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Protein

Type-1 fimbrial protein, A chain

Gene

fimA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10308-MONOMER.
ECOL316407:JW4277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 fimbrial protein, A chain
Alternative name(s):
Type-1A pilin
Gene namesi
Name:fimA
Synonyms:pilA
Ordered Locus Names:b4314, JW4277
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10308. fimA.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000917024 – 182Type-1 fimbrial protein, A chainAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 84Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP04128.
PRIDEiP04128.

Interactioni

Protein-protein interaction databases

BioGridi4262746. 6 interactors.
DIPiDIP-9609N.
STRINGi511145.b4314.

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Beta strandi45 – 51Combined sources7
Beta strandi54 – 56Combined sources3
Turni62 – 64Combined sources3
Beta strandi67 – 71Combined sources5
Beta strandi75 – 84Combined sources10
Helixi86 – 90Combined sources5
Beta strandi93 – 97Combined sources5
Beta strandi100 – 102Combined sources3
Helixi103 – 105Combined sources3
Turni115 – 117Combined sources3
Beta strandi120 – 127Combined sources8
Beta strandi131 – 134Combined sources4
Beta strandi136 – 138Combined sources3
Helixi148 – 150Combined sources3
Beta strandi152 – 167Combined sources16
Beta strandi173 – 180Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JTYNMR-A24-182[»]
2M5GNMR-A24-182[»]
2N7HNMR-A/B/C/D/E/F24-182[»]
3SQBX-ray3.20B/D/F/H37-182[»]
4DWHX-ray2.50B/D41-182[»]
ProteinModelPortaliP04128.
SMRiP04128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04128.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108RQP. Bacteria.
ENOG4111KX6. LUCA.
HOGENOMiHOG000260127.
InParanoidiP04128.
KOiK07345.
OMAiNDCDTSV.
PhylomeDBiP04128.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTLAIVV LSALSLSSTA ALAAATTVNG GTVHFKGEVV NAACAVDAGS
60 70 80 90 100
VDQTVQLGQV RTASLAQEGA TSSAVGFNIQ LNDCDTNVAS KAAVAFLGTA
110 120 130 140 150
IDAGHTNVLA LQSSAAGSAT NVGVQILDRT GAALTLDGAT FSSETTLNNG
160 170 180
TNTIPFQARY FATGAATPGA ANADATFKVQ YQ
Length:182
Mass (Da):18,111
Last modified:February 1, 1995 - v2
Checksum:i35B2016BDD21A2C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → T in AAA24389 (PubMed:2858471).Curated1
Sequence conflicti163Missing in CAA25489 (PubMed:6147250).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00981 Genomic DNA. Translation: CAA25489.1.
M27603 Genomic DNA. Translation: AAA24389.1.
U14003 Genomic DNA. Translation: AAA97210.1.
U00096 Genomic DNA. Translation: AAC77270.1.
AP009048 Genomic DNA. Translation: BAE78307.1.
PIRiS56539. YQECT1.
RefSeqiNP_418734.1. NC_000913.3.
WP_000695564.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77270; AAC77270; b4314.
BAE78307; BAE78307; BAE78307.
GeneIDi948838.
KEGGiecj:JW4277.
eco:b4314.
PATRICi32124224. VBIEscCol129921_4455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00981 Genomic DNA. Translation: CAA25489.1.
M27603 Genomic DNA. Translation: AAA24389.1.
U14003 Genomic DNA. Translation: AAA97210.1.
U00096 Genomic DNA. Translation: AAC77270.1.
AP009048 Genomic DNA. Translation: BAE78307.1.
PIRiS56539. YQECT1.
RefSeqiNP_418734.1. NC_000913.3.
WP_000695564.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JTYNMR-A24-182[»]
2M5GNMR-A24-182[»]
2N7HNMR-A/B/C/D/E/F24-182[»]
3SQBX-ray3.20B/D/F/H37-182[»]
4DWHX-ray2.50B/D41-182[»]
ProteinModelPortaliP04128.
SMRiP04128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262746. 6 interactors.
DIPiDIP-9609N.
STRINGi511145.b4314.

Proteomic databases

PaxDbiP04128.
PRIDEiP04128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77270; AAC77270; b4314.
BAE78307; BAE78307; BAE78307.
GeneIDi948838.
KEGGiecj:JW4277.
eco:b4314.
PATRICi32124224. VBIEscCol129921_4455.

Organism-specific databases

EchoBASEiEB0304.
EcoGeneiEG10308. fimA.

Phylogenomic databases

eggNOGiENOG4108RQP. Bacteria.
ENOG4111KX6. LUCA.
HOGENOMiHOG000260127.
InParanoidiP04128.
KOiK07345.
OMAiNDCDTSV.
PhylomeDBiP04128.

Enzyme and pathway databases

BioCyciEcoCyc:EG10308-MONOMER.
ECOL316407:JW4277-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP04128.
PROiP04128.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFIMA1_ECOLI
AccessioniPrimary (citable) accession number: P04128
Secondary accession number(s): Q2M5Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.