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P04083

- ANXA1_HUMAN

UniProt

P04083 - ANXA1_HUMAN

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Protein

Annexin A1

Gene
ANXA1, ANX1, LPC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB
  2. calcium-dependent protein binding Source: AgBase
  3. calcium ion binding Source: ProtInc
  4. phospholipase A2 inhibitor activity Source: UniProtKB
  5. phospholipid binding Source: ProtInc
  6. protein binding Source: IntAct
  7. protein binding, bridging Source: UniProtKB
  8. receptor binding Source: ProtInc
  9. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. alpha-beta T cell differentiation Source: BHF-UCL
  2. arachidonic acid secretion Source: Ensembl
  3. cell surface receptor signaling pathway Source: ProtInc
  4. cellular component movement Source: ProtInc
  5. cellular response to glucocorticoid stimulus Source: BHF-UCL
  6. cellular response to hydrogen peroxide Source: Ensembl
  7. endocrine pancreas development Source: Ensembl
  8. estrous cycle phase Source: Ensembl
  9. gliogenesis Source: Ensembl
  10. hepatocyte differentiation Source: Ensembl
  11. inflammatory response Source: ProtInc
  12. insulin secretion Source: Ensembl
  13. keratinocyte differentiation Source: UniProtKB
  14. negative regulation of acute inflammatory response Source: Ensembl
  15. negative regulation of apoptotic process Source: UniProtKB
  16. negative regulation of catalytic activity Source: GOC
  17. negative regulation of interleukin-8 secretion Source: BHF-UCL
  18. neutrophil clearance Source: BHF-UCL
  19. neutrophil homeostasis Source: BHF-UCL
  20. peptide cross-linking Source: UniProtKB
  21. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  22. positive regulation of neutrophil apoptotic process Source: Ensembl
  23. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  24. positive regulation of vesicle fusion Source: UniProtKB
  25. regulation of cell proliferation Source: Ensembl
  26. response to drug Source: Ensembl
  27. response to estradiol Source: Ensembl
  28. response to interleukin-1 Source: Ensembl
  29. response to peptide hormone Source: Ensembl
  30. response to X-ray Source: Ensembl
  31. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.
SignaLinkiP04083.

Protein family/group databases

TCDBi1.A.31.1.3. the annexin (annexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A1
Alternative name(s):
Annexin I
Annexin-1
Calpactin II
Calpactin-2
Chromobindin-9
Lipocortin I
Phospholipase A2 inhibitory protein
p35
Gene namesi
Name:ANXA1
Synonyms:ANX1, LPC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:533. ANXA1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity. Basolateral cell membrane By similarity
Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium By similarity. Found in the cytoplasm of type II pneumocytes and alveolar macrophages By similarity.

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. cell surface Source: BHF-UCL
  3. cilium Source: UniProtKB-SubCell
  4. cornified envelope Source: UniProtKB
  5. cytoplasm Source: UniProtKB
  6. extracellular region Source: Reactome
  7. extracellular space Source: UniProt
  8. extracellular vesicular exosome Source: UniProtKB
  9. mitochondrial membrane Source: Ensembl
  10. nucleus Source: BHF-UCL
  11. plasma membrane Source: HPA
  12. protein complex Source: Ensembl
  13. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 346345Annexin A1PRO_0000067460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei5 – 51Phosphoserine; by TRPM71 Publication
Cross-linki19 – 19Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Modified residuei21 – 211Phosphotyrosine; by EGFR1 Publication
Modified residuei24 – 241Phosphothreonine
Modified residuei27 – 271Phosphoserine; by PKC1 Publication
Modified residuei37 – 371Phosphoserine1 Publication
Modified residuei58 – 581N6-acetyllysine By similarity
Modified residuei239 – 2391N6-acetyllysine1 Publication
Modified residuei312 – 3121N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein

Proteomic databases

MaxQBiP04083.
PaxDbiP04083.
PeptideAtlasiP04083.
PRIDEiP04083.

2D gel databases

DOSAC-COBS-2DPAGEP04083.
REPRODUCTION-2DPAGEIPI00218918.
P04083.
UCD-2DPAGEP04083.

PTM databases

PhosphoSiteiP04083.

Expressioni

Gene expression databases

ArrayExpressiP04083.
BgeeiP04083.
CleanExiHS_ANXA1.
GenevestigatoriP04083.

Organism-specific databases

HPAiCAB013023.
CAB035987.
CAB058693.
HPA011271.
HPA011272.

Interactioni

Subunit structurei

Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IKBKGQ9Y6K96EBI-354007,EBI-81279
RIPK1Q135465EBI-354007,EBI-358507

Protein-protein interaction databases

BioGridi106798. 53 interactions.
DIPiDIP-32875N.
IntActiP04083. 59 interactions.
MINTiMINT-1212274.
STRINGi9606.ENSP00000257497.

Structurei

Secondary structure

1
346
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108
Helixi46 – 5510
Beta strandi62 – 643
Helixi65 – 717
Helixi77 – 8711
Helixi94 – 996
Helixi106 – 1094
Helixi110 – 1123

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AINX-ray2.50A33-346[»]
1BO9NMR-A41-113[»]
1QLSX-ray2.30D2-12[»]
ProteinModelPortaliP04083.
SMRiP04083. Positions 2-344.

Miscellaneous databases

EvolutionaryTraceiP04083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 11161Annexin 1Add
BLAST
Repeati123 – 18361Annexin 2Add
BLAST
Repeati207 – 26761Annexin 3Add
BLAST
Repeati282 – 34261Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG282829.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP04083.
KOiK17091.
OMAiGTRHKTL.
OrthoDBiEOG74XS72.
PhylomeDBiP04083.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04083-1 [UniParc]FASTAAdd to Basket

« Hide

MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA    50
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL 100
TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR 150
DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD 200
SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK 250
VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 300
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN 346
Length:346
Mass (Da):38,714
Last modified:January 23, 2007 - v2
Checksum:i14B42E1FA4178EC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05908 mRNA. Translation: CAA29338.1.
BC001275 mRNA. Translation: AAH01275.1.
BC035993 mRNA. Translation: AAH35993.1.
CCDSiCCDS6645.1.
PIRiA03080. LUHU.
RefSeqiNP_000691.1. NM_000700.1.
UniGeneiHs.494173.

Genome annotation databases

EnsembliENST00000257497; ENSP00000257497; ENSG00000135046.
ENST00000376911; ENSP00000366109; ENSG00000135046.
GeneIDi301.
KEGGihsa:301.
UCSCiuc004ajf.1. human.

Polymorphism databases

DMDMi113944.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05908 mRNA. Translation: CAA29338.1 .
BC001275 mRNA. Translation: AAH01275.1 .
BC035993 mRNA. Translation: AAH35993.1 .
CCDSi CCDS6645.1.
PIRi A03080. LUHU.
RefSeqi NP_000691.1. NM_000700.1.
UniGenei Hs.494173.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AIN X-ray 2.50 A 33-346 [» ]
1BO9 NMR - A 41-113 [» ]
1QLS X-ray 2.30 D 2-12 [» ]
ProteinModelPortali P04083.
SMRi P04083. Positions 2-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106798. 53 interactions.
DIPi DIP-32875N.
IntActi P04083. 59 interactions.
MINTi MINT-1212274.
STRINGi 9606.ENSP00000257497.

Chemistry

DrugBanki DB00240. Alclometasone.
DB00288. Amcinonide.
DB00394. Beclomethasone.
DB00443. Betamethasone.
DB01013. Clobetasol.
DB00838. Clocortolone.
DB01260. Desonide.
DB00547. Desoximetasone.
DB01234. Dexamethasone.
DB00223. Diflorasone.
DB00663. Flumethasone Pivalate.
DB00596. Halobetasol Propionate.
DB00769. Hydrocortamate.
DB00741. Hydrocortisone.
DB00873. Loteprednol Etabonate.
DB00959. Methylprednisolone.
DB00764. Mometasone.
DB01130. Prednicarbate.
DB00635. Prednisone.
DB00896. Rimexolone.
DB00620. Triamcinolone.

Protein family/group databases

TCDBi 1.A.31.1.3. the annexin (annexin) family.

PTM databases

PhosphoSitei P04083.

Polymorphism databases

DMDMi 113944.

2D gel databases

DOSAC-COBS-2DPAGE P04083.
REPRODUCTION-2DPAGE IPI00218918.
P04083.
UCD-2DPAGE P04083.

Proteomic databases

MaxQBi P04083.
PaxDbi P04083.
PeptideAtlasi P04083.
PRIDEi P04083.

Protocols and materials databases

DNASUi 301.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257497 ; ENSP00000257497 ; ENSG00000135046 .
ENST00000376911 ; ENSP00000366109 ; ENSG00000135046 .
GeneIDi 301.
KEGGi hsa:301.
UCSCi uc004ajf.1. human.

Organism-specific databases

CTDi 301.
GeneCardsi GC09P075766.
HGNCi HGNC:533. ANXA1.
HPAi CAB013023.
CAB035987.
CAB058693.
HPA011271.
HPA011272.
MIMi 151690. gene.
neXtProti NX_P04083.
PharmGKBi PA24823.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282829.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P04083.
KOi K17091.
OMAi GTRHKTL.
OrthoDBi EOG74XS72.
PhylomeDBi P04083.
TreeFami TF105452.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.
SignaLinki P04083.

Miscellaneous databases

ChiTaRSi ANXA1. human.
EvolutionaryTracei P04083.
GeneWikii Annexin_A1.
GenomeRNAii 301.
NextBioi 1213.
PROi P04083.
SOURCEi Search...

Gene expression databases

ArrayExpressi P04083.
Bgeei P04083.
CleanExi HS_ANXA1.
Genevestigatori P04083.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view ]
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity."
    Wallner B.P., Mattaliano R.J., Hession C., Cate R.L., Tizard R., Sinclair L.K., Foeller C., Chow E.P., Browning J.L., Ramachandran K.L., Pepinsky R.B.
    Nature 320:77-81(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Correlation of gene and protein structure of rat and human lipocortin I."
    Kovacic R.T., Tizard R., Cate R.L., Frey A.Z., Wallner B.P.
    Biochemistry 30:9015-9021(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli."
    Arcone R., Arpaia G., Ruoppolo M., Malorni A., Pucci P., Marino G., Ialenti A., di Rosa M., Ciliberto G.
    Eur. J. Biochem. 211:347-355(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Lung.
  5. "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C."
    Varticovski L., Chahwala S.B., Whitman M., Cantley L., Schindler D., Chow E.P., Sinclair L.K., Pepinsky R.B.
    Biochemistry 27:3682-3690(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-21 BY EGFR AND SER-27 BY PKC.
  6. "Characterization by tandem mass spectrometry of structural modifications in proteins."
    Biemann K., Scoble H.A.
    Science 237:992-998(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "A dimeric form of lipocortin-1 in human placenta."
    Pepinsky R.B., Sinclair L.K., Chow E.P., O'Brine-Greco B.
    Biochem. J. 263:97-103(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DIMERIZATION.
  8. "Phosphorylation of annexin I by TRPM7 channel-kinase."
    Dorovkov M.V., Ryazanov A.G.
    J. Biol. Chem. 279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-5 BY TRPM7.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-239 AND LYS-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Crystal structure of human annexin I at 2.5-A resolution."
    Weng X., Luecke H., Song I.S., Kang D.S., Kim S.-H., Huber R.
    Protein Sci. 2:448-458(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  14. "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit."
    Gao J., Li Y., Yan H.
    J. Biol. Chem. 274:2971-2977(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 41-113.

Entry informationi

Entry nameiANXA1_HUMAN
AccessioniPrimary (citable) accession number: P04083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 188 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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