P03986 (TRGC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell receptor gamma-2 chain C region

Alternative name(s):
T-cell receptor gamma chain C region PT-gamma-1/2

Gene names

Name:	TRGC2
Synonyms:	TCRGC2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	transmembrane signaling receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 189

›189

T-cell receptor gamma-2 chain C region

PRO_0000184530

Regions

Transmembrane

157 – 177

21

Helical; Potential

Topological domain

178 – 189

12

Cytoplasmic Potential

Domain

10 – 104

95

Ig-like

Region

1 – 156

156

C region

Amino acid modifications

Glycosylation

66

1

N-linked (GlcNAc...) Potential

Glycosylation

136

1

N-linked (GlcNAc...) Potential

Glycosylation

142

1

N-linked (GlcNAc...) Potential

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Disulfide bond

32 ↔ 88

Disulfide bond

183

Interchain Potential

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

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.

.

.

.

.

.

.

.

189

Helix Strand Turn

Details...

Helix

19 – 23

5

Beta strand

24 – 26

3

Beta strand

28 – 39

12

Beta strand

42 – 51

10

Beta strand

66 – 77

12

Helix

80 – 83

4

Beta strand

86 – 92

7

Helix

96 – 98

3

Beta strand

101 – 105

5

Sequences

	Sequence		Length	Mass (Da)
	P03986 [UniParc]. Last modified October 23, 1986. Version 1. Checksum: 4F8CCBA7EC15195E	FASTA	189	21,554
	10 20 30 40 50 60 DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD IIKIHWQEKK SNTILGSQEG 70 80 90 100 110 120 NTMKTNDTYM KFSWLTVPEE SLDKEHRCIV RHENNKNGID QEIIFPPIKT DVTTVDPKDS 130 140 150 160 170 180 YSKDANDVIT MDPKDNWSKD ANDTLLLQLT NTSAYYMYLL LLLKSVVYFA IITCCLLGRT AFCCNGEKS

References

[1]	"Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain." Dialynas D.P., Murre C., Quertermous T., Boss J.M., Leiden J.M., Seidman J.G., Strominger J.L. Proc. Natl. Acad. Sci. U.S.A. 83:2619-2623(1986) [PubMed: 3458221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma." Lefranc M.P., Forster A., Rabbitts T.H. Proc. Natl. Acad. Sci. U.S.A. 83:9596-9600(1986) [PubMed: 2879283] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-110.
[3]	"Structure of a human gammadelta T-cell antigen receptor." Allison T.J., Winter C.C., Fournie J.-J., Bonneville M., Garboczi D.N. Nature 411:820-824(2001) [PubMed: 11459064] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 1-119.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M13231 mRNA. No translation available.
M15002 Genomic DNA. No translation available.

IPI

IPI00922278.

PIR

RWHUGC. A02141.
A22340.

UniGene

Hs.534032.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HXM	X-ray	3.12	B/D/F/H	1-119	[»]

ProteinModelPortal

P03986.

SMR

P03986. Positions 1-108.

ModBase

Search...

Protein-protein interaction databases

STRING

P03986.

Polymorphism databases

DMDM

135528.

Proteomic databases

PRIDE

P03986.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000436911; ENSP00000413437; ENSG00000227191.

UCSC

uc003tfu.2. human.

Organism-specific databases

GeneCards

GC07M038246.

H-InvDB

HIX0006611.

HGNC

HGNC:12276. TRGC2.

neXtProt

NX_P03986.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG564571.

HOVERGEN

HBG017900.

InParanoid

P03986.

OrthoDB

EOG4CVG85.

Gene expression databases

Genevestigator

P03986.

GermOnline

ENSG00000155857. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TRGC2_HUMAN

Accession

Primary (citable) accession number: P03986

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
Last sequence update:	October 23, 1986
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.