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P03952

- KLKB1_HUMAN

UniProt

P03952 - KLKB1_HUMAN

Protein

Plasma kallikrein

Gene

KLKB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 168 (01 Oct 2014)
      Sequence version 1 (23 Oct 1986)
      Previous versions | rss
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    Functioni

    The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

    Catalytic activityi

    Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

    Enzyme regulationi

    Inhibited by SERPINA5.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei434 – 4341Charge relay system
    Active sitei483 – 4831Charge relay system
    Active sitei578 – 5781Charge relay system

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. serine-type endopeptidase activity Source: ProtInc

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. blood coagulation, intrinsic pathway Source: Reactome
    3. extracellular matrix disassembly Source: Reactome
    4. extracellular matrix organization Source: Reactome
    5. Factor XII activation Source: BHF-UCL
    6. fibrinolysis Source: UniProtKB-KW
    7. plasminogen activation Source: BHF-UCL
    8. positive regulation of fibrinolysis Source: BHF-UCL
    9. proteolysis Source: ProtInc
    10. zymogen activation Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Blood coagulation, Fibrinolysis, Hemostasis, Inflammatory response

    Enzyme and pathway databases

    BRENDAi3.4.21.34. 2681.
    ReactomeiREACT_118682. Activation of Matrix Metalloproteinases.
    REACT_326. Intrinsic Pathway.

    Protein family/group databases

    MEROPSiS01.212.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma kallikrein (EC:3.4.21.34)
    Alternative name(s):
    Fletcher factor
    Kininogenin
    Plasma prekallikrein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:KLKB1
    Synonyms:KLK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:6371. KLKB1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: BHF-UCL
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 Publication
    VAR_054907
    Natural varianti143 – 1431N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 Publications
    Corresponds to variant rs3733402 [ dbSNP | Ensembl ].
    VAR_013598
    Natural varianti548 – 5481C → Y in PKK deficiency. 1 Publication
    VAR_054908

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi612423. phenotype.
    Orphaneti749. Congenital prekallikrein deficiency.
    PharmGKBiPA30160.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 390371Plasma kallikrein heavy chainPRO_0000028021Add
    BLAST
    Chaini391 – 638248Plasma kallikrein light chainPRO_0000028022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi21 ↔ 1041 Publication
    Disulfide bondi47 ↔ 771 Publication
    Disulfide bondi51 ↔ 571 Publication
    Disulfide bondi111 ↔ 1941 Publication
    Glycosylationi127 – 1271N-linked (GlcNAc...)2 Publications
    Disulfide bondi137 ↔ 1661 Publication
    Disulfide bondi141 ↔ 1471 Publication
    Disulfide bondi201 ↔ 2841 Publication
    Disulfide bondi227 ↔ 2561 Publication
    Disulfide bondi231 ↔ 2371 Publication
    Disulfide bondi292 ↔ 3751 Publication
    Glycosylationi308 – 3081N-linked (GlcNAc...)3 Publications
    Disulfide bondi318 ↔ 3471 Publication
    Disulfide bondi322 ↔ 3281 Publication
    Disulfide bondi340 ↔ 3451 Publication
    Disulfide bondi383 ↔ 5031 Publication
    Glycosylationi396 – 3961N-linked (GlcNAc...)3 Publications
    Disulfide bondi419 ↔ 4351 Publication
    Glycosylationi453 – 4531N-linked (GlcNAc...)4 Publications
    Glycosylationi494 – 4941N-linked (GlcNAc...)3 Publications
    Disulfide bondi517 ↔ 5841 Publication
    Disulfide bondi548 ↔ 5631 Publication
    Disulfide bondi574 ↔ 6021 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP03952.
    PRIDEiP03952.

    PTM databases

    PhosphoSiteiP03952.

    Miscellaneous databases

    PMAP-CutDBQ4W5C3.

    Expressioni

    Gene expression databases

    ArrayExpressiP03952.
    BgeeiP03952.
    CleanExiHS_KLK3.
    HS_KLKB1.
    GenevestigatoriP03952.

    Organism-specific databases

    HPAiHPA005634.

    Interactioni

    Subunit structurei

    Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

    Protein-protein interaction databases

    BioGridi110018. 2 interactions.
    STRINGi9606.ENSP00000264690.

