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P03986 (TRGC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell receptor gamma-2 chain C region
Alternative name(s):
T-cell receptor gamma chain C region PT-gamma-1/2
Gene names
Name:TRGC2
Synonyms:TCRGC2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processimmune response

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular componentintegral to plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular functiontransmembrane signaling receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 189›189T-cell receptor gamma-2 chain C region
PRO_0000184530

Regions

Transmembrane157 – 17721Helical; Potential
Topological domain178 – 18912Cytoplasmic Potential
Domain10 – 10495Ig-like
Region1 – 156156C region

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 88
Disulfide bond183Interchain Potential

Experimental info

Non-terminal residue11

Secondary structure

.................. 189
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03986 [UniParc].

Last modified October 23, 1986. Version 1.
Checksum: 4F8CCBA7EC15195E

FASTA18921,554
        10         20         30         40         50         60 
DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD IIKIHWQEKK SNTILGSQEG 

        70         80         90        100        110        120 
NTMKTNDTYM KFSWLTVPEE SLDKEHRCIV RHENNKNGID QEIIFPPIKT DVTTVDPKDS 

       130        140        150        160        170        180 
YSKDANDVIT MDPKDNWSKD ANDTLLLQLT NTSAYYMYLL LLLKSVVYFA IITCCLLGRT 


AFCCNGEKS 

« Hide

References

[1]"Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain."
Dialynas D.P., Murre C., Quertermous T., Boss J.M., Leiden J.M., Seidman J.G., Strominger J.L.
Proc. Natl. Acad. Sci. U.S.A. 83:2619-2623(1986) [PubMed: 3458221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma."
Lefranc M.P., Forster A., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 83:9596-9600(1986) [PubMed: 2879283] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-110.
[3]"Structure of a human gammadelta T-cell antigen receptor."
Allison T.J., Winter C.C., Fournie J.-J., Bonneville M., Garboczi D.N.
Nature 411:820-824(2001) [PubMed: 11459064] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 1-119.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13231 mRNA. No translation available.
M15002 Genomic DNA. No translation available.
IPIIPI00922278.
PIRRWHUGC. A02141.
A22340.
UniGeneHs.534032.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HXMX-ray3.12B/D/F/H1-119[»]
ProteinModelPortalP03986.
SMRP03986. Positions 1-108.
ModBaseSearch...

Protein-protein interaction databases

STRINGP03986.

Polymorphism databases

DMDM135528.

Proteomic databases

PRIDEP03986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000436911; ENSP00000413437; ENSG00000227191.
UCSCuc003tfu.2. human.

Organism-specific databases

GeneCardsGC07M038246.
H-InvDBHIX0006611.
HGNCHGNC:12276. TRGC2.
neXtProtNX_P03986.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG564571.
HOVERGENHBG017900.
InParanoidP03986.
OrthoDBEOG4CVG85.

Gene expression databases

GenevestigatorP03986.
GermOnlineENSG00000155857. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRGC2_HUMAN
AccessionPrimary (citable) accession number: P03986
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families