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P03952

- KLKB1_HUMAN

UniProt

P03952 - KLKB1_HUMAN

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Protein

Plasma kallikrein

Gene

KLKB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Catalytic activityi

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

Enzyme regulationi

Inhibited by SERPINA5.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei434 – 4341Charge relay system
Active sitei483 – 4831Charge relay system
Active sitei578 – 5781Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. blood coagulation, intrinsic pathway Source: Reactome
  3. extracellular matrix disassembly Source: Reactome
  4. extracellular matrix organization Source: Reactome
  5. Factor XII activation Source: BHF-UCL
  6. fibrinolysis Source: UniProtKB-KW
  7. plasminogen activation Source: BHF-UCL
  8. positive regulation of fibrinolysis Source: BHF-UCL
  9. proteolysis Source: ProtInc
  10. zymogen activation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis, Inflammatory response

Enzyme and pathway databases

BRENDAi3.4.21.34. 2681.
ReactomeiREACT_118682. Activation of Matrix Metalloproteinases.
REACT_326. Intrinsic Pathway.

Protein family/group databases

MEROPSiS01.212.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma kallikrein (EC:3.4.21.34)
Alternative name(s):
Fletcher factor
Kininogenin
Plasma prekallikrein
Cleaved into the following 2 chains:
Gene namesi
Name:KLKB1
Synonyms:KLK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:6371. KLKB1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 Publication
VAR_054907
Natural varianti143 – 1431N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 Publications
Corresponds to variant rs3733402 [ dbSNP | Ensembl ].
VAR_013598
Natural varianti548 – 5481C → Y in PKK deficiency. 1 Publication
VAR_054908

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612423. phenotype.
Orphaneti749. Congenital prekallikrein deficiency.
PharmGKBiPA30160.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 390371Plasma kallikrein heavy chainPRO_0000028021Add
BLAST
Chaini391 – 638248Plasma kallikrein light chainPRO_0000028022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 1041 Publication
Disulfide bondi47 ↔ 771 Publication
Disulfide bondi51 ↔ 571 Publication
Disulfide bondi111 ↔ 1941 Publication
Glycosylationi127 – 1271N-linked (GlcNAc...)2 Publications
Disulfide bondi137 ↔ 1661 Publication
Disulfide bondi141 ↔ 1471 Publication
Disulfide bondi201 ↔ 2841 Publication
Disulfide bondi227 ↔ 2561 Publication
Disulfide bondi231 ↔ 2371 Publication
Disulfide bondi292 ↔ 3751 Publication
Glycosylationi308 – 3081N-linked (GlcNAc...)3 Publications
Disulfide bondi318 ↔ 3471 Publication
Disulfide bondi322 ↔ 3281 Publication
Disulfide bondi340 ↔ 3451 Publication
Disulfide bondi383 ↔ 5031 Publication
Glycosylationi396 – 3961N-linked (GlcNAc...)3 Publications
Disulfide bondi419 ↔ 4351 Publication
Glycosylationi453 – 4531N-linked (GlcNAc...)4 Publications
Glycosylationi494 – 4941N-linked (GlcNAc...)3 Publications
Disulfide bondi517 ↔ 5841 Publication
Disulfide bondi548 ↔ 5631 Publication
Disulfide bondi574 ↔ 6021 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP03952.
PRIDEiP03952.

PTM databases

PhosphoSiteiP03952.

Miscellaneous databases

PMAP-CutDBQ4W5C3.

Expressioni

Gene expression databases

BgeeiP03952.
CleanExiHS_KLK3.
HS_KLKB1.
ExpressionAtlasiP03952. baseline and differential.
GenevestigatoriP03952.

Organism-specific databases

HPAiHPA005634.

Interactioni

Subunit structurei

Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

Protein-protein interaction databases

BioGridi110018. 2 interactions.
STRINGi9606.ENSP00000264690.

