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P03966

- MYCN_MOUSE

UniProt

P03966 - MYCN_MOUSE

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Protein
N-myc proto-oncogene protein
Gene
Mycn, Nmyc, Nmyc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. branching morphogenesis of an epithelial tube Source: MGI
  2. cartilage condensation Source: MGI
  3. embryonic digit morphogenesis Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. lung development Source: MGI
  6. negative regulation of astrocyte differentiation Source: MGI
  7. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  8. positive regulation of cell death Source: MGI
  9. positive regulation of cell proliferation Source: MGI
  10. positive regulation of mesenchymal cell proliferation Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  12. positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc proto-oncogene protein
Gene namesi
Name:Mycn
Synonyms:Nmyc, Nmyc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:97357. Mycn.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462N-myc proto-oncogene protein
PRO_0000127325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei259 – 2591Phosphoserine; by CK2 By similarity
Modified residuei261 – 2611Phosphoserine; by CK2 By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP03966.

PTM databases

PhosphoSiteiP03966.

Expressioni

Developmental stagei

Expressed in the proliferating cells of the developing CNS and the epidermis. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the proliferating cells of the ventricular zone of the neural tube and is expressed at reduced levels in the intermediate zone. At 14.5 dpc, found in regions containing differentiating post-mitotic neurons. In the developing epidermis at 17 dpc, expression is restricted to primary hair germ cells only.1 Publication

Gene expression databases

ArrayExpressiP03966.
BgeeiP03966.
GenevestigatoriP03966.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1 By similarity.

Protein-protein interaction databases

BioGridi201795. 5 interactions.
IntActiP03966. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP03966.
SMRiP03966. Positions 380-458.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini379 – 43153bHLH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni431 – 45222Leucine-zipper
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 27617Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG83719.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP03966.
KOiK09109.
OMAiGMICKNP.
OrthoDBiEOG7GJ6CX.
PhylomeDBiP03966.
TreeFamiTF106001.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03966-1 [UniParc]FASTAAdd to Basket

« Hide

MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW    50
KKFELLPTPP LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL 100
GGLGGLTPNP VILQDCMWSG FSAREKLERA VNEKLQHGHG PPGVSSACSA 150
PGVGASSPGG RALGGSSSAS HTGATLPTDL SHPAAECVDP AVVFPFPVNK 200
RESASVPAAP TSAPATSAAV TSVSVPATAP VAAPARAGGR PASSGEAKAL 250
STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR 300
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS 350
EASPRPLKSV VPAKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL 400
TLRDHVPELV KNEKAAKVVI LKKATEYVHA LQANEHQLLL EKEKLQARQQ 450
QLLKKIEHAR TC 462
Length:462
Mass (Da):49,572
Last modified:December 15, 1998 - v2
Checksum:iE7AFD3DCBCABF290
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292FY → LH in AAA39788. 1 Publication
Sequence conflicti36 – 361Y → H in AAA39788. 1 Publication
Sequence conflicti246 – 2472EA → GT in AAA39788. 1 Publication
Sequence conflicti313 – 3131P → L in AAA39788. 1 Publication
Sequence conflicti390 – 3901Q → E in CAA27557. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12731 Genomic DNA. Translation: AAA39788.1.
X03919 Genomic DNA. Translation: CAA27557.1.
M36277 mRNA. Translation: AAA39833.1.
M29208 Genomic DNA. Translation: AAA39830.1.
X06993 Genomic DNA. No translation available.
CCDSiCCDS25818.1.
PIRiA01356. TVMSMC.
A01357. TVMSM2.
RefSeqiNP_032735.3. NM_008709.3.
UniGeneiMm.16469.

Genome annotation databases

EnsembliENSMUST00000043396; ENSMUSP00000045993; ENSMUSG00000037169.
ENSMUST00000130990; ENSMUSP00000114225; ENSMUSG00000037169.
GeneIDi18109.
KEGGimmu:18109.
UCSCiuc007nbf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12731 Genomic DNA. Translation: AAA39788.1 .
X03919 Genomic DNA. Translation: CAA27557.1 .
M36277 mRNA. Translation: AAA39833.1 .
M29208 Genomic DNA. Translation: AAA39830.1 .
X06993 Genomic DNA. No translation available.
CCDSi CCDS25818.1.
PIRi A01356. TVMSMC.
A01357. TVMSM2.
RefSeqi NP_032735.3. NM_008709.3.
UniGenei Mm.16469.

3D structure databases

ProteinModelPortali P03966.
SMRi P03966. Positions 380-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201795. 5 interactions.
IntActi P03966. 2 interactions.

PTM databases

PhosphoSitei P03966.

Proteomic databases

PRIDEi P03966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043396 ; ENSMUSP00000045993 ; ENSMUSG00000037169 .
ENSMUST00000130990 ; ENSMUSP00000114225 ; ENSMUSG00000037169 .
GeneIDi 18109.
KEGGi mmu:18109.
UCSCi uc007nbf.1. mouse.

Organism-specific databases

CTDi 4613.
MGIi MGI:97357. Mycn.

Phylogenomic databases

eggNOGi NOG83719.
HOGENOMi HOG000043075.
HOVERGENi HBG000472.
InParanoidi P03966.
KOi K09109.
OMAi GMICKNP.
OrthoDBi EOG7GJ6CX.
PhylomeDBi P03966.
TreeFami TF106001.

Miscellaneous databases

NextBioi 293301.
PROi P03966.
SOURCEi Search...

Gene expression databases

ArrayExpressi P03966.
Bgeei P03966.
Genevestigatori P03966.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001705. Myc_protein. 1 hit.
PRINTSi PR00044. LEUZIPPRMYC.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the coding region of the mouse N-myc gene."
    Taya Y., Mizusawa S., Nishimura S.
    EMBO J. 5:1215-1219(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Expression of murine N-myc by insertion of retrovirus sequences in murine macrophage cell lines."
    Nasu N., Setoguchi M., Yoshiyama K., Matsuura K., Yamamoto S.
    Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-456.
    Strain: BALB/c.
  4. "Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids."
    Setoguchi M., Higuchi Y., Yoshida S., Nasu N., Miyazaki Y., Akizuki S., Yamamoto S.
    Mol. Cell. Biol. 9:4515-4522(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 327-462.
  5. "Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene."
    Katoh K., Sawai S., Ueno K., Kondoh H.
    Nucleic Acids Res. 16:3589-3589(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
  6. "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation."
    Hurlin P.J., Queva C., Koskinen P.J., Steingrimsson E., Ayer D.E., Copeland N.G., Jenkins N.A., Eisenman R.N.
    EMBO J. 14:5646-5659(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMYCN_MOUSE
AccessioniPrimary (citable) accession number: P03966
Secondary accession number(s): Q61978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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