P04157 (PTPRC_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase C
EC=3.1.3.48

Alternative name(s):
Leukocyte common antigen
Short name=L-CA
T200
CD_antigen=CD45

Gene names

Name:

Ptprc

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN By similarity. Dephosphorylates LYN, and thereby modulates LYN activity By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts By similarity.
Tissue specificity	Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.
Domain	The first PTPase domain interacts with SKAP1 By similarity.
Post-translational modification	Heavily N- and O-glycosylated. The cytoplasmic domain contains potential phosphorylation sites.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	B cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB B cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB T cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB defense response to virus Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell mediated cytotoxicity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cytokine-mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of antigen receptor-mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB response to gamma radiation Inferred from direct assay. Source: RGD
Cellular component	cell surface Inferred from direct assay. Source: RGD focal adhesion Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Inferred from direct assay Ref.4. Source: UniProtKB internal side of plasma membrane Traceable author statement. Source: RGD membrane raft Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase regulator activity Traceable author statement. Source: RGD transmembrane receptor protein tyrosine phosphatase activity Traceable author statement. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P04157-1)

Also known as: L-CA variant 4;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P04157-2)

Also known as: L-CA variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     30-161: Missing.

Isoform 3 (identifier: P04157-3)

Also known as: L-CA variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     30-120: Missing.

Isoform 4 (identifier: P04157-4)

Also known as: L-CA variant 3;

The sequence of this isoform differs from the canonical sequence as follows:
     30-71: Missing.
     121-161: Missing.

Isoform 5 (identifier: P04157-5)