    Structurei

    Secondary structure

    1
    638
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi405 – 42521
    Beta strandi428 – 4314
    Helixi433 – 4364
    Helixi442 – 4443
    Beta strandi445 – 4484
    Helixi454 – 4563
    Beta strandi466 – 4716
    Beta strandi479 – 4824
    Beta strandi485 – 4917
    Helixi507 – 5115
    Beta strandi515 – 5239
    Beta strandi525 – 5284
    Beta strandi536 – 5438
    Helixi545 – 5495
    Beta strandi561 – 5644
    Beta strandi581 – 5866
    Beta strandi589 – 59810
    Beta strandi600 – 6034
    Beta strandi609 – 6135
    Helixi614 – 6174
    Helixi618 – 6258

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ANWX-ray1.85A391-631[»]
    2ANYX-ray1.40A391-631[»]
    ProteinModelPortaliP03952.
    SMRiP03952. Positions 21-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP03952.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 10484Apple 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 19484Apple 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini201 – 28484Apple 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini292 – 37584Apple 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini391 – 626236Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
    Contains 4 apple domains.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000112467.
    HOVERGENiHBG000399.
    InParanoidiP03952.
    KOiK01324.
    PhylomeDBiP03952.
    TreeFamiTF343687.

    Family and domain databases

    InterProiIPR000177. Apple.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00024. PAN_1. 4 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00005. APPLEDOMAIN.
    PR00722. CHYMOTRYPSIN.
    SMARTiSM00223. APPLE. 4 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS00495. APPLE. 4 hits.
    PS50948. PAN. 4 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P03952-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR    50
    CTFHPRCLLF SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS 100
    LKQCGHQISA CHRDIYKGVD MRGVNFNVSK VSSVEECQKR CTNNIRCQFF 150
    SYATQTFHKA EYRNNCLLKY SPGGTPTAIK VLSNVESGFS LKPCALSEIG 200
    CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF TFYTNVWKIE 250
    SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 300
    DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR 350
    LSMDGSPTRI AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG 400
    EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG 450
    ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK 500
    PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI PLVTNEECQK 550
    RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 600
    GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA 638
    Length:638
    Mass (Da):71,370
    Last modified:October 23, 1986 - v1
    Checksum:iE62F9C1053838FB4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 Publication
    VAR_054907
    Natural varianti143 – 1431N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 Publications
    Corresponds to variant rs3733402 [ dbSNP | Ensembl ].
    VAR_013598
    Natural varianti178 – 1781A → T.1 Publication
    Corresponds to variant rs4253257 [ dbSNP | Ensembl ].
    VAR_016280
    Natural varianti202 – 2021H → Q.2 Publications
    Corresponds to variant rs4253373 [ dbSNP | Ensembl ].
    VAR_013599
    Natural varianti208 – 2081H → P.1 Publication
    VAR_013600
    Natural varianti210 – 2101A → E.
    Corresponds to variant rs2278542 [ dbSNP | Ensembl ].
    VAR_020180
    Natural varianti269 – 2691S → C.1 Publication
    Corresponds to variant rs4253376 [ dbSNP | Ensembl ].
    VAR_016281
    Natural varianti311 – 3111F → V.1 Publication
    Corresponds to variant rs4253377 [ dbSNP | Ensembl ].
    VAR_016282
    Natural varianti358 – 3581T → A.1 Publication
    Corresponds to variant rs4253379 [ dbSNP | Ensembl ].
    VAR_016283
    Natural varianti381 – 3811S → A.1 Publication
    Corresponds to variant rs4253301 [ dbSNP | Ensembl ].
    VAR_016284
    Natural varianti442 – 4421Q → P.1 Publication
    Corresponds to variant rs4253316 [ dbSNP | Ensembl ].
    VAR_016285
    Natural varianti548 – 5481C → Y in PKK deficiency. 1 Publication
    VAR_054908
    Natural varianti560 – 5601R → Q.2 Publications
    Corresponds to variant rs4253325 [ dbSNP | Ensembl ].
    VAR_016286

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13143 mRNA. Translation: AAA60153.1.
    AF232742
    , AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741 Genomic DNA. Translation: AAF79940.1.
    AK313378 mRNA. Translation: BAG36176.1.
    AY190920 Genomic DNA. Translation: AAN84794.1.
    AC110771 Genomic DNA. Translation: AAY40900.1.
    CH471056 Genomic DNA. Translation: EAX04623.1.
    BC117349 mRNA. Translation: AAI17350.1.
    BC117351 mRNA. Translation: AAI17352.1.
    CCDSiCCDS34120.1.
    PIRiA00921. KQHUP.
    RefSeqiNP_000883.2. NM_000892.3.
    UniGeneiHs.237642.

    Genome annotation databases

    EnsembliENST00000264690; ENSP00000264690; ENSG00000164344.
    GeneIDi3818.
    KEGGihsa:3818.
    UCSCiuc011clc.2. human.

