Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04038 (COX6C_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
Gene names
Name:COX6C
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length74 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 6c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2 Ref.3
Chain2 – 7473Cytochrome c oxidase subunit 6C
PRO_0000191301

Regions

Topological domain2 – 1211Mitochondrial matrix
Transmembrane13 – 5341Helical
Topological domain54 – 7421Mitochondrial intermembrane

Secondary structure

....... 74
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04038 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: E063BDB1B7AE9E4C

FASTA748,610
        10         20         30         40         50         60 
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD FYRNYDSMKD 

        70 
FEEMRKAGIF QSAK 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal medulla.
[2]"Studies on cytochrome c oxidase, XI. The amino-acid sequence of bovine heart polypeptide VIc."
Erdweg M., Buse G.
Biol. Chem. Hoppe-Seyler 366:257-263(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-74.
Tissue: Liver.
[3]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-21.
Tissue: Liver.
[4]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[5]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[6]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC126788 mRNA. Translation: AAI26789.1.
PIROGBO6C. A00496.
RefSeqNP_001231040.1. NM_001244111.1.
UniGeneBt.28261.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-73[»]
1OCRX-ray2.35I/V2-73[»]
1OCZX-ray2.90I/V2-73[»]
1V54X-ray1.80I/V2-73[»]
1V55X-ray1.90I/V2-73[»]
2DYRX-ray1.80I/V2-73[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-73[»]
2EIKX-ray2.10I/V2-73[»]
2EILX-ray2.10I/V2-73[»]
2EIMX-ray2.60I/V2-73[»]
2EINX-ray2.70I/V2-73[»]
2OCCX-ray2.30I/V2-73[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
ProteinModelPortalP04038.
SMRP04038. Positions 2-74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04038. 2 interactions.

Proteomic databases

PRIDEP04038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
GeneID614700.
KEGGbta:614700.

Phylogenomic databases

eggNOGNOG86594.
GeneTreeENSGT00390000004573.
HOGENOMHOG000039249.
HOVERGENHBG051091.
InParanoidP04038.
KOK02268.
OMAADNERMT.
OrthoDBEOG73807S.
TreeFamTF353619.

Family and domain databases

Gene3D4.10.93.10. 1 hit.
InterProIPR004204. COX6C.
[Graphical view]
PANTHERPTHR12916. PTHR12916. 1 hit.
PfamPF02937. COX6C. 1 hit.
[Graphical view]
ProDomPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceP04038.
NextBio20899236.

Entry information

Entry nameCOX6C_BOVIN
AccessionPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references