Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P04118

- COL_HUMAN

UniProt

P04118 - COL_HUMAN

Protein

Colipase

Gene

CLPS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
    Enterostatin has a biological activity as a satiety signal.

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. lipid digestion Source: Reactome
    3. lipid metabolic process Source: ProtInc
    4. phototransduction, visible light Source: Reactome
    5. retinoid metabolic process Source: Reactome
    6. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Digestion, Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_24968. Retinoid metabolism and transport.
    REACT_9518. Digestion of dietary lipid.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Colipase
    Gene namesi
    Name:CLPS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2085. CLPS.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    PharmGKBiPA26611.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Add
    BLAST
    Propeptidei18 – 225Enterostatin, activation peptideSequence AnalysisPRO_0000005696
    Chaini23 – 11290ColipasePRO_0000005697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
    Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP04118.
    PeptideAtlasiP04118.
    PRIDEiP04118.

    PTM databases

    PhosphoSiteiP04118.

    Miscellaneous databases

    PMAP-CutDBP04118.

    Expressioni

    Tissue specificityi

    Expressed by the pancreas.

    Gene expression databases

    BgeeiP04118.
    CleanExiHS_CLPS.
    GenevestigatoriP04118.

    Organism-specific databases

    HPAiHPA010512.

    Interactioni

    Subunit structurei

    Forms a 1:1 stoichiometric complex with pancreatic lipase.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000259938.

    Structurei

    3D structure databases

    ProteinModelPortaliP04118.
    SMRiP04118. Positions 21-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the colipase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42456.
    HOGENOMiHOG000059253.
    HOVERGENiHBG005373.
    InParanoidiP04118.
    KOiK14460.
    OMAiCSAKTLY.
    OrthoDBiEOG74N5K5.
    PhylomeDBiP04118.
    TreeFamiTF336178.

    Family and domain databases

    InterProiIPR001981. Colipase.
    IPR017914. Colipase_C.
    IPR017915. Colipase_CS.
    IPR017913. Colipase_N.
    [Graphical view]
    PANTHERiPTHR10041. PTHR10041. 1 hit.
    PfamiPF01114. Colipase. 1 hit.
    PF02740. Colipase_C. 1 hit.
    [Graphical view]
    PRINTSiPR00128. COLIPASE.
    SMARTiSM00023. COLIPASE. 1 hit.
    [Graphical view]
    PROSITEiPS00121. COLIPASE_1. 1 hit.
    PS51342. COLIPASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKILILLLV ALSVAYAAPG PRGIIINLEN GELCMNSAQC KSNCCQHSSA    50
    LGLARCTSMA SENSECSVKT LYGIYYKCPC ERGLTCEGDK TIVGSITNTN 100
    FGICHDAGRS KQ 112
    Length:112
    Mass (Da):11,954
    Last modified:April 1, 1990 - v2
    Checksum:i772872EBBE7C4DF8
    GO

    Polymorphismi

    Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81L → P.
    Corresponds to variant rs2766597 [ dbSNP | Ensembl ].
    VAR_053040
    Natural varianti109 – 1091R → C.1 Publication
    Corresponds to variant rs41270082 [ dbSNP | Ensembl ].
    VAR_047105

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02883 mRNA. Translation: AAA52054.1.
    M95529 Genomic DNA. Translation: AAB05818.1.
    BT006812 mRNA. Translation: AAP35458.1.
    AL157823 Genomic DNA. Translation: CAI21642.1.
    CH471081 Genomic DNA. Translation: EAX03850.1.
    BC007061 mRNA. Translation: AAH07061.1.
    BC017897 mRNA. Translation: AAH17897.1.
    AY780648 mRNA. Translation: AAV35728.1.
    CCDSiCCDS4811.1.
    PIRiA42568. XLHU.
    RefSeqiNP_001823.1. NM_001832.3.
    UniGeneiHs.1340.

    Genome annotation databases

    EnsembliENST00000259938; ENSP00000259938; ENSG00000137392.
    GeneIDi1208.
    KEGGihsa:1208.
    UCSCiuc003ole.2. human.

    Polymorphism databases

    DMDMi116900.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Colipase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02883 mRNA. Translation: AAA52054.1 .
    M95529 Genomic DNA. Translation: AAB05818.1 .
    BT006812 mRNA. Translation: AAP35458.1 .
    AL157823 Genomic DNA. Translation: CAI21642.1 .
    CH471081 Genomic DNA. Translation: EAX03850.1 .
    BC007061 mRNA. Translation: AAH07061.1 .
    BC017897 mRNA. Translation: AAH17897.1 .
    AY780648 mRNA. Translation: AAV35728.1 .
    CCDSi CCDS4811.1.
    PIRi A42568. XLHU.
    RefSeqi NP_001823.1. NM_001832.3.
    UniGenei Hs.1340.

    3D structure databases

    ProteinModelPortali P04118.
    SMRi P04118. Positions 21-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000259938.

    PTM databases

    PhosphoSitei P04118.

    Polymorphism databases

    DMDMi 116900.

    Proteomic databases

    PaxDbi P04118.
    PeptideAtlasi P04118.
    PRIDEi P04118.

    Protocols and materials databases

    DNASUi 1208.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259938 ; ENSP00000259938 ; ENSG00000137392 .
    GeneIDi 1208.
    KEGGi hsa:1208.
    UCSCi uc003ole.2. human.

    Organism-specific databases

    CTDi 1208.
    GeneCardsi GC06M035765.
    HGNCi HGNC:2085. CLPS.
    HPAi HPA010512.
    MIMi 120105. gene.
    neXtProti NX_P04118.
    PharmGKBi PA26611.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42456.
    HOGENOMi HOG000059253.
    HOVERGENi HBG005373.
    InParanoidi P04118.
    KOi K14460.
    OMAi CSAKTLY.
    OrthoDBi EOG74N5K5.
    PhylomeDBi P04118.
    TreeFami TF336178.

    Enzyme and pathway databases

    Reactomei REACT_24968. Retinoid metabolism and transport.
    REACT_9518. Digestion of dietary lipid.

    Miscellaneous databases

    GeneWikii Colipase.
    GenomeRNAii 1208.
    NextBioi 4977.
    PMAP-CutDB P04118.
    PROi P04118.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04118.
    CleanExi HS_CLPS.
    Genevestigatori P04118.

    Family and domain databases

    InterProi IPR001981. Colipase.
    IPR017914. Colipase_C.
    IPR017915. Colipase_CS.
    IPR017913. Colipase_N.
    [Graphical view ]
    PANTHERi PTHR10041. PTHR10041. 1 hit.
    Pfami PF01114. Colipase. 1 hit.
    PF02740. Colipase_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00128. COLIPASE.
    SMARTi SM00023. COLIPASE. 1 hit.
    [Graphical view ]
    PROSITEi PS00121. COLIPASE_1. 1 hit.
    PS51342. COLIPASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the human colipase cDNA."
      Lowe M.E., Rosenblum J.L., McEwen P., Strauss A.W.
      Biochemistry 29:823-828(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human colipase gene: isolation, chromosomal location, and tissue-specific expression."
      Sims H.F., Lowe M.E.
      Biochemistry 31:7120-7125(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    7. "Structure of human pancreatic colipase gene (CLPS)."
      Reichwald K., Petz U., Platzer M.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-112.
      Tissue: Pancreas.
    8. Cited for: PROTEIN SEQUENCE OF 23-108.
      Tissue: Pancreas.
    9. "Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography."
      van Tilbeurgh H., Egloff M.-P., Martinez C., Rugani N., Verger R., Cambillau C.
      Nature 362:814-820(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    10. "Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations."
      Lindner I., Helwig U., Rubin D., Li Y., Fisher E., Boeing H., Mohlig M., Spranger J., Pfeiffer A., Hampe J., Schreiber S., Doring F., Schrezenmeir J.
      Mol. Nutr. Food Res. 49:972-976(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-109, ASSOCIATION WITH TYPE 2 DIABETES.

    Entry informationi

    Entry nameiCOL_HUMAN
    AccessioniPrimary (citable) accession number: P04118
    Secondary accession number(s): Q5T9G7, Q5U809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3