Reviewed,
UniProtKB/Swiss-Prot P04054 (PA21B_HUMAN)
Last modified
July 7, 2009.
Version 100.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospholipase A2 EC=3.1.1.4 Alternative name(s): Phosphatidylcholine 2-acylhydrolase Group IB phospholipase A2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 148 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
| Catalytic activity | Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the phospholipase A2 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 15 | 15 | Ref.7 | ||||||||
| Propeptide | 16 – 22 | 7 | Activation peptide Ref.8 | PRO_0000022739 | |||||||
| Chain | 23 – 148 | 126 | Phospholipase A2 Ref.1 | PRO_0000022740 | |||||||
Sites | |||||||||||
| Active site | 70 | 1 | By similarity | ||||||||
| Active site | 121 | 1 | By similarity | ||||||||
| Metal binding | 50 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 52 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 54 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 71 | 1 | Calcium By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 33 ↔ 99 | ||||||||||
| Disulfide bond | 49 ↔ 146 | ||||||||||
| Disulfide bond | 51 ↔ 67 | ||||||||||
| Disulfide bond | 66 ↔ 127 | ||||||||||
| Disulfide bond | 73 ↔ 120 | ||||||||||
| Disulfide bond | 83 ↔ 113 | ||||||||||
| Disulfide bond | 106 ↔ 118 | ||||||||||
Natural variations | |||||||||||
| Natural variant | 16 | 1 | D → A: dbSNP rs5632. | VAR_011911 | |||||||
| Natural variant | 89 | 1 | N → K: dbSNP rs5636. | VAR_011913 | |||||||
| Natural variant | 89 | 1 | N → T: dbSNP rs5635. | VAR_011912 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 144 | 1 | Missing AA sequence Ref.8 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung." Seilhamer J.J., Randall T.L., Yamanaka M., Johnson L.K. DNA 5:519-527(1986) [PubMed: 3028739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lung. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder. |
| [3] | NIEHS SNPs program Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. Gibbs R.A.Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region." Grataroli R., Dijkman R., Dutilh C.E., van der Ouderaa F., de Haas G.H., Figarella C. Eur. J. Biochem. 122:111-117(1982) [PubMed: 7060561] [Abstract] Cited for: PROTEIN SEQUENCE OF 16-22. Tissue: Pancreas. |
| [8] | "The complete primary structure of phospholipase A2 from human pancreas." Verheij H.M., Westerman J., Sternby B., de Haas G.H. Biochim. Biophys. Acta 747:93-99(1983) [PubMed: 6349696] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-148. Tissue: Pancreas. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M21056, M22970 Genomic DNA. Translation: AAA60107.1. M21054 mRNA. Translation: AAA36450.1. AK311830 mRNA. Translation: BAG34772.1. AY438977 Genomic DNA. Translation: AAR05441.1. AC003982 Genomic DNA. Translation: AAB95635.1. CH471054 Genomic DNA. Translation: EAW98184.1. BC106725 mRNA. Translation: AAI06726.1. BC106726 mRNA. Translation: AAI06727.1. | |||||||||||||||||||
| IPI | IPI00021792. | ||||||||||||||||||
| PIR | PSHU. C25793. | ||||||||||||||||||
| RefSeq | NP_000919.1. | ||||||||||||||||||
| UniGene | Hs.992 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| |||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | P04054. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P04054. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSG00000170890. Homo sapiens. [Contig view] | ||||||||||||||||||
| GeneID | 5319. | ||||||||||||||||||
| KEGG | hsa:5319. | ||||||||||||||||||
| UCSC | uc001tyd.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| GeneCards | GC12M119244. | ||||||||||||||||||
| H-InvDB | HIX0011060. | ||||||||||||||||||
| HGNC | HGNC:9030. PLA2G1B. | ||||||||||||||||||
| MIM | 172410. gene. | ||||||||||||||||||
| PharmGKB | PA33361. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | P04054. | ||||||||||||||||||
| HOVERGEN | P04054. | ||||||||||||||||||
| OMA | P04054. AKKLDSC. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| BRENDA | 3.1.1.4. 247. | ||||||||||||||||||
| Pathway_Interaction_DB | fcer1pathway. Fc-epsilon receptor I signaling in mast cells. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P04054. | ||||||||||||||||||
| Bgee | P04054. | ||||||||||||||||||
| CleanEx | HS_PLA2G1B. | ||||||||||||||||||
| GermOnline | ENSG00000170890. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR016090. Phospholipase_A2. IPR013090. Phospholipase_A2_AS. IPR001211. Phospholipase_A2_euk. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:1.20.90.10. Phospholipase_A2. 1 hit. | ||||||||||||||||||
| PANTHER | PTHR11716. Phospholipase_A2. 1 hit. | ||||||||||||||||||
| Pfam | PF00068. Phospholip_A2_1. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00389. PHPHLIPASEA2. | ||||||||||||||||||
| ProDom | PD000303. PhospholipaseA2. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||
| SMART | SM00085. PA2c. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00119. PA2_ASP. 1 hit. PS00118. PA2_HIS. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 20578. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | PA21B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P04054 Secondary accession number(s): B2R4H5, Q3KPI1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


