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P04201 (MAS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proto-oncogene Mas
Gene names
Name:MAS1
Synonyms:MAS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for angiotensin 1-7 By similarity. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Ref.6 Ref.7 Ref.8

Subunit structure

Interacts with AGTR1 Probable. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.8.

Involvement in disease

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.6) thought to be a receptor for angiotensin II.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DiseaseProto-oncogene
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.6. Source: ProtInc

activation of NF-kappaB-inducing kinase activity

Inferred from electronic annotation. Source: Ensembl

anatomical structure morphogenesis

Traceable author statement PubMed 8661154. Source: ProtInc

cell proliferation

Traceable author statement Ref.6. Source: ProtInc

cellular response to peptide hormone stimulus

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of inositol phosphate biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein kinase C signaling

Inferred from mutant phenotype Ref.8. Source: UniProtKB

regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to gonadotropin

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.6. Source: ProtInc

plasma membrane

Inferred from direct assay Ref.8. Source: UniProtKB

   Molecular_functionG-protein coupled receptor activity

Inferred from direct assay Ref.8. Source: UniProtKB

angiotensin receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

angiotensin type II receptor activity

Traceable author statement Ref.6. Source: ProtInc

peptide binding

Inferred from sequence or structural similarity. Source: UniProtKB

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Proto-oncogene Mas
PRO_0000069714

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 6125Helical; Name=1; Potential
Topological domain62 – 654Cytoplasmic Potential
Transmembrane66 – 8621Helical; Name=2; Potential
Topological domain87 – 10418Extracellular Potential
Transmembrane105 – 12824Helical; Name=3; Potential
Topological domain129 – 14921Cytoplasmic Potential
Transmembrane150 – 17223Helical; Name=4; Potential
Topological domain173 – 18513Extracellular Potential
Transmembrane186 – 20621Helical; Name=5; Potential
Topological domain207 – 22418Cytoplasmic Potential
Transmembrane225 – 24521Helical; Name=6; Potential
Topological domain246 – 26318Extracellular Potential
Transmembrane264 – 28421Helical; Name=7; Potential
Topological domain285 – 32541Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis1381I → D: Fails to activate GNA11. Ref.8

Sequences

Sequence LengthMass (Da)Tools
P04201 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: 3368E7B174744B83

FASTA32537,465
        10         20         30         40         50         60 
MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN GILLWFLCFR 

        70         80         90        100        110        120 
MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG HYYTIVTLSV TFLFGYNTGL 

       130        140        150        160        170        180 
YLLTAISVER CLSVLYPIWY RCHRPKYQSA LVCALLWALS CLVTTMEYVM CIDREEESHS 

       190        200        210        220        230        240 
RNDCRAVIIF IAILSFLVFT PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF 

       250        260        270        280        290        300 
AMPMRLLYLL YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT 

       310        320 
RAFKDEMQPR RQKDNCNTVT VETVV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains."
Young D., Waitches G., Birchmeier C., Fasano O., Wigler M.
Cell 45:711-719(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The mas oncogene encodes an angiotensin receptor."
Jackson T.R., Blair L.A.C., Marshall J., Goedert M., Hanley M.R.
Nature 335:437-440(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY FUNCTION.
[7]"G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor."
Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.
Circulation 111:1806-1813(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS AGTR1 ANTAGONIST, INTERACTION WITH AGTR1.
[8]"Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS."
Canals M., Jenkins L., Kellett E., Milligan G.
J. Biol. Chem. 281:16757-16767(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ILE-138.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13150 mRNA. Translation: AAA36199.1.
CR542261 mRNA. Translation: CAG47057.1.
AL035691 Genomic DNA. Translation: CAB72444.1.
CH471051 Genomic DNA. Translation: EAW47610.1.
CH471051 Genomic DNA. Translation: EAW47611.1.
BC069142 mRNA. Translation: AAH69142.1.
BC069581 mRNA. Translation: AAH69581.1.
BC110454 mRNA. Translation: AAI10455.1.
PIRTVHUAS. A01375.
RefSeqNP_002368.1. NM_002377.2.
UniGeneHs.99900.

3D structure databases

ProteinModelPortalP04201.
SMRP04201. Positions 118-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110312. 1 interaction.
STRING9606.ENSP00000252660.

Chemistry

GuidetoPHARMACOLOGY150.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP04201.

Polymorphism databases

DMDM135920.

Proteomic databases

PaxDbP04201.
PRIDEP04201.

Protocols and materials databases

DNASU4142.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252660; ENSP00000252660; ENSG00000130368.
GeneID4142.
KEGGhsa:4142.
UCSCuc003qsz.3. human.

Organism-specific databases

CTD4142.
GeneCardsGC06P160327.
HGNCHGNC:6899. MAS1.
HPAHPA013564.
MIM165180. gene.
neXtProtNX_P04201.
PharmGKBPA30643.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG137333.
HOGENOMHOG000015412.
HOVERGENHBG098384.
InParanoidP04201.
KOK04303.
OMAYELSSGH.
OrthoDBEOG79PJPH.
PhylomeDBP04201.
TreeFamTF336336.

Gene expression databases

BgeeP04201.
CleanExHS_MAS1.
GenevestigatorP04201.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMAS1.
GenomeRNAi4142.
NextBio16268.
PROP04201.
SOURCESearch...

Entry information

Entry nameMAS_HUMAN
AccessionPrimary (citable) accession number: P04201
Secondary accession number(s): E1P5B3, Q2TBC9, Q6FG47
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries