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P04001

- OPSG_HUMAN

UniProt

P04001 - OPSG_HUMAN

Protein

Medium-wave-sensitive opsin 1

Gene

OPN1MW

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (23 Oct 1986)
      Previous versions | rss
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    Functioni

    Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

    Absorptioni

    Abs(max)=530 nm

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. phototransduction, visible light Source: Reactome
    3. positive regulation of cytokinesis Source: UniProt
    4. protein-chromophore linkage Source: UniProtKB-KW
    5. retinoid metabolic process Source: Reactome
    6. visual perception Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_160083. The retinoid cycle in cones (daylight vision).
    REACT_160130. Retinoid cycle disease events.
    REACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Medium-wave-sensitive opsin 1
    Alternative name(s):
    Green cone photoreceptor pigment
    Green-sensitive opsin
    Short name:
    GOP
    Gene namesi
    Name:OPN1MW
    Synonyms:GCP
    AND
    Name:OPN1MW2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4206. OPN1MW.
    HGNC:26952. OPN1MW2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. photoreceptor outer segment membrane Source: Reactome
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Colorblindness, partial, deutan series (CBD) [MIM:303800]: A color vision defect characterized by a dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum. Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus green in protanopia.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941N → K in CBD. 1 Publication
    VAR_064051
    Natural varianti203 – 2031C → R in CBD and BCM. 2 Publications
    VAR_004841
    Natural varianti330 – 3301R → Q in CBD. 1 Publication
    VAR_064053
    Blue cone monochromacy (BCM) [MIM:303700]: A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti203 – 2031C → R in CBD and BCM. 2 Publications
    VAR_004841
    Cone dystrophy 5 (COD5) [MIM:303700]: A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti177 – 1771W → R in COD5; results in protein misfolding and retention in the endoplasmic reticulum. 1 Publication
    VAR_064052

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi303700. phenotype.
    303800. phenotype.
    Orphaneti16. Blue cone monochromatism.
    1872. Cone rod dystrophy.
    319698. Partial color blindness, deutan type.
    PharmGKBiPA142671229.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Medium-wave-sensitive opsin 1PRO_0000197785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Curated
    Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
    Modified residuei312 – 3121N6-(retinylidene)lysine

    Post-translational modificationi

    Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP04001.
    PRIDEiP04001.

    PTM databases

    PhosphoSiteiP04001.

    Expressioni

    Tissue specificityi

    The three color pigments are found in the cone photoreceptor cells.

    Gene expression databases

    BgeeiP04001.
    CleanExiHS_OPN1MW.
    HS_OPN1MW2.
    GenevestigatoriP04001.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000358945.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KPWmodel-A1-364[»]
    ProteinModelPortaliP04001.
    SMRiP04001. Positions 23-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularAdd
    BLAST
    Topological domaini78 – 8912CytoplasmicAdd
    BLAST
    Topological domaini116 – 12914ExtracellularAdd
    BLAST
    Topological domaini150 – 16819CytoplasmicAdd
    BLAST
    Topological domaini193 – 21826ExtracellularAdd
    BLAST
    Topological domaini247 – 26822CytoplasmicAdd
    BLAST
    Topological domaini293 – 3008Extracellular
    Topological domaini326 – 36439CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7725Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11526Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 14920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 19224Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 24628Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29224Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32525Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240324.
    HOGENOMiHOG000253932.
    HOVERGENiHBG107442.
    InParanoidiP04001.
    KOiK04251.
    OMAiFCWGPYT.
    OrthoDBiEOG72NRQJ.
    PhylomeDBiP04001.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR000378. Opsin_red/grn.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00575. OPSINREDGRN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR    50
    WVYHLTSVWM IFVVIASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL 100
    AETVIASTIS VVNQVYGYFV LGHPMCVLEG YTVSLCGITG LWSLAIISWE 150
    RWMVVCKPFG NVRFDAKLAI VGIAFSWIWA AVWTAPPIFG WSRYWPHGLK 200
    TSCGPDVFSG SSYPGVQSYM IVLMVTCCIT PLSIIVLCYL QVWLAIRAVA 250
    KQQKESESTQ KAEKEVTRMV VVMVLAFCFC WGPYAFFACF AAANPGYPFH 300
    PLMAALPAFF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA 350
    SKTEVSSVSS VSPA 364
    Length:364
    Mass (Da):40,584
    Last modified:October 23, 1986 - v1
    Checksum:iA98D046958C72AE9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941N → K in CBD. 1 Publication
    VAR_064051
    Natural varianti177 – 1771W → R in COD5; results in protein misfolding and retention in the endoplasmic reticulum. 1 Publication
    VAR_064052
    Natural varianti203 – 2031C → R in CBD and BCM. 2 Publications
    VAR_004841
    Natural varianti330 – 3301R → Q in CBD. 1 Publication
    VAR_064053

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03494
    , M13306, K03490, K03491, K03492, K03493 Genomic DNA. Translation: AAB59503.1.
    K03497, K03495, K03496 Genomic DNA. Translation: AAB59525.1. Sequence problems.
    AC092402 Genomic DNA. No translation available.
    Z46936 Genomic DNA. No translation available.
    CCDSiCCDS14743.1.
    CCDS35447.1.
    PIRiA03158. OOHUG.
    RefSeqiNP_000504.1. NM_000513.2.
    NP_001041646.1. NM_001048181.2.
    XP_003960138.1. XM_003960089.2.
    XP_005276782.1. XM_005276725.1.
    UniGeneiHs.247787.
    Hs.571751.

