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P03950

- ANGI_HUMAN

UniProt

P03950 - ANGI_HUMAN

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Protein

Angiogenin

Gene

ANG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor
Active sitei138 – 1381Proton donor

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. DNA binding Source: UniProtKB
  4. endonuclease activity Source: UniProtKB
  5. heparin binding Source: UniProtKB
  6. peptide binding Source: UniProtKB
  7. receptor binding Source: UniProtKB
  8. ribonuclease activity Source: UniProtKB
  9. rRNA binding Source: UniProtKB

GO - Biological processi

  1. actin filament polymerization Source: UniProtKB
  2. activation of phospholipase A2 activity Source: UniProtKB
  3. activation of phospholipase C activity Source: UniProtKB
  4. activation of protein kinase B activity Source: UniProtKB
  5. angiogenesis Source: UniProtKB
  6. cell communication Source: UniProtKB
  7. cell death Source: UniProtKB-KW
  8. cell migration Source: UniProtKB
  9. diacylglycerol biosynthetic process Source: UniProtKB
  10. homeostatic process Source: UniProtKB
  11. negative regulation of smooth muscle cell proliferation Source: UniProtKB
  12. negative regulation of translation Source: UniProtKB-KW
  13. nucleic acid phosphodiester bond hydrolysis Source: GOC
  14. oocyte maturation Source: UniProtKB
  15. ovarian follicle development Source: UniProtKB
  16. placenta development Source: UniProtKB
  17. positive regulation of endothelial cell proliferation Source: UniProtKB
  18. positive regulation of phosphorylation Source: UniProtKB
  19. positive regulation of protein secretion Source: UniProtKB
  20. response to hormone Source: UniProtKB
  21. response to hypoxia Source: UniProtKB
  22. RNA phosphodiester bond hydrolysis Source: GOC
  23. rRNA transcription Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Endonuclease, Hydrolase, Nuclease, Protein synthesis inhibitor

Keywords - Biological processi

Angiogenesis, Differentiation, Stress response

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Angiogenin (EC:3.1.27.-)
Alternative name(s):
Ribonuclease 5
Short name:
RNase 5
Gene namesi
Name:ANG
Synonyms:RNASE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:483. ANG.

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane. Nucleusnucleolus
Note: Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.

GO - Cellular componenti

  1. angiogenin-PRI complex Source: UniProtKB
  2. basal lamina Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. growth cone Source: UniProtKB
  6. neuronal cell body Source: UniProtKB
  7. nucleolus Source: UniProtKB
  8. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.5 Publications
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121F → S in ALS9. 1 Publication
VAR_044145
Natural varianti20 – 201P → S in ALS9. 2 Publications
VAR_044146
Natural varianti36 – 361Q → L in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; wild type far-UV CD spectra. 1 Publication
VAR_044147
Natural varianti41 – 411K → E in ALS9; reduced ribonucleolytic activity. 1 Publication
VAR_044148
Natural varianti41 – 411K → I in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; retains nuclear translocation. 2 Publications
VAR_044149
Natural varianti52 – 521S → N in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; unable to translocate to the nucleus. 1 Publication
VAR_044150
Natural varianti55 – 551R → K in ALS9; marginally reduced ribonucleolytic activity; wild type far-UV CD spectra. 1 Publication
VAR_044151
Natural varianti63 – 631C → W in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; reduced thermal stability. 1 Publication
VAR_044152
Natural varianti64 – 641K → I in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; moderate reduction of thermal stability. 2 Publications
VAR_044153
Natural varianti70 – 701I → V in some ALS9 patients; pathogenicity uncertain; reduced ribonucleolytic activity; moderate reduction of thermal stability. 2 Publications
VAR_044154
Natural varianti136 – 1361P → L in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; unable to translocate to the nucleus. 1 Publication
VAR_044155
Natural varianti137 – 1371V → I in ALS9. 1 Publication
VAR_044156
Natural varianti138 – 1381H → R in ALS9. 1 Publication
VAR_044157

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi29 – 291R → A: Significantly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi32 – 321H → A: Significantly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi36 – 361Q → A: Slightly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi64 – 641K → Q: Significantly decreases binding affinity for RNH1. 2 Publications
Mutagenesisi92 – 921N → A: Slightly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi109 – 1102GG → RR: Significantly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi132 – 1321E → A: Slightly decreases binding affinity for RNH1. 1 Publication
Mutagenesisi140 – 1401D → H, S or A: 15- to 18-fold increase in RNase activity. 1 Publication
Mutagenesisi141 – 1411Q → G: Over 18-fold increase in RNase activity. 1 Publication
Mutagenesisi143 – 1442IF → AA: 3- to 5-fold increase in RNase activity. 1 Publication

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

MIMi611895. phenotype.
Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA24790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 147123Angiogenin2 PublicationsPRO_0000030843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acid1 Publication
Disulfide bondi50 ↔ 1051 Publication
Disulfide bondi63 ↔ 1161 Publication
Disulfide bondi81 ↔ 1311 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP03950.
PeptideAtlasiP03950.
PRIDEiP03950.

