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P03952 (KLKB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 164. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma kallikrein

EC=3.4.21.34
Alternative name(s):
Fletcher factor
Kininogenin
Plasma prekallikrein
Gene names
Name:KLKB1
Synonyms:KLK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Catalytic activity

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

Enzyme regulation

Inhibited by SERPINA5. Ref.9

Subunit structure

Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

Subcellular location

Secreted.

Involvement in disease

Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Contains 4 apple domains.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processBlood coagulation
Fibrinolysis
Hemostasis
Inflammatory response
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainRepeat
Signal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processFactor XII activation

Traceable author statement PubMed 2510163. Source: BHF-UCL

blood coagulation

Traceable author statement. Source: Reactome

blood coagulation, intrinsic pathway

Traceable author statement. Source: Reactome

extracellular matrix disassembly

Traceable author statement. Source: Reactome

extracellular matrix organization

Traceable author statement. Source: Reactome

fibrinolysis

Inferred from electronic annotation. Source: UniProtKB-KW

plasminogen activation

Inferred from direct assay PubMed 89876. Source: BHF-UCL

positive regulation of fibrinolysis

Inferred from direct assay PubMed 89876. Source: BHF-UCL

proteolysis

Traceable author statement PubMed 1993180. Source: ProtInc

zymogen activation

Traceable author statement PubMed 2510163. Source: BHF-UCL

   Cellular_componentextracellular region

Non-traceable author statement PubMed 14718574. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 89876. Source: BHF-UCL

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionserine-type endopeptidase activity

Traceable author statement PubMed 1993180. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 390371Plasma kallikrein heavy chain
PRO_0000028021
Chain391 – 638248Plasma kallikrein light chain
PRO_0000028022

Regions

Domain21 – 10484Apple 1
Domain111 – 19484Apple 2
Domain201 – 28484Apple 3
Domain292 – 37584Apple 4
Domain391 – 626236Peptidase S1

Sites

Active site4341Charge relay system
Active site4831Charge relay system
Active site5781Charge relay system

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Ref.1 Ref.11
Glycosylation3081N-linked (GlcNAc...) Ref.1 Ref.11 Ref.12
Glycosylation3961N-linked (GlcNAc...) Ref.1 Ref.11 Ref.12
Glycosylation4531N-linked (GlcNAc...) Ref.1 Ref.10 Ref.11 Ref.12
Glycosylation4941N-linked (GlcNAc...) Ref.1 Ref.11 Ref.12
Disulfide bond21 ↔ 104 Ref.8
Disulfide bond47 ↔ 77 Ref.8
Disulfide bond51 ↔ 57 Ref.8
Disulfide bond111 ↔ 194 Ref.8
Disulfide bond137 ↔ 166 Ref.8
Disulfide bond141 ↔ 147 Ref.8
Disulfide bond201 ↔ 284 Ref.8
Disulfide bond227 ↔ 256 Ref.8
Disulfide bond231 ↔ 237 Ref.8
Disulfide bond292 ↔ 375 Ref.8
Disulfide bond318 ↔ 347 Ref.8
Disulfide bond322 ↔ 328 Ref.8
Disulfide bond340 ↔ 345 Ref.8
Disulfide bond383 ↔ 503 Ref.8
Disulfide bond419 ↔ 435 Ref.8
Disulfide bond517 ↔ 584 Ref.8
Disulfide bond548 ↔ 563 Ref.8
Disulfide bond574 ↔ 602 Ref.8

Natural variations

Natural variant1231G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. Ref.14
VAR_054907
Natural variant1431N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. Ref.2 Ref.4 Ref.14
Corresponds to variant rs3733402 [ dbSNP | Ensembl ].
VAR_013598
Natural variant1781A → T. Ref.4
Corresponds to variant rs4253257 [ dbSNP | Ensembl ].
VAR_016280
Natural variant2021H → Q. Ref.2 Ref.4
Corresponds to variant rs4253373 [ dbSNP | Ensembl ].
VAR_013599
Natural variant2081H → P. Ref.2
VAR_013600
Natural variant2101A → E.
Corresponds to variant rs2278542 [ dbSNP | Ensembl ].
VAR_020180
Natural variant2691S → C. Ref.4
Corresponds to variant rs4253376 [ dbSNP | Ensembl ].
VAR_016281
Natural variant3111F → V. Ref.4
Corresponds to variant rs4253377 [ dbSNP | Ensembl ].
VAR_016282
Natural variant3581T → A. Ref.4
Corresponds to variant rs4253379 [ dbSNP | Ensembl ].
VAR_016283
Natural variant3811S → A. Ref.4
Corresponds to variant rs4253301 [ dbSNP | Ensembl ].
VAR_016284
Natural variant4421Q → P. Ref.4
Corresponds to variant rs4253316 [ dbSNP | Ensembl ].
VAR_016285
Natural variant5481C → Y in PKK deficiency. Ref.13
VAR_054908
Natural variant5601R → Q. Ref.4 Ref.7
Corresponds to variant rs4253325 [ dbSNP | Ensembl ].
VAR_016286

Secondary structure

........................................ 638
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03952 [UniParc].

