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Protein

T-cell receptor gamma-2 chain C region

Gene

TRGC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor gamma-2 chain C region
Alternative name(s):
T-cell receptor gamma chain C region PT-gamma-1/2
Gene namesi
Name:TRGC2
Synonyms:TCRGC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12276. TRGC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 18912CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi135528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 189›189T-cell receptor gamma-2 chain C regionPRO_0000184530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 88
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi183 – 183InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP03986.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 235Combined sources
Beta strandi24 – 263Combined sources
Beta strandi28 – 3912Combined sources
Beta strandi42 – 5110Combined sources
Beta strandi66 – 7712Combined sources
Helixi80 – 834Combined sources
Beta strandi86 – 927Combined sources
Helixi96 – 983Combined sources
Beta strandi101 – 1055Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HXMX-ray3.12B/D/F/H1-119[»]
ProteinModelPortaliP03986.
SMRiP03986. Positions 1-112.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 10495Ig-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 156156C regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017900.
InParanoidiP03986.
PhylomeDBiP03986.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD IIKIHWQEKK
60 70 80 90 100
SNTILGSQEG NTMKTNDTYM KFSWLTVPEE SLDKEHRCIV RHENNKNGID
110 120 130 140 150
QEIIFPPIKT DVTTVDPKDS YSKDANDVIT MDPKDNWSKD ANDTLLLQLT
160 170 180
NTSAYYMYLL LLLKSVVYFA IITCCLLGRT AFCCNGEKS
Length:189
Mass (Da):21,554
Last modified:October 23, 1986 - v1
Checksum:i4F8CCBA7EC15195E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13231 mRNA. No translation available.
M15002 Genomic DNA. No translation available.
PIRiA02141. RWHUGC.
A22340.
UniGeneiHs.731375.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13231 mRNA. No translation available.
M15002 Genomic DNA. No translation available.
PIRiA02141. RWHUGC.
A22340.
UniGeneiHs.731375.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HXMX-ray3.12B/D/F/H1-119[»]
ProteinModelPortaliP03986.
SMRiP03986. Positions 1-112.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi135528.

Proteomic databases

PRIDEiP03986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiTRGC2.
H-InvDBHIX0006611.
HGNCiHGNC:12276. TRGC2.
MIMi615450. gene.
neXtProtiNX_P03986.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017900.
InParanoidiP03986.
PhylomeDBiP03986.

Miscellaneous databases

ChiTaRSiTRGC2. human.
EvolutionaryTraceiP03986.
PROiP03986.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain."
    Dialynas D.P., Murre C., Quertermous T., Boss J.M., Leiden J.M., Seidman J.G., Strominger J.L.
    Proc. Natl. Acad. Sci. U.S.A. 83:2619-2623(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma."
    Lefranc M.P., Forster A., Rabbitts T.H.
    Proc. Natl. Acad. Sci. U.S.A. 83:9596-9600(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-110.
  3. "Structure of a human gammadelta T-cell antigen receptor."
    Allison T.J., Winter C.C., Fournie J.-J., Bonneville M., Garboczi D.N.
    Nature 411:820-824(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 1-119.

Entry informationi

Entry nameiTRGC2_HUMAN
AccessioniPrimary (citable) accession number: P03986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.