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P03949 (ABL1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase abl-1

EC=2.7.10.2
Gene names
Name:abl-1
ORF Names:M79.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
SH3 domain
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage checkpoint

Inferred from genetic interaction PubMed 15273685. Source: WormBase

defense response to Gram-negative bacterium

Inferred from genetic interaction PubMed 21399680. Source: WormBase

defense response to fungus

Inferred from mutant phenotype PubMed 21399680. Source: WormBase

negative regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from mutant phenotype PubMed 15273685. Source: WormBase

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15273685. Source: WormBase

negative regulation of cell migration

Inferred from genetic interaction PubMed 19402756. Source: WormBase

negative regulation of engulfment of apoptotic cell

Inferred from genetic interaction PubMed 19402756. Source: WormBase

peptidyl-tyrosine phosphorylation

Inferred from sequence or structural similarity PubMed 15273685. Source: GOC

response to ionizing radiation

Inferred from mutant phenotype PubMed 15273685. Source: WormBase

spermatogenesis

Inferred from mutant phenotype PubMed 11076749. Source: WormBase

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity PubMed 15273685. Source: WormBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from sequence or structural similarity PubMed 15273685. Source: WormBase

protein binding

Inferred from physical interaction PubMed 19123269PubMed 19447967PubMed 23549480. Source: IntAct

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform a (identifier: P03949-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: P03949-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-63: Missing.
Isoform c (identifier: P03949-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MGHSHSTGKE...SSTFRGSQSR → MIMNPCFRER...CFITATIDSL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12241224Tyrosine-protein kinase abl-1
PRO_0000088055

Regions

Domain115 – 18874SH3
Domain194 – 28491SH2
Domain311 – 562252Protein kinase
Nucleotide binding317 – 3259ATP By similarity
Nucleotide binding385 – 3917ATP By similarity
Motif450 – 47425Kinase activation loop By similarity

Sites

Active site4321Proton acceptor By similarity
Binding site3401ATP By similarity

Natural variations

Alternative sequence1 – 8888MGHSH…GSQSR → MIMNPCFRERSQKRTKKRAK NRAKSRSTMYLSKVGDSSLA MSRSLPSVALPMHYLHHKLA ESICFITATIDSL in isoform c.
VSP_004962
Alternative sequence54 – 6310Missing in isoform b.
VSP_004963

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified January 17, 2003. Version 4.
Checksum: 56D8513DD2061071

FASTA1,224138,326
        10         20         30         40         50         60 
MGHSHSTGKE INDNELFTCE DPVFDQPVAS PKSEISSKLA EEIERSKSPL ILEVSPRTPD 

        70         80         90        100        110        120 
SVQMFRPTFD TFRPPNSDSS TFRGSQSRED LVACSSMNSV NNVHDMNTVS SSSSSSAPLF 

       130        140        150        160        170        180 
VALYDFHGVG EEQLSLRKGD QVRILGYNKN NEWCEARLYS TRKNDASNQR RLGEIGWVPS 

       190        200        210        220        230        240 
NFIAPYNSLD KYTWYHGKIS RSDSEAILGS GITGSFLVRE SETSIGQYTI SVRHDGRVFH 

       250        260        270        280        290        300 
YRINVDNTEK MFITQEVKFR TLGELVHHHS VHADGLICLL MYPASKKDKG RGLFSLSPNA 

       310        320        330        340        350        360 
PDEWELDRSE IIMHNKLGGG QYGDVYEGYW KRHDCTIAVK ALKEDAMPLH EFLAEAAIMK 

       370        380        390        400        410        420 
DLHHKNLVRL LGVCTHEAPF YIITEFMCNG NLLEYLRRTD KSLLPPIILV QMASQIASGM 

       430        440        450        460        470        480 
SYLEARHFIH RDLAARNCLV SEHNIVKIAD FGLARFMKED TYTAHAGAKF PIKWTAPEGL 

       490        500        510        520        530        540 
AFNTFSSKSD VWAFGVLLWE IATYGMAPYP GVELSNVYGL LENGFRMDGP QGCPPSVYRL 

       550        560        570        580        590        600 
MLQCWNWSPS DRPRFRDIHF NLENLISSNS LNDEVQKQLK KNNDKKLESD KRRSNVRERS 