Last modified October 23, 1986. Version 1.
Checksum: E62F9C1053838FB4

FASTA63871,370
        10         20         30         40         50         60 
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF 

        70         80         90        100        110        120 
SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD 

       130        140        150        160        170        180 
MRGVNFNVSK VSSVEECQKR CTNNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK 

       190        200        210        220        230        240 
VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF 

       250        260        270        280        290        300 
TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 

       310        320        330        340        350        360 
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI 

       370        380        390        400        410        420 
AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG 

       430        440        450        460        470        480 
GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG 

       490        500        510        520        530        540 
NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI 

       550        560        570        580        590        600 
PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 

       610        620        630 
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA 

« Hide

References

« Hide 'large scale' references
[1]"Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats."
Chung D.W., Fujikawa K., McMullen B.A., Davie E.W.
Biochemistry 25:2410-2417(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease."
Yu H., Anderson P.J., Freedman B.I., Rich S.S., Bowden D.W.
Genomics 69:225-234(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; GLN-202 AND PRO-208.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]SeattleSNPs variation discovery resource
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; THR-178; GLN-202; CYS-269; VAL-311; ALA-358; ALA-381; PRO-442 AND GLN-560.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-560.
Tissue: Colon.
[8]"Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule."
McMullen B.A., Fujikawa K., Davie E.W.
Biochemistry 30:2050-2056(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
[9]"Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
Meijers J.C., Kanters D.H., Vlooswijk R.A., van Erp H.E., Hessing M., Bouma B.N.
Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION, HETERODIMER WITH SERPINA5.
[10]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-453.
[11]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127; ASN-308; ASN-396; ASN-453 AND ASN-494.
Tissue: Plasma.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-308; ASN-396; ASN-453 AND ASN-494.
Tissue: Liver.
[13]"Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)."
Lombardi A.M., Sartori M.T., Cabrio L., Fadin M., Zanon E., Girolami A.
Thromb. Haemost. 90:1040-1045(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PKK DEFICIENCY TYR-548.
[14]"A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region."
Katsuda I., Maruyama F., Ezaki K., Sawamura T., Ichihara Y.
Eur. J. Haematol. 79:59-68(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PKK DEFICIENCY ARG-123 AND SER-143.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13143 mRNA. Translation: AAA60153.1.
AF232742 expand/collapse EMBL AC list , AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741 Genomic DNA. Translation: AAF79940.1.
AK313378 mRNA. Translation: BAG36176.1.
AY190920 Genomic DNA. Translation: AAN84794.1.
AC110771 Genomic DNA. Translation: AAY40900.1.
CH471056 Genomic DNA. Translation: EAX04623.1.
BC117349 mRNA. Translation: AAI17350.1.
BC117351 mRNA. Translation: AAI17352.1.
PIRKQHUP. A00921.
RefSeqNP_000883.2. NM_000892.3.
UniGeneHs.237642.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ANWX-ray1.85A391-631[»]
2ANYX-ray1.40A391-631[»]
ProteinModelPortalP03952.
SMRP03952. Positions 21-628.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110018. 2 interactions.
STRING9606.ENSP00000264690.

Chemistry

BindingDBP03952.
ChEMBLCHEMBL2111419.

Protein family/group databases

MEROPSS01.212.

PTM databases

PhosphoSiteP03952.

Polymorphism databases

DMDM125184.

Proteomic databases

PaxDbP03952.
PRIDEP03952.

Protocols and materials databases

DNASU3818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264690; ENSP00000264690; ENSG00000164344.
GeneID3818.
KEGGhsa:3818.
UCSCuc011clc.2. human.

Organism-specific databases

CTD3818.
GeneCardsGC04P187130.
HGNCHGNC:6371. KLKB1.
HPAHPA005634.
MIM229000. gene.
612423. phenotype.
neXtProtNX_P03952.
Orphanet749. Congenital prekallikrein deficiency.
PharmGKBPA30160.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000112467.
HOVERGENHBG000399.
InParanoidP03952.
KOK01324.
PhylomeDBP03952.
TreeFamTF343687.

Enzyme and pathway databases

BRENDA3.4.21.34. 2681.
ReactomeREACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP03952.
BgeeP03952.
CleanExHS_KLK3.
HS_KLKB1.
GenevestigatorP03952.

Family and domain databases

InterProIPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS00495. APPLE. 4 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP03952.
GeneWikiKLKB1.
GenomeRNAi3818.
NextBio15011.
PMAP-CutDBQ4W5C3.
PROP03952.
SOURCESearch...

Entry information

Entry nameKLKB1_HUMAN
AccessionPrimary (citable) accession number: P03952
Secondary accession number(s): A6NH96 expand/collapse secondary AC list , B2R8H9, Q17RE8, Q17RE9, Q4W5C3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: April 16, 2014
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM