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Protein

Ornithine aminotransferase, mitochondrial

Gene

OAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS00832-MONOMER.
ZFISH:HS00832-MONOMER.
BRENDAi2.6.1.13. 2681.
ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP04181.
UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine delta-aminotransferase
Ornithine--oxo-acid aminotransferase
Cleaved into the following 2 chains:
Gene namesi
Name:OAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:8091. OAT.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: Reactome
  • mitochondrion Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.
See also OMIM:258870
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07192451G → D in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs11553554dbSNPEnsembl.1
Natural variantiVAR_00056554N → K in HOGA. 1 PublicationCorresponds to variant rs121965048dbSNPEnsembl.1
Natural variantiVAR_00056655Y → H in HOGA. 1 PublicationCorresponds to variant rs121965037dbSNPEnsembl.1
Natural variantiVAR_00056789N → K in HOGA. 1 PublicationCorresponds to variant rs386833602dbSNPEnsembl.1
Natural variantiVAR_01564890Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant rs121965060dbSNPEnsembl.1
Natural variantiVAR_00056893C → F in HOGA. 1 PublicationCorresponds to variant rs121965038dbSNPEnsembl.1
Natural variantiVAR_071925104Q → R in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833604dbSNPEnsembl.1
Natural variantiVAR_000569154R → L in HOGA; complete loss of activity. 1 PublicationCorresponds to variant rs121965039dbSNPEnsembl.1
Natural variantiVAR_000570180R → T in HOGA; complete loss of activity. 2 PublicationsCorresponds to variant rs121965040dbSNPEnsembl.1
Natural variantiVAR_000571184Missing in HOGA. 1 Publication1
Natural variantiVAR_071926199P → Q in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs267606925dbSNPEnsembl.1
Natural variantiVAR_000572226A → V in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965059dbSNPEnsembl.1
Natural variantiVAR_000573241P → L in HOGA. 2 PublicationsCorresponds to variant rs121965051dbSNPEnsembl.1
Natural variantiVAR_000574245Y → C in HOGA. 1 PublicationCorresponds to variant rs121965046dbSNPEnsembl.1
Natural variantiVAR_000575250R → P in HOGA. 2 PublicationsCorresponds to variant rs121965052dbSNPEnsembl.1
Natural variantiVAR_000576267T → I in HOGA. 1 PublicationCorresponds to variant rs386833618dbSNPEnsembl.1
Natural variantiVAR_000577270A → P in HOGA. Corresponds to variant rs121965041dbSNPEnsembl.1
Natural variantiVAR_000578271R → K in HOGA. 1 PublicationCorresponds to variant rs121965042dbSNPEnsembl.1
Natural variantiVAR_071927318E → K in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833621dbSNPEnsembl.1
Natural variantiVAR_000579319H → Y in HOGA. 1 PublicationCorresponds to variant rs121965049dbSNPEnsembl.1
Natural variantiVAR_000580332V → M in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965047dbSNPEnsembl.1
Natural variantiVAR_000581353G → D in HOGA. 2 PublicationsCorresponds to variant rs121965053dbSNPEnsembl.1
Natural variantiVAR_000582375G → A in HOGA. 1 PublicationCorresponds to variant rs121965045dbSNPEnsembl.1
Natural variantiVAR_000583394C → R in HOGA. 2 PublicationsCorresponds to variant rs121965054dbSNPEnsembl.1
Natural variantiVAR_071928394C → Y in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833597dbSNPEnsembl.1
Natural variantiVAR_000584402L → P in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965043dbSNPEnsembl.1
Natural variantiVAR_000585417P → L in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965044dbSNPEnsembl.1
Natural variantiVAR_071929436I → N in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833598dbSNPEnsembl.1
Natural variantiVAR_000586437L → F in HOGA; no effect on activity and protein stability. 2 PublicationsCorresponds to variant rs1800456dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4942.
MalaCardsiOAT.
MIMi258870. phenotype.
OpenTargetsiENSG00000065154.
Orphaneti414. Gyrate atrophy of choroid and retina.
PharmGKBiPA31880.

Chemistry databases

ChEMBLiCHEMBL5954.
DrugBankiDB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiOAT.
DMDMi129018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35Mitochondrion; in renal form1 PublicationAdd BLAST35
Transit peptidei1 – 25Mitochondrion; in hepatic formAdd BLAST25
ChainiPRO_000000126226 – 439Ornithine aminotransferase, hepatic formAdd BLAST414
ChainiPRO_000000126336 – 439Ornithine aminotransferase, renal formAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei102N6-succinyllysineBy similarity1
Modified residuei107N6-acetyllysine; alternateBy similarity1
Modified residuei107N6-succinyllysine; alternateBy similarity1
Modified residuei292N6-(pyridoxal phosphate)lysine1 Publication1
Modified residuei362N6-acetyllysine; alternateBy similarity1
Modified residuei362N6-succinyllysine; alternateBy similarity1
Modified residuei386N6-acetyllysineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei405N6-acetyllysine; alternateBy similarity1
Modified residuei405N6-succinyllysine; alternateBy similarity1
Modified residuei421N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP04181.
MaxQBiP04181.
PaxDbiP04181.
PeptideAtlasiP04181.
PRIDEiP04181.

