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P04012 (VL1_HPV11) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Major capsid protein L1
Gene names
Name:L1
OrganismHuman papillomavirus type 11 [Complete proteome]
Taxonomic identifier10580 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Papillomaviridae › Alphapapillomavirus ›
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.

Subunit structure

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the papillomaviridae L1 protein family.

Ontologies

Keywords
   Biological processHost-virus interaction
Viral attachment to host cell
Virus entry into host cell
   Cellular componentVirion
   Developmental stageLate protein
   Molecular functionCapsid protein
T=7 icosahedral capsid protein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processviral attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentT=7 icosahedral viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Major capsid protein L1
PRO_0000133495

Secondary structure

1 ........................................................................... 501
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04012 [UniParc].

Last modified October 23, 1986. Version 1.
Checksum: 88957D023CC182A7

FASTA50155,835
        10         20         30         40         50         60 
MWRPSDSTVY VPPPNPVSKV VATDAYVKRT NIFYHASSSR LLAVGHPYYS IKKVNKTVVP 

        70         80         90        100        110        120 
KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT GLEVGRGQPL GVGVSGHPLL 

       130        140        150        160        170        180 
NKYDDVENSG GYGGNPGQDN RVNVGMDYKQ TQLCMVGCAP PLGEHWGKGT QCSNTSVQNG 

       190        200        210        220        230        240 
DCPPLELITS VIQDGDMVDT GFGAMNFADL QTNKSDVPLD ICGTVCKYPD YLQMAADPYG 

       250        260        270        280        290        300 
DRLFFYLRKE QMFARHFFNR AGTVGEPVPD DLLVKGGNNR SSVASSIYVH TPSGSLVSSE 

       310        320        330        340        350        360 
AQLFNKPYWL QKAQGHNNGI CWGNHLFVTV VDTTRSTNMT LCASVSKSAT YTNSDYKEYM 

       370        380        390        400        410        420 
RHVEEFDLQF IFQLCSITLS AEVMAYIHTM NPSVLEDWNF GLSPPPNGTL EDTYRYVQSQ 

       430        440        450        460        470        480 
AITCQKPTPE KEKQDPYKDM SFWEVNLKEK FSSELDQFPL GRKFLLQSGY RGRTSARTGI 

       490        500 
KRPAVSKPST APKRKRTKTK K

« Hide

References

[1]"The nucleotide sequence and genome organization of human papilloma virus type 11."
Dartmann K., Schwarz E., Gissmann L., zur Hausen H.
Virology 151:124-130(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M14119 Genomic DNA. Translation: AAA46935.1.
PIRP1WL11. A03639.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2R5KX-ray3.20A/B/C/D/E20-470[»]
ProteinModelPortalP04012.
SMRP04012. Positions 20-470.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-260992.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.175.20. 1 hit.
InterProIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSPR00865. HPVCAPSIDL1.
SUPFAMSSF88648. dsDNA_vir_gr_I_capsid. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP04012.

Entry information

Entry nameVL1_HPV11
AccessionPrimary (citable) accession number: P04012
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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