PTM databases

PhosphoSiteiP03950.

Expressioni

Tissue specificityi

Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.2 Publications

Developmental stagei

Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.

Gene expression databases

BgeeiP03950.
CleanExiHS_ANG.
ExpressionAtlasiP03950. baseline and differential.
GenevestigatoriP03950.

Interactioni

Subunit structurei

Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356094EBI-525291,EBI-77797
FSTP198833EBI-525291,EBI-1571188
RNH1P134892EBI-525291,EBI-1237106

Protein-protein interaction databases

BioGridi106780. 7 interactions.
IntActiP03950. 7 interactions.
STRINGi9606.ENSP00000336762.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 3710Combined sources
Helixi47 – 5610Combined sources
Turni60 – 634Combined sources
Beta strandi65 – 706Combined sources
Helixi74 – 785Combined sources
Helixi79 – 813Combined sources
Turni83 – 853Combined sources
Beta strandi86 – 894Combined sources
Turni90 – 923Combined sources
Beta strandi93 – 986Combined sources
Beta strandi100 – 11011Combined sources
Beta strandi112 – 1154Combined sources
Beta strandi117 – 1259Combined sources
Beta strandi128 – 1325Combined sources
Beta strandi135 – 1395Combined sources
Helixi141 – 1444Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4YX-ray2.00B/E25-147[»]
1ANGX-ray2.40A25-147[»]
1AWZNMR-A25-147[»]
1B1EX-ray2.00A25-147[»]
1B1IX-ray1.80A26-147[»]
1B1JX-ray2.00A25-147[»]
1GV7X-ray2.10A26-145[»]
1H0DX-ray2.00C26-147[»]
1H52X-ray2.00A25-147[»]
1H53X-ray2.00A26-147[»]
1HBYX-ray2.00A25-147[»]
1K58X-ray2.70A25-147[»]
1K59X-ray1.80A25-147[»]
1K5AX-ray2.33A25-147[»]
1K5BX-ray1.80A25-144[»]
1UN3X-ray1.70A26-147[»]
1UN4X-ray2.10A26-147[»]
1UN5X-ray2.60A25-147[»]
2ANGX-ray2.00A25-147[»]
4AHDX-ray2.47A/B25-147[»]
4AHEX-ray2.08A25-147[»]
4AHFX-ray2.12A25-147[»]
4AHGX-ray2.45A25-147[»]
4AHHX-ray2.50A25-147[»]
4AHIX-ray2.80A25-147[»]
4AHJX-ray2.03A25-147[»]
4AHKX-ray1.97A/B25-147[»]
4AHLX-ray2.05A25-147[»]
4AHMX-ray1.96A25-147[»]
4AHNX-ray2.98A25-147[»]
4AOHX-ray1.04A24-147[»]
4B36X-ray1.76A/B25-147[»]
ProteinModelPortaliP03950.
SMRiP03950. Positions 24-145.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03950.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 685Substrate binding

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 595Nucleolar localization signal

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG283332.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiP03950.
KOiK16631.
OMAiPCKYRAT.
OrthoDBiEOG7J1826.
PhylomeDBiP03950.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03950-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVMGLGVLLL VFVLGLGLTP PTLAQDNSRY THFLTQHYDA KPQGRDDRYC
60 70 80 90 100
ESIMRRRGLT SPCKDINTFI HGNKRSIKAI CENKNGNPHR ENLRISKSSF
110 120 130 140
QVTTCKLHGG SPWPPCQYRA TAGFRNVVVA CENGLPVHLD QSIFRRP
Length:147
Mass (Da):16,550
Last modified:October 23, 1986 - v1
Checksum:i9C462DA3C8D39ACC
GO

Sequence cautioni

The sequence AAH20704.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591L → P in AAH62698. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121F → S in ALS9. 1 Publication
VAR_044145
Natural varianti20 – 201P → S in ALS9. 2 Publications
VAR_044146
Natural varianti36 – 361Q → L in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; wild type far-UV CD spectra. 1 Publication
VAR_044147
Natural varianti41 – 411K → E in ALS9; reduced ribonucleolytic activity. 1 Publication
VAR_044148
Natural varianti41 – 411K → I in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; retains nuclear translocation. 2 Publications
VAR_044149
Natural varianti52 – 521S → N in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; unable to translocate to the nucleus. 1 Publication
VAR_044150
Natural varianti55 – 551R → K in ALS9; marginally reduced ribonucleolytic activity; wild type far-UV CD spectra. 1 Publication
VAR_044151
Natural varianti63 – 631C → W in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; reduced thermal stability. 1 Publication
VAR_044152
Natural varianti64 – 641K → I in ALS9; reduced ribonucleolytic activity; low angiogenic activity; reduced mitogenic activity; moderate reduction of thermal stability. 2 Publications
VAR_044153
Natural varianti70 – 701I → V in some ALS9 patients; pathogenicity uncertain; reduced ribonucleolytic activity; moderate reduction of thermal stability. 2 Publications
VAR_044154
Natural varianti84 – 841K → E.1 Publication
Corresponds to variant rs17560 [ dbSNP | Ensembl ].
VAR_013148
Natural varianti136 – 1361P → L in ALS9; loss of angiogenic activity; reduced ribonucleolytic activity; unable to translocate to the nucleus. 1 Publication
VAR_044155
Natural varianti137 – 1371V → I in ALS9. 1 Publication
VAR_044156
Natural varianti138 – 1381H → R in ALS9. 1 Publication
VAR_044157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11567 Genomic DNA. Translation: AAA51678.1.
AF449647 Genomic DNA. Translation: AAL67710.1.
AF449648 Genomic DNA. Translation: AAL67711.1.
AF449649 Genomic DNA. Translation: AAL67712.1.
AF449650 Genomic DNA. Translation: AAL67713.1.
AF449651 Genomic DNA. Translation: AAL67714.1.
FJ236304 mRNA. Translation: ACI45236.1.
CR407633 mRNA. Translation: CAG28561.1.
AK313989 mRNA. Translation: BAG36701.1.
CH471078 Genomic DNA. Translation: EAW66450.1.
CH471078 Genomic DNA. Translation: EAW66451.1.
BC020704 mRNA. Translation: AAH20704.1. Different initiation.
BC054880 mRNA. Translation: AAH54880.1.
BC062698 mRNA. Translation: AAH62698.1.
CCDSiCCDS9554.1.
PIRiA90498. NRHUAG.
RefSeqiNP_001091046.1. NM_001097577.2.
NP_001136.1. NM_001145.4.
UniGeneiHs.283749.

Genome annotation databases

EnsembliENST00000336811; ENSP00000336762; ENSG00000214274.
ENST00000397990; ENSP00000381077; ENSG00000214274.
GeneIDi283.
KEGGihsa:283.
UCSCiuc001vxw.4. human.

Polymorphism databases

DMDMi113873.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

R&D Systems' cytokine mini-reviews: Angiogenin
Functional Glycomics Gateway - Glycan Binding

Angiogenin

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11567 Genomic DNA. Translation: AAA51678.1 .
AF449647 Genomic DNA. Translation: AAL67710.1 .
AF449648 Genomic DNA. Translation: AAL67711.1 .
AF449649 Genomic DNA. Translation: AAL67712.1 .
AF449650 Genomic DNA. Translation: AAL67713.1 .
AF449651 Genomic DNA. Translation: AAL67714.1 .
FJ236304 mRNA. Translation: ACI45236.1 .
CR407633 mRNA. Translation: CAG28561.1 .
AK313989 mRNA. Translation: BAG36701.1 .
CH471078 Genomic DNA. Translation: EAW66450.1 .
CH471078 Genomic DNA. Translation: EAW66451.1 .
BC020704 mRNA. Translation: AAH20704.1 . Different initiation.
BC054880 mRNA. Translation: AAH54880.1 .
BC062698 mRNA. Translation: AAH62698.1 .
CCDSi CCDS9554.1.
PIRi A90498. NRHUAG.
RefSeqi NP_001091046.1. NM_001097577.2.
NP_001136.1. NM_001145.4.
UniGenei Hs.283749.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A4Y X-ray 2.00 B/E 25-147 [» ]
1ANG X-ray 2.40 A 25-147 [» ]
1AWZ NMR - A 25-147 [» ]
1B1E X-ray 2.00 A 25-147 [» ]
1B1I X-ray 1.80 A 26-147 [» ]
1B1J X-ray 2.00 A 25-147 [» ]
1GV7 X-ray 2.10 A 26-145 [» ]
1H0D X-ray 2.00 C 26-147 [» ]
1H52 X-ray 2.00 A 25-147 [» ]
1H53 X-ray 2.00 A 26-147 [» ]
1HBY X-ray 2.00 A 25-147 [» ]
1K58 X-ray 2.70 A 25-147 [» ]
1K59 X-ray 1.80 A 25-147 [» ]
1K5A X-ray 2.33 A 25-147 [» ]
1K5B X-ray 1.80 A 25-144 [» ]
1UN3 X-ray 1.70 A 26-147 [» ]
1UN4 X-ray 2.10 A 26-147 [» ]
1UN5 X-ray 2.60 A 25-147 [» ]
2ANG X-ray 2.00 A 25-147 [» ]
4AHD X-ray 2.47 A/B 25-147 [» ]
4AHE X-ray 2.08 A 25-147 [» ]
4AHF X-ray 2.12 A 25-147 [» ]
4AHG X-ray 2.45 A 25-147 [» ]
4AHH X-ray 2.50 A 25-147 [» ]
4AHI X-ray 2.80 A 25-147 [» ]
4AHJ X-ray 2.03 A 25-147 [» ]
4AHK X-ray 1.97 A/B 25-147 [» ]
4AHL X-ray 2.05 A 25-147 [» ]
4AHM X-ray 1.96 A 25-147 [» ]
4AHN X-ray 2.98 A 25-147 [» ]
4AOH X-ray 1.04 A 24-147 [» ]
4B36 X-ray 1.76 A/B 25-147 [» ]
ProteinModelPortali P03950.
SMRi P03950. Positions 24-145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106780. 7 interactions.
IntActi P03950. 7 interactions.
STRINGi 9606.ENSP00000336762.