    Genome annotation databases

    EnsembliENST00000369929; ENSP00000358945; ENSG00000166160.
    ENST00000595290; ENSP00000472316; ENSG00000268221.
    GeneIDi101060233.
    2652.
    728458.
    KEGGihsa:101060233.
    hsa:2652.
    hsa:728458.
    UCSCiuc004fkb.3. human.

    Polymorphism databases

    DMDMi129215.

    Cross-referencesi

    Web resourcesi

    Mutations of the color pigment genes

    Retina International's Scientific Newsletter

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03494
    , M13306 , K03490 , K03491 , K03492 , K03493 Genomic DNA. Translation: AAB59503.1 .
    K03497 , K03495 , K03496 Genomic DNA. Translation: AAB59525.1 . Sequence problems.
    AC092402 Genomic DNA. No translation available.
    Z46936 Genomic DNA. No translation available.
    CCDSi CCDS14743.1.
    CCDS35447.1.
    PIRi A03158. OOHUG.
    RefSeqi NP_000504.1. NM_000513.2.
    NP_001041646.1. NM_001048181.2.
    XP_003960138.1. XM_003960089.2.
    XP_005276782.1. XM_005276725.1.
    UniGenei Hs.247787.
    Hs.571751.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KPW model - A 1-364 [» ]
    ProteinModelPortali P04001.
    SMRi P04001. Positions 23-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000358945.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P04001.

    Polymorphism databases

    DMDMi 129215.

    Proteomic databases

    PaxDbi P04001.
    PRIDEi P04001.

    Protocols and materials databases

    DNASUi 2652.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369929 ; ENSP00000358945 ; ENSG00000166160 .
    ENST00000595290 ; ENSP00000472316 ; ENSG00000268221 .
    GeneIDi 101060233.
    2652.
    728458.
    KEGGi hsa:101060233.
    hsa:2652.
    hsa:728458.
    UCSCi uc004fkb.3. human.

    Organism-specific databases

    CTDi 2652.
    728458.
    GeneCardsi GC0XP153448.
    GC0XP153485.
    GeneReviewsi OPN1MW.
    H-InvDB HIX0056274.
    HGNCi HGNC:4206. OPN1MW.
    HGNC:26952. OPN1MW2.
    MIMi 300821. gene.
    303700. phenotype.
    303800. phenotype.
    neXtProti NX_P04001.
    Orphaneti 16. Blue cone monochromatism.
    1872. Cone rod dystrophy.
    319698. Partial color blindness, deutan type.
    PharmGKBi PA142671229.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240324.
    HOGENOMi HOG000253932.
    HOVERGENi HBG107442.
    InParanoidi P04001.
    KOi K04251.
    OMAi FCWGPYT.
    OrthoDBi EOG72NRQJ.
    PhylomeDBi P04001.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_160083. The retinoid cycle in cones (daylight vision).
    REACT_160130. Retinoid cycle disease events.
    REACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii OPN1MW.
    NextBioi 10480.
    PROi P04001.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04001.
    CleanExi HS_OPN1MW.
    HS_OPN1MW2.
    Genevestigatori P04001.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR000378. Opsin_red/grn.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00575. OPSINREDGRN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments."
      Nathans J., Thomas D., Hogness D.S.
      Science 232:193-202(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Retinal cone cell.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Buck D.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-364.
    4. "Molecular biology of the visual pigments."
      Applebury M.L., Hargrave P.A.
      Vision Res. 26:1881-1895(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    5. "Defective colour vision associated with a missense mutation in the human green visual pigment gene."
      Winderickx J., Sanocki E., Lindsey D.T., Teller D.Y., Motulsky A.G., Deeb S.S.
      Nat. Genet. 1:251-256(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CBD ARG-203.
    6. "Gene conversion between red and defective green opsin gene in blue cone monochromacy."
      Reyniers E., Van Thienen M.N., Meire F., De Boulle K., Devries K., Kestelijn P., Willems P.J.
      Genomics 29:323-328(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT BCM ARG-203.
    7. "Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies."
      Ueyama H., Kuwayama S., Imai H., Tanabe S., Oda S., Nishida Y., Wada A., Shichida Y., Yamade S.
      Biochem. Biophys. Res. Commun. 294:205-209(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CBD LYS-94 AND GLN-330.
    8. Cited for: VARIANT COD5 ARG-177, CHARACTERIZATION OF VARIANT COD5 ARG-177.

    Entry informationi

    Entry nameiOPSG_HUMAN
    AccessioniPrimary (citable) accession number: P04001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 1986
    Last sequence update: October 23, 1986
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3