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Protein

ATP synthase protein 8

Gene

Mtatp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
F-ATPase subunit 8
Gene namesi
Name:Mtatp8
Synonyms:Atp8, mt-Atp8
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:99926. mt-Atp8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2417HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767ATP synthase protein 8PRO_0000195551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-acetyllysine; alternateCombined sources
Modified residuei54 – 541N6-succinyllysine; alternateCombined sources
Modified residuei57 – 571N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP03930.
PaxDbiP03930.
PRIDEiP03930.

PTM databases

iPTMnetiP03930.
PhosphoSiteiP03930.

Expressioni

Gene expression databases

BgeeiP03930.
ExpressionAtlasiP03930. baseline and differential.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201540. 1 interaction.
STRINGi10090.ENSMUSP00000080995.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J587. Eukaryota.
ENOG411154N. LUCA.
HOGENOMiHOG000251628.
HOVERGENiHBG017400.
InParanoidiP03930.
KOiK02125.
OMAiLDTSTWF.
OrthoDBiEOG7SXW6D.
PhylomeDBiP03930.
TreeFamiTF343854.

Family and domain databases

InterProiIPR001421. ATP8_metazoa.
[Graphical view]
PfamiPF00895. ATP-synt_8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLDTSTWF ITIISSMITL FILFQLKVSS QTFPLAPSPK SLTTMKVKTP
60
WELKWTKIYL PHSLPQQ
Length:67
Mass (Da):7,766
Last modified:July 21, 1986 - v1
Checksum:i49C9BB34FF275349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48648.1.
V00711 Genomic DNA. Translation: CAA24084.1.
AY172335 Genomic DNA. Translation: AAN85126.1.
PIRiA01064. PWMS8.
RefSeqiNP_904332.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082407; ENSMUSP00000080995; ENSMUSG00000064356.
GeneIDi17706.
KEGGimmu:17706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48648.1.
V00711 Genomic DNA. Translation: CAA24084.1.
AY172335 Genomic DNA. Translation: AAN85126.1.
PIRiA01064. PWMS8.
RefSeqiNP_904332.1. NC_005089.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201540. 1 interaction.
STRINGi10090.ENSMUSP00000080995.

PTM databases

iPTMnetiP03930.
PhosphoSiteiP03930.

Proteomic databases

EPDiP03930.
PaxDbiP03930.
PRIDEiP03930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082407; ENSMUSP00000080995; ENSMUSG00000064356.
GeneIDi17706.
KEGGimmu:17706.

Organism-specific databases

CTDi4509.
MGIiMGI:99926. mt-Atp8.

Phylogenomic databases

eggNOGiENOG410J587. Eukaryota.
ENOG411154N. LUCA.
HOGENOMiHOG000251628.
HOVERGENiHBG017400.
InParanoidiP03930.
KOiK02125.
OMAiLDTSTWF.
OrthoDBiEOG7SXW6D.
PhylomeDBiP03930.
TreeFamiTF343854.

Miscellaneous databases

NextBioi292309.
PROiP03930.
SOURCEiSearch...

Gene expression databases

BgeeiP03930.
ExpressionAtlasiP03930. baseline and differential.

Family and domain databases

InterProiIPR001421. ATP8_metazoa.
[Graphical view]
PfamiPF00895. ATP-synt_8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 58-67, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-54 AND LYS-57, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiATP8_MOUSE
AccessioniPrimary (citable) accession number: P03930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.