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Protein

Cytochrome c oxidase subunit 1

Gene

cox-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron (heme A axial ligand)Curated1
Metal bindingi246Copper BCurated1
Metal bindingi250Copper BCurated1
Metal bindingi295Copper BCurated1
Metal bindingi296Copper BCurated1
Metal bindingi381Iron (heme A3 axial ligand)Curated1
Metal bindingi383Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox-1
Synonyms:coi, cox1
ORF Names:NCM025, NCU16016
Encoded oniMitochondrion
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:NCU16016.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833661 – 557Cytochrome c oxidase subunit 1Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity
Lipidationi324N6-myristoyl lysine1 Publication1

Post-translational modificationi

The amino end of the mature protein may be Ser-3.

Keywords - PTMi

Lipoprotein, Myristate

Structurei

3D structure databases

ProteinModelPortaliP03945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP03945.
OrthoDBiEOG092C2KU4.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSISIWTER WFLSTNAKDI GVLYLIFALF SGLLGTAFSV LIRMELSGPG
60 70 80 90 100
VQYIADNQLY NAIITAHAIL MIFFMVMPAL IGGFGNFLLP LLVGGPDMAF
110 120 130 140 150
PRLNNISFWL LPPSLLLLVF SACIEGGAGT GWTIYPPLSG VQSHSGPSVD
160 170 180 190 200
LAIFALHLSG VSSLLGSINF ITTIVNMRTP GIRLHKLALF GWAVVITAVL
210 220 230 240 250
LLLSLPVLAG AITMLLTDRN FNTSFFETAG GGDPILFQHL FWFFGHPEVY
260 270 280 290 300
ILIIPGFGII STTISAYSNK SVFGYIGMVY AMMSIGILGF IVWSHHMYTV
310 320 330 340 350
GLDVDTRAYF TAATLIIAVP TGIKIFSWLA TCYGGSIRLT PSMLFALGFV
360 370 380 390 400
FMFTIGGLSG VVLANASLDI AFHDTYYVVA HFHYVLSMGA VFAMFSGWYH
410 420 430 440 450
WVPKILGLNY NMVLSKAQFW LLFIGVNLTF FPQHFLGLQG MPRRISDYPD
460 470 480 490 500
AFSGWNLISS FGSIVSVVAS WLFLYIVYIQ LVQGEYAGRY PWSIPQFYTD
510 520 530 540 550
SLRALLNRSY PSLEWSISSP PKPHSFVSLP LQSSSFFLSF FRLSSYGEQK

EISGRQN
Length:557
Mass (Da):61,522
Last modified:December 14, 2011 - v2
Checksum:i8AC9618704E5C91D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527V → A in CAA25976 (PubMed:6327266).Curated1
Sequence conflicti527V → A in CAA28195 (PubMed:2531370).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01850 Genomic DNA. Translation: CAA25976.1.
M36958 Genomic DNA. No translation available.
X14669 Genomic DNA. Translation: CAA32799.1.
KC683708 Genomic DNA. Translation: AGG16005.1.
X04512 Genomic DNA. Translation: CAA28195.1.
PIRiA00469. ODNC1.
RefSeqiYP_009126717.1. NC_026614.1.

Genome annotation databases

EnsemblFungiiAGG16005; AGG16005; NCU16016.
GeneIDi23681570.
KEGGincr:NCU16016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01850 Genomic DNA. Translation: CAA25976.1.
M36958 Genomic DNA. No translation available.
X14669 Genomic DNA. Translation: CAA32799.1.
KC683708 Genomic DNA. Translation: AGG16005.1.
X04512 Genomic DNA. Translation: CAA28195.1.
PIRiA00469. ODNC1.
RefSeqiYP_009126717.1. NC_026614.1.

3D structure databases

ProteinModelPortaliP03945.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAGG16005; AGG16005; NCU16016.
GeneIDi23681570.
KEGGincr:NCU16016.

Organism-specific databases

EuPathDBiFungiDB:NCU16016.

Phylogenomic databases

InParanoidiP03945.
OrthoDBiEOG092C2KU4.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_NEUCR
AccessioniPrimary (citable) accession number: P03945
Secondary accession number(s): M1RV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.