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Protein

Prorelaxin H2

Gene

RLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

GO - Molecular functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
  • positive regulation of angiogenesis Source: CACAO
  • positive regulation of cAMP biosynthetic process Source: CACAO
  • positive regulation of gene expression Source: CACAO
  • regulation of catalytic activity Source: CACAO

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-444821. Relaxin receptors.
SIGNORiP04090.

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin H2
Cleaved into the following 2 chains:
Gene namesi
Name:RLN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10027. RLN2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6019.
OpenTargetsiENSG00000107014.
PharmGKBiPA34400.

Polymorphism and mutation databases

DMDMi132281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001607925 – 53Relaxin B chainAdd BLAST29
PropeptideiPRO_000001608056 – 157Connecting peptideAdd BLAST102
PeptideiPRO_0000016081162 – 185Relaxin A chainAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 172Interchain (between B and A chains)
Disulfide bondi47 ↔ 185Interchain (between B and A chains)
Modified residuei162Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi171 ↔ 1761 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP04090.
PeptideAtlasiP04090.
PRIDEiP04090.

PTM databases

iPTMnetiP04090.

Expressioni

Tissue specificityi

Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary.2 Publications

Gene expression databases

BgeeiENSG00000107014.
CleanExiHS_RLN2.
ExpressionAtlasiP04090. baseline and differential.
GenevisibleiP04090. HS.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111951. 7 interactors.
STRINGi9606.ENSP00000371040.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 29Combined sources3
Helixi36 – 49Combined sources14
Helixi163 – 173Combined sources11
Helixi178 – 182Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MV1NMR-A163-185[»]
B25-53[»]
6RLXX-ray1.50A/C163-185[»]
B/D26-53[»]
ProteinModelPortaliP04090.
SMRiP04090.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04090.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP04090.
KOiK05255.
OMAiIKACGRE.
OrthoDBiEOG091G0SV7.
PhylomeDBiP04090.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
IPR022421. Relaxin.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR00276. INSULINFAMLY.
PR02004. RELAXIN.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04090-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRLFFFHLL GVCLLLNQFS RAVADSWMEE VIKLCGRELV RAQIAICGMS
60 70 80 90 100
TWSKRSLSQE DAPQTPRPVA EIVPSFINKD TETINMMSEF VANLPQELKL
110 120 130 140 150
TLSEMQPALP QLQQHVPVLK DSSLLFEEFK KLIRNRQSEA ADSSPSELKY
160 170 180
LGLDTHSRKK RQLYSALANK CCHVGCTKRS LARFC
Length:185
Mass (Da):21,043
Last modified:November 1, 1986 - v1
Checksum:iAC73DBDE2090091B
GO
Isoform 2 (identifier: P04090-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-117: EIVPSFINKD...ALPQLQQHVP → GDFIQTVSLG...HPSSTKIQKP
     118-185: Missing.

Show »
Length:117
Mass (Da):12,883
Checksum:i087AE9F24582740A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05000712V → F. Corresponds to variant dbSNP:rs2020050Ensembl.1
Natural variantiVAR_03444428M → K. Corresponds to variant dbSNP:rs618066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00271171 – 117EIVPS…QQHVP → GDFIQTVSLGISPDGGKALR TGSCFTREFLGALSKLCHPS STKIQKP in isoform 2. CuratedAdd BLAST47
Alternative sequenceiVSP_002712118 – 185Missing in isoform 2. CuratedAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00948 mRNA. Translation: CAA25460.1.
AL135786 Genomic DNA. Translation: CAC04177.1.
BC126415 mRNA. Translation: AAI26416.1.
BC126419 mRNA. Translation: AAI26420.1.
S83200 Genomic DNA. Translation: AAD14429.1. Sequence problems.
AF104935 Genomic DNA. Translation: AAD21961.1.
CCDSiCCDS6460.1. [P04090-1]
PIRiA05092. A60982.
RefSeqiNP_005050.2. NM_005059.3. [P04090-2]
NP_604390.1. NM_134441.2. [P04090-1]
UniGeneiHs.127032.
Hs.368996.

Genome annotation databases

EnsembliENST00000381627; ENSP00000371040; ENSG00000107014. [P04090-1]
GeneIDi6019.
KEGGihsa:6019.
UCSCiuc003zja.3. human. [P04090-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiREL2_HUMAN
AccessioniPrimary (citable) accession number: P04090
Secondary accession number(s): A0AVM0
, Q99936, Q9UCX3, Q9UQJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: August 30, 2017
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families