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Protein

Acidic phospholipase A2 homolog vipoxin A chain

Gene
N/A
Organism
Vipera ammodytes meridionalis (Eastern sand viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterodimer: postsynaptic neurotoxin.1 Publication
Monomer: Acidic phospholipase A2 homolog that is non-toxic.1 Publication

Caution

In contrast to other phospholipases, it lacks the typical His active site (His->Gln in position 47).Curated
The acidic chain was originally postulated to act as an inhibitor of the basic chain.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic phospholipase A2 homolog vipoxin A chain
Short name:
svPLA2 homolog
Alternative name(s):
Acidic phospholipase A2 inhibitor vipoxin A chain
Vipoxin acidic component
Short name:
VAC
Vipoxin non-toxic component
OrganismiVipera ammodytes meridionalis (Eastern sand viper)
Taxonomic identifieri73841 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeVipera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 of the heterodimer is 0.7-1.2 mg/kg by intraperitoneal injection into mice and 0.9-1.3 mg/kg by intravenous injection into mice.1 Publication
LD50 of the acidic component is >30 mg/kg by intraperitoneal injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617131 – 122Acidic phospholipase A2 homolog vipoxin A chainAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 115Combined sources2 Publications
Disulfide bondi28 ↔ 44Combined sources2 Publications
Disulfide bondi43 ↔ 95Combined sources2 Publications
Disulfide bondi49 ↔ 122Combined sources2 Publications
Disulfide bondi50 ↔ 88Combined sources2 Publications
Disulfide bondi57 ↔ 81Combined sources2 Publications
Disulfide bondi75 ↔ 86Combined sources2 Publications

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer of A and B (AC P14420) chains; non-covalently linked. The A chain (acidic) is non-toxic, and increases the toxicity of the B chain (basic). The A chain may act as factor stabilizing the complex structure and hence retaining its toxicity by preventing non-specific binding. Upon binding to the target membranes the A chain may dissociate.4 Publications

Protein-protein interaction databases

IntActiP04084, 1 interactor
MINTiP04084

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Helixi17 – 19Combined sources3
Helixi21 – 23Combined sources3
Turni25 – 28Combined sources4
Beta strandi32 – 34Combined sources3
Helixi39 – 52Combined sources14
Beta strandi54 – 56Combined sources3
Turni59 – 61Combined sources3
Beta strandi66 – 69Combined sources4
Beta strandi72 – 75Combined sources4
Helixi80 – 98Combined sources19
Helixi99 – 102Combined sources4
Helixi105 – 107Combined sources3
Helixi111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOKX-ray2.00A1-122[»]
1JLTX-ray1.40A1-122[»]
1Q5TX-ray1.90A/B1-112[»]
1VPIX-ray1.76A1-122[»]
ProteinModelPortaliP04084
SMRiP04084
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04084

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit

Sequencei

Sequence statusi: Complete.

P04084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NLFQFGDMIL QKTGKEAVHS YAIYGCYCGW GGQGRAQDAT DRCCFAQDCC
60 70 80 90 100
YGRVNDCNPK TATYTYSFEN GDIVCGDNDL CLRAVCECDR AAAICLGENV
110 120
NTYDKNYEYY SISHCTEESE QC
Length:122
Mass (Da):13,639
Last modified:July 15, 1998 - v3
Checksum:i3759601D80ABA697
GO

Sequence databases

PIRiB29290 PSVII

Similar proteinsi

Entry informationi

Entry nameiPA2A_VIPAE
AccessioniPrimary (citable) accession number: P04084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health