P03976 (KV2A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-II region 17S29.1
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Anti-streptococcal group A carbohydrate antibody.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Hybridoma Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›113	›113	Ig kappa chain V-II region 17S29.1		PRO_0000059774
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 39	16	Complementarity-determining-1
	Region	40 – 54	15	Framework-2
	Region	55 – 61	7	Complementarity-determining-2
	Region	62 – 93	32	Framework-3
	Region	94 – 102	9	Complementarity-determining-3
	Region	103 – 112	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 93		By similarity
Experimental info
	Non-terminal residue	113	1

Sequences

	Sequence		Length	Mass (Da)
	P03976 [UniParc]. Last modified October 23, 1986. Version 1. Checksum: 4E93797046F8DB33	FASTA	113	12,390
	10 20 30 40 50 60 DIVMTQAVFS NPVTLGTSAS ISCRSSKSLL HSNGITYLYW YLQKPGQSPQ LLLYQMSNLA 70 80 90 100 110 SGVPDRFSSS GSGTDFTLRI SRVEAEDVGV YYCAHNLELP YTFGGGTKLE IKR

References

[1]	"Murine V kappa 25 and V kappa 27 amino-acid sequences of C57B1/6 origin: monoclonal antibodies 17S29.1 and 22S25.1 specific for the group A-streptococcal polysaccharide." Aebersold R., Herbst H., Grutter T., Chang J.Y., Braun D.G. Hoppe-Seyler's Z. Physiol. Chem. 365:1375-1383(1984) [PubMed: 6441768] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Hybridoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00404094.

PIR

KVMS17. A01912.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DX2	model	-	L	1-113	[»]
3CFB	X-ray	1.60	A/L	1-113	[»]
3CFC	X-ray	1.70	L	1-113	[»]

ProteinModelPortal

P03976.

SMR

P03976. Positions 1-113.

ModBase

Search...

Protein-protein interaction databases

STRING

P03976.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG018013.

Gene expression databases

Genevestigator

P03976.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

KV2A5_MOUSE

Accession

Primary (citable) accession number: P03976

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
Last sequence update:	October 23, 1986
Last modified:	September 21, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program