The sequence of this isoform differs from the canonical sequence as follows:
     72-161: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 1273	1250	Receptor-type tyrosine-protein phosphatase C		PRO_0000025472
Regions
	Topological domain	24 – 546	523	Extracellular Potential
	Transmembrane	547 – 567	21	Helical; Potential
	Topological domain	568 – 1273	706	Cytoplasmic Potential
	Domain	361 – 449	89	Fibronectin type-III 1
	Domain	454 – 541	88	Fibronectin type-III 2
	Domain	622 – 881	260	Tyrosine-protein phosphatase 1
	Domain	913 – 1196	284	Tyrosine-protein phosphatase 2
	Region	822 – 828	7	Substrate binding By similarity
Sites
	Active site	822	1	Phosphocysteine intermediate By similarity
	Active site	1137	1	Phosphocysteine intermediate By similarity
	Binding site	790	1	Substrate By similarity
	Binding site	866	1	Substrate By similarity
Amino acid modifications
	Modified residue	922	1	Phosphoserine By similarity
	Modified residue	944	1	Phosphoserine By similarity
	Modified residue	966	1	Phosphoserine By similarity
	Modified residue	974	1	Phosphoserine By similarity
	Modified residue	978	1	Phosphoserine By similarity
	Modified residue	1266	1	Phosphoserine By similarity
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	142	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
	Glycosylation	245	1	N-linked (GlcNAc...) Potential
	Glycosylation	250	1	N-linked (GlcNAc...) Potential
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Glycosylation	333	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	374	1	N-linked (GlcNAc...) Potential
	Glycosylation	471	1	N-linked (GlcNAc...) Potential
	Glycosylation	502	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	30 – 161	132	Missing in isoform 2.		VSP_005167
	Alternative sequence	30 – 120	91	Missing in isoform 3.		VSP_005166
	Alternative sequence	30 – 71	42	Missing in isoform 4.		VSP_005165
	Alternative sequence	72 – 161	90	Missing in isoform 5.		VSP_026163
	Alternative sequence	121 – 161	41	Missing in isoform 4.		VSP_005168
Experimental info
	Sequence conflict	56	1	S → R in AAA41518. Ref.3
	Sequence conflict	56	1	S → R in AAA41521. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (L-CA variant 4) [UniParc]. Last modified June 12, 2007. Version 2. Checksum: EDFA48100ACF2CB2	FASTA	1,273	143,269
	10 20 30 40 50 60 MYLWLKLLAF SLALLGPEVF VTGQGTTDDG LDTTEIVLLP QTDPLPARTT EFTPPSISER 70 80 90 100 110 120 GNGSSETTYL PGFSSTLMPH LTPQPDSQTP SARGADTQTL SSQADLTTLT AAPSGETDPP 130 140 150 160 170 180 GVPEESTVPE TFPGGTPILA RNSTAPSPTH TSNVSTTDIS SGANLTTPAP STLGFASNTT 190 200 210 220 230 240 TSTEIATPQT KPSCDEKFGN VTVRYIYDDS SKNFNANLEG DKKPKCEYTD CEKELKNLPE 250 260 270 280 290 300 CSQKNVTLSN GSCTPDKIIN LDVPPGTHNF NLTNCTPDIE ANTSICLEWK IKNKFTCDIQ 310 320 330 340 350 360 KISYNFRCTP EMKTFALDKH GTLWLHNLTV RTNYTCAAEV LYNNVILLKQ DRRVQTDFGT 370 380 390 400 410 420 PEMLPHVQCK NSTNSTTLVS WAEPASKHHG YILCYKKTPS EKCENLANDV NSFEVKNLRP 430 