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Protein

Muellerian-inhibiting factor

Gene

AMH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Biological processi

Differentiation, Gonadal differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Muellerian-inhibiting factor
Alternative name(s):
Anti-Muellerian hormone
Short name:
AMH
Muellerian-inhibiting substance
Short name:
MIS
Gene namesi
Name:AMH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Propeptidei18 – 247Sequence analysisPRO_0000033744
Chaini25 – 575551Muellerian-inhibiting factorPRO_0000033745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi477 ↔ 541By similarity
Disulfide bondi503 ↔ 572By similarity
Disulfide bondi507 ↔ 574By similarity
Disulfide bondi540 – 540InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP03972.
PRIDEiP03972.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019912.

Structurei

3D structure databases

ProteinModelPortaliP03972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113593.
HOVERGENiHBG006358.
InParanoidiP03972.
KOiK04665.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006799. AMH_N.
IPR029034. Cystine-knot_cytokine.
IPR021203. Muellerian-inhibiting_factor.
IPR001839. TGF-b_C.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR15009. PTHR15009. 1 hit.
PfamiPF04709. AMH_N. 1 hit.
PF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037270. Muellerian-inhibiting_factor. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPSLSLAL VLSAMGALLR PGTPREEVFS TSALPREQAT GSGALIFQQA
60 70 80 90 100
WDWPLSSLWL PGSPLDPLCL VTLHGSGNGS RAPLRVVGVL SSYEQAFLEA
110 120 130 140 150
VRRTHWGLSD LTTFAVCPAG NGQPVLPHLQ RLQAWLGEPG GRWLVVLHLE
160 170 180 190 200
EVTWEPTPLL RFQEPPPGGA SPPELALLVV YPGPGLEVTV TGAGLPGTQS
210 220 230 240 250
LCLTADSDFL ALVVDHPEGA WRRPGLALTL RRRGNGALLS TAQLQALLFG
260 270 280 290 300
ADSRCFTRKT PALLLLLPAR SSAPMPAHGR LDLVPFPQPR ASPEPEEAPP
310 320 330 340 350
SADPFLETLT RLVRALAGPP ARASPPRLAL DPGALAGFPQ GQVNLSDPAA
360 370 380 390 400
LERLLDGEEP LLLLLPPTAA TTGVPATPQG PKSPLWAAGL ARRVAAELQA
410 420 430 440 450
VAAELRALPG LPPAAPPLLA RLLALCPGNP DSPGGPLRAL LLLKALQGLR
460 470 480 490 500
AEWRGRERSG SARAQRSAGA AAADGPCALR ELSVDLRAER SVLIPETYQA
510 520 530 540 550
NNCQGACGWP QSDRNPRYGN HVVLLLKMQA RGATLARPPC CVPTAYTGKL
560 570
LISLSEERIS AHHVPNMVAT ECGCR
Length:575
Mass (Da):60,624
Last modified:October 23, 1986 - v1
Checksum:i892B89C11AC8B5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13151 Genomic DNA. Translation: AAA98765.1.
PIRiA01398. WFBOM.
RefSeqiNP_776315.1. NM_173890.1.
UniGeneiBt.7050.

Genome annotation databases

GeneIDi280718.
KEGGibta:280718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13151 Genomic DNA. Translation: AAA98765.1.
PIRiA01398. WFBOM.
RefSeqiNP_776315.1. NM_173890.1.
UniGeneiBt.7050.

3D structure databases

ProteinModelPortaliP03972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019912.

Proteomic databases

PaxDbiP03972.
PRIDEiP03972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280718.
KEGGibta:280718.

Organism-specific databases

CTDi268.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113593.
HOVERGENiHBG006358.
InParanoidiP03972.
KOiK04665.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006799. AMH_N.
IPR029034. Cystine-knot_cytokine.
IPR021203. Muellerian-inhibiting_factor.
IPR001839. TGF-b_C.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR15009. PTHR15009. 1 hit.
PfamiPF04709. AMH_N. 1 hit.
PF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037270. Muellerian-inhibiting_factor. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiMIS_BOVIN
AccessioniPrimary (citable) accession number: P03972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.