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P03949

- ABL1_CAEEL

UniProt

P03949 - ABL1_CAEEL

Protein

Tyrosine-protein kinase abl-1

Gene

abl-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 4 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei340 – 3401ATPPROSITE-ProRule annotation
    Active sitei432 – 4321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi317 – 3259ATPPROSITE-ProRule annotation
    Nucleotide bindingi385 – 3917ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: WormBase
    3. protein binding Source: IntAct

    GO - Biological processi

    1. defense response to fungus Source: WormBase
    2. defense response to Gram-negative bacterium Source: WormBase
    3. DNA damage checkpoint Source: WormBase
    4. negative regulation of apoptotic process Source: WormBase
    5. negative regulation of cell migration Source: WormBase
    6. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: WormBase
    7. negative regulation of engulfment of apoptotic cell Source: WormBase
    8. peptidyl-tyrosine phosphorylation Source: GOC
    9. response to ionizing radiation Source: WormBase
    10. spermatogenesis Source: WormBase

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1045.
    ReactomeiREACT_183197. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiP03949.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase abl-1 (EC:2.7.10.2)
    Gene namesi
    Name:abl-1
    ORF Names:M79.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiM79.1a; CE31570; WBGene00000018; abl-1.
    M79.1b; CE31571; WBGene00000018; abl-1.
    M79.1c; CE31572; WBGene00000018; abl-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12241224Tyrosine-protein kinase abl-1PRO_0000088055Add
    BLAST

    Proteomic databases

    PaxDbiP03949.
    PRIDEiP03949.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    alp-1G5EEL14EBI-2315883,EBI-2315902
    C05D10.4Q111816EBI-2315883,EBI-2316016
    eps-8G5ED336EBI-2315883,EBI-2315916
    M57.1Q9TYX94EBI-2315883,EBI-2315745
    mig-5G5EC493EBI-2315883,EBI-2315994
    secs-1Q189537EBI-2315883,EBI-318539
    swsn-1G5EF875EBI-2315883,EBI-311928
    szy-4Q183203EBI-2315883,EBI-327120
    vab-3G5EDS14EBI-2315883,EBI-319610
    zfp-3O021745EBI-2315883,EBI-2315779

    Protein-protein interaction databases

    BioGridi46173. 18 interactions.
    DIPiDIP-48409N.
    IntActiP03949. 46 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP03949.
    SMRiP03949. Positions 119-618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 18874SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 28491SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 562252Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi450 – 47425Kinase activation loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00640000091347.
    HOGENOMiHOG000017506.
    InParanoidiP03949.
    KOiK06619.
    OMAiCTHEAPF.
    OrthoDBiEOG7GTT2V.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform a (identifier: P03949-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGHSHSTGKE INDNELFTCE DPVFDQPVAS PKSEISSKLA EEIERSKSPL     50
    ILEVSPRTPD SVQMFRPTFD TFRPPNSDSS TFRGSQSRED LVACSSMNSV 100
    NNVHDMNTVS SSSSSSAPLF VALYDFHGVG EEQLSLRKGD QVRILGYNKN 150
    NEWCEARLYS TRKNDASNQR RLGEIGWVPS NFIAPYNSLD KYTWYHGKIS 200
    RSDSEAILGS GITGSFLVRE SETSIGQYTI SVRHDGRVFH YRINVDNTEK 250
    MFITQEVKFR TLGELVHHHS VHADGLICLL MYPASKKDKG RGLFSLSPNA 300
    PDEWELDRSE IIMHNKLGGG QYGDVYEGYW KRHDCTIAVK ALKEDAMPLH 350
    EFLAEAAIMK DLHHKNLVRL LGVCTHEAPF YIITEFMCNG NLLEYLRRTD 400
    KSLLPPIILV QMASQIASGM SYLEARHFIH RDLAARNCLV SEHNIVKIAD 450
    FGLARFMKED TYTAHAGAKF PIKWTAPEGL AFNTFSSKSD VWAFGVLLWE 500
    IATYGMAPYP GVELSNVYGL LENGFRMDGP QGCPPSVYRL MLQCWNWSPS 550
    DRPRFRDIHF NLENLISSNS LNDEVQKQLK KNNDKKLESD KRRSNVRERS 600
    DSKSRHSSHH DRDRDRESLH SRNSNPEIPN RSFIRTDDSV SFFNPSTTSK 650
    VTSFRAQGPP FPPPPQQNTK PKLLKSVLNS NARHASEEFE RNEQDDVVPL 700
    AEKNVRKAVT RLGGTMPKGQ RIDAYLDSMR RVDSWKESTD ADNEGAGSSS 750
    LSRTVSNDSL DTLPLPDSMN SSTYVKMHPA SGENVFLRQI RSKLKKRSET 800
    PELDHIDSDT ADETTKSEKS PFGSLNKSSI KYPIKNAPEF SENHSRVSPV 850
    PVPPSRNASV SVRPDSKAED SSDETTKDVG MWGPKHAVTR KIEIVKNDSY 900
    PNVEGELKAK IRNLRHVPKE ESNTSSQEDL PLDATDNTND SIIVIPRDEK 950
    AKVRQLVTQK VSPLQHHRPF SLQCPNNSTS SAISHSEHAD SSETSSLSGV 1000
    YEERMKPELP RKRSNGDTKV VPVTWIINGE KEPNGMARTK SLRDITSKFE 1050
    QLGTASTIES KIEEAVPYRE HALEKKGTSK RFSMLEGSNE LKHVVPPRKN 1100
    RNQDESGSID EEPVSKDMIV SLLKVIQKEF VNLFNLASSE ITDEKLQQFV 1150
    IMADNVQKLH STCSVYAEQI SPHSKFRFKE LLSQLEIYNR QIKFSHNPRA 1200
    KPVDDKLKMA FQDCFDQIMR LVDR 1224
    Length:1,224
    Mass (Da):138,326
    Last modified:January 17, 2003 - v4
    Checksum:i56D8513DD2061071
    GO
    Isoform b (identifier: P03949-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-63: Missing.