440 450 460 470 480 YTEYTVSLFA YVIGRVQRNG PAKDCNFRTK AARPGKVNGM KTSRASDNSI NVTCNSPYEI 490 500 510 520 530 540 NGPEARYILE VKSGGSLVKT FNQSTCKFVV DNLYYSTDYE FLVYFYNGEY LGDPEIKPQS 550 560 570 580 590 600 TSYNSKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN LDEQQELVER DEEKQLINVD 610 620 630 640 650 660 PIHSDLLLET YKRKIADEGR LFLAEFQSIP RVFSKFPIKD ARKSQNQNKN RYVDILPYDY 670 680 690 700 710 720 NRVELSEING DAGSTYINAS YIDGFKEPRK YIAAQGPRDE TVDDFWKMIW EQKATVIVMV 730 740 750 760 770 780 TRCEEGNRNK CAEYWPCMEE GTRTFRDVVV TINDHKRCPD YIIQKLSIAH KKEKATGREV 790 800 810 820 830 840 THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG TYIGIDAMLE 850 860 870 880 890 900 SLEAEGKVDV YGYVVNLRRQ RCLMVQVEAQ YILIHQALVE YNQFGETEVN LSELHSCLQN 910 920 930 940 950 960 LKKRDPPSDP SPLEAEYQRL PSYRSWRTQH IGNQEENKKK NRSSNVVPYD FNRVPLKHEL 970 980 990 1000 1010 1020 EMSKESEAES DESSDEDSDS EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF 1030 1040 1050 1060 1070 1080 QRKVKVIVML TELMSGDQEV CAQYWGEGKQ TYGDMEVMLK DTNKSSAYIL RAFELRHSKR 1090 1100 1110 1120 1130 1140 KEPRTVYQYQ CTTWKGEELP AEPKDLVTLI QNIKQKLPKS GSEGMKYHKH ASILVHCRDG 1150 1160 1170 1180 1190 1200 SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGMV GSFEQYQFLY DIMASIYPTQ 1210 1220 1230 1240 1250 1260 NGQVKKANSQ DKIEFHNEVD GAKQDANCVQ PADPLNKAQE DSKEVGASEP ASGSEEPEHS 1270 ANGPMSPALT PSS
	Isoform 2 (L-CA variant 1) [UniParc]. Checksum: D8CD289BA1873388	FASTA	1,141	129,697
	10 20 30 40 50 60 MYLWLKLLAF SLALLGPEVF VTGQGTTDDG ANLTTPAPST LGFASNTTTS TEIATPQTKP 70 80 90 100 110 120 SCDEKFGNVT VRYIYDDSSK NFNANLEGDK KPKCEYTDCE KELKNLPECS QKNVTLSNGS 130 140 150 160 170 180 CTPDKIINLD VPPGTHNFNL TNCTPDIEAN TSICLEWKIK NKFTCDIQKI SYNFRCTPEM 190 200 210 220 230 240 KTFALDKHGT LWLHNLTVRT NYTCAAEVLY NNVILLKQDR RVQTDFGTPE MLPHVQCKNS 250 260 270 280 290 300 TNSTTLVSWA EPASKHHGYI LCYKKTPSEK CENLANDVNS FEVKNLRPYT EYTVSLFAYV 310 320 330 340 350 360 IGRVQRNGPA KDCNFRTKAA RPGKVNGMKT SRASDNSINV TCNSPYEING PEARYILEVK 370 380 390 400 410 420 SGGSLVKTFN QSTCKFVVDN LYYSTDYEFL VYFYNGEYLG DPEIKPQSTS YNSKALIIFL 430 440 450 460 470 480 VFLIIVTSIA LLVVLYKIYD LRKKRSSNLD EQQELVERDE EKQLINVDPI HSDLLLETYK 490 500 510 520 530 540 RKIADEGRLF LAEFQSIPRV FSKFPIKDAR KSQNQNKNRY VDILPYDYNR VELSEINGDA 550 560 570 580 590 600 GSTYINASYI DGFKEPRKYI AAQGPRDETV DDFWKMIWEQ KATVIVMVTR CEEGNRNKCA 610 620 630 640 650 660 EYWPCMEEGT RTFRDVVVTI NDHKRCPDYI IQKLSIAHKK EKATGREVTH IQFTSWPDHG 670 680 690 700 710 720 VPEDPHLLLK LRRRVNAFSN FFSGPIVVHC SAGVGRTGTY IGIDAMLESL EAEGKVDVYG 730 740 750 760 770 780 YVVNLRRQRC LMVQVEAQYI LIHQALVEYN QFGETEVNLS ELHSCLQNLK KRDPPSDPSP 790 800 810 820 830 840 LEAEYQRLPS YRSWRTQHIG NQEENKKKNR SSNVVPYDFN RVPLKHELEM SKESEAESDE 850 860 870 880 890 900 SSDEDSDSEE TSKYINASFV MSYWKPEMMI AAQGPLKETI GDFWQMIFQR KVKVIVMLTE 910 920 930 940 950 960 LMSGDQEVCA QYWGEGKQTY GDMEVMLKDT NKSSAYILRA FELRHSKRKE PRTVYQYQCT 970 980 990 1000 1010 1020 TWKGEELPAE PKDLVTLIQN IKQKLPKSGS EGMKYHKHAS ILVHCRDGSQ QTGLFCALFN 1030 1040 1050 1060 1070 1080 LLESAETEDV VDVFQVVKSL RKARPGMVGS FEQYQFLYDI MASIYPTQNG QVKKANSQDK 1090 1100 1110 1120 1130 1140 IEFHNEVDGA KQDANCVQPA DPLNKAQEDS KEVGASEPAS GSEEPEHSAN GPMSPALTPS S