Chemistry

BindingDBi P03950.
ChEMBLi CHEMBL5829.

PTM databases

PhosphoSitei P03950.

Polymorphism databases

DMDMi 113873.

Proteomic databases

PaxDbi P03950.
PeptideAtlasi P03950.
PRIDEi P03950.

Protocols and materials databases

DNASUi 283.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336811 ; ENSP00000336762 ; ENSG00000214274 .
ENST00000397990 ; ENSP00000381077 ; ENSG00000214274 .
GeneIDi 283.
KEGGi hsa:283.
UCSCi uc001vxw.4. human.

Organism-specific databases

CTDi 283.
GeneCardsi GC14P021152.
GeneReviewsi ANG.
HGNCi HGNC:483. ANG.
MIMi 105850. gene.
611895. phenotype.
neXtProti NX_P03950.
Orphaneti 803. Amyotrophic lateral sclerosis.
PharmGKBi PA24790.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283332.
HOGENOMi HOG000276883.
HOVERGENi HBG008396.
InParanoidi P03950.
KOi K16631.
OMAi PCKYRAT.
OrthoDBi EOG7J1826.
PhylomeDBi P03950.
TreeFami TF333393.

Miscellaneous databases

EvolutionaryTracei P03950.
GeneWikii Angiogenin.
GenomeRNAii 283.
NextBioi 1141.
PROi P03950.
SOURCEi Search...

