Cytochrome c oxidase subunit 6C - Bos taurus (Bovine)

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P04038 (COX6C_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 6C

Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA

Gene names

Name:

COX6C

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6c family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.2 Ref.3

Chain

2 – 74

Cytochrome c oxidase subunit 6C

PRO_0000191301

Regions

Topological domain

2 – 12

Mitochondrial matrix

Transmembrane

13 – 53

Helical

Topological domain

54 – 74

Mitochondrial intermembrane

Amino acid modifications

Modified residue

N6-acetyllysine By similarity

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P04038 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: E063BDB1B7AE9E4C
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FASTA

8,610

        10         20         30         40         50         60 
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD FYRNYDSMKD 

        70 
FEEMRKAGIF QSAK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal medulla.
[2]	"Studies on cytochrome c oxidase, XI. The amino-acid sequence of bovine heart polypeptide VIc." Erdweg M., Buse G. Biol. Chem. Hoppe-Seyler 366:257-263(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-74. Tissue: Liver.
[3]	"Tissue-specific differences between heart and liver cytochrome c oxidase." Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A. Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21. Tissue: Liver.
[4]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[5]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). Tissue: Heart.
[6]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC126788 mRNA. Translation: AAI26789.1.

IPI

IPI00707430.

PIR

OGBO6C. A00496.

RefSeq

NP_001231040.1. NM_001244111.1.

UniGene

Bt.28261.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	I/V	2-74	[»]
1OCO	X-ray	2.80	I/V	2-73	[»]
1OCR	X-ray	2.35	I/V	2-73	[»]
1OCZ	X-ray	2.90	I/V	2-73	[»]
1V54	X-ray	1.80	I/V	2-73	[»]
1V55	X-ray	1.90	I/V	2-73	[»]
2DYR	X-ray	1.80	I/V	2-73	[»]
2DYS	X-ray	2.20	I/V	2-74	[»]
2EIJ	X-ray	1.90	I/V	2-73	[»]
2EIK	X-ray	2.10	I/V	2-73	[»]
2EIL	X-ray	2.10	I/V	2-73	[»]
2EIM	X-ray	2.60	I/V	2-73	[»]
2EIN	X-ray	2.70	I/V	2-73	[»]
2OCC	X-ray	2.30	I/V	2-73	[»]
2Y69	X-ray	1.95	I/V	1-74	[»]
2YBB	electron microscopy	19.00	T	2-74	[»]
2ZXW	X-ray	2.50	I/V	2-74	[»]
3ABK	X-ray	2.00	I/V	2-74	[»]
3ABL	X-ray	2.10	I/V	2-74	[»]
3ABM	X-ray	1.95	I/V	2-74	[»]
3AG1	X-ray	2.20	I/V	2-74	[»]
3AG2	X-ray	1.80	I/V	2-74	[»]
3AG3	X-ray	1.80	I/V	2-74	[»]
3AG4	X-ray	2.05	I/V	2-74	[»]
3ASN	X-ray	3.00	I/V	2-74	[»]
3ASO	X-ray	2.30	I/V	2-74	[»]

ProteinModelPortal

P04038.

SMR

P04038. Positions 2-74.

ModBase

Search...

Protein-protein interaction databases

IntAct

P04038. 2 interactions.

Proteomic databases

PRIDE

P04038.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.

GeneID

614700.

KEGG

bta:614700.

Phylogenomic databases

eggNOG

NOG86594.

GeneTree

ENSGT00390000004573.

HOGENOM

HOG000039249.

HOVERGEN

HBG051091.

InParanoid

P04038.

K02268.

OMA

ADNERMT.

OrthoDB

EOG42JNT3.

Family and domain databases

Gene3D

4.10.93.10. 1 hit.

InterPro

IPR004204. Cyt_c_oxidase_su6c.
[Graphical view]

PANTHER

PTHR12916. PTHR12916. 1 hit.

Pfam

PF02937. COX6C. 1 hit.
[Graphical view]

ProDom

PD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF81415. COX6C. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P04038.

NextBio

20899236.

Entry information

Entry name

COX6C_BOVIN

Accession

Primary (citable) accession number: P04038
Secondary accession number(s): A0JNM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
Last sequence update:	April 14, 2009
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents