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Protein

Ras-like protein rasD

Gene

rasD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi116 – 1194GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: dictyBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • activation of MAPK activity Source: dictyBase
  • chemotaxis Source: dictyBase
  • mitotic cytokinesis Source: dictyBase
  • multicellular organism development Source: dictyBase
  • phototaxis Source: dictyBase
  • Ras protein signal transduction Source: dictyBase
  • thermotaxis Source: dictyBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-171007. p38MAPK events.
R-DDI-5218921. VEGFR2 mediated cell proliferation.
R-DDI-5621575. CD209 (DC-SIGN) signaling.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-5673001. RAF/MAP kinase cascade.
R-DDI-5674135. MAP2K and MAPK activation.
R-DDI-5675221. Negative regulation of MAPK pathway.
R-DDI-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein rasD
Alternative name(s):
Transforming protein p23 homolog
Gene namesi
Name:rasD
Synonyms:ras, rasA
ORF Names:DDB_G0292996
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292996. rasD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Ras-like protein rasDPRO_0000082662Add
BLAST
Propeptidei185 – 1873Removed in mature formBy similarityPRO_0000281310

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841Cysteine methyl esterBy similarity
Lipidationi184 – 1841S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP03967.

Expressioni

Developmental stagei

Expressed at a low level in vegetative cells; not expressed between the onset of development and aggregation, and is then re-expressed in the multicellular aggregate stages.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0216195.

Structurei

3D structure databases

ProteinModelPortaliP03967.
SMRiP03967. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
InParanoidiP03967.
OMAiRSSYDEI.
PhylomeDBiP03967.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVIVG GGGVGKSALT IQLIQNHFID EYDPTIEDSY RKQVSIDDET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGQGFLC VYSITSRSSY DEIASFREQI
110 120 130 140 150
LRVKDKDRVP LILVGNKADL DHERQVSVNE GQELAKGFNC PFMESSAKSR
160 170 180
INVEEAFYSL VREIRKELKG DQSSGKAQKK KKQCLIL
Length:187
Mass (Da):21,202
Last modified:February 1, 1995 - v2
Checksum:i7F526253B8316678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11804 Genomic DNA. Translation: CAA77848.1.
AAFI02000199 Genomic DNA. Translation: EAL60850.1.
PIRiA01371. TVDORS.
RefSeqiXP_629338.1. XM_629336.1.

Genome annotation databases

EnsemblProtistsiDDB0216195; DDB0216195; DDB_G0292996.
GeneIDi8629062.
KEGGiddi:DDB_G0292996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11804 Genomic DNA. Translation: CAA77848.1.
AAFI02000199 Genomic DNA. Translation: EAL60850.1.
PIRiA01371. TVDORS.
RefSeqiXP_629338.1. XM_629336.1.

3D structure databases

ProteinModelPortaliP03967.
SMRiP03967. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216195.

Proteomic databases

PaxDbiP03967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0216195; DDB0216195; DDB_G0292996.
GeneIDi8629062.
KEGGiddi:DDB_G0292996.

Organism-specific databases

dictyBaseiDDB_G0292996. rasD.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
InParanoidiP03967.
OMAiRSSYDEI.
PhylomeDBiP03967.

Enzyme and pathway databases

ReactomeiR-DDI-171007. p38MAPK events.
R-DDI-5218921. VEGFR2 mediated cell proliferation.
R-DDI-5621575. CD209 (DC-SIGN) signaling.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-5673001. RAF/MAP kinase cascade.
R-DDI-5674135. MAP2K and MAPK activation.
R-DDI-5675221. Negative regulation of MAPK pathway.
R-DDI-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Miscellaneous databases

PROiP03967.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASD_DICDI
AccessioniPrimary (citable) accession number: P03967
Secondary accession number(s): Q54C81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.