Structurei

Secondary structure

1
638
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi405 – 42521
Beta strandi428 – 4314
Helixi433 – 4364
Helixi442 – 4443
Beta strandi445 – 4484
Helixi454 – 4563
Beta strandi466 – 4716
Beta strandi479 – 4824
Beta strandi485 – 4917
Helixi507 – 5115
Beta strandi515 – 5239
Beta strandi525 – 5284
Beta strandi536 – 5438
Helixi545 – 5495
Beta strandi561 – 5644
Beta strandi581 – 5866
Beta strandi589 – 59810
Beta strandi600 – 6034
Beta strandi609 – 6135
Helixi614 – 6174
Helixi618 – 6258

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ANWX-ray1.85A391-631[»]
2ANYX-ray1.40A391-631[»]
4OGXX-ray2.40A391-631[»]
4OGYX-ray2.10A/B391-631[»]
ProteinModelPortaliP03952.
SMRiP03952. Positions 21-628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03952.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10484Apple 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 19484Apple 2PROSITE-ProRule annotationAdd
BLAST
Domaini201 – 28484Apple 3PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 37584Apple 4PROSITE-ProRule annotationAdd
BLAST
Domaini391 – 626236Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
Contains 4 apple domains.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112467.
HOVERGENiHBG000399.
InParanoidiP03952.
KOiK01324.
PhylomeDBiP03952.
TreeFamiTF343687.

Family and domain databases

InterProiIPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTiSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00495. APPLE. 4 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03952-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR
60 70 80 90 100
CTFHPRCLLF SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS
110 120 130 140 150
LKQCGHQISA CHRDIYKGVD MRGVNFNVSK VSSVEECQKR CTNNIRCQFF
160 170 180 190 200
SYATQTFHKA EYRNNCLLKY SPGGTPTAIK VLSNVESGFS LKPCALSEIG
210 220 230 240 250
CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF TFYTNVWKIE
260 270 280 290 300
SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV
310 320 330 340 350
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR
360 370 380 390 400
LSMDGSPTRI AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG
410 420 430 440 450
EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG
460 470 480 490 500
ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK
510 520 530 540 550
PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI PLVTNEECQK
560 570 580 590 600
RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE
610 620 630
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA
Length:638
Mass (Da):71,370
Last modified:October 23, 1986 - v1
Checksum:iE62F9C1053838FB4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 Publication
VAR_054907
Natural varianti143 – 1431N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 Publications
Corresponds to variant rs3733402 [ dbSNP | Ensembl ].
VAR_013598
Natural varianti178 – 1781A → T.1 Publication
Corresponds to variant rs4253257 [ dbSNP | Ensembl ].
VAR_016280
Natural varianti202 – 2021H → Q.2 Publications
Corresponds to variant rs4253373 [ dbSNP | Ensembl ].
VAR_013599
Natural varianti208 – 2081H → P.1 Publication
VAR_013600
Natural varianti210 – 2101A → E.
Corresponds to variant rs2278542 [ dbSNP | Ensembl ].
VAR_020180
Natural varianti269 – 2691S → C.1 Publication
Corresponds to variant rs4253376 [ dbSNP | Ensembl ].
VAR_016281
Natural varianti311 – 3111F → V.1 Publication
Corresponds to variant rs4253377 [ dbSNP | Ensembl ].
VAR_016282
Natural varianti358 – 3581T → A.1 Publication
Corresponds to variant rs4253379 [ dbSNP | Ensembl ].
VAR_016283
Natural varianti381 – 3811S → A.1 Publication
Corresponds to variant rs4253301 [ dbSNP | Ensembl ].
VAR_016284
Natural varianti442 – 4421Q → P.1 Publication
Corresponds to variant rs4253316 [ dbSNP | Ensembl ].
VAR_016285
Natural varianti548 – 5481C → Y in PKK deficiency. 1 Publication
VAR_054908
Natural varianti560 – 5601R → Q.2 Publications
Corresponds to variant rs4253325 [ dbSNP | Ensembl ].
VAR_016286

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13143 mRNA. Translation: AAA60153.1.
AF232742
, AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741 Genomic DNA. Translation: AAF79940.1.
AK313378 mRNA. Translation: BAG36176.1.
AY190920 Genomic DNA. Translation: AAN84794.1.
AC110771 Genomic DNA. Translation: AAY40900.1.
CH471056 Genomic DNA. Translation: EAX04623.1.
BC117349 mRNA. Translation: AAI17350.1.
BC117351 mRNA. Translation: AAI17352.1.
CCDSiCCDS34120.1.
PIRiA00921. KQHUP.
RefSeqiNP_000883.2. NM_000892.3.
UniGeneiHs.237642.

Genome annotation databases

EnsembliENST00000264690; ENSP00000264690; ENSG00000164344.
GeneIDi3818.
KEGGihsa:3818.
UCSCiuc011clc.2. human.

Polymorphism databases

DMDMi125184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13143 mRNA. Translation: AAA60153.1 .
AF232742
, AF232734 , AF232735 , AF232736 , AF232737 , AF232738 , AF232739 , AF232740 , AF232741 Genomic DNA. Translation: AAF79940.1 .
AK313378 mRNA. Translation: BAG36176.1 .
AY190920 Genomic DNA. Translation: AAN84794.1 .
AC110771 Genomic DNA. Translation: AAY40900.1 .
CH471056 Genomic DNA. Translation: EAX04623.1 .
BC117349 mRNA. Translation: AAI17350.1 .
BC117351 mRNA. Translation: AAI17352.1 .
CCDSi CCDS34120.1.
PIRi A00921. KQHUP.
RefSeqi NP_000883.2. NM_000892.3.
UniGenei Hs.237642.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ANW X-ray 1.85 A 391-631 [» ]
2ANY X-ray 1.40 A 391-631 [» ]
4OGX X-ray 2.40 A 391-631 [» ]
4OGY X-ray 2.10 A/B 391-631 [» ]
ProteinModelPortali P03952.
SMRi P03952. Positions 21-628.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110018. 2 interactions.
STRINGi 9606.ENSP00000264690.

Chemistry

BindingDBi P03952.
ChEMBLi CHEMBL2111419.

Protein family/group databases

MEROPSi S01.212.

PTM databases

PhosphoSitei P03952.

Polymorphism databases

DMDMi 125184.

Proteomic databases

PaxDbi P03952.
PRIDEi P03952.

Protocols and materials databases

DNASUi 3818.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264690 ; ENSP00000264690 ; ENSG00000164344 .
GeneIDi 3818.
KEGGi hsa:3818.
UCSCi uc011clc.2. human.

Organism-specific databases

CTDi 3818.
GeneCardsi GC04P187130.
HGNCi HGNC:6371. KLKB1.
HPAi HPA005634.
MIMi 229000. gene.
612423. phenotype.
neXtProti NX_P03952.
Orphaneti 749. Congenital prekallikrein deficiency.
PharmGKBi PA30160.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118962.
HOGENOMi HOG000112467.
HOVERGENi HBG000399.
InParanoidi P03952.
KOi K01324.
PhylomeDBi P03952.
TreeFami TF343687.

Enzyme and pathway databases

BRENDAi 3.4.21.34. 2681.
Reactomei REACT_118682. Activation of Matrix Metalloproteinases.
REACT_326. Intrinsic Pathway.

Miscellaneous databases

EvolutionaryTracei P03952.
GeneWikii KLKB1.
GenomeRNAii 3818.
NextBioi 15011.
PMAP-CutDB Q4W5C3.
PROi P03952.
SOURCEi Search...

Gene expression databases

Bgeei P03952.
CleanExi HS_KLK3.
HS_KLKB1.
ExpressionAtlasi P03952. baseline and differential.
Genevestigatori P03952.

Family and domain databases

InterProi IPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTi SM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS00495. APPLE. 4 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats."
    Chung D.W., Fujikawa K., McMullen B.A., Davie E.W.
    Biochemistry 25:2410-2417(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease."
    Yu H., Anderson P.J., Freedman B.I., Rich S.S., Bowden D.W.
    Genomics 69:225-234(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; GLN-202 AND PRO-208.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-143; THR-178; GLN-202; CYS-269; VAL-311; ALA-358; ALA-381; PRO-442 AND GLN-560.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-560.
    Tissue: Colon.
  8. "Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule."
    McMullen B.A., Fujikawa K., Davie E.W.
    Biochemistry 30:2050-2056(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
  9. "Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
    Meijers J.C., Kanters D.H., Vlooswijk R.A., van Erp H.E., Hessing M., Bouma B.N.
    Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, HETERODIMER WITH SERPINA5.
  10. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-453.
  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127; ASN-308; ASN-396; ASN-453 AND ASN-494.
    Tissue: Plasma.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-308; ASN-396; ASN-453 AND ASN-494.
    Tissue: Liver.
  13. "Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)."
    Lombardi A.M., Sartori M.T., Cabrio L., Fadin M., Zanon E., Girolami A.
    Thromb. Haemost. 90:1040-1045(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PKK DEFICIENCY TYR-548.
  14. "A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region."
    Katsuda I., Maruyama F., Ezaki K., Sawamura T., Ichihara Y.
    Eur. J. Haematol. 79:59-68(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PKK DEFICIENCY ARG-123 AND SER-143.

Entry informationi

Entry nameiKLKB1_HUMAN
AccessioniPrimary (citable) accession number: P03952
Secondary accession number(s): A6NH96
, B2R8H9, Q17RE8, Q17RE9, Q4W5C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: October 29, 2014
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3