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Reviewed, UniProtKB/Swiss-Prot P03964 (TRPC_BACSU)

Last modified November 3, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48
Gene names
Name: trpC
Ordered Locus Names: BSU22660
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134

Sequence similarities

Belongs to the trpC family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Indole-3-glycerol phosphate synthase HAMAP MF_00134
PRO_0000154213

Experimental info

Sequence conflict41K → N in AAA22867. Ref.1
Sequence conflict41K → N Ref.5
Sequence conflict201V → E in AAA22867. Ref.1
Sequence conflict201V → E Ref.5
Sequence conflict361P → L in AAA22867. Ref.1
Sequence conflict361P → L Ref.5
Sequence conflict591D → N in AAA22867. Ref.1
Sequence conflict591D → N Ref.5
Sequence conflict641Q → R in AAA22867. Ref.1
Sequence conflict641Q → R Ref.5
Sequence conflict711A → T in AAA22867. Ref.1
Sequence conflict711A → T Ref.5
Sequence conflict74 – 785ADAIS → RMRFP Ref.5
Sequence conflict741A → P in AAA22867. Ref.1
Sequence conflict771I → L in AAA22867. Ref.1
Sequence conflict1101I → II in AAA22867. Ref.1
Sequence conflict1101I → II Ref.5
Sequence conflict1491G → E in AAA22867. Ref.1
Sequence conflict1491G → E Ref.5
Sequence conflict1601S → T in AAA22867. Ref.1
Sequence conflict1601S → T Ref.5
Sequence conflict1761V → I in AAA22867. Ref.1
Sequence conflict1761V → I Ref.5
Sequence conflict1981V → A in AAA22867. Ref.1
Sequence conflict1981V → A Ref.5
Sequence conflict2201N → K in AAA22867. Ref.1
Sequence conflict2201N → K Ref.5
Sequence conflict2401R → Q in AAA22867. Ref.1
Sequence conflict2401R → Q Ref.5
Sequence conflict2481R → G in AAA22867. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P03964-1 [UniParc].

Last modified July 28, 2009. Version 3.
Checksum: B9F9FC8EB1C62F7B

FASTA24927,741
        10         20         30         40         50         60 
MLEKIIKQKK EEVKTLVLPV EQPFEKRSFK EALASPNRFI GLIAEVKKAS PSKGLIKEDF 

        70         80         90        100        110        120 
VPVQIAKDYE AAKADAISVL TDTPFFQGEN SYLSDVKRAV SIPVLRKDFI DSLQVEESRR 

       130        140        150        160        170        180 
IGADAILLIG EVLDPLHLHE LYLEAGEKGM DVLVEVHDAS TLEQILKVFT PDILGVNNRN 

       190        200        210        220        230        240 
LKTFETSVKQ TEQIASLVPK ESLLVSESGI GSLEHLTFVN EHGARAVLIG ESLMRQTSQR 


KAIHALFRE

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Bacillus subtilis tryptophan operon."
Henner D.J., Band L., Shimotsu H.
Gene 34:169-177(1985) [PubMed: 3924737] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence."
Medigue C., Rose M., Viari A., Danchin A.
Genome Res. 9:1116-1127(1999) [PubMed: 10568751] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract]
Cited for: SEQUENCE REVISION TO 33 AND 110.
[5]"Nucleotide sequence of the Bacillus subtilis trpE and trpD genes."
Band L., Shimotsu H., Henner D.J.
Gene 27:55-65(1984) [PubMed: 6425119] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-245.

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Cross-references

Sequence databases

K01391 Genomic DNA. Translation: AAA22867.1.
AL009126 Genomic DNA. Translation: CAB14182.3.
PIRGWBS. A01134.
RefSeqNP_390147.3.

3D structure databases

HSSPHSSP built from PDB template 1J5T based on UniProtKB Q56319.
ModBaseSearch...

Genome annotation databases

GeneID939004.
GenomeReviewsGene locus BSU22660 in contig AL009126_GR.
KEGGbsu:BSU22660.

Organism-specific databases

SubtiListBG11038. trpC. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP03964.
OMAPLLCKDF.

Enzyme and pathway databases

BioCycBSUB224308:BSU2265-MON.
BRENDA4.1.1.48. 150.

Family and domain databases

HAMAPMF_00134.
[Tree]
InterProIPR001468. Indole-3-GPS_central.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00218. IGPS. 1 hit.
[Graphical view]
ProDomPD001511. IGPS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTRPC_BACSU
AccessionPrimary (citable) accession number: P03964
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: July 28, 2009
Last modified: November 3, 2009
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents