P04048 (KIT_FSVHZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein kit
EC=2.7.10.1

Gene names

Name:

V-KIT

Organism

Feline sarcoma virus (strain Hardy-Zuckerman 4)

Taxonomic identifier

11777 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses › Hardy-Zuckerman feline sarcoma virus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Domain	Lacks the transmembrane and extracellular domains.
Miscellaneous	This protein is synthesized as a Gag-Kit-Pol polyprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Tyrosine-protein kinase transforming protein kit		PRO_0000155208
Regions
	Domain	27 – 370	344	Protein kinase
	Nucleotide binding	33 – 41	9	ATP By similarity
Sites
	Active site	230	1	Proton acceptor By similarity
	Binding site	61	1	ATP By similarity
Amino acid modifications
	Modified residue	261	1	Phosphotyrosine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P04048 [UniParc]. Last modified November 1, 1986. Version 1. Checksum: 71D32BEDEFE25F2D	FASTA	370	41,849
	10 20 30 40 50 60 EEINGNNYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK VVEATAYGLI KSDAAMTVAV 70 80 90 100 110 120 KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV GGPTLVITEY CCYGDLLNFL 130 140 150 160 170 180 RRKRDSFICS KQEDHAEVAL YKNLLQSKES SCNDSTNEYM DMKPGVSYVV PTKADKRRSA 190 200 210 220 230 240 RIGSYIERDV TPAIMEDGEL ALDLEDLLSF SYQVAKGMAF LASKNCIHRD LAARNILLTH 250 260 270 280 290 300 GRITKICDFG LARDIKNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGIFLWEL 310 320 330 340 350 360 FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI MKTCWDADPL KRPTFKQIVQ 370 LIEKQKNKNE

References

[1]

"A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family." Besmer P., Murphy J.E., George P.C., Qiu F., Bergold P.J., Lederman L., Snyder H.W. Jr., Brodeur D., Zuckerman E.E., Hardy W.D. Nature 320:415-421(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03711 Genomic DNA. Translation: CAA27339.1.
3D structure databases
ProteinModelPortal	P04048.
SMR	P04048. Positions 1-365.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.1. 2234.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR001824. Tyr_kinase_rcpt_3_CS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00240. RECEPTOR_TYR_KIN_III. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KIT_FSVHZ

Accession

Primary (citable) accession number: P04048

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
Last sequence update:	November 1, 1986
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program