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P03949

- ABL1_CAEEL

UniProt

P03949 - ABL1_CAEEL

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Protein

Tyrosine-protein kinase abl-1

Gene

abl-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei340 – 3401ATPPROSITE-ProRule annotation
Active sitei432 – 4321Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3259ATPPROSITE-ProRule annotation
Nucleotide bindingi385 – 3917ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: WormBase

GO - Biological processi

  1. defense response to fungus Source: WormBase
  2. defense response to Gram-negative bacterium Source: WormBase
  3. DNA damage checkpoint Source: WormBase
  4. negative regulation of apoptotic process Source: WormBase
  5. negative regulation of cell migration Source: WormBase
  6. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: WormBase
  7. negative regulation of engulfment of apoptotic cell Source: WormBase
  8. peptidyl-tyrosine phosphorylation Source: GOC
  9. response to ionizing radiation Source: WormBase
  10. spermatogenesis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
ReactomeiREACT_183197. Factors involved in megakaryocyte development and platelet production.
REACT_239816. CDO in myogenesis.
REACT_253843. Role of Abl in Robo-Slit signaling.
SignaLinkiP03949.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase abl-1 (EC:2.7.10.2)
Gene namesi
Name:abl-1
ORF Names:M79.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiM79.1a; CE31570; WBGene00000018; abl-1.
M79.1b; CE31571; WBGene00000018; abl-1.
M79.1c; CE31572; WBGene00000018; abl-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224Tyrosine-protein kinase abl-1PRO_0000088055Add
BLAST

Proteomic databases

PaxDbiP03949.
PRIDEiP03949.

Expressioni

Gene expression databases

ExpressionAtlasiP03949. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
alp-1G5EEL14EBI-2315883,EBI-2315902
C05D10.4Q111816EBI-2315883,EBI-2316016
eps-8G5ED336EBI-2315883,EBI-2315916
M57.1Q9TYX94EBI-2315883,EBI-2315745
mig-5G5EC493EBI-2315883,EBI-2315994
secs-1Q189537EBI-2315883,EBI-318539
swsn-1G5EF875EBI-2315883,EBI-311928
szy-4Q183203EBI-2315883,EBI-327120
vab-3G5EDS14EBI-2315883,EBI-319610
zfp-3O021745EBI-2315883,EBI-2315779

Protein-protein interaction databases

BioGridi46173. 18 interactions.
DIPiDIP-48409N.
IntActiP03949. 46 interactions.

Structurei

3D structure databases

ProteinModelPortaliP03949.
SMRiP03949. Positions 119-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 18874SH3PROSITE-ProRule annotationAdd
BLAST
Domaini194 – 28491SH2PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 562252Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi450 – 47425Kinase activation loopBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000017506.
InParanoidiP03949.
KOiK06619.
OMAiCTHEAPF.
OrthoDBiEOG7GTT2V.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform a (identifier: P03949-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHSHSTGKE INDNELFTCE DPVFDQPVAS PKSEISSKLA EEIERSKSPL
60 70 80 90 100
ILEVSPRTPD SVQMFRPTFD TFRPPNSDSS TFRGSQSRED LVACSSMNSV
110 120 130 140 150
NNVHDMNTVS SSSSSSAPLF VALYDFHGVG EEQLSLRKGD QVRILGYNKN
160 170 180 190 200
NEWCEARLYS TRKNDASNQR RLGEIGWVPS NFIAPYNSLD KYTWYHGKIS
210 220 230 240 250
RSDSEAILGS GITGSFLVRE SETSIGQYTI SVRHDGRVFH YRINVDNTEK
260 270 280 290 300
MFITQEVKFR TLGELVHHHS VHADGLICLL MYPASKKDKG RGLFSLSPNA
310 320 330 340 350
PDEWELDRSE IIMHNKLGGG QYGDVYEGYW KRHDCTIAVK ALKEDAMPLH
360 370 380 390 400
EFLAEAAIMK DLHHKNLVRL LGVCTHEAPF YIITEFMCNG NLLEYLRRTD
410 420 430 440 450
KSLLPPIILV QMASQIASGM SYLEARHFIH RDLAARNCLV SEHNIVKIAD
460 470 480 490 500
FGLARFMKED TYTAHAGAKF PIKWTAPEGL AFNTFSSKSD VWAFGVLLWE
510 520 530 540 550
IATYGMAPYP GVELSNVYGL LENGFRMDGP QGCPPSVYRL MLQCWNWSPS
560 570 580 590 600
DRPRFRDIHF NLENLISSNS LNDEVQKQLK KNNDKKLESD KRRSNVRERS
610 620 630 640 650
DSKSRHSSHH DRDRDRESLH SRNSNPEIPN RSFIRTDDSV SFFNPSTTSK
660 670 680 690 700
VTSFRAQGPP FPPPPQQNTK PKLLKSVLNS NARHASEEFE RNEQDDVVPL
710 720 730 740 750
AEKNVRKAVT RLGGTMPKGQ RIDAYLDSMR RVDSWKESTD ADNEGAGSSS
760 770 780 790 800
LSRTVSNDSL DTLPLPDSMN SSTYVKMHPA SGENVFLRQI RSKLKKRSET
810 820 830 840 850
PELDHIDSDT ADETTKSEKS PFGSLNKSSI KYPIKNAPEF SENHSRVSPV
860 870 880 890 900
PVPPSRNASV SVRPDSKAED SSDETTKDVG MWGPKHAVTR KIEIVKNDSY
910 920 930 940 950
PNVEGELKAK IRNLRHVPKE ESNTSSQEDL PLDATDNTND SIIVIPRDEK
960 970 980 990 1000
AKVRQLVTQK VSPLQHHRPF SLQCPNNSTS SAISHSEHAD SSETSSLSGV
1010 1020 1030 1040 1050
YEERMKPELP RKRSNGDTKV VPVTWIINGE KEPNGMARTK SLRDITSKFE
1060 1070 1080 1090 1100
QLGTASTIES KIEEAVPYRE HALEKKGTSK RFSMLEGSNE LKHVVPPRKN
1110 1120 1130 1140 1150
RNQDESGSID EEPVSKDMIV SLLKVIQKEF VNLFNLASSE ITDEKLQQFV
1160 1170 1180 1190 1200
IMADNVQKLH STCSVYAEQI SPHSKFRFKE LLSQLEIYNR QIKFSHNPRA
1210 1220
KPVDDKLKMA FQDCFDQIMR LVDR
Length:1,224
Mass (Da):138,326
Last modified:January 17, 2003 - v4
Checksum:i56D8513DD2061071
GO
Isoform b (identifier: P03949-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-63: Missing.

Show »
Length:1,214
Mass (Da):137,259
Checksum:iB0535D6CC47604C1
GO
Isoform c (identifier: P03949-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MGHSHSTGKE...SSTFRGSQSR → MIMNPCFRER...CFITATIDSL

Show »
Length:1,209
Mass (Da):136,811
Checksum:i733EA68DDB491076
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888MGHSH…GSQSR → MIMNPCFRERSQKRTKKRAK NRAKSRSTMYLSKVGDSSLA MSRSLPSVALPMHYLHHKLA ESICFITATIDSL in isoform c. CuratedVSP_004962Add
BLAST
Alternative sequencei54 – 6310Missing in isoform b. CuratedVSP_004963

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50806 Genomic DNA. Translation: CAA90691.2.
Z50806 Genomic DNA. Translation: CAB60296.2.
Z50806 Genomic DNA. Translation: CAB60297.2.
M13235 Genomic DNA. Translation: AAA28129.1.
PIRiT23832.
RefSeqiNP_509777.2. NM_077376.6. [P03949-2]
NP_509778.2. NM_077377.4. [P03949-1]
NP_509779.2. NM_077378.2. [P03949-3]
UniGeneiCel.19997.

Genome annotation databases

EnsemblMetazoaiM79.1a; M79.1a; WBGene00000018. [P03949-1]
GeneIDi181261.
KEGGicel:CELE_M79.1.
UCSCiM79.1b. c. elegans. [P03949-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50806 Genomic DNA. Translation: CAA90691.2 .
Z50806 Genomic DNA. Translation: CAB60296.2 .
Z50806 Genomic DNA. Translation: CAB60297.2 .
M13235 Genomic DNA. Translation: AAA28129.1 .
PIRi T23832.
RefSeqi NP_509777.2. NM_077376.6. [P03949-2 ]
NP_509778.2. NM_077377.4. [P03949-1 ]
NP_509779.2. NM_077378.2. [P03949-3 ]
UniGenei Cel.19997.

3D structure databases

ProteinModelPortali P03949.
SMRi P03949. Positions 119-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46173. 18 interactions.
DIPi DIP-48409N.
IntActi P03949. 46 interactions.

Proteomic databases

PaxDbi P03949.
PRIDEi P03949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai M79.1a ; M79.1a ; WBGene00000018 . [P03949-1 ]
GeneIDi 181261.
KEGGi cel:CELE_M79.1.
UCSCi M79.1b. c. elegans. [P03949-1 ]

Organism-specific databases

CTDi 181261.
WormBasei M79.1a ; CE31570 ; WBGene00000018 ; abl-1.
M79.1b ; CE31571 ; WBGene00000018 ; abl-1.
M79.1c ; CE31572 ; WBGene00000018 ; abl-1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118938.
HOGENOMi HOG000017506.
InParanoidi P03949.
KOi K06619.
OMAi CTHEAPF.
OrthoDBi EOG7GTT2V.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1045.
Reactomei REACT_183197. Factors involved in megakaryocyte development and platelet production.
REACT_239816. CDO in myogenesis.
REACT_253843. Role of Abl in Robo-Slit signaling.
SignaLinki P03949.

Miscellaneous databases

NextBioi 913152.
PROi P03949.

Gene expression databases

ExpressionAtlasi P03949. baseline.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene."
    Goddard J.M., Weiland J.J., Capecchi M.R.
    Proc. Natl. Acad. Sci. U.S.A. 83:2172-2176(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-706.

Entry informationi

Entry nameiABL1_CAEEL
AccessioniPrimary (citable) accession number: P03949
Secondary accession number(s): Q9U3A2, Q9U3A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: January 17, 2003
Last modified: November 26, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3