    Show »
    Length:1,214
    Mass (Da):137,259
    Checksum:iB0535D6CC47604C1
    GO
    Isoform c (identifier: P03949-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MGHSHSTGKE...SSTFRGSQSR → MIMNPCFRER...CFITATIDSL

    Show »
    Length:1,209
    Mass (Da):136,811
    Checksum:i733EA68DDB491076
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8888MGHSH…GSQSR → MIMNPCFRERSQKRTKKRAK NRAKSRSTMYLSKVGDSSLA MSRSLPSVALPMHYLHHKLA ESICFITATIDSL in isoform c. CuratedVSP_004962Add
    BLAST
    Alternative sequencei54 – 6310Missing in isoform b. CuratedVSP_004963

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50806 Genomic DNA. Translation: CAA90691.2.
    Z50806 Genomic DNA. Translation: CAB60296.2.
    Z50806 Genomic DNA. Translation: CAB60297.2.
    M13235 Genomic DNA. Translation: AAA28129.1.
    PIRiT23832.
    RefSeqiNP_509777.2. NM_077376.6. [P03949-2]
    NP_509778.2. NM_077377.4. [P03949-1]
    NP_509779.2. NM_077378.2. [P03949-3]
    UniGeneiCel.19997.

    Genome annotation databases

    EnsemblMetazoaiM79.1a; M79.1a; WBGene00000018. [P03949-1]
    GeneIDi181261.
    KEGGicel:CELE_M79.1.
    UCSCiM79.1b. c. elegans. [P03949-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50806 Genomic DNA. Translation: CAA90691.2 .
    Z50806 Genomic DNA. Translation: CAB60296.2 .
    Z50806 Genomic DNA. Translation: CAB60297.2 .
    M13235 Genomic DNA. Translation: AAA28129.1 .
    PIRi T23832.
    RefSeqi NP_509777.2. NM_077376.6. [P03949-2 ]
    NP_509778.2. NM_077377.4. [P03949-1 ]
    NP_509779.2. NM_077378.2. [P03949-3 ]
    UniGenei Cel.19997.

    3D structure databases

    ProteinModelPortali P03949.
    SMRi P03949. Positions 119-618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46173. 18 interactions.
    DIPi DIP-48409N.
    IntActi P03949. 46 interactions.

    Proteomic databases

    PaxDbi P03949.
    PRIDEi P03949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai M79.1a ; M79.1a ; WBGene00000018 . [P03949-1 ]
    GeneIDi 181261.
    KEGGi cel:CELE_M79.1.
    UCSCi M79.1b. c. elegans. [P03949-1 ]

    Organism-specific databases

    CTDi 181261.
    WormBasei M79.1a ; CE31570 ; WBGene00000018 ; abl-1.
    M79.1b ; CE31571 ; WBGene00000018 ; abl-1.
    M79.1c ; CE31572 ; WBGene00000018 ; abl-1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00640000091347.
    HOGENOMi HOG000017506.
    InParanoidi P03949.
    KOi K06619.
    OMAi CTHEAPF.
    OrthoDBi EOG7GTT2V.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1045.
    Reactomei REACT_183197. Factors involved in megakaryocyte development and platelet production.
    SignaLinki P03949.

    Miscellaneous databases

    NextBioi 913152.
    PROi P03949.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene."
      Goddard J.M., Weiland J.J., Capecchi M.R.
      Proc. Natl. Acad. Sci. U.S.A. 83:2172-2176(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-706.

    Entry informationi

    Entry nameiABL1_CAEEL
    AccessioniPrimary (citable) accession number: P03949
    Secondary accession number(s): Q9U3A2, Q9U3A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 1986
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 137 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3