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Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 11
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation. In turn, apoptosis induced by DNA damage is inhibited. E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.UniRule annotation3 Publications

Miscellaneous

Belongs to the low risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate but low risk E6s do not possess this domain.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 67UniRule annotationAdd BLAST37
Zinc fingeri104 – 140UniRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6UniRule annotation
Gene namesi
Name:E6UniRule annotation
OrganismiHuman papillomavirus type 11
Taxonomic identifieri10580 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008222 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotationBy similarity
  • Host nucleus UniRule annotationBy similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333311 – 150Protein E6Add BLAST150

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host TP53 and EP300; this interaction inhibits TP53 activity.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE3AQ050865EBI-1177232,EBI-954357From Homo sapiens.

Protein-protein interaction databases

IntActiP04019. 9 interactors.
MINTiMINT-96648.

Structurei

3D structure databases

ProteinModelPortaliP04019.
SMRiP04019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 67UniRule annotationAdd BLAST37
Zinc fingeri104 – 140UniRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900011D.

Family and domain databases

HAMAPiMF_04006. HPV_E6. 1 hit.
InterProiView protein in InterPro
IPR001334. E6.
PfamiView protein in Pfam
PF00518. E6. 1 hit.

Sequencei

Sequence statusi: Complete.

P04019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDASTSA TSIDQLCKTF NLSLHTLQIQ CVFCRNALTT AEIYAYAYKN
60 70 80 90 100
LKVVWRDNFP FAACACCLEL QGKINQYRHF NYAAYAPTVE EETNEDILKV
110 120 130 140 150
LIRCYLCHKP LCEIEKLKHI LGKARFIKLN NQWKGRCLHC WTTCMEDLLP
Length:150
Mass (Da):17,406
Last modified:October 23, 1986 - v1
Checksum:iA685DC7DCA090CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46927.1.
L36108 Genomic DNA. Translation: AAA21703.1.
PIRiA03684. W6WL11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14119 Genomic DNA. Translation: AAA46927.1.
L36108 Genomic DNA. Translation: AAA21703.1.
PIRiA03684. W6WL11.

3D structure databases

ProteinModelPortaliP04019.
SMRiP04019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04019. 9 interactors.
MINTiMINT-96648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900011D.

Family and domain databases

HAMAPiMF_04006. HPV_E6. 1 hit.
InterProiView protein in InterPro
IPR001334. E6.
PfamiView protein in Pfam
PF00518. E6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVE6_HPV11
AccessioniPrimary (citable) accession number: P04019
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: May 10, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.