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Protein

Parathyroid hormone

Gene

Pth

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone resorption Source: RGD
  • cell-cell signaling Source: RGD
  • cellular calcium ion homeostasis Source: MGI
  • cellular macromolecule biosynthetic process Source: Ensembl
  • homeostasis of number of cells within a tissue Source: Ensembl
  • negative regulation of apoptotic process in bone marrow Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • ossification Source: RGD
  • positive regulation of bone mineralization Source: RGD
  • positive regulation of cAMP biosynthetic process Source: Ensembl
  • positive regulation of cell proliferation in bone marrow Source: Ensembl
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of ossification Source: RGD
  • positive regulation of osteoclast proliferation Source: Ensembl
  • positive regulation of signal transduction Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • response to cadmium ion Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to lead ion Source: RGD
  • response to nutrient levels Source: RGD
  • response to parathyroid hormone Source: RGD
  • response to vitamin D Source: RGD
  • Rho protein signal transduction Source: RGD
  • skeletal system development Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:Pth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3440. Pth.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Propeptidei26 – 316PRO_0000023255
Chaini32 – 11584Parathyroid hormonePRO_0000023256Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP04089.
PRIDEiP04089.

Expressioni

Tissue specificityi

Hypothalamus and parathyroid gland.

Gene expression databases

GenevisibleiP04089. RN.

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

  • hormone activity Source: GO_Central
  • parathyroid hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: UniProtKB
  • type 1 parathyroid hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019199.

Structurei

3D structure databases

ProteinModelPortaliP04089.
SMRiP04089. Positions 32-69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6919Important for receptor bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP04089.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG7ZGX5Q.
PhylomeDBiP04089.
TreeFamiTF336197.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSASTMAKV MILMLAVCLL TQADGKPVKK RAVSEIQLMH NLGKHLASVE
60 70 80 90 100
RMQWLRKKLQ DVHNFVSLGV QMAAREGSYQ RPTKKEENVL VDGNSKSLGE
110
GDKADVDVLV KAKSQ
Length:115
Mass (Da):12,722
Last modified:November 1, 1986 - v1
Checksum:i7B434CFCA528B230
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181C → Y in AAA57156 (Ref. 3) Curated
Sequence conflicti23 – 231A → T in AAA57156 (Ref. 3) Curated
Sequence conflicti33 – 331V → I in AAA57156 (Ref. 3) Curated
Sequence conflicti62 – 621V → G in AAA57156 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01268 Genomic DNA. Translation: AAA41979.1.
X05721 mRNA. Translation: CAA29192.1.
M54875 mRNA. Translation: AAA57156.1.
S80127 mRNA. No translation available.
PIRiA05091.
RefSeqiNP_058740.1. NM_017044.1.
UniGeneiRn.9768.

Genome annotation databases

EnsembliENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
GeneIDi24694.
KEGGirno:24694.
UCSCiRGD:3440. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01268 Genomic DNA. Translation: AAA41979.1.
X05721 mRNA. Translation: CAA29192.1.
M54875 mRNA. Translation: AAA57156.1.
S80127 mRNA. No translation available.
PIRiA05091.
RefSeqiNP_058740.1. NM_017044.1.
UniGeneiRn.9768.

3D structure databases

ProteinModelPortaliP04089.
SMRiP04089. Positions 32-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019199.

Proteomic databases

PaxDbiP04089.
PRIDEiP04089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019199; ENSRNOP00000019199; ENSRNOG00000014318.
GeneIDi24694.
KEGGirno:24694.
UCSCiRGD:3440. rat.

Organism-specific databases

CTDi5741.
RGDi3440. Pth.

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP04089.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG7ZGX5Q.
PhylomeDBiP04089.
TreeFamiTF336197.

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP04089.

Gene expression databases

GenevisibleiP04089. RN.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone."
    Heinrich G., Kronenberg H.M., Potts J.T. Jr., Habener J.F.
    J. Biol. Chem. 259:3320-3329(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
    Schmelzer H.-J., Gross G., Widera G., Mayer H.
    Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Nucleotide sequence of cloned cDNA encoding rat prepro parathyroid hormone."
    Schmelzer H.J., Gross G., Mayer H.
    Adv. Gene Technol. 21:228-229(1984)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-115.
    Tissue: Parathyroid.
  4. "Sequence analysis of hypothalamic parathyroid hormone messenger ribonucleic acid."
    Nutley M.T., Parimi S.A., Harvey S.
    Endocrinology 136:5600-5607(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 32-115.
    Strain: Sprague-Dawley.
    Tissue: Brain, Liver and Parathyroid.

Entry informationi

Entry nameiPTHY_RAT
AccessioniPrimary (citable) accession number: P04089
Secondary accession number(s): Q63473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.