Reviewed, UniProtKB/Swiss-Prot P03986 (TCC_HUMAN)

Names and origin

Protein names	Recommended name:     T-cell receptor gamma chain C region PT-gamma-1/2
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	transmembrane receptor activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 189

›189

T-cell receptor gamma chain C region PT-gamma-1/2

PRO_0000184530

Regions

Transmembrane

157 – 177

21

Potential

Topological domain

178 – 189

12

Cytoplasmic Potential

Region

1 – 156

156

C region

Amino acid modifications

Glycosylation

66

1

N-linked (GlcNAc...) Potential

Glycosylation

136

1

N-linked (GlcNAc...) Potential

Glycosylation

142

1

N-linked (GlcNAc...) Potential

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Disulfide bond

32 ↔ 88

Disulfide bond

183

Interchain Potential

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

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.

.

.

.

.

.

.

.

.

.

.

189

Helix Strand Turn

Details...

Helix

19 – 23

5

Beta strand

24 – 26

3

Beta strand

28 – 39

12

Beta strand

42 – 51

10

Beta strand

66 – 77

12

Helix

80 – 83

4

Beta strand

86 – 92

7

Helix

96 – 98

3

Beta strand

101 – 105

5

Sequences

	Sequence		Length	Mass (Da)
	P03986-1 [UniParc]. Last modified October 23, 1986. Version 1. Checksum: 4F8CCBA7EC15195E	FASTA	189	21,554
	10 20 30 40 50 60 DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD IIKIHWQEKK SNTILGSQEG 70 80 90 100 110 120 NTMKTNDTYM KFSWLTVPEE SLDKEHRCIV RHENNKNGID QEIIFPPIKT DVTTVDPKDS 130 140 150 160 170 180 YSKDANDVIT MDPKDNWSKD ANDTLLLQLT NTSAYYMYLL LLLKSVVYFA IITCCLLGRT AFCCNGEKS

References

[1]	"Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain." Dialynas D.P., Murre C., Quertermous T., Boss J.M., Leiden J.M., Seidman J.G., Strominger J.L. Proc. Natl. Acad. Sci. U.S.A. 83:2619-2623(1986) [PubMed: 3458221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of a human gammadelta T-cell antigen receptor." Allison T.J., Winter C.C., Fournie J.-J., Bonneville M., Garboczi D.N. Nature 411:820-824(2001) [PubMed: 11459064] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 1-119.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00922278.

PIR

RWHUGC. A02141.
A22340.

UniGene

Hs.534032

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HXM	X-ray	3.12	B/D/F/H	1-119	[»]

SMR

P03986. Positions 1-108.

ModBase

Search...

Proteomic databases

PRIDE

P03986.

Genome annotation databases

Ensembl

ENSG00000211686. Homo sapiens. [Contig view]

Organism-specific databases

GeneCards

GC07M038246.

H-InvDB

HIX0006611.

HGNC

HGNC:12271. TRG@.

PharmGKB

PA74.

Phylogenomic databases

HOVERGEN

P03986.

Gene expression databases

GermOnline

ENSG00000155857. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TCC_HUMAN

Accession

Primary (citable) accession number: P03986

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
Last sequence update:	October 23, 1986
Last modified:	May 5, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)