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P04056

- PA2BB_PSEAU

UniProt

P04056 - PA2BB_PSEAU

Protein

Basic phospholipase A2 PA-11

Gene
N/A
Organism
Pseudechis australis (Mulga snake) (King brown snake)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Calcium; via carbonyl oxygenBy similarity
    Metal bindingi30 – 301Calcium; via carbonyl oxygenBy similarity
    Metal bindingi32 – 321Calcium; via carbonyl oxygenBy similarity
    Active sitei48 – 481By similarity
    Metal bindingi49 – 491CalciumBy similarity
    Active sitei92 – 921By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phospholipase A2 activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phospholipid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basic phospholipase A2 PA-11 (EC:3.1.1.4)
    Short name:
    svPLA2
    Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase
    OrganismiPseudechis australis (Mulga snake) (King brown snake)
    Taxonomic identifieri8670 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaePseudechis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    LD50 is 0.24 mg/kg by intravenous injection.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118Basic phospholipase A2 PA-11PRO_0000161686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi11 ↔ 71By similarity
    Disulfide bondi27 ↔ 117By similarity
    Disulfide bondi29 ↔ 45By similarity
    Disulfide bondi44 ↔ 98By similarity
    Disulfide bondi51 ↔ 91By similarity
    Disulfide bondi60 ↔ 84By similarity
    Disulfide bondi78 ↔ 89By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 1211
    Turni13 – 153
    Helixi19 – 224
    Beta strandi23 – 253
    Turni26 – 283
    Beta strandi29 – 313
    Helixi40 – 5718
    Turni62 – 643
    Beta strandi69 – 724
    Beta strandi75 – 784
    Helixi83 – 10119
    Helixi106 – 1083
    Helixi113 – 1164

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3V9MX-ray1.56A/B1-118[»]
    ProteinModelPortaliP04056.
    SMRiP04056. Positions 1-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG008137.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view]
    PANTHERiPTHR11716. PTHR11716. 1 hit.
    PfamiPF00068. Phospholip_A2_1. 1 hit.
    [Graphical view]
    PRINTSiPR00389. PHPHLIPASEA2.
    SMARTiSM00085. PA2c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04056-1 [UniParc]FASTAAdd to Basket

    « Hide

    NLIQFGNMIQ CANKGSRPSL DYADYGCYCG WGGSGTPVDE LDRCCQVHDN    50
    CYEQAGKKGC FPKLTLYSWK CTGNVPTCNS KPGCKSFVCA CDAAAAKCFA 100
    KAPYKKENYN IDTKKRCK 118
    Length:118
    Mass (Da):12,966
    Last modified:November 1, 1986 - v1
    Checksum:iF7C90529BB12D5A1
    GO

    Sequence databases

    PIRiA00747. PSSNK1.

    Cross-referencesi

    Sequence databases

    PIRi A00747. PSSNK1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3V9M X-ray 1.56 A/B 1-118 [» ]
    ProteinModelPortali P04056.
    SMRi P04056. Positions 1-118.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG008137.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view ]
    PANTHERi PTHR11716. PTHR11716. 1 hit.
    Pfami PF00068. Phospholip_A2_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00389. PHPHLIPASEA2.
    SMARTi SM00085. PA2c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequences of phospholipases A2 from the venom of an Australian elapid snake (king brown snake, Pseudechis australis)."
      Nishida S., Terashima M., Tamiya N.
      Toxicon 23:87-104(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiPA2BB_PSEAU
    AccessioniPrimary (citable) accession number: P04056
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: November 1, 1986
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3