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Protein

Cell surface-binding protein

Gene

VACWR113

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface-binding protein
Alternative name(s):
Carbonic anhydrase homolog
Gene namesi
Ordered Locus Names:VACWR113
ORF Names:D8L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Virion membrane Curated
  • Note: Component of the mature virion (MV) membrane.Curated

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 275Virion surfaceSequence analysisAdd BLAST275
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Topological domaini295 – 304IntravirionSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774511 – 304Cell surface-binding proteinAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi262InterchainBy similarity

Post-translational modificationi

Apparently non-glycosylated.

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP04195.
SMRiP04195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 235Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000IE.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiView protein in InterPro
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiView protein in Pfam
PF00194. Carb_anhydrase. 1 hit.
SMARTiView protein in SMART
SM01057. Carb_anhydrase. 1 hit.
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiView protein in PROSITE
PS51144. ALPHA_CA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P04195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQQLSPINI ETKKAISNAR LKPLDIHYNE SKPTTIQNTG KLVRINFKGG
60 70 80 90 100
YISGGFLPNE YVLSSLHIYW GKEDDYGSNH LIDVYKYSGE INLVHWNKKK
110 120 130 140 150
YSSYEEAKKH DDGLIIISIF LQVLDHKNVY FQKIVNQLDS IRSANTSAPF
160 170 180 190 200
DSVFYLDNLL PSKLDYFTYL GTTINHSADA VWIIFPTPIN IHSDQLSKFR
210 220 230 240 250
TLLSSSNHDG KPHYITENYR NPYKLNDDTQ VYYSGEIIRA ATTSPARENY
260 270 280 290 300
FMRWLSDLRE TCFSYYQKYI EENKTFAIIA IVFVFILTAI LFFMSRRYSR

EKQN
Length:304
Mass (Da):35,446
Last modified:March 20, 1987 - v1
Checksum:i67F195C8875455BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139D → H in AAA48233 (PubMed:2104847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05190 Genomic DNA. Translation: AAA48233.1.
AY243312 Genomic DNA. Translation: AAO89392.1.
PIRiA01146. CRVZW.
RefSeqiYP_232995.1. NC_006998.1.

Genome annotation databases

GeneIDi3707569.
KEGGivg:3707569.

Similar proteinsi

Entry informationi

Entry nameiCAHH_VACCW
AccessioniPrimary (citable) accession number: P04195
Secondary accession number(s): Q76ZR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families