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P04038

- COX6C_BOVIN

UniProt

P04038 - COX6C_BOVIN

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Protein
Cytochrome c oxidase subunit 6C
Gene
COX6C
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
Gene namesi
Name:COX6C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1211Mitochondrial matrix
Add
BLAST
Transmembranei13 – 5341Helical
Add
BLAST
Topological domaini54 – 7421Mitochondrial intermembrane
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 7473Cytochrome c oxidase subunit 6C
PRO_0000191301Add
BLAST

Proteomic databases

PRIDEiP04038.

Interactioni

Protein-protein interaction databases

IntActiP04038. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 3927
Helixi41 – 5313
Helixi57 – 6610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
ProteinModelPortaliP04038.
SMRiP04038. Positions 2-74.

Miscellaneous databases

EvolutionaryTraceiP04038.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86594.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP04038.
KOiK02268.
OMAiQVARIPK.
OrthoDBiEOG73807S.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04038-1 [UniParc]FASTAAdd to Basket

« Hide

MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD   50
FYRNYDSMKD FEEMRKAGIF QSAK 74
Length:74
Mass (Da):8,610
Last modified:April 14, 2009 - v2
Checksum:iE063BDB1B7AE9E4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126788 mRNA. Translation: AAI26789.1.
PIRiA00496. OGBO6C.
RefSeqiNP_001231040.1. NM_001244111.1.
UniGeneiBt.28261.

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
GeneIDi614700.
KEGGibta:614700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126788 mRNA. Translation: AAI26789.1 .
PIRi A00496. OGBO6C.
RefSeqi NP_001231040.1. NM_001244111.1.
UniGenei Bt.28261.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 I/V 2-74 [» ]
1OCO X-ray 2.80 I/V 2-74 [» ]
1OCR X-ray 2.35 I/V 2-74 [» ]
1OCZ X-ray 2.90 I/V 2-74 [» ]
1V54 X-ray 1.80 I/V 2-74 [» ]
1V55 X-ray 1.90 I/V 2-74 [» ]
2DYR X-ray 1.80 I/V 2-74 [» ]
2DYS X-ray 2.20 I/V 2-74 [» ]
2EIJ X-ray 1.90 I/V 2-74 [» ]
2EIK X-ray 2.10 I/V 2-74 [» ]
2EIL X-ray 2.10 I/V 2-74 [» ]
2EIM X-ray 2.60 I/V 2-74 [» ]
2EIN X-ray 2.70 I/V 2-74 [» ]
2OCC X-ray 2.30 I/V 2-74 [» ]
2Y69 X-ray 1.95 I/V 1-74 [» ]
2YBB electron microscopy 19.00 T 2-74 [» ]
2ZXW X-ray 2.50 I/V 2-74 [» ]
3ABK X-ray 2.00 I/V 2-74 [» ]
3ABL X-ray 2.10 I/V 2-74 [» ]
3ABM X-ray 1.95 I/V 2-74 [» ]
3AG1 X-ray 2.20 I/V 2-74 [» ]
3AG2 X-ray 1.80 I/V 2-74 [» ]
3AG3 X-ray 1.80 I/V 2-74 [» ]
3AG4 X-ray 2.05 I/V 2-74 [» ]
3ASN X-ray 3.00 I/V 2-74 [» ]
3ASO X-ray 2.30 I/V 2-74 [» ]
3WG7 X-ray 1.90 I/V 2-74 [» ]
ProteinModelPortali P04038.
SMRi P04038. Positions 2-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04038. 2 interactions.

Proteomic databases

PRIDEi P04038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018778 ; ENSBTAP00000018778 ; ENSBTAG00000014130 .
GeneIDi 614700.
KEGGi bta:614700.

Phylogenomic databases

eggNOGi NOG86594.
GeneTreei ENSGT00390000004573.
HOGENOMi HOG000039249.
HOVERGENi HBG051091.
InParanoidi P04038.
KOi K02268.
OMAi QVARIPK.
OrthoDBi EOG73807S.
TreeFami TF353619.

Miscellaneous databases

EvolutionaryTracei P04038.
NextBioi 20899236.

Family and domain databases

Gene3Di 4.10.93.10. 1 hit.
InterProi IPR004204. COX6C.
[Graphical view ]
PANTHERi PTHR12916. PTHR12916. 1 hit.
Pfami PF02937. COX6C. 1 hit.
[Graphical view ]
ProDomi PD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.
  2. "Studies on cytochrome c oxidase, XI. The amino-acid sequence of bovine heart polypeptide VIc."
    Erdweg M., Buse G.
    Biol. Chem. Hoppe-Seyler 366:257-263(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-74.
    Tissue: Liver.
  3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Tissue: Liver.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX6C_BOVIN
AccessioniPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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