Gene expression databases

Bgeei P03950.
CleanExi HS_ANG.
ExpressionAtlasi P03950. baseline and differential.
Genevestigatori P03950.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor."
    Kurachi K., Davie E.W., Strydom D.J., Riordan J.F., Vallee B.L.
    Biochemistry 24:5494-5499(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Diversifying selection of the tumor-growth promoter angiogenin in primate evolution."
    Zhang J., Rosenberg H.F.
    Mol. Biol. Evol. 19:438-445(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-84.
  3. Li J., Wang H.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  8. Cited for: PROTEIN SEQUENCE OF 25-147, PYROGLUTAMATE FORMATION AT GLN-25, DISULFIDE BONDS.
  9. "Tissue distribution and developmental expression of the messenger RNA encoding angiogenin."
    Weiner H.L., Weiner L.H., Swain J.L.
    Science 237:280-282(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily."
    Saxena S.K., Rybak S.M., Davey R.T. Jr., Youle R.J., Ackerman E.J.
    J. Biol. Chem. 267:21982-21986(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Identification of the nucleolar targeting signal of human angiogenin."
    Moroianu J., Riordan J.F.
    Biochem. Biophys. Res. Commun. 203:1765-1772(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEOLAR LOCALIZATION SIGNAL.
  12. "Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A."
    Chen C.Z., Shapiro R.
    Proc. Natl. Acad. Sci. U.S.A. 94:1761-1766(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF HIS-32; GLN-36; LYS-64; ASN-92 AND GLU-132.
  13. "Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A."
    Chen C.Z., Shapiro R.
    Biochemistry 38:9273-9285(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNH1, MUTAGENESIS OF ARG-29 AND LYS-64.
  14. "The nuclear function of angiogenin in endothelial cells is related to rRNA production."
    Xu Z.P., Tsuji T., Riordan J.F., Hu G.F.
    Biochem. Biophys. Res. Commun. 294:287-292(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING.
  15. "Ribonuclease inhibitor regulates neovascularization by human angiogenin."
    Dickson K.A., Kang D.K., Kwon Y.S., Kim J.C., Leland P.A., Kim B.M., Chang S.I., Raines R.T.
    Biochemistry 48:3804-3806(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RNH1, MUTAGENESIS OF 109-GLY-GLY-110.
  16. "Angiogenin-induced tRNA fragments inhibit translation initiation."
    Ivanov P., Emara M.M., Villen J., Gygi S.P., Anderson P.
    Mol. Cell 43:613-623(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease."
    Acharya K.R., Shapiro R., Allen S.C., Riordan J.F., Vallee B.L.
    Proc. Natl. Acad. Sci. U.S.A. 91:2915-2919(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 25-147.
  18. "Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution."
    Papageorgiou A.C., Shapiro R., Acharya K.R.
    EMBO J. 16:5162-5177(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 25-147 IN COMPLEX WITH RNH1 AND SUBUNIT.
  19. "Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth."
    Leonidas D.D., Shapiro R., Allen S.C., Subbarao G.V., Veluraja K., Acharya K.R.
    J. Mol. Biol. 285:1209-1233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 26-147.
  20. "Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography."
    Leonidas D.D., Chavali G.B., Jardine A.M., Li S., Shapiro R., Acharya K.R.
    Protein Sci. 10:1669-1676(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 26-147 OF MUTANT GLY-141 IN COMPLEX WITH PHOSPHATE AND PYROPHOSPHATE.
  21. "Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency."
    Leonidas D.D., Shapiro R., Subbarao G.V., Russo A., Acharya K.R.
    Biochemistry 41:2552-2562(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 26-147, MUTAGENESIS OF ASP-140; GLN-141 AND 143-ILE-PHE-144.
  22. "The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody."
    Chavali G.B., Papageorgiou A.C., Olson K.A., Fett J.W., Hu G., Shapiro R., Acharya K.R.
    Structure 11:875-885(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 26-147.
  23. "Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41."
    Holloway D.E., Chavali G.B., Hares M.C., Baker M.D., Subbarao G.V., Shapiro R., Acharya K.R.
    Biochemistry 43:1230-1241(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF MUTANTS ASP-68 AND ALA-104.
  24. "Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy -- characterization of histidine protonation states and pKa values."
    Lequin O., Thuering H., Robin M., Lallemand J.-Y.
    Eur. J. Biochem. 250:712-726(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  25. "Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis."
    Padhi A.K., Kumar H., Vasaikar S.V., Jayaram B., Gomes J.
    PLoS ONE 7:E32479-E32479(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  26. Cited for: VARIANT ALS9 ILE-64.
  27. Cited for: VARIANTS ALS9 LEU-36; ILE-41; GLU-41; LYS-55; TRP-63 AND ILE-64, VARIANT VAL-70.
  28. "Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis."
    Wu D., Yu W., Kishikawa H., Folkerth R.D., Iafrate A.J., Shen Y., Xin W., Sims K., Hu G.-F.
    Ann. Neurol. 62:609-617(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALS9 SER-20; ILE-41; ASN-52 AND LEU-136, CHARACTERIZATION OF VARIANTS ALS9 ILE-41; ASN-52 AND LEU-136, TISSUE SPECIFICITY.
  29. "Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis."
    Crabtree B., Thiyagarajan N., Prior S.H., Wilson P., Iyer S., Ferns T., Shapiro R., Brew K., Subramanian V., Acharya K.R.
    Biochemistry 46:11810-11818(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANTS ALS9 LEU-36; ILE-41; GLU-41; LYS-55; TRP-63 AND ILE-64, CHARACTERIZATION OF VARIANT VAL-70.
  30. "Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis."
    Gellera C., Colombrita C., Ticozzi N., Castellotti B., Bragato C., Ratti A., Taroni F., Silani V.
    Neurogenetics 9:33-40(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALS9 SER-12; SER-20; ILE-137 AND ARG-138, VARIANT VAL-70.
  31. Cited for: INVOLVEMENT IN ALS9.

Entry informationi

Entry nameiANGI_HUMAN
AccessioniPrimary (citable) accession number: P03950
Secondary accession number(s): Q05CV1
, Q53X86, Q6P5T2, Q8WXE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: November 26, 2014
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3