       610        620        630        640        650        660 
DSKSRHSSHH DRDRDRESLH SRNSNPEIPN RSFIRTDDSV SFFNPSTTSK VTSFRAQGPP 

       670        680        690        700        710        720 
FPPPPQQNTK PKLLKSVLNS NARHASEEFE RNEQDDVVPL AEKNVRKAVT RLGGTMPKGQ 

       730        740        750        760        770        780 
RIDAYLDSMR RVDSWKESTD ADNEGAGSSS LSRTVSNDSL DTLPLPDSMN SSTYVKMHPA 

       790        800        810        820        830        840 
SGENVFLRQI RSKLKKRSET PELDHIDSDT ADETTKSEKS PFGSLNKSSI KYPIKNAPEF 

       850        860        870        880        890        900 
SENHSRVSPV PVPPSRNASV SVRPDSKAED SSDETTKDVG MWGPKHAVTR KIEIVKNDSY 

       910        920        930        940        950        960 
PNVEGELKAK IRNLRHVPKE ESNTSSQEDL PLDATDNTND SIIVIPRDEK AKVRQLVTQK 

       970        980        990       1000       1010       1020 
VSPLQHHRPF SLQCPNNSTS SAISHSEHAD SSETSSLSGV YEERMKPELP RKRSNGDTKV 

      1030       1040       1050       1060       1070       1080 
VPVTWIINGE KEPNGMARTK SLRDITSKFE QLGTASTIES KIEEAVPYRE HALEKKGTSK 

      1090       1100       1110       1120       1130       1140 
RFSMLEGSNE LKHVVPPRKN RNQDESGSID EEPVSKDMIV SLLKVIQKEF VNLFNLASSE 

      1150       1160       1170       1180       1190       1200 
ITDEKLQQFV IMADNVQKLH STCSVYAEQI SPHSKFRFKE LLSQLEIYNR QIKFSHNPRA 

      1210       1220 
KPVDDKLKMA FQDCFDQIMR LVDR 

« Hide

Isoform b [UniParc].

Checksum: B0535D6CC47604C1
Show »

FASTA1,214137,259
Isoform c [UniParc].

Checksum: 733EA68DDB491076
Show »

FASTA1,209136,811

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[2]"Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene."
Goddard J.M., Weiland J.J., Capecchi M.R.
Proc. Natl. Acad. Sci. U.S.A. 83:2172-2176(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-706.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z50806 Genomic DNA. Translation: CAA90691.2.
Z50806 Genomic DNA. Translation: CAB60296.2.
Z50806 Genomic DNA. Translation: CAB60297.2.
M13235 Genomic DNA. Translation: AAA28129.1.
PIRT23832.
RefSeqNP_509777.2. NM_077376.6. [P03949-2]
NP_509778.2. NM_077377.4. [P03949-1]
NP_509779.2. NM_077378.2. [P03949-3]
UniGeneCel.19997.

3D structure databases

ProteinModelPortalP03949.
SMRP03949. Positions 119-618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid46173. 18 interactions.
DIPDIP-48409N.
IntActP03949. 46 interactions.

Proteomic databases

PaxDbP03949.
PRIDEP03949.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaM79.1a; M79.1a; WBGene00000018. [P03949-1]
GeneID181261.
KEGGcel:CELE_M79.1.
UCSCM79.1b. c. elegans. [P03949-1]

Organism-specific databases

CTD181261.
WormBaseM79.1a; CE31570; WBGene00000018; abl-1.
M79.1b; CE31571; WBGene00000018; abl-1.
M79.1c; CE31572; WBGene00000018; abl-1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00640000091347.
HOGENOMHOG000017506.
InParanoidP03949.
KOK06619.
OMACTHEAPF.
OrthoDBEOG7GTT2V.

Enzyme and pathway databases

BRENDA2.7.10.2. 1045.
SignaLinkP03949.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio913152.
PROP03949.

Entry information

Entry nameABL1_CAEEL
AccessionPrimary (citable) accession number: P03949
Secondary accession number(s): Q9U3A2, Q9U3A3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: January 17, 2003
Last modified: June 11, 2014
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase