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Reviewed, UniProtKB/Swiss-Prot P04055 (PA21B_RAT)

Last modified February 9, 2010. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phospholipase A2
    EC=3.1.1.4
Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase 1B
    Group IB phospholipase A2
Gene names
Name: Pla2g1b
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activity

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the phospholipase A2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Propeptide16 – 227Activation peptide
PRO_0000022747
Chain23 – 146124Phospholipase A2
PRO_0000022748

Sites

Active site701
Active site1211
Metal binding501Calcium; via carbonyl oxygen By similarity
Metal binding521Calcium; via carbonyl oxygen By similarity
Metal binding541Calcium; via carbonyl oxygen By similarity
Metal binding711Calcium By similarity

Amino acid modifications

Disulfide bond33 ↔ 99 By similarity
Disulfide bond49 ↔ 146 By similarity
Disulfide bond51 ↔ 67 By similarity
Disulfide bond66 ↔ 127 By similarity
Disulfide bond73 ↔ 120 By similarity
Disulfide bond83 ↔ 113 By similarity
Disulfide bond106 ↔ 118 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04055-1 [UniParc].

Last modified November 1, 1986. Version 1.
Checksum: 7EC4F7A491B913D0

FASTA14616,424
        10         20         30         40         50         60 
MKLLLLAALL TAGVTAHSIS TRAVWQFRNM IKCTIPGSDP LREYNNYGCY CGLGGSGTPV 

        70         80         90        100        110        120 
DDLDRCCQTH DHCYNQAKKL ESCKFLIDNP YTNTYSYKCS GNVITCSDKN NDCESFICNC 

       130        140 
DRQAAICFSK VPYNKEYKDL DTKKHC 

« Hide

References

[1]"Dog and rat pancreatic phospholipases A2: complete amino acid sequences deduced from complementary DNAs."
Ohara O., Tamaki M., Nakamura E., Tsuruta Y., Fujii Y., Shin M., Teraoka H., Okamoto M.
J. Biochem. 99:733-739(1986) [PubMed: 3754861] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Presence of pancreatic-type phospholipase A2 mRNA in rat gastric mucosa and lung."
Sakata T., Nakamura E., Tsuruta Y., Tamaki M., Teraoka H., Tojo H., Ono T., Okamoto M.
Biochim. Biophys. Acta 1007:124-126(1989) [PubMed: 2909239] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Rat pancreatic phospholipase A2: purification, characterization, and N-terminal amino acid sequence."
Ono T., Tojo H., Inoue K., Kagamiyama H., Yamano T., Okamoto M.
J. Biochem. 96:785-792(1984) [PubMed: 6501264] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-54.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00036 mRNA. Translation: BAA00024.1.
IPIIPI00192334.
PIRPSRT. A92008.
RefSeqNP_113773.1.
UniGeneRn.4283

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP04055.

Genome annotation databases

EnsemblENSRNOT00000001525; ENSRNOP00000001525; ENSRNOG00000001153; Rattus norvegicus. [Genome view]
GeneID29526.
KEGGrno:29526.
UCSCNM_031585. rat.

Organism-specific databases

CTD29526.
RGD61949. Pla2g1b.

Phylogenomic databases

eggNOGroNOG16901.
HOVERGENP04055.
InParanoidP04055.
OMAAKKLDSC.
OrthoDBEOG98GZPW.
PhylomeDBP04055.

Enzyme and pathway databases

BRENDA3.1.1.4. 248.

Gene expression databases

ArrayExpressP04055.
GenevestigatorP04055.
GermOnlineENSRNOG00000001153. Rattus norvegicus.

Family and domain databases

InterProIPR016090. Phospholipase_A2.
IPR013090. Phospholipase_A2_AS.
IPR001211. Phospholipase_A2_euk.
[Graphical view]
Gene3DG3DSA:1.20.90.10. Phospholipase_A2. 1 hit.
PANTHERPTHR11716. Phospholipase_A2. 1 hit.
PfamPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSPR00389. PHPHLIPASEA2.
SMARTSM00085. PA2c. 1 hit.
[Graphical view]
PROSITEPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio609488.

Entry information

Entry namePA21B_RAT
AccessionPrimary (citable) accession number: P04055
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: February 9, 2010
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents