Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04152 (UMUC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UmuC
Gene names
Name:umuC
Ordered Locus Names:b1184, JW1173
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Contains 1 umuC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Protein UmuC
PRO_0000173982

Regions

Domain2 – 188187UmuC

Experimental info

Mutagenesis751E → K in umuC36; non-mutable.
Mutagenesis1011D → N in umuC104; non-mutable.
Mutagenesis2901T → K in umuC25; non-mutable.
Sequence conflict1521A → E in AAA24729. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P04152 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 0F1855D802A3F5F8

FASTA42247,680
        10         20         30         40         50         60 
MFALCDVNAF YASCETVFRP DLWGKPVVVL SNNDGCVIAR NAEAKALGVK MGDPWFKQKD 

        70         80         90        100        110        120 
LFRRCGVVCF SSNYELYADM SNRVMSTLEE LSPRVEIYSI DEAFCDLTGV RNCRDLTDFG 

       130        140        150        160        170        180 
REIRATVLQR THLTVGVGIA QTKTLAKLAN HAAKKWQRQT GGVVDLSNLE RQRKLMSALP 

       190        200        210        220        230        240 
VDDVWGIGRR ISKKLDAMGI KTVLDLADTD IRFIRKHFNV VLERTVRELR GEPCLQLEEF 

       250        260        270        280        290        300 
APTKQEIICS RSFGERITDY PSMRQAICSY AARAAEKLRS EHQYCRFIST FIKTSPFALN 

       310        320        330        340        350        360 
EPYYGNSASV KLLTPTQDSR DIINAATRSL DAIWQAGHRY QKAGVMLGDF FSQGVAQLNL 

       370        380        390        400        410        420 
FDDNAPRPGS EQLMTVMDTL NAKEGRGTLY FAGQGIQQQW QMKRAMLSPR YTTRSSDLLR 


VK 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli."
Kitagawa Y., Akaboshi E., Shinagawa H., Horii T., Ogawa H., Kato T.
Proc. Natl. Acad. Sci. U.S.A. 82:4336-4340(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology."
Perry K.L., Elledge S.J., Mitchell B.B., Marsh L., Walker G.C.
Proc. Natl. Acad. Sci. U.S.A. 82:4331-4335(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage."
Koch W.H., Ennis D.G., Levine A.S., Woodgate R.
Mol. Gen. Genet. 233:443-448(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10107 Genomic DNA. Translation: AAA24729.1.
M13387 Genomic DNA. Translation: AAA98074.1.
U00096 Genomic DNA. Translation: AAC74268.1.
AP009048 Genomic DNA. Translation: BAA36031.1.
PIRZWECC. E64864.
RefSeqNP_415702.1. NC_000913.3.
YP_489451.1. NC_007779.1.

3D structure databases

ProteinModelPortalP04152.
SMRP04152. Positions 1-351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-11090N.
IntActP04152. 9 interactions.
MINTMINT-1516814.
STRING511145.b1184.

Proteomic databases

PRIDEP04152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74268; AAC74268; b1184.
BAA36031; BAA36031; BAA36031.
GeneID12932822.
946359.
KEGGecj:Y75_p1156.
eco:b1184.
PATRIC32117614. VBIEscCol129921_1229.

Organism-specific databases

EchoBASEEB1049.
EcoGeneEG11056. umuC.

Phylogenomic databases

eggNOGCOG0389.
HOGENOMHOG000252172.
KOK03502.
OMAPMGAPYF.
OrthoDBEOG6CZQNH.
PhylomeDBP04152.

Enzyme and pathway databases

BioCycEcoCyc:EG11056-MONOMER.
ECOL316407:JW1173-MONOMER.
MetaCyc:EG11056-MONOMER.

Gene expression databases

GenevestigatorP04152.

Family and domain databases

Gene3D3.30.1490.100. 1 hit.
InterProIPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR025188. DUF4113.
IPR024728. PolY_HhH_motif.
[Graphical view]
PfamPF13438. DUF4113. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view]
SUPFAMSSF100879. SSF100879. 1 hit.
PROSITEPS50173. UMUC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP04152.

Entry information

Entry nameUMUC_ECOLI
AccessionPrimary (citable) accession number: P04152
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene