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P04048 (KIT_FSVHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein kit

EC=2.7.10.1
Gene names
Name:V-KIT
OrganismFeline sarcoma virus (strain Hardy-Zuckerman 4)
Taxonomic identifier11777 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Domain

Lacks the transmembrane and extracellular domains.

Miscellaneous

This protein is synthesized as a Gag-Kit-Pol polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Tyrosine-protein kinase transforming protein kit
PRO_0000155208

Regions

Domain27 – 370344Protein kinase
Nucleotide binding33 – 419ATP By similarity

Sites

Active site2301Proton acceptor By similarity
Binding site611ATP By similarity

Amino acid modifications

Modified residue2611Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P04048 [UniParc].

Last modified November 1, 1986. Version 1.
Checksum: 71D32BEDEFE25F2D

FASTA37041,849
        10         20         30         40         50         60 
EEINGNNYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK VVEATAYGLI KSDAAMTVAV 

        70         80         90        100        110        120 
KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV GGPTLVITEY CCYGDLLNFL 

       130        140        150        160        170        180 
RRKRDSFICS KQEDHAEVAL YKNLLQSKES SCNDSTNEYM DMKPGVSYVV PTKADKRRSA 

       190        200        210        220        230        240 
RIGSYIERDV TPAIMEDGEL ALDLEDLLSF SYQVAKGMAF LASKNCIHRD LAARNILLTH 

       250        260        270        280        290        300 
GRITKICDFG LARDIKNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGIFLWEL 

       310        320        330        340        350        360 
FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI MKTCWDADPL KRPTFKQIVQ 

       370 
LIEKQKNKNE 

« Hide

References

[1]"A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family."
Besmer P., Murphy J.E., George P.C., Qiu F., Bergold P.J., Lederman L., Snyder H.W. Jr., Brodeur D., Zuckerman E.E., Hardy W.D.
Nature 320:415-421(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03711 Genomic DNA. Translation: CAA27339.1.

3D structure databases

ProteinModelPortalP04048.
SMRP04048. Positions 1-365.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.1. 2234.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKIT_FSVHZ
AccessionPrimary (citable) accession number: P04048
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families