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Protein

Thermitase

Gene
N/A
Organism
Thermoactinomyces vulgaris
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of proteins, including collagen.

Cofactori

Note: Binds 3 calcium ions or 2 calcium ions and 1 sodium ion per subunit. The sodium ion is bound at calcium concentrations up to 5 mM. At 100 mM calcium 3 calcium ions are bound.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Calcium 11
Active sitei381
Metal bindingi47Calcium 11
Metal bindingi57Calcium 21
Metal bindingi60Calcium 21
Metal bindingi62Calcium 21
Metal bindingi64Calcium 21
Metal bindingi66Calcium 21
Active sitei711
Metal bindingi82Calcium 1; via carbonyl oxygen1
Metal bindingi85Calcium 11
Metal bindingi87Calcium 1; via carbonyl oxygen1
Metal bindingi89Calcium 1; via carbonyl oxygen1
Active sitei2251

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.66 6282

Protein family/group databases

MEROPSiS08.007

Names & Taxonomyi

Protein namesi
Recommended name:
Thermitase (EC:3.4.21.66)
OrganismiThermoactinomyces vulgaris
Taxonomic identifieri2026 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesThermoactinomycetaceaeThermoactinomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764211 – 279ThermitaseAdd BLAST279

Proteomic databases

PRIDEiP04072

Interactioni

Protein-protein interaction databases

MINTiP04072

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 11Combined sources4
Helixi14 – 17Combined sources4
Helixi20 – 24Combined sources5
Beta strandi33 – 39Combined sources7
Turni46 – 51Combined sources6
Beta strandi52 – 57Combined sources6
Turni58 – 61Combined sources4
Beta strandi68 – 70Combined sources3
Helixi71 – 80Combined sources10
Beta strandi84 – 88Combined sources5
Beta strandi97 – 102Combined sources6
Beta strandi108 – 110Combined sources3
Helixi112 – 124Combined sources13
Beta strandi128 – 132Combined sources5
Beta strandi136 – 138Combined sources3
Helixi141 – 152Combined sources12
Beta strandi156 – 160Combined sources5
Beta strandi163 – 166Combined sources4
Turni172 – 174Combined sources3
Beta strandi178 – 184Combined sources7
Beta strandi202 – 205Combined sources4
Beta strandi207 – 213Combined sources7
Turni214 – 216Combined sources3
Beta strandi217 – 221Combined sources5
Helixi224 – 239Combined sources16
Turni240 – 242Combined sources3
Helixi245 – 254Combined sources10
Beta strandi255 – 257Combined sources3
Turni260 – 264Combined sources5
Beta strandi267 – 270Combined sources4
Helixi273 – 278Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TECX-ray2.20E1-279[»]
1THMX-ray1.37A1-279[»]
2TECX-ray1.98E1-279[»]
3TECX-ray2.00E1-279[»]
ProteinModelPortaliP04072
SMRiP04072
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04072

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 277Peptidase S8Add BLAST245

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Family and domain databases

CDDicd07484 Peptidases_S8_Thermitase_like, 1 hit
Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR034084 Thermitase-like_dom
PfamiView protein in Pfam
PF00082 Peptidase_S8, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P04072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YTPNDPYFSS RQYGPQKIQA PQAWDIAEGS GAKIAIVDTG VQSNHPDLAG
60 70 80 90 100
KVVGGWDFVD NDSTPQNGNG HGTHCAGIAA AVTNNSTGIA GTAPKASILA
110 120 130 140 150
VRVLDNSGSG TWTAVANGIT YAADQGAKVI SLSLGGTVGN SGLQQAVNYA
160 170 180 190 200
WNKGSVVVAA AGNAGNTAPN YPAYYSNAIA VASTDQNDNK SSFSTYGSVV
210 220 230 240 250
DVAAPGSWIY STYPTSTYAS LSGTSMATPH VAGVAGLLAS QGRSASNIRA
260 270
AIENTADKIS GTGTYWAKGR VNAYKAVQY
Length:279
Mass (Da):28,366
Last modified:November 1, 1986 - v1
Checksum:i8065049BC8927AC0
GO

Sequence databases

PIRiA00973 SUMYTV

Similar proteinsi

Entry informationi

Entry nameiTHET_THEVU
AccessioniPrimary (citable) accession number: P04072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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