2D gel databases

REPRODUCTION-2DPAGEIPI00022334.

PTM databases

iPTMnetiP04181.
PhosphoSitePlusiP04181.
SwissPalmiP04181.

Expressioni

Gene expression databases

BgeeiENSG00000065154.
CleanExiHS_OAT.
ExpressionAtlasiP04181. baseline and differential.
GenevisibleiP04181. HS.

Organism-specific databases

HPAiCAB033576.
HPA040098.
HPA064742.

Interactioni

Subunit structurei

Homohexamer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110996. 39 interactors.
IntActiP04181. 13 interactors.
MINTiMINT-1387274.
STRINGi9606.ENSP00000357838.

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 50Combined sources11
Beta strandi61 – 67Combined sources7
Beta strandi69 – 72Combined sources4
Beta strandi77 – 82Combined sources6
Helixi83 – 86Combined sources4
Turni87 – 90Combined sources4
Helixi95 – 105Combined sources11
Beta strandi115 – 119Combined sources5
Helixi120 – 131Combined sources12
Beta strandi134 – 141Combined sources8
Helixi142 – 159Combined sources18
Beta strandi169 – 173Combined sources5
Helixi182 – 185Combined sources4
Helixi191 – 194Combined sources4
Beta strandi204 – 207Combined sources4
Helixi212 – 218Combined sources7
Beta strandi224 – 229Combined sources6
Beta strandi231 – 233Combined sources3
Turni234 – 237Combined sources4
Helixi245 – 255Combined sources11
Beta strandi259 – 263Combined sources5
Turni265 – 272Combined sources8
Beta strandi273 – 276Combined sources4
Helixi277 – 281Combined sources5
Beta strandi286 – 290Combined sources5
Helixi292 – 295Combined sources4
Beta strandi302 – 306Combined sources5
Helixi308 – 311Combined sources4
Helixi327 – 342Combined sources16
Helixi345 – 360Combined sources16
Turni365 – 367Combined sources3
Beta strandi368 – 374Combined sources7
Beta strandi377 – 382Combined sources6
Helixi390 – 399Combined sources10
Beta strandi406 – 414Combined sources9
Helixi422 – 437Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GBNX-ray2.30A/B/C38-439[»]
1OATX-ray2.50A/B/C1-439[»]
2BYJX-ray3.02A/B/C1-439[»]
2BYLX-ray2.15A/B/C1-439[»]
2CANX-ray2.30A/B/C38-439[»]
2OATX-ray1.95A/B/C1-439[»]
ProteinModelPortaliP04181.
SMRiP04181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04181.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP04181.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP04181.
TreeFamiTF105720.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04181-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA
110 120 130 140 150
LKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYHKVLPMN TGVEAGETAC
160 170 180 190 200
KLARKWGYTV KGIQKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLMGVR
260 270 280 290 300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD
360 370 380 390 400
KLGIILRNEL MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRFAPPLVI KEDELRESIE IINKTILSF
Length:439
Mass (Da):48,535
Last modified:March 20, 1987 - v1
Checksum:iE9D0636824A83220
GO
Isoform 2 (identifier: P04181-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:301
Mass (Da):32,853
Checksum:i9CFA7F66DDB264F0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07192451G → D in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs11553554dbSNPEnsembl.1
Natural variantiVAR_00056554N → K in HOGA. 1 PublicationCorresponds to variant rs121965048dbSNPEnsembl.1
Natural variantiVAR_00056655Y → H in HOGA. 1 PublicationCorresponds to variant rs121965037dbSNPEnsembl.1
Natural variantiVAR_00056789N → K in HOGA. 1 PublicationCorresponds to variant rs386833602dbSNPEnsembl.1
Natural variantiVAR_01564890Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant rs121965060dbSNPEnsembl.1
Natural variantiVAR_00056893C → F in HOGA. 1 PublicationCorresponds to variant rs121965038dbSNPEnsembl.1
Natural variantiVAR_071925104Q → R in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833604dbSNPEnsembl.1
Natural variantiVAR_000569154R → L in HOGA; complete loss of activity. 1 PublicationCorresponds to variant rs121965039dbSNPEnsembl.1
Natural variantiVAR_000570180R → T in HOGA; complete loss of activity. 2 PublicationsCorresponds to variant rs121965040dbSNPEnsembl.1
Natural variantiVAR_000571184Missing in HOGA. 1 Publication1
Natural variantiVAR_071926199P → Q in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs267606925dbSNPEnsembl.1
Natural variantiVAR_000572226A → V in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965059dbSNPEnsembl.1
Natural variantiVAR_000573241P → L in HOGA. 2 PublicationsCorresponds to variant rs121965051dbSNPEnsembl.1
Natural variantiVAR_000574245Y → C in HOGA. 1 PublicationCorresponds to variant rs121965046dbSNPEnsembl.1
Natural variantiVAR_000575250R → P in HOGA. 2 PublicationsCorresponds to variant rs121965052dbSNPEnsembl.1
Natural variantiVAR_000576267T → I in HOGA. 1 PublicationCorresponds to variant rs386833618dbSNPEnsembl.1
Natural variantiVAR_000577270A → P in HOGA. Corresponds to variant rs121965041dbSNPEnsembl.1
Natural variantiVAR_000578271R → K in HOGA. 1 PublicationCorresponds to variant rs121965042dbSNPEnsembl.1
Natural variantiVAR_071927318E → K in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833621dbSNPEnsembl.1
Natural variantiVAR_000579319H → Y in HOGA. 1 PublicationCorresponds to variant rs121965049dbSNPEnsembl.1
Natural variantiVAR_000580332V → M in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965047dbSNPEnsembl.1
Natural variantiVAR_000581353G → D in HOGA. 2 PublicationsCorresponds to variant rs121965053dbSNPEnsembl.1
Natural variantiVAR_000582375G → A in HOGA. 1 PublicationCorresponds to variant rs121965045dbSNPEnsembl.1
Natural variantiVAR_000583394C → R in HOGA. 2 PublicationsCorresponds to variant rs121965054dbSNPEnsembl.1
Natural variantiVAR_071928394C → Y in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833597dbSNPEnsembl.1
Natural variantiVAR_000584402L → P in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965043dbSNPEnsembl.1
Natural variantiVAR_000585417P → L in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant rs121965044dbSNPEnsembl.1
Natural variantiVAR_071929436I → N in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant rs386833598dbSNPEnsembl.1
Natural variantiVAR_000586437L → F in HOGA; no effect on activity and protein stability. 2 PublicationsCorresponds to variant rs1800456dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430851 – 138Missing in isoform 2. 2 PublicationsAdd BLAST138

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12267 mRNA. Translation: AAA59956.1.
M14963 mRNA. Translation: AAA59959.1.
Y07511 mRNA. Translation: CAA68809.1.
M23204 mRNA. Translation: AAA36386.1.
M23205 Genomic DNA. No translation available.
M88760 Genomic DNA. Translation: AAA59958.1. Sequence problems.
M29927
, M29919, M29920, M29921, M29922, M29923, M29924, M29925, M29926 Genomic DNA. Translation: AAA59957.1.
AK296032 mRNA. Translation: BAH12241.1.
AK312561 mRNA. Translation: BAG35458.1.
AK315947 mRNA. Translation: BAH14318.1.
CR457045 mRNA. Translation: CAG33326.1.
CR749808 mRNA. Translation: CAH18668.1.
AL445237 Genomic DNA. Translation: CAI17293.1.
CH471066 Genomic DNA. Translation: EAW49271.1.
CH471066 Genomic DNA. Translation: EAW49272.1.
BC000964 mRNA. Translation: AAH00964.1.
BC016928 mRNA. Translation: AAH16928.1.
S66418 mRNA. Translation: AAB20298.1.
S66421 mRNA. Translation: AAB20297.1.
CCDSiCCDS53586.1. [P04181-2]
CCDS7639.1. [P04181-1]
PIRiA30806. XNHUO.
I55360.
RefSeqiNP_000265.1. NM_000274.3. [P04181-1]
NP_001165285.1. NM_001171814.1. [P04181-2]
NP_001309894.1. NM_001322965.1. [P04181-1]
NP_001309895.1. NM_001322966.1. [P04181-1]
NP_001309896.1. NM_001322967.1. [P04181-1]
NP_001309897.1. NM_001322968.1. [P04181-1]
NP_001309898.1. NM_001322969.1. [P04181-1]
NP_001309899.1. NM_001322970.1. [P04181-1]
NP_001309900.1. NM_001322971.1.
UniGeneiHs.523332.

