Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 11
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional transactivator. Binds double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 6737Sequence analysisAdd
BLAST
Zinc fingeri104 – 14037Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6
Gene namesi
Name:E6
OrganismiHuman papillomavirus type 11
Taxonomic identifieri10580 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008222 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Protein E6PRO_0000133331Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE3AQ050863EBI-1177232,EBI-954357From a different organism.

Protein-protein interaction databases

IntActiP04019. 6 interactions.
MINTiMINT-96648.

Structurei

3D structure databases

ProteinModelPortaliP04019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 6737Sequence analysisAdd
BLAST
Zinc fingeri104 – 14037Sequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDASTSA TSIDQLCKTF NLSLHTLQIQ CVFCRNALTT AEIYAYAYKN
60 70 80 90 100
LKVVWRDNFP FAACACCLEL QGKINQYRHF NYAAYAPTVE EETNEDILKV
110 120 130 140 150
LIRCYLCHKP LCEIEKLKHI LGKARFIKLN NQWKGRCLHC WTTCMEDLLP
Length:150
Mass (Da):17,406
Last modified:October 23, 1986 - v1
Checksum:iA685DC7DCA090CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46927.1.
L36108 Genomic DNA. Translation: AAA21703.1.
PIRiA03684. W6WL11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46927.1.
L36108 Genomic DNA. Translation: AAA21703.1.
PIRiA03684. W6WL11.

3D structure databases

ProteinModelPortaliP04019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04019. 6 interactions.
MINTiMINT-96648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence and genome organization of human papilloma virus type 11."
    Dartmann K., Schwarz E., Gissmann L., zur Hausen H.
    Virology 151:124-130(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Association of human papillomavirus type 11 DNA with squamous cell carcinoma of the tongue."
    Fife K.H., Fan L., Fritsch M.H., Bryan J., Brown D.R.
    Arch. Otolaryngol. Head Neck Surg. 122:1404-1408(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVE6_HPV11
AccessioniPrimary (citable) accession number: P04019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.