Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Parathyroid hormone

Gene

Pth

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone resorption Source: RGD
  • cell-cell signaling Source: RGD
  • cellular calcium ion homeostasis Source: MGI
  • cellular macromolecule biosynthetic process Source: Ensembl
  • homeostasis of number of cells within a tissue Source: Ensembl
  • negative regulation of apoptotic process in bone marrow Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • ossification Source: RGD
  • positive regulation of bone mineralization Source: RGD
  • positive regulation of cAMP biosynthetic process Source: Ensembl
  • positive regulation of cell proliferation in bone marrow Source: Ensembl
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of ossification Source: RGD
  • positive regulation of osteoclast proliferation Source: Ensembl
  • positive regulation of signal transduction Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • response to cadmium ion Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to lead ion Source: RGD
  • response to nutrient levels Source: RGD
  • response to parathyroid hormone Source: RGD
  • response to vitamin D Source: RGD
  • Rho protein signal transduction Source: RGD
  • skeletal system development Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:Pth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3440. Pth.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Propeptidei26 – 316PRO_0000023255
Chaini32 – 11584Parathyroid hormonePRO_0000023256Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP04089.
PRIDEiP04089.

Expressioni

Tissue specificityi

Hypothalamus and parathyroid gland.

Gene expression databases

GenevisibleiP04089. RN.

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

  • hormone activity Source: GO_Central
  • parathyroid hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: UniProtKB
  • type 1 parathyroid hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019199.

Structurei

3D structure databases

ProteinModelPortaliP04089.
SMRiP04089. Positions 32-69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6919Important for receptor bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP04089.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG091G13ZF.
PhylomeDBiP04089.
TreeFamiTF336197.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSASTMAKV MILMLAVCLL TQADGKPVKK RAVSEIQLMH NLGKHLASVE
60 70 80 90 100
RMQWLRKKLQ DVHNFVSLGV QMAAREGSYQ RPTKKEENVL VDGNSKSLGE
110
GDKADVDVLV KAKSQ
Length:115
Mass (Da):12,722
Last modified:November 1, 1986 - v1
Checksum:i7B434CFCA528B230
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181C → Y in AAA57156 (Ref. 3) Curated
Sequence conflicti23 – 231A → T in AAA57156 (Ref. 3) Curated
Sequence conflicti33 – 331V → I in AAA57156 (Ref. 3) Curated
Sequence conflicti62 – 621V → G in AAA57156 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01268 Genomic DNA. Translation: AAA41979.1.
X05721 mRNA. Translation: CAA29192.1.
M54875 mRNA. Translation: AAA57156.1.
S80127 mRNA. No translation available.
PIRiA05091.
RefSeqiNP_058740.1. NM_017044.1.
UniGeneiRn.9768.

Genome annotation databases

EnsembliENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
GeneIDi24694.
KEGGirno:24694.
UCSCiRGD:3440. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01268 Genomic DNA. Translation: AAA41979.1.
X05721 mRNA. Translation: CAA29192.1.
M54875 mRNA. Translation: AAA57156.1.
S80127 mRNA. No translation available.
PIRiA05091.
RefSeqiNP_058740.1. NM_017044.1.
UniGeneiRn.9768.

3D structure databases

ProteinModelPortaliP04089.
SMRiP04089. Positions 32-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019199.

Proteomic databases

PaxDbiP04089.
PRIDEiP04089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
GeneIDi24694.
KEGGirno:24694.
UCSCiRGD:3440. rat.

Organism-specific databases

CTDi5741.
RGDi3440. Pth.

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP04089.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG091G13ZF.
PhylomeDBiP04089.
TreeFamiTF336197.

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP04089.

Gene expression databases

GenevisibleiP04089. RN.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTHY_RAT
AccessioniPrimary (citable) accession number: P04089
Secondary accession number(s): Q63473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.