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P04157

- PTPRC_RAT

UniProt

P04157 - PTPRC_RAT

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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

Ptprc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei790 – 7901SubstrateBy similarity
Active sitei822 – 8221Phosphocysteine intermediateBy similarity
Binding sitei866 – 8661SubstrateBy similarity
Active sitei1137 – 11371Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. protein kinase binding Source: UniProtKB
  3. protein kinase regulator activity Source: RGD
  4. protein tyrosine phosphatase activity Source: UniProtKB
  5. transmembrane receptor protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. B cell differentiation Source: Ensembl
  3. B cell proliferation Source: UniProtKB
  4. B cell receptor signaling pathway Source: UniProtKB
  5. bone marrow development Source: Ensembl
  6. cell cycle phase transition Source: Ensembl
  7. defense response to virus Source: UniProtKB
  8. dephosphorylation Source: UniProtKB
  9. hematopoietic progenitor cell differentiation Source: Ensembl
  10. heterotypic cell-cell adhesion Source: Ensembl
  11. immunoglobulin biosynthetic process Source: Ensembl
  12. leukocyte cell-cell adhesion Source: Ensembl
  13. negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
  14. negative regulation of cytokine-mediated signaling pathway Source: UniProtKB
  15. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  16. negative regulation of protein autophosphorylation Source: Ensembl
  17. negative regulation of protein kinase activity Source: UniProtKB
  18. negative regulation of T cell mediated cytotoxicity Source: UniProtKB
  19. negative thymic T cell selection Source: Ensembl
  20. peptidyl-tyrosine dephosphorylation Source: GOC
  21. positive regulation of alpha-beta T cell proliferation Source: Ensembl
  22. positive regulation of antigen receptor-mediated signaling pathway Source: UniProtKB
  23. positive regulation of B cell proliferation Source: Ensembl
  24. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  25. positive regulation of gamma-delta T cell differentiation Source: Ensembl
  26. positive regulation of hematopoietic stem cell migration Source: Ensembl
  27. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  29. positive regulation of stem cell proliferation Source: Ensembl
  30. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  31. positive regulation of T cell proliferation Source: UniProtKB
  32. positive thymic T cell selection Source: Ensembl
  33. protein dephosphorylation Source: UniProtKB
  34. regulation of B cell differentiation Source: Ensembl
  35. regulation of B cell receptor signaling pathway Source: Ensembl
  36. regulation of cell cycle Source: UniProtKB
  37. release of sequestered calcium ion into cytosol Source: UniProtKB
  38. response to gamma radiation Source: RGD
  39. stem cell development Source: Ensembl
  40. T cell differentiation Source: UniProtKB
  41. T cell proliferation Source: Ensembl
  42. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_238902. Other semaphorin interactions.
REACT_253779. Phosphorylation of CD3 and TCR zeta chains.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
Short name:
L-CA
T200
CD_antigen: CD45
Gene namesi
Name:Ptprc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi3451. Ptprc.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 546523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence AnalysisAdd
BLAST
Topological domaini568 – 1273706CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasmic side of plasma membrane Source: RGD
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. focal adhesion Source: UniProtKB
  6. integral component of membrane Source: RGD
  7. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 12731250Receptor-type tyrosine-protein phosphatase CPRO_0000025472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
Modified residuei944 – 9441PhosphoserineBy similarity
Modified residuei1266 – 12661PhosphoserineBy similarity

Post-translational modificationi

Heavily N- and O-glycosylated.
The cytoplasmic domain contains potential phosphorylation sites.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04157.
PRIDEiP04157.

PTM databases

PhosphoSiteiP04157.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.

Gene expression databases

ExpressionAtlasiP04157. baseline and differential.
GenevestigatoriP04157.

Interactioni

Subunit structurei

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH (By similarity).By similarity

Protein-protein interaction databases

BioGridi246829. 1 interaction.
IntActiP04157. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP04157.
SMRiP04157. Positions 594-1198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini361 – 45292Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 54593Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini622 – 881260Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini913 – 1196284Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni822 – 8287Substrate bindingBy similarity

Domaini

The first PTPase domain interacts with SKAP1.By similarity

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049064.
HOVERGENiHBG000066.
InParanoidiP04157.
KOiK06478.
OMAiKANTSIC.
OrthoDBiEOG7XSTCW.
PhylomeDBiP04157.
TreeFamiTF351829.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR024739. PTP_recept_N.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF12567. CD45. 1 hit.
PF00041. fn3. 1 hit.
PF12453. PTP_N. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P04157-1) [UniParc]FASTAAdd to Basket

