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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.
ReactomeiREACT_281214. Respiratory electron transport.
REACT_321619. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
Gene namesi
Name:COX6C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1211Mitochondrial matrixAdd
BLAST
Transmembranei13 – 5341HelicalAdd
BLAST
Topological domaini54 – 7421Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 7473Cytochrome c oxidase subunit 6CPRO_0000191301Add
BLAST

Proteomic databases

PRIDEiP04038.

Interactioni

Protein-protein interaction databases

DIPiDIP-38980N.
IntActiP04038. 2 interactions.

Structurei

Secondary structure

1
74
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 3927Combined sources
Helixi41 – 5313Combined sources
Helixi57 – 6610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
SMRiP04038. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04038.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86594.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP04038.
KOiK02268.
OMAiMAVADPR.
OrthoDBiEOG73807S.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD
60 70
FYRNYDSMKD FEEMRKAGIF QSAK
Length:74
Mass (Da):8,610
Last modified:April 13, 2009 - v2
Checksum:iE063BDB1B7AE9E4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA. Translation: AAI26789.1.
PIRiA00496. OGBO6C.
RefSeqiNP_001231040.1. NM_001244111.1.
UniGeneiBt.28261.

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
GeneIDi614700.
KEGGibta:614700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA. Translation: AAI26789.1.
PIRiA00496. OGBO6C.
RefSeqiNP_001231040.1. NM_001244111.1.
UniGeneiBt.28261.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
SMRiP04038. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38980N.
IntActiP04038. 2 interactions.

Proteomic databases

PRIDEiP04038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
GeneIDi614700.
KEGGibta:614700.

Phylogenomic databases

eggNOGiNOG86594.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP04038.
KOiK02268.
OMAiMAVADPR.
OrthoDBiEOG73807S.
TreeFamiTF353619.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.
ReactomeiREACT_281214. Respiratory electron transport.
REACT_321619. Orphan transporters.

Miscellaneous databases

EvolutionaryTraceiP04038.
NextBioi20899236.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.
  2. "Studies on cytochrome c oxidase, XI. The amino-acid sequence of bovine heart polypeptide VIc."
    Erdweg M., Buse G.
    Biol. Chem. Hoppe-Seyler 366:257-263(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-74.
    Tissue: Liver.
  3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Tissue: Liver.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX6C_BOVIN
AccessioniPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1986
Last sequence update: April 13, 2009
Last modified: March 31, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.