	Isoform 3 (L-CA variant 2) [UniParc]. Checksum: EDF2153D0EBBF86E	FASTA	1,182	133,819
	10 20 30 40 50 60 MYLWLKLLAF SLALLGPEVF VTGQGTTDDG VPEESTVPET FPGGTPILAR NSTAPSPTHT 70 80 90 100 110 120 SNVSTTDISS GANLTTPAPS TLGFASNTTT STEIATPQTK PSCDEKFGNV TVRYIYDDSS 130 140 150 160 170 180 KNFNANLEGD KKPKCEYTDC EKELKNLPEC SQKNVTLSNG SCTPDKIINL DVPPGTHNFN 190 200 210 220 230 240 LTNCTPDIEA NTSICLEWKI KNKFTCDIQK ISYNFRCTPE MKTFALDKHG TLWLHNLTVR 250 260 270 280 290 300 TNYTCAAEVL YNNVILLKQD RRVQTDFGTP EMLPHVQCKN STNSTTLVSW AEPASKHHGY 310 320 330 340 350 360 ILCYKKTPSE KCENLANDVN SFEVKNLRPY TEYTVSLFAY VIGRVQRNGP AKDCNFRTKA 370 380 390 400 410 420 ARPGKVNGMK TSRASDNSIN VTCNSPYEIN GPEARYILEV KSGGSLVKTF NQSTCKFVVD 430 440 450 460 470 480 NLYYSTDYEF LVYFYNGEYL GDPEIKPQST SYNSKALIIF LVFLIIVTSI ALLVVLYKIY 490 500 510 520 530 540 DLRKKRSSNL DEQQELVERD EEKQLINVDP IHSDLLLETY KRKIADEGRL FLAEFQSIPR 550 560 570 580 590 600 VFSKFPIKDA RKSQNQNKNR YVDILPYDYN RVELSEINGD AGSTYINASY IDGFKEPRKY 610 620 630 640 650 660 IAAQGPRDET VDDFWKMIWE QKATVIVMVT RCEEGNRNKC AEYWPCMEEG TRTFRDVVVT 670 680 690 700 710 720 INDHKRCPDY IIQKLSIAHK KEKATGREVT HIQFTSWPDH GVPEDPHLLL KLRRRVNAFS 730 740 750 760 770 780 NFFSGPIVVH CSAGVGRTGT YIGIDAMLES LEAEGKVDVY GYVVNLRRQR CLMVQVEAQY 790 800 810 820 830 840 ILIHQALVEY NQFGETEVNL SELHSCLQNL KKRDPPSDPS PLEAEYQRLP SYRSWRTQHI 850 860 870 880 890 900 GNQEENKKKN RSSNVVPYDF NRVPLKHELE MSKESEAESD ESSDEDSDSE ETSKYINASF 910 920 930 940 950 960 VMSYWKPEMM IAAQGPLKET IGDFWQMIFQ RKVKVIVMLT ELMSGDQEVC AQYWGEGKQT 970 980 990 1000 1010 1020 YGDMEVMLKD TNKSSAYILR AFELRHSKRK EPRTVYQYQC TTWKGEELPA EPKDLVTLIQ 1030 1040 1050 1060 1070 1080 NIKQKLPKSG SEGMKYHKHA SILVHCRDGS QQTGLFCALF NLLESAETED VVDVFQVVKS 1090 1100 1110 1120 1130 1140 LRKARPGMVG SFEQYQFLYD IMASIYPTQN GQVKKANSQD KIEFHNEVDG AKQDANCVQP 1150 1160 1170 1180 ADPLNKAQED SKEVGASEPA SGSEEPEHSA NGPMSPALTP SS
	Isoform 4 (L-CA variant 3) [UniParc]. Checksum: 61CD4F787C7E695F	FASTA	1,190	134,662
	10 20 30 40 50 60 MYLWLKLLAF SLALLGPEVF VTGQGTTDDG FSSTLMPHLT PQPDSQTPSA RGADTQTLSS 70 80 90 100 110 120 QADLTTLTAA PSGETDPPGA NLTTPAPSTL GFASNTTTST EIATPQTKPS CDEKFGNVTV 130 140 150 160 170 180 RYIYDDSSKN FNANLEGDKK PKCEYTDCEK ELKNLPECSQ KNVTLSNGSC TPDKIINLDV 190 200 210 220 230 240 PPGTHNFNLT NCTPDIEANT SICLEWKIKN KFTCDIQKIS YNFRCTPEMK TFALDKHGTL 250 260 270 280 290 300 WLHNLTVRTN YTCAAEVLYN NVILLKQDRR VQTDFGTPEM LPHVQCKNST NSTTLVSWAE 310 320 330 340 350 360 PASKHHGYIL CYKKTPSEKC ENLANDVNSF EVKNLRPYTE YTVSLFAYVI GRVQRNGPAK 370 380 390 400 410 420 DCNFRTKAAR PGKVNGMKTS RASDNSINVT CNSPYEINGP EARYILEVKS GGSLVKTFNQ 430 440 450 460 470 480 STCKFVVDNL YYSTDYEFLV YFYNGEYLGD PEIKPQSTSY NSKALIIFLV FLIIVTSIAL 490 500 510 520 530 540 LVVLYKIYDL RKKRSSNLDE QQELVERDEE KQLINVDPIH SDLLLETYKR KIADEGRLFL 550 560 570 580 590 600 AEFQSIPRVF SKFPIKDARK SQNQNKNRYV DILPYDYNRV ELSEINGDAG STYINASYID 610 620 630 640 650 660 GFKEPRKYIA AQGPRDETVD DFWKMIWEQK ATVIVMVTRC EEGNRNKCAE YWPCMEEGTR 670 680 690 700 710 720 TFRDVVVTIN DHKRCPDYII QKLSIAHKKE KATGREVTHI QFTSWPDHGV PEDPHLLLKL 730 740 750 760 770 780 RRRVNAFSNF FSGPIVVHCS AGVGRTGTYI GIDAMLESLE AEGKVDVYGY VVNLRRQRCL 790 800 810 820 830 840 MVQVEAQYIL IHQALVEYNQ FGETEVNLSE LHSCLQNLKK RDPPSDPSPL EAEYQRLPSY 850 860 870 880 890 900 RSWRTQHIGN QEENKKKNRS SNVVPYDFNR VPLKHELEMS KESEAESDES SDEDSDSEET 910 920 930 940 950 960 SKYINASFVM SYWKPEMMIA AQGPLKETIG DFWQMIFQRK VKVIVMLTEL MSGDQEVCAQ 970 980 990 1000 1010 1020 YWGEGKQTYG DMEVMLKDTN KSSAYILRAF ELRHSKRKEP RTVYQYQCTT WKGEELPAEP 1030 1040 1050 1060 1070 1080 KDLVTLIQNI KQKLPKSGSE GMKYHKHASI LVHCRDGSQQ TGLFCALFNL LESAETEDVV 1090 1100 1110 1120 1130 1140 DVFQVVKSLR KARPGMVGSF EQYQFLYDIM ASIYPTQNGQ VKKANSQDKI EFHNEVDGAK 1150 1160 1170 1180 1190 QDANCVQPAD PLNKAQEDSK EVGASEPASG SEEPEHSANG PMSPALTPSS
	Isoform 5 [UniParc]. Checksum: 1076BD878F13B5CA	FASTA	1,183	134,182
	10 20 30 40 50 60 MYLWLKLLAF SLALLGPEVF VTGQGTTDDG LDTTEIVLLP QTDPLPARTT EFTPPSISER 70 80 90 100 110 120 GNGSSETTYL PGANLTTPAP STLGFASNTT TSTEIATPQT KPSCDEKFGN VTVRYIYDDS 130 140 150 160 170 180 SKNFNANLEG DKKPKCEYTD CEKELKNLPE CSQKNVTLSN GSCTPDKIIN LDVPPGTHNF 190 200 210 220 230 240 NLTNCTPDIE ANTSICLEWK IKNKFTCDIQ KISYNFRCTP EMKTFALDKH GTLWLHNLTV 250 260 270 280 290 300 RTNYTCAAEV LYNNVILLKQ DRRVQTDFGT PEMLPHVQCK NSTNSTTLVS WAEPASKHHG 310 320 330 340 350 360 YILCYKKTPS EKCENLANDV NSFEVKNLRP YTEYTVSLFA YVIGRVQRNG PAKDCNFRTK 370 380 390 400 410 420 AARPGKVNGM KTSRASDNSI NVTCNSPYEI NGPEARYILE VKSGGSLVKT FNQSTCKFVV 430 440 450 460 470 480 DNLYYSTDYE FLVYFYNGEY LGDPEIKPQS TSYNSKALII FLVFLIIVTS IALLVVLYKI 490 500 510 520 530 540 YDLRKKRSSN LDEQQELVER DEEKQLINVD PIHSDLLLET YKRKIADEGR LFLAEFQSIP 550 560 570 580 590 600 RVFSKFPIKD ARKSQNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS YIDGFKEPRK 610 620 630 640 650 660 YIAAQGPRDE TVDDFWKMIW EQKATVIVMV TRCEEGNRNK CAEYWPCMEE GTRTFRDVVV 670 680 690 700 710 720 TINDHKRCPD YIIQKLSIAH KKEKATGREV THIQFTSWPD HGVPEDPHLL LKLRRRVNAF 730 740 750 760 770 780 SNFFSGPIVV HCSAGVGRTG TYIGIDAMLE SLEAEGKVDV YGYVVNLRRQ RCLMVQVEAQ 790 800 810 820 830 840 YILIHQALVE YNQFGETEVN LSELHSCLQN LKKRDPPSDP SPLEAEYQRL PSYRSWRTQH 850 860 870 880 890 900 IGNQEENKKK NRSSNVVPYD FNRVPLKHEL EMSKESEAES DESSDEDSDS EETSKYINAS 910 920 930 940 950 960 FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML TELMSGDQEV CAQYWGEGKQ 970 980 990 1000 1010 1020 TYGDMEVMLK DTNKSSAYIL RAFELRHSKR KEPRTVYQYQ CTTWKGEELP AEPKDLVTLI 1030 1040 1050 1060 1070 1080 QNIKQKLPKS GSEGMKYHKH ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK 1090 1100 1110 1120 1130 1140 SLRKARPGMV GSFEQYQFLY DIMASIYPTQ NGQVKKANSQ DKIEFHNEVD GAKQDANCVQ 1150 1160 1170 1180 PADPLNKAQE DSKEVGASEP ASGSEEPEHS ANGPMSPALT PSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Amgen rat EST program." Amgen EST program Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-147 (ISOFORM 4).