Also known as: L-CA variant 4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLWLKLLAF SLALLGPEVF VTGQGTTDDG LDTTEIVLLP QTDPLPARTT
60 70 80 90 100
EFTPPSISER GNGSSETTYL PGFSSTLMPH LTPQPDSQTP SARGADTQTL
110 120 130 140 150
SSQADLTTLT AAPSGETDPP GVPEESTVPE TFPGGTPILA RNSTAPSPTH
160 170 180 190 200
TSNVSTTDIS SGANLTTPAP STLGFASNTT TSTEIATPQT KPSCDEKFGN
210 220 230 240 250
VTVRYIYDDS SKNFNANLEG DKKPKCEYTD CEKELKNLPE CSQKNVTLSN
260 270 280 290 300
GSCTPDKIIN LDVPPGTHNF NLTNCTPDIE ANTSICLEWK IKNKFTCDIQ
310 320 330 340 350
KISYNFRCTP EMKTFALDKH GTLWLHNLTV RTNYTCAAEV LYNNVILLKQ
360 370 380 390 400
DRRVQTDFGT PEMLPHVQCK NSTNSTTLVS WAEPASKHHG YILCYKKTPS
410 420 430 440 450
EKCENLANDV NSFEVKNLRP YTEYTVSLFA YVIGRVQRNG PAKDCNFRTK
460 470 480 490 500
AARPGKVNGM KTSRASDNSI NVTCNSPYEI NGPEARYILE VKSGGSLVKT
510 520 530 540 550
FNQSTCKFVV DNLYYSTDYE FLVYFYNGEY LGDPEIKPQS TSYNSKALII
560 570 580 590 600
FLVFLIIVTS IALLVVLYKI YDLRKKRSSN LDEQQELVER DEEKQLINVD
610 620 630 640 650
PIHSDLLLET YKRKIADEGR LFLAEFQSIP RVFSKFPIKD ARKSQNQNKN
660 670 680 690 700
RYVDILPYDY NRVELSEING DAGSTYINAS YIDGFKEPRK YIAAQGPRDE
710 720 730 740 750
TVDDFWKMIW EQKATVIVMV TRCEEGNRNK CAEYWPCMEE GTRTFRDVVV
760 770 780 790 800
TINDHKRCPD YIIQKLSIAH KKEKATGREV THIQFTSWPD HGVPEDPHLL
810 820 830 840 850
LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG TYIGIDAMLE SLEAEGKVDV
860 870 880 890 900
YGYVVNLRRQ RCLMVQVEAQ YILIHQALVE YNQFGETEVN LSELHSCLQN
910 920 930 940 950
LKKRDPPSDP SPLEAEYQRL PSYRSWRTQH IGNQEENKKK NRSSNVVPYD
960 970 980 990 1000
FNRVPLKHEL EMSKESEAES DESSDEDSDS EETSKYINAS FVMSYWKPEM
1010 1020 1030 1040 1050
MIAAQGPLKE TIGDFWQMIF QRKVKVIVML TELMSGDQEV CAQYWGEGKQ
1060 1070 1080 1090 1100
TYGDMEVMLK DTNKSSAYIL RAFELRHSKR KEPRTVYQYQ CTTWKGEELP
1110 1120 1130 1140 1150
AEPKDLVTLI QNIKQKLPKS GSEGMKYHKH ASILVHCRDG SQQTGLFCAL
1160 1170 1180 1190 1200
FNLLESAETE DVVDVFQVVK SLRKARPGMV GSFEQYQFLY DIMASIYPTQ
1210 1220 1230 1240 1250
NGQVKKANSQ DKIEFHNEVD GAKQDANCVQ PADPLNKAQE DSKEVGASEP
1260 1270
ASGSEEPEHS ANGPMSPALT PSS
Length:1,273
Mass (Da):143,269
Last modified:June 12, 2007 - v2
Checksum:iEDFA48100ACF2CB2
GO
Isoform 2 (identifier: P04157-2) [UniParc]FASTAAdd to Basket

Also known as: L-CA variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     30-161: Missing.

Show »
Length:1,141
Mass (Da):129,697
Checksum:iD8CD289BA1873388
GO
Isoform 3 (identifier: P04157-3) [UniParc]FASTAAdd to Basket

Also known as: L-CA variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     30-120: Missing.

Show »
Length:1,182
Mass (Da):133,819
Checksum:iEDF2153D0EBBF86E
GO
Isoform 4 (identifier: P04157-4) [UniParc]FASTAAdd to Basket

Also known as: L-CA variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     30-71: Missing.
     121-161: Missing.

Show »
Length:1,190
Mass (Da):134,662
Checksum:i61CD4F787C7E695F
GO
Isoform 5 (identifier: P04157-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-161: Missing.

Show »
Length:1,183
Mass (Da):134,182
Checksum:i1076BD878F13B5CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561S → R in AAA41518. 1 PublicationCurated
Sequence conflicti56 – 561S → R in AAA41521. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 161132Missing in isoform 2. 1 PublicationVSP_005167Add
BLAST
Alternative sequencei30 – 12091Missing in isoform 3. 2 PublicationsVSP_005166Add
BLAST
Alternative sequencei30 – 7142Missing in isoform 4. 3 PublicationsVSP_005165Add
BLAST
Alternative sequencei72 – 16190Missing in isoform 5. 1 PublicationVSP_026163Add
BLAST
Alternative sequencei121 – 16141Missing in isoform 4. 3 PublicationsVSP_005168Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB793707 mRNA. No translation available.
Y00065 mRNA. Translation: CAA68272.1.
Y00065 mRNA. Translation: CAA68273.1.
Y00065 mRNA. Translation: CAA68274.1.
Y00065 mRNA. Translation: CAA68275.1.
M25820 mRNA. Translation: AAA41518.1.
M25821 mRNA. Translation: AAA41519.1.
M25822 mRNA. Translation: AAA41520.1.
M25823 mRNA. Translation: AAA41521.1.
PIRiA45854.
RefSeqiNP_001103357.1. NM_001109887.1. [P04157-4]
NP_001103358.1. NM_001109888.1. [P04157-5]
NP_001103359.1. NM_001109889.1. [P04157-3]
NP_001103360.1. NM_001109890.1. [P04157-2]
NP_612516.2. NM_138507.2. [P04157-1]
XP_006249972.1. XM_006249910.2. [P04157-1]
UniGeneiRn.90166.

Genome annotation databases

EnsembliENSRNOT00000000814; ENSRNOP00000000814; ENSRNOG00000000655. [P04157-2]
ENSRNOT00000029865; ENSRNOP00000029889; ENSRNOG00000000655. [P04157-5]
ENSRNOT00000029878; ENSRNOP00000030503; ENSRNOG00000000655. [P04157-4]
ENSRNOT00000060292; ENSRNOP00000057042; ENSRNOG00000000655. [P04157-3]
ENSRNOT00000064785; ENSRNOP00000063859; ENSRNOG00000000655. [P04157-1]
GeneIDi24699.
KEGGirno:24699.
UCSCiRGD:3451. rat. [P04157-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB793707 mRNA. No translation available.
Y00065 mRNA. Translation: CAA68272.1 .
Y00065 mRNA. Translation: CAA68273.1 .
Y00065 mRNA. Translation: CAA68274.1 .
Y00065 mRNA. Translation: CAA68275.1 .
M25820 mRNA. Translation: AAA41518.1 .
M25821 mRNA. Translation: AAA41519.1 .
M25822 mRNA. Translation: AAA41520.1 .
M25823 mRNA. Translation: AAA41521.1 .
PIRi A45854.
RefSeqi NP_001103357.1. NM_001109887.1. [P04157-4 ]
NP_001103358.1. NM_001109888.1. [P04157-5 ]
NP_001103359.1. NM_001109889.1. [P04157-3 ]
NP_001103360.1. NM_001109890.1. [P04157-2 ]
NP_612516.2. NM_138507.2. [P04157-1 ]
XP_006249972.1. XM_006249910.2. [P04157-1 ]
UniGenei Rn.90166.

3D structure databases

ProteinModelPortali P04157.
SMRi P04157. Positions 594-1198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246829. 1 interaction.
IntActi P04157. 2 interactions.

Chemistry

GuidetoPHARMACOLOGYi 1852.

PTM databases

PhosphoSitei P04157.

Proteomic databases

PaxDbi P04157.
PRIDEi P04157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000814 ; ENSRNOP00000000814 ; ENSRNOG00000000655 . [P04157-2 ]
ENSRNOT00000029865 ; ENSRNOP00000029889 ; ENSRNOG00000000655 . [P04157-5 ]
ENSRNOT00000029878 ; ENSRNOP00000030503 ; ENSRNOG00000000655 . [P04157-4 ]
ENSRNOT00000060292 ; ENSRNOP00000057042 ; ENSRNOG00000000655 . [P04157-3 ]
ENSRNOT00000064785 ; ENSRNOP00000063859 ; ENSRNOG00000000655 . [P04157-1 ]
GeneIDi 24699.
KEGGi rno:24699.
UCSCi RGD:3451. rat. [P04157-1 ]

Organism-specific databases

CTDi 5788.
RGDi 3451. Ptprc.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000049064.
HOVERGENi HBG000066.
InParanoidi P04157.
KOi K06478.
OMAi KANTSIC.
OrthoDBi EOG7XSTCW.
PhylomeDBi P04157.
TreeFami TF351829.

Enzyme and pathway databases

Reactomei REACT_238902. Other semaphorin interactions.
REACT_253779. Phosphorylation of CD3 and TCR zeta chains.

Miscellaneous databases

NextBioi 604155.
PROi P04157.

Gene expression databases

ExpressionAtlasi P04157. baseline and differential.
Genevestigatori P04157.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR024739. PTP_recept_N.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF12567. CD45. 1 hit.
PF00041. fn3. 1 hit.
PF12453. PTP_N. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Amgen rat EST program."
    Amgen EST program
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-147 (ISOFORM 4).
  2. "Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus."
    Barclay A.N., Jackson D.I., Willis A.C., Williams A.F.
    EMBO J. 6:1259-1264(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-218 (ISOFORMS 1; 2; 3 AND 4).
  3. Barclay A.N., Jackson D.I., Willis A.C., Williams A.F.
    Submitted (MAY-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-1273 (ISOFORMS 1; 3; 4 AND 5).
  4. "Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr."
    Thomas M.L., Barclay A.N., Gagnon J., Williams A.F.
    Cell 41:83-93(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1255 (ISOFORM 1).

Entry informationi

Entry nameiPTPRC_RAT
AccessioniPrimary (citable) accession number: P04157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3