Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 11
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 9437UniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

G1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7UniRule annotation
Gene namesi
Name:E7UniRule annotation
OrganismiHuman papillomavirus type 11
Taxonomic identifieri10580 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008222 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

  • Note: Predominantly found in the host nucleus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein E7PRO_0000133410Add
BLAST

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host ZUBR1.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-7005254,EBI-447544From a different organism.
PPP2CAP677752EBI-7005254,EBI-712311From a different organism.
PPP2R1AP301532EBI-7005254,EBI-302388From a different organism.
RB1P064003EBI-7005254,EBI-491274From a different organism.
UBR4Q5T4S72EBI-7005254,EBI-1995940From a different organism.

Protein-protein interaction databases

IntActiP04020. 43 interactions.
MINTiMINT-123217.

Structurei

3D structure databases

ProteinModelPortaliP04020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4242DisorderedUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi23 – 275LXCXE motif; interaction with host RB1UniRule annotation
Motifi76 – 849Nuclear export signalUniRule annotation

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 9437UniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.

Sequencei

Sequence statusi: Complete.

P04020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGRLVTLKD IVLDLQPPDP VGLHCYEQLE DSSEDEVDKV DKQDAQPLTQ
60 70 80 90
HYQILTCCCG CDSNVRLVVE CTDGDIRQLQ DLLLGTLNIV CPICAPKP
Length:98
Mass (Da):10,889
Last modified:October 23, 1986 - v1
Checksum:iAACA9A60C933E1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46928.1.
L36108 Genomic DNA. Translation: AAA21704.1.
PIRiA03690. W7WL11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46928.1.
L36108 Genomic DNA. Translation: AAA21704.1.
PIRiA03690. W7WL11.

3D structure databases

ProteinModelPortaliP04020.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04020. 43 interactions.
MINTiMINT-123217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVE7_HPV11
AccessioniPrimary (citable) accession number: P04020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.