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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
Gene namesi
Name:COX6C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12Mitochondrial matrixAdd BLAST11
Transmembranei13 – 53HelicalAdd BLAST41
Topological domaini54 – 74Mitochondrial intermembraneAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001913012 – 74Cytochrome c oxidase subunit 6CAdd BLAST73

Proteomic databases

PaxDbiP04038.
PRIDEiP04038.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014130.

Interactioni

Protein-protein interaction databases

CORUMiP04038.
DIPiDIP-38980N.
IntActiP04038. 3 interactors.
STRINGi9913.ENSBTAP00000018778.

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 39Combined sources27
Helixi41 – 53Combined sources13
Helixi57 – 66Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
3X2QX-ray2.00I/V2-74[»]
5B1AX-ray1.50I/V2-74[»]
5B1BX-ray1.60I/V2-74[»]
5B3SX-ray1.68I/V3-74[»]
5GPNelectron microscopy5.4062-74[»]
5IY5X-ray2.00I/V2-74[»]
5LUFelectron microscopy9.1062-74[»]
5W97X-ray2.30I/i2-74[»]
5WAUX-ray1.95I/i2-74[»]
5X19X-ray2.20I/V2-74[»]
5X1BX-ray2.40I/V2-74[»]
5X1FX-ray2.20I/V2-74[»]
5XDQX-ray1.77I/V2-74[»]
5XTHelectron microscopy3.9052-74[»]
5XTIelectron microscopy17.405/B52-74[»]
ProteinModelPortaliP04038.
SMRiP04038.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04038.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP04038.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
TreeFamiTF353619.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiView protein in InterPro
IPR004204. COX6C.
IPR034884. Cytochrome_c_oxidase_VIc/VIIs.
IPR037169. Cytochrome_c_oxidase_VIc_sf.
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiView protein in Pfam
PF02937. COX6C. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032. Cyt_c_oxidase_su6c. 1 hit.
SUPFAMiSSF81415. SSF81415. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD
60 70
FYRNYDSMKD FEEMRKAGIF QSAK
Length:74
Mass (Da):8,610
Last modified:April 14, 2009 - v2
Checksum:iE063BDB1B7AE9E4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA. Translation: AAI26789.1.
PIRiA00496. OGBO6C.
RefSeqiNP_001231040.1. NM_001244111.1.
UniGeneiBt.28261.

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
GeneIDi614700.
KEGGibta:614700.

Similar proteinsi

Entry informationi

Entry nameiCOX6C_BOVIN
AccessioniPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 14, 2009
Last modified: October 25, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families