Cytochrome c oxidase subunit 4, mitochondrial precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P04037 (COX4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide IV

Gene names

Name:	COX4
Ordered Locus Names:	YGL187C
ORF Names:	G1362

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.
Subcellular location	Mitochondrion inner membrane.
Miscellaneous	Present with 9410 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 5B family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from physical interaction. Source: SGD mitochondrial electron transport, cytochrome c to oxygen Inferred from direct assay. Source: SGD
Cellular component	mitochondrial respiratory chain complex IV Inferred from physical interaction. Source: SGD
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSL7	P38274	2	EBI-5039,EBI-21618
SKI8	Q02793	1	EBI-5039,EBI-17260

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 25

Mitochondrion Ref.7

Chain

26 – 155

130

Cytochrome c oxidase subunit 4, mitochondrial

PRO_0000006114

Sites

Metal binding

111

Zinc Potential

Metal binding

134

Zinc Potential

Metal binding

137

Zinc Potential

Amino acid modifications

Modified residue

Phosphothreonine Ref.9

Experimental info

Sequence conflict

Q → E AA sequence Ref.7

Sequence conflict

G → C AA sequence Ref.7

Secondary structure

155

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P04037 [UniParc].

Last modified November 1, 1986. Version 1.
Checksum: AB2EE69878819E0F
Show »

FASTA

155

17,143

        10         20         30         40         50         60 
MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG AKEGTVPTDL 

        70         80         90        100        110        120 
DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII ESYDDYRYVG CTGSPAGSHT 

       130        140        150 
IMWLKPTVNE VARCWECGSV YKLNPVGVPN DDHHH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein." Maarse A.C., van Loon A.P.G.M., Riezman H., Gregor I., Schatz G., Grivell L.A. EMBO J. 3:2831-2837(1984) [PubMed: 6098449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae." Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V. Yeast 13:55-64(1997) [PubMed: 9046087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing." Juneau K., Palm C., Miranda M., Davis R.W. Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed: 17244705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-33. Strain: ATCC 201390 / BY4743.
[6]	"The untranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron." Schneider J.C., Guarente L. Nucleic Acids Res. 15:3515-3529(1987) [PubMed: 3033605] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3.
[7]	"The nuclear-coded subunits of yeast cytochrome c oxidase. III. Identification of homologous subunits in yeast, bovine heart, and Neurospora crassa cytochrome c oxidases." Power S.D., Lochrie M.A., Poyton R.O. J. Biol. Chem. 259:6575-6578(1984) [PubMed: 6327686] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-79.
[8]	"Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G. Eur. J. Biochem. 227:296-302(1995) [PubMed: 7851399] [Abstract] Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
[9]	"Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C. Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed: 17761666] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[10]	"Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences." Taylor A.B., Smith B.S., Kitada S., Kojima K., Miyaura H., Otwinowski Z., Ito A., Deisenhofer J. Structure 9:615-625(2001) [PubMed: 11470436] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-25 IN COMPLEX WITH MAS1/MAS2 HETERODIMER.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X01418 Genomic DNA. Translation: CAA25665.1.
X91489 Genomic DNA. Translation: CAA62787.1.
Z72709 Genomic DNA. Translation: CAA96899.1.
EF123139 mRNA. Translation: ABM97483.1.
Y00152 Genomic DNA. Translation: CAA68347.1.
BK006941 Genomic DNA. Translation: DAA07928.1.

PIR

OLBY4. A22786.

RefSeq

NP_011328.1. NM_001181052.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HR8	X-ray	2.70	O/P/Q/R	2-25	[»]
2ODX	NMR	-	A	79-155	[»]

ProteinModelPortal

P04037.

SMR

P04037. Positions 51-148.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2763N.

IntAct

P04037. 9 interactions.

MINT

MINT-521387.

STRING

P04037.

Protein family/group databases

TCDB

3.D.4.8.1. proton-translocating cytochrome oxidase (COX) superfamily.

Proteomic databases

PeptideAtlas

P04037.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YGL187C; YGL187C; YGL187C.

GeneID

852688.

KEGG

sce:YGL187C.

NMPDR

fig|4932.3.peg.2432.

Organism-specific databases

CYGD

YGL187c.

SGD

S000003155. COX4.

Phylogenomic databases

eggNOG

fuNOG09265.

GeneTree

EFGT00050000005668.

HOGENOM

HBG324015.

OMA

YWMKVEE.

OrthoDB

EOG408RJS.

Gene expression databases

ArrayExpress

P04037.

Genevestigator

P04037.

GermOnline

YGL187C. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]

Gene3D

G3DSA:2.60.11.10. COX5B. 1 hit.

K02265.

PANTHER

PTHR10122. COX5B. 1 hit.

Pfam

PF01215. COX5B. 1 hit.
[Graphical view]

ProDom

PD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

972014.

Entry information

Entry name

COX4_YEAST

Accession

Primary (citable) accession number: P04037
Secondary accession number(s): A2TBN6, D6VTW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
Last sequence update:	November 1, 1986
Last modified:	December 14, 2011
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents