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P04039

- COX8_YEAST

UniProt

P04039 - COX8_YEAST

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Protein
Cytochrome c oxidase polypeptide VIII, mitochondrial
Gene
COX8, YLR395C, L8084.14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YLR395C-MONOMER.
YEAST:YLR395C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide VIII, mitochondrial (EC:1.9.3.1)
Gene namesi
Name:COX8
Ordered Locus Names:YLR395C
ORF Names:L8084.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR395c.
SGDiS000004387. COX8.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion2 Publications
Add
BLAST
Chaini28 – 7447Cytochrome c oxidase polypeptide VIII, mitochondrial
PRO_0000006173Add
BLAST
Propeptidei75 – 784
PRO_0000006174

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiP04039.
PaxDbiP04039.

Expressioni

Gene expression databases

GenevestigatoriP04039.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31654. 89 interactions.
DIPiDIP-5445N.
IntActiP04039. 1 interaction.
MINTiMINT-494943.
STRINGi4932.YLR395C.

Structurei

3D structure databases

ProteinModelPortaliP04039.
SMRiP04039. Positions 29-75.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG287990.
HOGENOMiHOG000001142.
KOiK02272.
OMAiKRSSNIM.
OrthoDBiEOG7M98W2.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04039-1 [UniParc]FASTAAdd to Basket

« Hide

MLCQQMIRTT AKRSSNIMTR PIIMKRSVHF KDGVYENIPF KVKGRKTPYA   50
LSHFGFFAIG FAVPFVACYV QLKKSGAF 78
Length:78
Mass (Da):8,907
Last modified:February 1, 1996 - v2
Checksum:i61ABE6001BDABDD0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471T → C AA sequence 1 Publication
Sequence conflicti68 – 681C → T AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02634 Genomic DNA. Translation: AAA34522.1.
U19729 Genomic DNA. Translation: AAB82353.1.
AY558228 Genomic DNA. Translation: AAS56554.1.
BK006945 Genomic DNA. Translation: DAA09696.1.
PIRiA25353.
RefSeqiNP_013499.1. NM_001182283.1.

Genome annotation databases

EnsemblFungiiYLR395C; YLR395C; YLR395C.
GeneIDi851111.
KEGGisce:YLR395C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02634 Genomic DNA. Translation: AAA34522.1 .
U19729 Genomic DNA. Translation: AAB82353.1 .
AY558228 Genomic DNA. Translation: AAS56554.1 .
BK006945 Genomic DNA. Translation: DAA09696.1 .
PIRi A25353.
RefSeqi NP_013499.1. NM_001182283.1.

3D structure databases

ProteinModelPortali P04039.
SMRi P04039. Positions 29-75.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31654. 89 interactions.
DIPi DIP-5445N.
IntActi P04039. 1 interaction.
MINTi MINT-494943.
STRINGi 4932.YLR395C.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBi P04039.
PaxDbi P04039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR395C ; YLR395C ; YLR395C .
GeneIDi 851111.
KEGGi sce:YLR395C.

Organism-specific databases

CYGDi YLR395c.
SGDi S000004387. COX8.

Phylogenomic databases

eggNOGi NOG287990.
HOGENOMi HOG000001142.
KOi K02272.
OMAi KRSSNIM.
OrthoDBi EOG7M98W2.

Enzyme and pathway databases

BioCyci MetaCyc:YLR395C-MONOMER.
YEAST:YLR395C-MONOMER.

Miscellaneous databases

NextBioi 967821.

Gene expression databases

Genevestigatori P04039.

Family and domain databases

Gene3Di 4.10.49.10. 1 hit.
InterProi IPR004202. COX7C/Cox8.
[Graphical view ]
PANTHERi PTHR13313. PTHR13313. 1 hit.
Pfami PF02935. COX7C. 1 hit.
[Graphical view ]
SUPFAMi SSF81427. SSF81427. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "COX8, the structural gene for yeast cytochrome c oxidase subunit VIII. DNA sequence and gene disruption indicate that subunit VIII is required for maximal levels of cellular respiration and is derived from a precursor which is extended at both its NH2 and COOH termini."
    Patterson T.E., Poyton R.O.
    J. Biol. Chem. 261:17192-17197(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The nuclear-coded subunits of yeast cytochrome c oxidase. II. The amino acid sequence of subunit VIII and a model for its disposition in the inner mitochondrial membrane."
    Power S.D., Lochrie M.A., Patterson T.E., Poyton R.O.
    J. Biol. Chem. 259:6571-6574(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-74.
  6. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42, COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX8_YEAST
AccessioniPrimary (citable) accession number: P04039
Secondary accession number(s): D6VZ30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

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