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P04048

- KIT_FSVHZ

UniProt

P04048 - KIT_FSVHZ

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Protein

Tyrosine-protein kinase transforming protein kit

Gene

V-KIT

Organism
Feline sarcoma virus (strain Hardy-Zuckerman 4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611ATPPROSITE-ProRule annotation
Active sitei230 – 2301Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 419ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein kit (EC:2.7.10.1)
Gene namesi
Name:V-KIT
OrganismiFeline sarcoma virus (strain Hardy-Zuckerman 4)
Taxonomic identifieri11777 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Tyrosine-protein kinase transforming protein kitPRO_0000155208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP04048.
SMRiP04048. Positions 1-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 370344Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

Lacks the transmembrane and extracellular domains.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04048-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EEINGNNYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK VVEATAYGLI
60 70 80 90 100
KSDAAMTVAV KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV
110 120 130 140 150
GGPTLVITEY CCYGDLLNFL RRKRDSFICS KQEDHAEVAL YKNLLQSKES
160 170 180 190 200
SCNDSTNEYM DMKPGVSYVV PTKADKRRSA RIGSYIERDV TPAIMEDGEL
210 220 230 240 250
ALDLEDLLSF SYQVAKGMAF LASKNCIHRD LAARNILLTH GRITKICDFG
260 270 280 290 300
LARDIKNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGIFLWEL
310 320 330 340 350
FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI MKTCWDADPL
360 370
KRPTFKQIVQ LIEKQKNKNE
Length:370
Mass (Da):41,849
Last modified:November 1, 1986 - v1
Checksum:i71D32BEDEFE25F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03711 Genomic DNA. Translation: CAA27339.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03711 Genomic DNA. Translation: CAA27339.1 .

3D structure databases

ProteinModelPortali P04048.
SMRi P04048. Positions 1-365.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.1. 2234.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family."
    Besmer P., Murphy J.E., George P.C., Qiu F., Bergold P.J., Lederman L., Snyder H.W. Jr., Brodeur D., Zuckerman E.E., Hardy W.D.
    Nature 320:415-421(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKIT_FSVHZ
AccessioniPrimary (citable) accession number: P04048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Kit-Pol polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3