[2]	"Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus." Barclay A.N., Jackson D.I., Willis A.C., Williams A.F. EMBO J. 6:1259-1264(1987) [PubMed: 2440674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-218 (ISOFORMS 1; 2; 3 AND 4).
[3]	Barclay A.N., Jackson D.I., Willis A.C., Williams A.F. Submitted (MAY-1987) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-1273 (ISOFORMS 1; 3; 4 AND 5).
[4]	"Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr." Thomas M.L., Barclay A.N., Gagnon J., Williams A.F. Cell 41:83-93(1985) [PubMed: 3158393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1255 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CB793707 mRNA. No translation available. Y00065 mRNA. Translation: CAA68272.1. Y00065 mRNA. Translation: CAA68273.1. Y00065 mRNA. Translation: CAA68274.1. Y00065 mRNA. Translation: CAA68275.1. M25820 mRNA. Translation: AAA41518.1. M25821 mRNA. Translation: AAA41519.1. M25822 mRNA. Translation: AAA41520.1. M25823 mRNA. Translation: AAA41521.1.
IPI	IPI00231601. IPI00389957. IPI00777870. IPI00851110. IPI00851132.
PIR	A45854.
RefSeq	NP_001103357.1. NM_001109887.1. NP_001103358.1. NM_001109888.1. NP_001103359.1. NM_001109889.1. NP_001103360.1. NM_001109890.1. NP_612516.2. NM_138507.2.
UniGene	Rn.90166.
3D structure databases
ProteinModelPortal	P04157.
SMR	P04157. Positions 594-1198.
ModBase	Search...
Protein-protein interaction databases
STRING	P04157.
PTM databases
PhosphoSite	P04157.
Proteomic databases
PRIDE	P04157.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000000814; ENSRNOP00000000814; ENSRNOG00000000655. ENSRNOT00000029865; ENSRNOP00000029889; ENSRNOG00000000655. ENSRNOT00000029878; ENSRNOP00000030503; ENSRNOG00000000655. ENSRNOT00000060292; ENSRNOP00000057042; ENSRNOG00000000655. ENSRNOT00000064785; ENSRNOP00000063859; ENSRNOG00000000655.
GeneID	24699.
KEGG	rno:24699.
Organism-specific databases
CTD	5788.
RGD	3451. Ptprc.
Phylogenomic databases
eggNOG	roNOG14381.
HOVERGEN	HBG000066.
Gene expression databases
ArrayExpress	P04157.
Genevestigator	P04157.
GermOnline	ENSRNOG00000000655. Rattus norvegicus.
Family and domain databases
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR024739. PTP_recept_N. IPR000387. Tyr/Dual-specificity_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
KO	K06478.
Pfam	PF00041. fn3. 1 hit. PF12453. PTP_N. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 2 hits. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	604155.

Entry information

Entry name

PTPRC_RAT

Accession

Primary (citable) accession number: P04157

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 130 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program