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Protein

Cytochrome c oxidase subunit 4, mitochondrial

Gene

COX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111ZincPROSITE-ProRule annotation1
Metal bindingi134ZincPROSITE-ProRule annotation1
Metal bindingi137ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB-EC
  • zinc ion binding Source: SGD

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial ATP synthesis coupled proton transport Source: GO_Central
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
  • mitochondrial respiratory chain complex IV assembly Source: CACAO
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YGL187C-MONOMER.
YEAST:YGL187C-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:COX4
Ordered Locus Names:YGL187C
ORF Names:G1362
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL187C.
SGDiS000003155. COX4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial intermembrane space Source: Reactome
  • mitochondrial respiratory chain complex IV Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000611426 – 155Cytochrome c oxidase subunit 4, mitochondrialAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04037.
PRIDEiP04037.

PTM databases

iPTMnetiP04037.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.1 Publication

Protein-protein interaction databases

BioGridi33068. 145 interactors.
DIPiDIP-2763N.
IntActiP04037. 14 interactors.
MINTiMINT-521387.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 17Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi103 – 106Combined sources4
Beta strandi109 – 114Combined sources6
Beta strandi122 – 124Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi140 – 143Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HR8X-ray2.70O/P/Q/R2-25[»]
2ODXNMR-A79-155[»]
ProteinModelPortaliP04037.
SMRiP04037.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04037.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000184129.
InParanoidiP04037.
KOiK02265.
OMAiARCWECG.
OrthoDBiEOG092C5SFW.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG
60 70 80 90 100
AKEGTVPTDL DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII
110 120 130 140 150
ESYDDYRYVG CTGSPAGSHT IMWLKPTVNE VARCWECGSV YKLNPVGVPN

DDHHH
Length:155
Mass (Da):17,143
Last modified:November 1, 1986 - v1
Checksum:iAB2EE69878819E0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Q → E AA sequence (PubMed:6327686).Curated1
Sequence conflicti73G → C AA sequence (PubMed:6327686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01418 Genomic DNA. Translation: CAA25665.1.
X91489 Genomic DNA. Translation: CAA62787.1.
Z72709 Genomic DNA. Translation: CAA96899.1.
EF123139 mRNA. Translation: ABM97483.1.
Y00152 Genomic DNA. Translation: CAA68347.1.
BK006941 Genomic DNA. Translation: DAA07928.1.
PIRiA22786. OLBY4.
RefSeqiNP_011328.1. NM_001181052.1.

Genome annotation databases

EnsemblFungiiYGL187C; YGL187C; YGL187C.
GeneIDi852688.
KEGGisce:YGL187C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01418 Genomic DNA. Translation: CAA25665.1.
X91489 Genomic DNA. Translation: CAA62787.1.
Z72709 Genomic DNA. Translation: CAA96899.1.
EF123139 mRNA. Translation: ABM97483.1.
Y00152 Genomic DNA. Translation: CAA68347.1.
BK006941 Genomic DNA. Translation: DAA07928.1.
PIRiA22786. OLBY4.
RefSeqiNP_011328.1. NM_001181052.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HR8X-ray2.70O/P/Q/R2-25[»]
2ODXNMR-A79-155[»]
ProteinModelPortaliP04037.
SMRiP04037.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33068. 145 interactors.
DIPiDIP-2763N.
IntActiP04037. 14 interactors.
MINTiMINT-521387.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiP04037.

Proteomic databases

MaxQBiP04037.
PRIDEiP04037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL187C; YGL187C; YGL187C.
GeneIDi852688.
KEGGisce:YGL187C.

Organism-specific databases

EuPathDBiFungiDB:YGL187C.
SGDiS000003155. COX4.

Phylogenomic databases

HOGENOMiHOG000184129.
InParanoidiP04037.
KOiK02265.
OMAiARCWECG.
OrthoDBiEOG092C5SFW.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciMetaCyc:YGL187C-MONOMER.
YEAST:YGL187C-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

EvolutionaryTraceiP04037.
PROiP04037.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX4_YEAST
AccessioniPrimary (citable) accession number: P04037
Secondary accession number(s): A2TBN6, D6VTW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9410 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.