Genome annotation databases

EnsembliENST00000368845; ENSP00000357838; ENSG00000065154. [P04181-1]
ENST00000539214; ENSP00000439042; ENSG00000065154. [P04181-2]
GeneIDi4942.
KEGGihsa:4942.
UCSCiuc001lhp.4. human. [P04181-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12267 mRNA. Translation: AAA59956.1.
M14963 mRNA. Translation: AAA59959.1.
Y07511 mRNA. Translation: CAA68809.1.
M23204 mRNA. Translation: AAA36386.1.
M23205 Genomic DNA. No translation available.
M88760 Genomic DNA. Translation: AAA59958.1. Sequence problems.
M29927
, M29919, M29920, M29921, M29922, M29923, M29924, M29925, M29926 Genomic DNA. Translation: AAA59957.1.
AK296032 mRNA. Translation: BAH12241.1.
AK312561 mRNA. Translation: BAG35458.1.
AK315947 mRNA. Translation: BAH14318.1.
CR457045 mRNA. Translation: CAG33326.1.
CR749808 mRNA. Translation: CAH18668.1.
AL445237 Genomic DNA. Translation: CAI17293.1.
CH471066 Genomic DNA. Translation: EAW49271.1.
CH471066 Genomic DNA. Translation: EAW49272.1.
BC000964 mRNA. Translation: AAH00964.1.
BC016928 mRNA. Translation: AAH16928.1.
S66418 mRNA. Translation: AAB20298.1.
S66421 mRNA. Translation: AAB20297.1.
CCDSiCCDS53586.1. [P04181-2]
CCDS7639.1. [P04181-1]
PIRiA30806. XNHUO.
I55360.
RefSeqiNP_000265.1. NM_000274.3. [P04181-1]
NP_001165285.1. NM_001171814.1. [P04181-2]
NP_001309894.1. NM_001322965.1. [P04181-1]
NP_001309895.1. NM_001322966.1. [P04181-1]
NP_001309896.1. NM_001322967.1. [P04181-1]
NP_001309897.1. NM_001322968.1. [P04181-1]
NP_001309898.1. NM_001322969.1. [P04181-1]
NP_001309899.1. NM_001322970.1. [P04181-1]
NP_001309900.1. NM_001322971.1.
UniGeneiHs.523332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GBNX-ray2.30A/B/C38-439[»]
1OATX-ray2.50A/B/C1-439[»]
2BYJX-ray3.02A/B/C1-439[»]
2BYLX-ray2.15A/B/C1-439[»]
2CANX-ray2.30A/B/C38-439[»]
2OATX-ray1.95A/B/C1-439[»]
ProteinModelPortaliP04181.
SMRiP04181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110996. 39 interactors.
IntActiP04181. 13 interactors.
MINTiMINT-1387274.
STRINGi9606.ENSP00000357838.

Chemistry databases

ChEMBLiCHEMBL5954.
DrugBankiDB00129. L-Ornithine.

PTM databases

iPTMnetiP04181.
PhosphoSitePlusiP04181.
SwissPalmiP04181.

Polymorphism and mutation databases

BioMutaiOAT.
DMDMi129018.

2D gel databases

REPRODUCTION-2DPAGEIPI00022334.

Proteomic databases

EPDiP04181.
MaxQBiP04181.
PaxDbiP04181.
PeptideAtlasiP04181.
PRIDEiP04181.

Protocols and materials databases

DNASUi4942.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368845; ENSP00000357838; ENSG00000065154. [P04181-1]
ENST00000539214; ENSP00000439042; ENSG00000065154. [P04181-2]
GeneIDi4942.
KEGGihsa:4942.
UCSCiuc001lhp.4. human. [P04181-1]

Organism-specific databases

CTDi4942.
DisGeNETi4942.
GeneCardsiOAT.
HGNCiHGNC:8091. OAT.
HPAiCAB033576.
HPA040098.
HPA064742.
MalaCardsiOAT.
MIMi258870. phenotype.
613349. gene.
neXtProtiNX_P04181.
OpenTargetsiENSG00000065154.
Orphaneti414. Gyrate atrophy of choroid and retina.
PharmGKBiPA31880.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP04181.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP04181.
TreeFamiTF105720.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.
BioCyciMetaCyc:HS00832-MONOMER.
ZFISH:HS00832-MONOMER.
BRENDAi2.6.1.13. 2681.
ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP04181.

Miscellaneous databases

EvolutionaryTraceiP04181.
GenomeRNAii4942.
PROiP04181.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065154.
CleanExiHS_OAT.
ExpressionAtlasiP04181. baseline and differential.
GenevisibleiP04181. HS.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_HUMAN
AccessioniPrimary (citable) accession number: P04181
Secondary accession number(s): D3DRF0
, Q16068, Q16069, Q68CS0, Q6IAV9, Q9UD03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: November 30, 2016
This is version 194 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.