citable) accession number: P04201
    Secondary accession number(s): E1P5B3, Q2TBC9, Q6FG47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: March 20, 1987
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a receptor for angiotensin II.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3