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Protein

Cytochrome c oxidase polypeptide VIII, mitochondrial

Gene

COX8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YLR395C-MONOMER.
YEAST:YLR395C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide VIII, mitochondrial (EC:1.9.3.1)
Gene namesi
Name:COX8
Ordered Locus Names:YLR395C
ORF Names:L8084.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR395C.
SGDiS000004387. COX8.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27Mitochondrion2 PublicationsAdd BLAST27
ChainiPRO_000000617328 – 74Cytochrome c oxidase polypeptide VIII, mitochondrialAdd BLAST47
PropeptideiPRO_000000617475 – 784

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiP04039.
PRIDEiP04039.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31654. 91 interactors.
DIPiDIP-5445N.
IntActiP04039. 1 interactor.
MINTiMINT-494943.

Structurei

3D structure databases

ProteinModelPortaliP04039.
SMRiP04039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000001142.
InParanoidiP04039.
KOiK02272.
OMAiHFKEGVY.
OrthoDBiEOG092C5VOM.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCQQMIRTT AKRSSNIMTR PIIMKRSVHF KDGVYENIPF KVKGRKTPYA
60 70
LSHFGFFAIG FAVPFVACYV QLKKSGAF
Length:78
Mass (Da):8,907
Last modified:February 1, 1996 - v2
Checksum:i61ABE6001BDABDD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47T → C AA sequence (PubMed:6327685).Curated1
Sequence conflicti68C → T AA sequence (PubMed:6327685).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02634 Genomic DNA. Translation: AAA34522.1.
U19729 Genomic DNA. Translation: AAB82353.1.
AY558228 Genomic DNA. Translation: AAS56554.1.
BK006945 Genomic DNA. Translation: DAA09696.1.
PIRiA25353.
RefSeqiNP_013499.1. NM_001182283.1.

Genome annotation databases

EnsemblFungiiYLR395C; YLR395C; YLR395C.
GeneIDi851111.
KEGGisce:YLR395C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02634 Genomic DNA. Translation: AAA34522.1.
U19729 Genomic DNA. Translation: AAB82353.1.
AY558228 Genomic DNA. Translation: AAS56554.1.
BK006945 Genomic DNA. Translation: DAA09696.1.
PIRiA25353.
RefSeqiNP_013499.1. NM_001182283.1.

3D structure databases

ProteinModelPortaliP04039.
SMRiP04039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31654. 91 interactors.
DIPiDIP-5445N.
IntActiP04039. 1 interactor.
MINTiMINT-494943.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP04039.
PRIDEiP04039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR395C; YLR395C; YLR395C.
GeneIDi851111.
KEGGisce:YLR395C.

Organism-specific databases

EuPathDBiFungiDB:YLR395C.
SGDiS000004387. COX8.

Phylogenomic databases

HOGENOMiHOG000001142.
InParanoidiP04039.
KOiK02272.
OMAiHFKEGVY.
OrthoDBiEOG092C5VOM.

Enzyme and pathway databases

BioCyciMetaCyc:YLR395C-MONOMER.
YEAST:YLR395C-MONOMER.

Miscellaneous databases

PROiP04039.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8_YEAST
AccessioniPrimary (citable) accession number: P04039
Secondary accession number(s): D6VZ30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.