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Protein

Parathyroid hormone

Gene

Pth

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

  • hormone activity Source: CAFA
  • parathyroid hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: CAFA
  • protein N-terminus binding Source: Ensembl
  • receptor agonist activity Source: CAFA
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
  • type 1 parathyroid hormone receptor binding Source: RGD

GO - Biological processi

  • activation of phospholipase C activity Source: Ensembl
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone resorption Source: RGD
  • cell-cell signaling Source: RGD
  • cellular calcium ion homeostasis Source: MGI
  • cellular macromolecule biosynthetic process Source: Ensembl
  • homeostasis of number of cells within a tissue Source: Ensembl
  • negative regulation of apoptotic process in bone marrow Source: Ensembl
  • negative regulation of bone mineralization involved in bone maturation Source: CAFA
  • negative regulation of chondrocyte differentiation Source: CAFA
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • ossification Source: RGD
  • positive regulation of bone mineralization Source: RGD
  • positive regulation of cAMP biosynthetic process Source: CAFA
  • positive regulation of cell proliferation in bone marrow Source: Ensembl
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  • positive regulation of ossification Source: RGD
  • positive regulation of osteoclast proliferation Source: Ensembl
  • positive regulation of signal transduction Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • response to cadmium ion Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to lead ion Source: RGD
  • response to nutrient levels Source: RGD
  • response to parathyroid hormone Source: RGD
  • response to vitamin D Source: RGD
  • Rho protein signal transduction Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:Pth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3440. Pth.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000002325526 – 316
ChainiPRO_000002325632 – 115Parathyroid hormoneAdd BLAST84

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP04089.
PRIDEiP04089.

Expressioni

Tissue specificityi

Hypothalamus and parathyroid gland.

Gene expression databases

BgeeiENSRNOG00000014318.
GenevisibleiP04089. RN.

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

  • hormone activity Source: CAFA
  • parathyroid hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: CAFA
  • protein N-terminus binding Source: Ensembl
  • receptor agonist activity Source: CAFA
  • type 1 parathyroid hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019199.

Structurei

3D structure databases

ProteinModelPortaliP04089.
SMRiP04089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 69Important for receptor bindingBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP04089.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG091G13ZF.
PhylomeDBiP04089.
TreeFamiTF336197.

Family and domain databases

InterProiView protein in InterPro
IPR003625. PTH.
IPR001415. PTH/PTH-rel.
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiView protein in Pfam
PF01279. Parathyroid. 1 hit.
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiView protein in SMART
SM00087. PTH. 1 hit.
PROSITEiView protein in PROSITE
PS00335. PARATHYROID. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSASTMAKV MILMLAVCLL TQADGKPVKK RAVSEIQLMH NLGKHLASVE
60 70 80 90 100
RMQWLRKKLQ DVHNFVSLGV QMAAREGSYQ RPTKKEENVL VDGNSKSLGE
110
GDKADVDVLV KAKSQ
Length:115
Mass (Da):12,722
Last modified:November 1, 1986 - v1
Checksum:i7B434CFCA528B230
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18C → Y in AAA57156 (Ref. 3) Curated1
Sequence conflicti23A → T in AAA57156 (Ref. 3) Curated1
Sequence conflicti33V → I in AAA57156 (Ref. 3) Curated1
Sequence conflicti62V → G in AAA57156 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01268 Genomic DNA. Translation: AAA41979.1.
X05721 mRNA. Translation: CAA29192.1.
M54875 mRNA. Translation: AAA57156.1.
S80127 mRNA. No translation available.
PIRiA05091.
RefSeqiNP_058740.1. NM_017044.1.
UniGeneiRn.9768.

Genome annotation databases

EnsembliENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
GeneIDi24694.
KEGGirno:24694.
UCSCiRGD:3440. rat.

Similar proteinsi

Entry informationi

Entry nameiPTHY_RAT
AccessioniPrimary (citable) accession number: P04089
Secondary accession number(s): Q63473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families