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Reviewed, UniProtKB/Swiss-Prot P04133 (HEX_ADE05)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hexon protein
Alternative name(s):
    Late protein 2
Gene names
Name: PII
OrganismHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Taxonomic identifier28285 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus C
Virus hostHomo sapiens (Human) [TaxID: 9606]

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Protein attributes

Sequence length952 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This protein is one of the structural proteins in the viral coat and is synthesized during late infection.

Subunit structure

Homotrimer By similarity.

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the adenoviridae hexon protein family.

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Ontologies

Keywords
   Cellular componentCapsid protein
Hexon protein
Virion
   Developmental stageLate protein
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentviral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

structural molecule activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

F10P007421EBI-1646019,EBI-719750From a different organism.
F7P087091EBI-1646019,EBI-355972From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host By similarity
Chain2 – 952951Hexon protein
PRO_0000221816

Regions

Compositional bias134 – 15926Asp/Glu-rich (acidic)

Secondary structure

1 ................................................................................................................................................................ 952
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P04133-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 822CCDE26E970C5A

FASTA952108,007
        10         20         30         40         50         60 
MATPSMMPQW SYMHISGQDA SEYLSPGLVQ FARATETYFS LNNKFRNPTV APTHDVTTDR 

        70         80         90        100        110        120 
SQRLTLRFIP VDREDTAYSY KARFTLAVGD NRVLDMASTY FDIRGVLDRG PTFKPYSGTA 

       130        140        150        160        170        180 
YNALAPKGAP NPCEWDEAAT ALEINLEEED DDNEDEVDEQ AEQQKTHVFG QAPYSGINIT 

       190        200        210        220        230        240 
KEGIQIGVEG QTPKYADKTF QPEPQIGESQ WYETEINHAA GRVLKKTTPM KPCYGSYAKP 

       250        260        270        280        290        300 
TNENGGQGIL VKQQNGKLES QVEMQFFSTT EATAGNGDNL TPKVVLYSED VDIETPDTHI 

       310        320        330        340        350        360 
SYMPTIKEGN SRELMGQQSM PNRPNYIAFR DNFIGLMYYN STGNMGVLAG QASQLNAVVD 

       370        380        390        400        410        420 
LQDRNTELSY QLLLDSIGDR TRYFSMWNQA VDSYDPDVRI IENHGTEDEL PNYCFPLGGV 

       430        440        450        460        470        480 
INTETLTKVK PKTGQENGWE KDATEFSDKN EIRVGNNFAM EINLNANLWR NFLYSNIALY 

       490        500        510        520        530        540 
LPDKLKYSPS NVKISDNPNT YDYMNKRVVA PGLVDCYINL GARWSLDYMD NVNPFNHHRN 

       550        560        570        580        590        600 
AGLRYRSMLL GNGRYVPFHI QVPQKFFAIK NLLLLPGSYT YEWNFRKDVN MVLQSSLGND 

       610        620        630        640        650        660 
LRVDGASIKF DSICLYATFF PMAHNTASTL EAMLRNDTND QSFNDYLSAA NMLYPIPANA 

       670        680        690        700        710        720 
TNVPISIPSR NWAAFRGWAF TRLKTKETPS LGSGYDPYYT YSGSIPYLDG TFYLNHTFKK 

       730        740        750        760        770        780 
VAITFDSSVS WPGNDRLLTP NEFEIKRSVD GEGYNVAQCN MTKDWFLVQM LANYNIGYQG 

       790        800        810        820        830        840 
FYIPESYKDR MYSFFRNFQP MSRQVVDDTK YKDYQQVGIL HQHNNSGFVG YLAPTMREGQ 

       850        860        870        880        890        900 
AYPANFPYPL IGKTAVDSIT QKKFLCDRTL WRIPFSSNFM SMGALTDLGQ NLLYANSAHA 

       910        920        930        940        950 
LDMTFEVDPM DEPTLLYVLF EVFDVVRVHR PHRGVIETVY LRTPFSAGNA TT

« Hide

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References

« Hide 'large scale' references
[1]"Adenovirus hexon. Sequence comparison of subgroup C serotypes 2 and 5."
Kinloch R., MacKay N., Mautner V.
J. Biol. Chem. 259:6431-6436(1984) [PubMed: 6202684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2."
Chroboczek J., Bieber F., Jacrot B.
Virology 186:280-285(1992) [PubMed: 1727603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

M73260 Genomic DNA. No translation available.
X02997 Genomic DNA. Translation: CAA26753.1.
PIRHXAD5. A03849.
RefSeqAP_000211.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1P30X-ray2.50A2-951[»]
2BVIelectron microscopy10.00F/G/H/I/J/K/L/M/N/O/P/Q2-951[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP04133. 2 interactions.

Family and domain databases

InterProIPR016111. Coat_hexon/vp54_sub4_dsDNA-vir.
IPR016108. Coat_hexon_C_Adenovir.
IPR016107. Coat_hexon_N_Adenovir.
IPR016110. Coat_hexon_sub3_Adenovir.
[Graphical view]
Gene3DG3DSA:2.70.9.10. Coat_hexon/vp54_sub4_dsDNA-vir. 1 hit.
G3DSA:3.90.249.10. Coat_hexon_sub3_Adenovir. 2 hits.
PfamPF01065. Adeno_hexon. 1 hit.
PF03678. Adeno_hexon_C. 1 hit.
[Graphical view]
ProDomPD002815. Adeno_hexon. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

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Entry information

Entry nameHEX_ADE05
AccessionPrimary (citable) accession number: P04133
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents