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Protein

Ornithine aminotransferase, mitochondrial

Gene

Oat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (Oat)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.13. 5301.
ReactomeiR-RNO-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP04182.
UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:Oat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621724. Oat.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

  • cytoplasm Source: RGD
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Mitochondrion1 PublicationAdd
BLAST
Chaini36 – 439404Ornithine aminotransferase, mitochondrialPRO_0000001265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-acetyllysineBy similarity
Modified residuei66 – 661N6-acetyllysineBy similarity
Modified residuei102 – 1021N6-succinyllysineBy similarity
Modified residuei107 – 1071N6-acetyllysine; alternateBy similarity
Modified residuei107 – 1071N6-succinyllysine; alternateBy similarity
Modified residuei292 – 2921N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei362 – 3621N6-acetyllysine; alternateBy similarity
Modified residuei362 – 3621N6-succinyllysine; alternateBy similarity
Modified residuei386 – 3861N6-acetyllysineBy similarity
Modified residuei392 – 3921N6-acetyllysineBy similarity
Modified residuei405 – 4051N6-acetyllysine; alternateBy similarity
Modified residuei405 – 4051N6-succinyllysine; alternateBy similarity
Modified residuei421 – 4211N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04182.
PRIDEiP04182.

PTM databases

iPTMnetiP04182.
PhosphoSiteiP04182.

Expressioni

Tissue specificityi

Expressed in the head and flagellum of epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000016807.
GenevisibleiP04182. RN.

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249025. 1 interaction.
IntActiP04182. 1 interaction.
STRINGi10116.ENSRNOP00000022628.

Structurei

3D structure databases

ProteinModelPortaliP04182.
SMRiP04182. Positions 36-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP04182.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP04182.
TreeFamiTF105720.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLASLQT VAALRRGLRT SVASATSVAT KKTEQGPPSS EYIFERESKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYM WDVEGRQYFD FLSAYGAVSQ GHCHPKIIEA
110 120 130 140 150
MKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYNKVLPMN TGVEAGETAC
160 170 180 190 200
KLARRWGYTV KGIQKYKAKI VFAVGNFWGR TLSAVSSSTD PTSYDGFGPF
210 220 230 240 250
MPGFETIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVIV PDPGYLTGVR
260 270 280 290 300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDH ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RIAIAALEVL EEEHLAENAD
360 370 380 390 400
KMGAILRKEL MKLPSDVVTA VRGKGLLNAI VIRETKDCDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRLAPPLVI KEDEIRESVE IINKTILSF
Length:439
Mass (Da):48,333
Last modified:March 20, 1987 - v1
Checksum:i254E5F541B92D461
GO

Mass spectrometryi

Molecular mass is 48302.04 Da from positions 1 - 439. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11842 mRNA. Translation: AAA41766.1.
BC061551 mRNA. Translation: AAH61551.1.
M93296, M93295 Genomic DNA. Translation: AAA42060.1.
M93301
, M93297, M93298, M93299, M93300 Genomic DNA. Translation: AAA42061.1.
PIRiA00600. XNRTO.
RefSeqiNP_071966.1. NM_022521.3.
UniGeneiRn.1430.

Genome annotation databases

EnsembliENSRNOT00000022628; ENSRNOP00000022628; ENSRNOG00000016807.
GeneIDi64313.
KEGGirno:64313.
UCSCiRGD:621724. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11842 mRNA. Translation: AAA41766.1.
BC061551 mRNA. Translation: AAH61551.1.
M93296, M93295 Genomic DNA. Translation: AAA42060.1.
M93301
, M93297, M93298, M93299, M93300 Genomic DNA. Translation: AAA42061.1.
PIRiA00600. XNRTO.
RefSeqiNP_071966.1. NM_022521.3.
UniGeneiRn.1430.

3D structure databases

ProteinModelPortaliP04182.
SMRiP04182. Positions 36-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249025. 1 interaction.
IntActiP04182. 1 interaction.
STRINGi10116.ENSRNOP00000022628.

PTM databases

iPTMnetiP04182.
PhosphoSiteiP04182.

Proteomic databases

PaxDbiP04182.
PRIDEiP04182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022628; ENSRNOP00000022628; ENSRNOG00000016807.
GeneIDi64313.
KEGGirno:64313.
UCSCiRGD:621724. rat.

Organism-specific databases

CTDi4942.
RGDi621724. Oat.

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP04182.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP04182.
TreeFamiTF105720.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.
BRENDAi2.6.1.13. 5301.
ReactomeiR-RNO-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP04182.

Miscellaneous databases

PROiP04182.

Gene expression databases

BgeeiENSRNOG00000016807.
GenevisibleiP04182. RN.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_RAT
AccessioniPrimary (citable) accession number: P04182
Secondary accession number(s): Q6LDF6, Q6LDF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 7, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.