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Protein

Trefoil factor 1

Gene

TFF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

SIGNORiP04155

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Breast cancer estrogen-inducible protein
PNR-2
Polypeptide P1.A
Short name:
hP1.A
Protein pS2
Gene namesi
Name:TFF1
Synonyms:BCEI, PS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160182.2
HGNCiHGNC:11755 TFF1
MIMi113710 gene
neXtProtiNX_P04155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82C → S: Abolishes inhibition of gastric cancer cell growth. 1 Publication1

Organism-specific databases

DisGeNETi7031
OpenTargetsiENSG00000160182
PharmGKBiPA36470

Polymorphism and mutation databases

BioMutaiTFF1
DMDMi131127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 245 PublicationsAdd BLAST24
ChainiPRO_000002345625 – 84Trefoil factor 1Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 57
Disulfide bondi41 ↔ 56
Disulfide bondi51 ↔ 68

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP04155
PaxDbiP04155
PeptideAtlasiP04155
PRIDEiP04155

Expressioni

Tissue specificityi

Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).7 Publications

Gene expression databases

BgeeiENSG00000160182
CleanExiHS_TFF1
GenevisibleiP04155 HS

Organism-specific databases

HPAiCAB002170
HPA003425

Interactioni

Subunit structurei

Heterodimer with GKN2; disulfide linked.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112889, 21 interactors
IntActiP04155, 18 interactors
MINTiP04155
STRINGi9606.ENSP00000291527

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Turni35 – 37Combined sources3
Beta strandi40 – 42Combined sources3
Helixi48 – 52Combined sources5
Turni53 – 55Combined sources3
Beta strandi61 – 65Combined sources5
Beta strandi67 – 69Combined sources3
Beta strandi72 – 74Combined sources3
Beta strandi79 – 82Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HI7NMR-A/B25-84[»]
1PS2NMR-A25-84[»]
ProteinModelPortaliP04155
SMRiP04155
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04155

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 72P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 83Glu-rich (acidic)5

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868 Eukaryota
ENOG410Z7FU LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000121778
HOVERGENiHBG004364
InParanoidiP04155
KOiK22456
OMAiPEEECEF
OrthoDBiEOG091G0XBT
PhylomeDBiP04155
TreeFamiTF336092

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
IPR028824 TFF1
PANTHERiPTHR13826:SF18 PTHR13826:SF18, 1 hit
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMENKVIC ALVLVSMLAL GTLAEAQTET CTVAPRERQN CGFPGVTPSQ
60 70 80
CANKGCCFDD TVRGVPWCFY PNTIDVPPEE ECEF
Length:84
Mass (Da):9,150
Last modified:November 1, 1986 - v1
Checksum:i65198523BAD6EBC7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05356322T → I. Corresponds to variant dbSNP:rs34795821Ensembl.1
Natural variantiVAR_01528132T → I in a gastric carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528232T → K in a gastric carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528334A → D in a gastric carcinoma sample; somatic mutation; abolishes inhibition of gastric cancer cell growth; abolishes inhibition of apoptosis in gasterointestinal epithelial cells; increases invasive activity in epithelial cells. 2 Publications1
Natural variantiVAR_01528437E → K in a gastric carcinoma sample; somatic mutation; abolishes inhibition of gastric cancer cell growth; abolishes inhibition of apoptosis in gasterointestinal epithelial cells; increases invasive activity in epithelial cells. 2 Publications1
Natural variantiVAR_01528546V → I in a gastric adenoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528655G → V in a gastric carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00474 mRNA Translation: CAA25155.1
M12075 mRNA Translation: AAA52402.1
X05030, X05321, X05322 Genomic DNA Translation: CAA28695.1
X52003 mRNA Translation: CAA36254.1
AB038162 Genomic DNA Translation: BAB13729.1
AP001746 Genomic DNA Translation: BAA95532.1
BC032811 mRNA Translation: AAH32811.1
CCDSiCCDS13685.1
PIRiA26667
RefSeqiNP_003216.1, NM_003225.2
UniGeneiHs.162807

Genome annotation databases

EnsembliENST00000291527; ENSP00000291527; ENSG00000160182
GeneIDi7031
KEGGihsa:7031
UCSCiuc002zax.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTFF1_HUMAN
AccessioniPrimary (citable) accession number: P04155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: April 25, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health