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Protein

Trefoil factor 1

Gene

TFF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Breast cancer estrogen-inducible protein
PNR-2
Polypeptide P1.A
Short name:
hP1.A
Protein pS2
Gene namesi
Name:TFF1
Synonyms:BCEI, PS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11755. TFF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82C → S: Abolishes inhibition of gastric cancer cell growth. 1 Publication1

Organism-specific databases

DisGeNETi7031.
OpenTargetsiENSG00000160182.
PharmGKBiPA36470.

Polymorphism and mutation databases

BioMutaiTFF1.
DMDMi131127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 245 PublicationsAdd BLAST24
ChainiPRO_000002345625 – 84Trefoil factor 1Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 57
Disulfide bondi41 ↔ 56
Disulfide bondi51 ↔ 68

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP04155.
PaxDbiP04155.
PeptideAtlasiP04155.
PRIDEiP04155.

Expressioni

Tissue specificityi

Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).7 Publications

Gene expression databases

BgeeiENSG00000160182.
CleanExiHS_TFF1.
GenevisibleiP04155. HS.

Organism-specific databases

HPAiCAB002170.
HPA003425.

Interactioni

Subunit structurei

Heterodimer with GKN2; disulfide linked.

Binary interactionsi

WithEntry#Exp.IntActNotes
BTN3A1O004813EBI-743871,EBI-2809309
BTNL8Q6UX413EBI-743871,EBI-4314379
CD300LDQ6UXZ33EBI-743871,EBI-4314468
FCRL4Q96PJ53EBI-743871,EBI-4314687
SIGLEC8Q9NYZ43EBI-743871,EBI-4314991
ZNF250P15622-33EBI-743871,EBI-10177272

Protein-protein interaction databases

BioGridi112889. 21 interactors.
IntActiP04155. 16 interactors.
MINTiMINT-1461530.
STRINGi9606.ENSP00000291527.

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Turni35 – 37Combined sources3
Beta strandi40 – 42Combined sources3
Helixi48 – 52Combined sources5
Turni53 – 55Combined sources3
Beta strandi61 – 65Combined sources5
Beta strandi67 – 69Combined sources3
Beta strandi72 – 74Combined sources3
Beta strandi79 – 82Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HI7NMR-A/B25-84[»]
1PS2NMR-A25-84[»]
ProteinModelPortaliP04155.
SMRiP04155.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 72P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 83Glu-rich (acidic)5

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiP04155.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiP04155.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMENKVIC ALVLVSMLAL GTLAEAQTET CTVAPRERQN CGFPGVTPSQ
60 70 80
CANKGCCFDD TVRGVPWCFY PNTIDVPPEE ECEF
Length:84
Mass (Da):9,150
Last modified:November 1, 1986 - v1
Checksum:i65198523BAD6EBC7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05356322T → I.Corresponds to variant rs34795821dbSNPEnsembl.1
Natural variantiVAR_01528132T → I in a gastric carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528232T → K in a gastric carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528334A → D in a gastric carcinoma sample; somatic mutation; abolishes inhibition of gastric cancer cell growth; abolishes inhibition of apoptosis in gasterointestinal epithelial cells; increases invasive activity in epithelial cells. 2 Publications1
Natural variantiVAR_01528437E → K in a gastric carcinoma sample; somatic mutation; abolishes inhibition of gastric cancer cell growth; abolishes inhibition of apoptosis in gasterointestinal epithelial cells; increases invasive activity in epithelial cells. 2 Publications1
Natural variantiVAR_01528546V → I in a gastric adenoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_01528655G → V in a gastric carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00474 mRNA. Translation: CAA25155.1.
M12075 mRNA. Translation: AAA52402.1.
X05030, X05321, X05322 Genomic DNA. Translation: CAA28695.1.
X52003 mRNA. Translation: CAA36254.1.
AB038162 Genomic DNA. Translation: BAB13729.1.
AP001746 Genomic DNA. Translation: BAA95532.1.
BC032811 mRNA. Translation: AAH32811.1.
CCDSiCCDS13685.1.
PIRiA26667.
RefSeqiNP_003216.1. NM_003225.2.
UniGeneiHs.162807.

Genome annotation databases

EnsembliENST00000291527; ENSP00000291527; ENSG00000160182.
GeneIDi7031.
KEGGihsa:7031.
UCSCiuc002zax.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00474 mRNA. Translation: CAA25155.1.
M12075 mRNA. Translation: AAA52402.1.
X05030, X05321, X05322 Genomic DNA. Translation: CAA28695.1.
X52003 mRNA. Translation: CAA36254.1.
AB038162 Genomic DNA. Translation: BAB13729.1.
AP001746 Genomic DNA. Translation: BAA95532.1.
BC032811 mRNA. Translation: AAH32811.1.
CCDSiCCDS13685.1.
PIRiA26667.
RefSeqiNP_003216.1. NM_003225.2.
UniGeneiHs.162807.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HI7NMR-A/B25-84[»]
1PS2NMR-A25-84[»]
ProteinModelPortaliP04155.
SMRiP04155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112889. 21 interactors.
IntActiP04155. 16 interactors.
MINTiMINT-1461530.
STRINGi9606.ENSP00000291527.

Polymorphism and mutation databases

BioMutaiTFF1.
DMDMi131127.

Proteomic databases

MaxQBiP04155.
PaxDbiP04155.
PeptideAtlasiP04155.
PRIDEiP04155.

Protocols and materials databases

DNASUi7031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291527; ENSP00000291527; ENSG00000160182.
GeneIDi7031.
KEGGihsa:7031.
UCSCiuc002zax.2. human.

Organism-specific databases

CTDi7031.
DisGeNETi7031.
GeneCardsiTFF1.
HGNCiHGNC:11755. TFF1.
HPAiCAB002170.
HPA003425.
MIMi113710. gene.
neXtProtiNX_P04155.
OpenTargetsiENSG00000160182.
PharmGKBiPA36470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiP04155.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiP04155.
TreeFamiTF336092.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160182-MONOMER.

Miscellaneous databases

ChiTaRSiTFF1. human.
EvolutionaryTraceiP04155.
GeneWikiiTrefoil_factor_1.
GenomeRNAii7031.
PROiP04155.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160182.
CleanExiHS_TFF1.
GenevisibleiP04155. HS.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFF1_HUMAN
AccessioniPrimary (citable) accession number: P04155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: November 2, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.