    Polymorphism databases

    DMDMi125184.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13143 mRNA. Translation: AAA60153.1 .
    AF232742
    , AF232734 , AF232735 , AF232736 , AF232737 , AF232738 , AF232739 , AF232740 , AF232741 Genomic DNA. Translation: AAF79940.1 .
    AK313378 mRNA. Translation: BAG36176.1 .
    AY190920 Genomic DNA. Translation: AAN84794.1 .
    AC110771 Genomic DNA. Translation: AAY40900.1 .
    CH471056 Genomic DNA. Translation: EAX04623.1 .
    BC117349 mRNA. Translation: AAI17350.1 .
    BC117351 mRNA. Translation: AAI17352.1 .
    CCDSi CCDS34120.1.
    PIRi A00921. KQHUP.
    RefSeqi NP_000883.2. NM_000892.3.
    UniGenei Hs.237642.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ANW X-ray 1.85 A 391-631 [» ]
    2ANY X-ray 1.40 A 391-631 [» ]
    ProteinModelPortali P03952.
    SMRi P03952. Positions 21-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110018. 2 interactions.
    STRINGi 9606.ENSP00000264690.

    Chemistry

    BindingDBi P03952.
    ChEMBLi CHEMBL2000.

    Protein family/group databases

    MEROPSi S01.212.

    PTM databases

    PhosphoSitei P03952.

    Polymorphism databases

    DMDMi 125184.

    Proteomic databases

    PaxDbi P03952.
    PRIDEi P03952.

    Protocols and materials databases

    DNASUi 3818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264690 ; ENSP00000264690 ; ENSG00000164344 .
    GeneIDi 3818.
    KEGGi hsa:3818.
    UCSCi uc011clc.2. human.

    Organism-specific databases

    CTDi 3818.
    GeneCardsi GC04P187130.
    HGNCi HGNC:6371. KLKB1.
    HPAi HPA005634.
    MIMi 229000. gene.
    612423. phenotype.
    neXtProti NX_P03952.
    Orphaneti 749. Congenital prekallikrein deficiency.
    PharmGKBi PA30160.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000112467.
    HOVERGENi HBG000399.
    InParanoidi P03952.
    KOi K01324.
    PhylomeDBi P03952.
    TreeFami TF343687.

    Enzyme and pathway databases

    BRENDAi 3.4.21.34. 2681.
    Reactomei REACT_118682. Activation of Matrix Metalloproteinases.
    REACT_326. Intrinsic Pathway.

    Miscellaneous databases

    EvolutionaryTracei P03952.
    GeneWikii KLKB1.
    GenomeRNAii 3818.
    NextBioi 15011.
    PMAP-CutDB Q4W5C3.
    PROi P03952.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P03952.
    Bgeei P03952.
    CleanExi HS_KLK3.
    HS_KLKB1.
    Genevestigatori P03952.

    Family and domain databases

    InterProi IPR000177. Apple.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00024. PAN_1. 4 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00005. APPLEDOMAIN.
    PR00722. CHYMOTRYPSIN.
    SMARTi SM00223. APPLE. 4 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS00495. APPLE. 4 hits.
    PS50948. PAN. 4 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats."
      Chung D.W., Fujikawa K., McMullen B.A., Davie E.W.
      Biochemistry 25:2410-2417(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease."
      Yu H., Anderson P.J., Freedman B.I., Rich S.S., Bowden D.W.
      Genomics 69:225-234(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; GLN-202 AND PRO-208.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. SeattleSNPs variation discovery resource
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; THR-178; GLN-202; CYS-269; VAL-311; ALA-358; ALA-381; PRO-442 AND GLN-560.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-560.
      Tissue: Colon.
    8. "Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule."
      McMullen B.A., Fujikawa K., Davie E.W.
      Biochemistry 30:2050-2056(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
    9. "Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
      Meijers J.C., Kanters D.H., Vlooswijk R.A., van Erp H.E., Hessing M., Bouma B.N.
      Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, HETERODIMER WITH SERPINA5.
    10. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-453.
    11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127; ASN-308; ASN-396; ASN-453 AND ASN-494.
      Tissue: Plasma.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-308; ASN-396; ASN-453 AND ASN-494.
      Tissue: Liver.
    13. "Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)."
      Lombardi A.M., Sartori M.T., Cabrio L., Fadin M., Zanon E., Girolami A.
      Thromb. Haemost. 90:1040-1045(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PKK DEFICIENCY TYR-548.
    14. "A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region."
      Katsuda I., Maruyama F., Ezaki K., Sawamura T., Ichihara Y.
      Eur. J. Haematol. 79:59-68(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PKK DEFICIENCY ARG-123 AND SER-143.

    Entry informationi

    Entry nameiKLKB1_HUMAN
    AccessioniPrimary (citable) accession number: P03952
    Secondary accession number(s): A6NH96
    , B2R8H9, Q17RE8, Q17RE9, Q4W5C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 1986
    Last sequence update: October 23, 1986
    Last modified: October 1, 2014
    This is version 168 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3