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P04056

- PA2BB_PSEAU

UniProt

P04056 - PA2BB_PSEAU

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Protein
Basic phospholipase A2 PA-11
Gene
N/A
Organism
Pseudechis australis (Mulga snake) (King brown snake)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactori

Binds 1 calcium ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Calcium; via carbonyl oxygen By similarity
Metal bindingi30 – 301Calcium; via carbonyl oxygen By similarity
Metal bindingi32 – 321Calcium; via carbonyl oxygen By similarity
Active sitei48 – 481 By similarity
Metal bindingi49 – 491Calcium By similarity
Active sitei92 – 921 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phospholipase A2 activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phospholipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 PA-11 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiPseudechis australis (Mulga snake) (King brown snake)
Taxonomic identifieri8670 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaePseudechis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.24 mg/kg by intravenous injection.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Basic phospholipase A2 PA-11
PRO_0000161686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 71 By similarity
Disulfide bondi27 ↔ 117 By similarity
Disulfide bondi29 ↔ 45 By similarity
Disulfide bondi44 ↔ 98 By similarity
Disulfide bondi51 ↔ 91 By similarity
Disulfide bondi60 ↔ 84 By similarity
Disulfide bondi78 ↔ 89 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1211
Turni13 – 153
Helixi19 – 224
Beta strandi23 – 253
Turni26 – 283
Beta strandi29 – 313
Helixi40 – 5718
Turni62 – 643
Beta strandi69 – 724
Beta strandi75 – 784
Helixi83 – 10119
Helixi106 – 1083
Helixi113 – 1164

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V9MX-ray1.56A/B1-118[»]
ProteinModelPortaliP04056.
SMRiP04056. Positions 1-118.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04056-1 [UniParc]FASTAAdd to Basket

« Hide

NLIQFGNMIQ CANKGSRPSL DYADYGCYCG WGGSGTPVDE LDRCCQVHDN    50
CYEQAGKKGC FPKLTLYSWK CTGNVPTCNS KPGCKSFVCA CDAAAAKCFA 100
KAPYKKENYN IDTKKRCK 118
Length:118
Mass (Da):12,966
Last modified:November 1, 1986 - v1
Checksum:iF7C90529BB12D5A1
GO

Sequence databases

PIRiA00747. PSSNK1.

Cross-referencesi

Sequence databases

PIRi A00747. PSSNK1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3V9M X-ray 1.56 A/B 1-118 [» ]
ProteinModelPortali P04056.
SMRi P04056. Positions 1-118.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008137.

Family and domain databases

Gene3Di 1.20.90.10. 1 hit.
InterProi IPR001211. PLipase_A2.
IPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
[Graphical view ]
PANTHERi PTHR11716. PTHR11716. 1 hit.
Pfami PF00068. Phospholip_A2_1. 1 hit.
[Graphical view ]
PRINTSi PR00389. PHPHLIPASEA2.
SMARTi SM00085. PA2c. 1 hit.
[Graphical view ]
SUPFAMi SSF48619. SSF48619. 1 hit.
PROSITEi PS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequences of phospholipases A2 from the venom of an Australian elapid snake (king brown snake, Pseudechis australis)."
    Nishida S., Terashima M., Tamiya N.
    Toxicon 23:87-104(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiPA2BB_PSEAU
AccessioniPrimary (citable) accession number: P04056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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