P03975 (IGEB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IgE-binding protein

Gene names

Name:

Iap

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Miscellaneous	This hybridoma was generated by fusion of rat lymphocytes with cells of the AKR mouse thyoma BW5147. This sequence binds only rat IgE.
Sequence similarities	Contains 1 integrase catalytic domain.

Ontologies

Keywords
Ligand	IgE-binding protein
Technical term	Complete proteome Hybridoma Reference proteome
Gene Ontology (GO)
Biological_process	DNA integration Inferred from electronic annotation. Source: InterPro viral reproduction Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	IgE-binding protein		PRO_0000084173
Regions
	Domain	344 – 534	191	Integrase catalytic

Sequences

	Sequence		Length	Mass (Da)
	P03975 [UniParc]. Last modified October 23, 1986. Version 1. Checksum: C53C479890B7FD82	FASTA	557	62,747
	10 20 30 40 50 60 MALQVMFGLE FFLVLEALLF LFTCYQVVKA GRILDEIQDK LSEVKRGERV GTKRKYGTQN 70 80 90 100 110 120 KYTGLSKGLE PEEKLRLGRN TWREIRRKRG KREKKKDQLA EVSRKRSLCS SLDGLGKPAL 130 140 150 160 170 180 SSSEAGEESS SEETDWEEEA AHYQPANWSR KKPKAAGEGQ FADWPQGSRL QGPPYAESPP 190 200 210 220 230 240 CVVRQQCAER CAERQCAERQ CADSFIPREE QRKIQQAFPV FEGAEGGRVH APVEYLQIKE 250 260 270 280 290 300 IAESVRKYGT NANFTLVQLD RLAGMALTPA DWQTVVKAAL PSMGKYMEWR ALWHEAAQAQ 310 320 330 340 350 360 ARANAAALTP EQRDWTFDLL TGQGAYSADQ TNYHWGAYAQ ISSTAIRPGR RSRAGETTGQ 370 380 390 400 410 420 LTKIIQGPQE SFSDFVARMT EAAERIFGES EQAAPLIEQL IYEQATKECR AVHSPKKEQR 430 440 450 460 470 480 LTRLAQGLSR AWGKPRLLKT DNGPAYTSQK FQQFCRQMDV THLTGLPYNP QGQGIVERAH 490 500 510 520 530 540 RTLKAYLIKQ KRGTFEETVP RAPRVSVSLA LFTLNFLNID AHGHTAAERH VQSQIGPMRW 550 LNGKMSLIIN GMARILS

References

[1]	"cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma." Martens C.L., Huff T.F., Jardieu P., Trounstine M.L., Coffman R.L., Ishizaka K., Moore K.W. Proc. Natl. Acad. Sci. U.S.A. 82:2460-2464(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10062 mRNA. Translation: AAA37291.1.
IPI	IPI00116996.
PIR	EBRTMS. A01858.
3D structure databases
ProteinModelPortal	P03975.
SMR	P03975. Positions 219-351, 433-534.
ModBase	Search...
Proteomic databases
PRIDE	P03975.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:96306. Iap.
Gene expression databases
Genevestigator	P03975.
Family and domain databases
Gene3D	1.10.1200.30. 1 hit. 1.10.375.10. 1 hit.
InterPro	IPR000721. Gag_p24. IPR001584. Integrase_cat-core. IPR008916. Retrov_capsid_C. IPR008919. Retrov_capsid_N. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00607. Gag_p24. 1 hit. PF00665. rve. 1 hit. [Graphical view]
SUPFAM	SSF47943. Retrov_capsid_N. 1 hit. SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS50994. INTEGRASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

IGEB_MOUSE

Accession

Primary (citable) accession number: P03975

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
Last sequence update:	October 23, 1986
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program