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Protein

T cell receptor gamma variable 3

Gene

TRGV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
T cell receptor gamma variable 3Imported
Alternative name(s):
T-cell receptor gamma V-gamma-1.1 region1 Publication
Gene namesi
Name:TRGV3Imported
Synonyms:TCRB, TCRGV3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000211699.2
HGNCiHGNC:12288 TRGV3
neXtProtiNX_P03979

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6976
OpenTargetsiENSG00000211699

Chemistry databases

ChEMBLiCHEMBL3580506

Polymorphism and mutation databases

DMDMi136506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003361118 – 118T cell receptor gamma variable 3Sequence analysisAdd BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP03979
PRIDEiP03979

PTM databases

iPTMnetiP03979
PhosphoSitePlusiP03979

Expressioni

Gene expression databases

BgeeiENSG00000211699

Interactioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliP03979
SMRiP03979
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – ›118Ig-likePROSITE-ProRule annotationAdd BLAST›101

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

GeneTreeiENSGT00440000034436
HOGENOMiHOG000169587
HOVERGENiHBG007785
InParanoidiP03979
OMAiRWSWILR
PhylomeDBiP03979

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWALLVLLA FLSPASQKSS NLEGRTKSVT RQTGSSAEIT CDLTVTNTFY
60 70 80 90 100
IHWYLHQEGK APQRLLYYDV STARDVLESG LSPGKYYTHT PRRWSWILRL
110
QNLIENDSGV YYCATWDR
Length:118
Mass (Da):13,664
Last modified:July 6, 2016 - v2
Checksum:i2C30297BFA6C584A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13231 mRNA No translation available.
AC007245 Genomic DNA No translation available.
X04038 Genomic DNA Translation: CAA27672.1
PIRiA02017 RWHUGV
UniGeneiHs.731375

Genome annotation databases

EnsembliENST00000390346; ENSP00000374869; ENSG00000211699
UCSCiuc064cyb.1 human

Similar proteinsi

Entry informationi

Entry nameiTRGV3_HUMAN
AccessioniPrimary (citable) accession number: P03979
Secondary accession number(s): A0A075B6L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: July 6, 2016
Last modified: February 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

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