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P04038

- COX6C_BOVIN

UniProt

P04038 - COX6C_BOVIN

Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6C
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIc
    Cytochrome c oxidase subunit STA
    Gene namesi
    Name:COX6C
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 14

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 7473Cytochrome c oxidase subunit 6CPRO_0000191301Add
    BLAST

    Proteomic databases

    PRIDEiP04038.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38980N.
    IntActiP04038. 2 interactions.

    Structurei

    Secondary structure

    1
    74
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 3927
    Helixi41 – 5313
    Helixi57 – 6610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80I/V2-74[»]
    1OCOX-ray2.80I/V2-74[»]
    1OCRX-ray2.35I/V2-74[»]
    1OCZX-ray2.90I/V2-74[»]
    1V54X-ray1.80I/V2-74[»]
    1V55X-ray1.90I/V2-74[»]
    2DYRX-ray1.80I/V2-74[»]
    2DYSX-ray2.20I/V2-74[»]
    2EIJX-ray1.90I/V2-74[»]
    2EIKX-ray2.10I/V2-74[»]
    2EILX-ray2.10I/V2-74[»]
    2EIMX-ray2.60I/V2-74[»]
    2EINX-ray2.70I/V2-74[»]
    2OCCX-ray2.30I/V2-74[»]
    2Y69X-ray1.95I/V1-74[»]
    2YBBelectron microscopy19.00T2-74[»]
    2ZXWX-ray2.50I/V2-74[»]
    3ABKX-ray2.00I/V2-74[»]
    3ABLX-ray2.10I/V2-74[»]
    3ABMX-ray1.95I/V2-74[»]
    3AG1X-ray2.20I/V2-74[»]
    3AG2X-ray1.80I/V2-74[»]
    3AG3X-ray1.80I/V2-74[»]
    3AG4X-ray2.05I/V2-74[»]
    3ASNX-ray3.00I/V2-74[»]
    3ASOX-ray2.30I/V2-74[»]
    3WG7X-ray1.90I/V2-74[»]
    ProteinModelPortaliP04038.
    SMRiP04038. Positions 2-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04038.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1211Mitochondrial matrixAdd
    BLAST
    Topological domaini54 – 7421Mitochondrial intermembraneAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 5341HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86594.
    GeneTreeiENSGT00390000004573.
    HOGENOMiHOG000039249.
    HOVERGENiHBG051091.
    InParanoidiP04038.
    KOiK02268.
    OMAiQVARIPK.
    OrthoDBiEOG73807S.
    TreeFamiTF353619.

    Family and domain databases

    Gene3Di4.10.93.10. 1 hit.
    InterProiIPR004204. COX6C.
    [Graphical view]
    PANTHERiPTHR12916. PTHR12916. 1 hit.
    PfamiPF02937. COX6C. 1 hit.
    [Graphical view]
    ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD   50
    FYRNYDSMKD FEEMRKAGIF QSAK 74
    Length:74
    Mass (Da):8,610
    Last modified:April 14, 2009 - v2
    Checksum:iE063BDB1B7AE9E4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126788 mRNA. Translation: AAI26789.1.
    PIRiA00496. OGBO6C.
    RefSeqiNP_001231040.1. NM_001244111.1.
    UniGeneiBt.28261.

    Genome annotation databases

    EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
    GeneIDi614700.
    KEGGibta:614700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126788 mRNA. Translation: AAI26789.1 .
    PIRi A00496. OGBO6C.
    RefSeqi NP_001231040.1. NM_001244111.1.
    UniGenei Bt.28261.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 I/V 2-74 [» ]
    1OCO X-ray 2.80 I/V 2-74 [» ]
    1OCR X-ray 2.35 I/V 2-74 [» ]
    1OCZ X-ray 2.90 I/V 2-74 [» ]
    1V54 X-ray 1.80 I/V 2-74 [» ]
    1V55 X-ray 1.90 I/V 2-74 [» ]
    2DYR X-ray 1.80 I/V 2-74 [» ]
    2DYS X-ray 2.20 I/V 2-74 [» ]
    2EIJ X-ray 1.90 I/V 2-74 [» ]
    2EIK X-ray 2.10 I/V 2-74 [» ]
    2EIL X-ray 2.10 I/V 2-74 [» ]
    2EIM X-ray 2.60 I/V 2-74 [» ]
    2EIN X-ray 2.70 I/V 2-74 [» ]
    2OCC X-ray 2.30 I/V 2-74 [» ]
    2Y69 X-ray 1.95 I/V 1-74 [» ]
    2YBB electron microscopy 19.00 T 2-74 [» ]
    2ZXW X-ray 2.50 I/V 2-74 [» ]
    3ABK X-ray 2.00 I/V 2-74 [» ]
    3ABL X-ray 2.10 I/V 2-74 [» ]
    3ABM X-ray 1.95 I/V 2-74 [» ]
    3AG1 X-ray 2.20 I/V 2-74 [» ]
    3AG2 X-ray 1.80 I/V 2-74 [» ]
    3AG3 X-ray 1.80 I/V 2-74 [» ]
    3AG4 X-ray 2.05 I/V 2-74 [» ]
    3ASN X-ray 3.00 I/V 2-74 [» ]
    3ASO X-ray 2.30 I/V 2-74 [» ]
    3WG7 X-ray 1.90 I/V 2-74 [» ]
    ProteinModelPortali P04038.
    SMRi P04038. Positions 2-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38980N.
    IntActi P04038. 2 interactions.

    Proteomic databases

    PRIDEi P04038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018778 ; ENSBTAP00000018778 ; ENSBTAG00000014130 .
    GeneIDi 614700.
    KEGGi bta:614700.

    Phylogenomic databases

    eggNOGi NOG86594.
    GeneTreei ENSGT00390000004573.
    HOGENOMi HOG000039249.
    HOVERGENi HBG051091.
    InParanoidi P04038.
    KOi K02268.
    OMAi QVARIPK.
    OrthoDBi EOG73807S.
    TreeFami TF353619.

    Miscellaneous databases

    EvolutionaryTracei P04038.
    NextBioi 20899236.

    Family and domain databases

    Gene3Di 4.10.93.10. 1 hit.
    InterProi IPR004204. COX6C.
    [Graphical view ]
    PANTHERi PTHR12916. PTHR12916. 1 hit.
    Pfami PF02937. COX6C. 1 hit.
    [Graphical view ]
    ProDomi PD015032. Cyt_c_oxidase_su6c. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal medulla.
    2. "Studies on cytochrome c oxidase, XI. The amino-acid sequence of bovine heart polypeptide VIc."
      Erdweg M., Buse G.
      Biol. Chem. Hoppe-Seyler 366:257-263(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-74.
      Tissue: Liver.
    3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
      Tissue: Liver.
    4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX6C_BOVIN
    AccessioniPrimary (citable) accession number: P04038
    Secondary accession number(s): A0JNM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3