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Protein

ATP synthase protein 8

Gene

Mtatp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
F-ATPase subunit 8
Gene namesi
Name:Mtatp8
Synonyms:Atp8, mt-Atp8
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:99926. mt-Atp8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001955511 – 67ATP synthase protein 8Add BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysine; alternateCombined sources1
Modified residuei54N6-succinyllysine; alternateCombined sources1
Modified residuei57N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP03930.
PaxDbiP03930.
PeptideAtlasiP03930.
PRIDEiP03930.

PTM databases

iPTMnetiP03930.
PhosphoSitePlusiP03930.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064356.
ExpressionAtlasiP03930. baseline and differential.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201540. 1 interactor.
STRINGi10090.ENSMUSP00000080995.

Structurei

3D structure databases

ProteinModelPortaliP03930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J587. Eukaryota.
ENOG411154N. LUCA.
GeneTreeiENSGT00390000008771.
HOGENOMiHOG000251628.
HOVERGENiHBG017400.
InParanoidiP03930.
KOiK02125.
OMAiLDTSTWF.
OrthoDBiEOG091G1977.
PhylomeDBiP03930.
TreeFamiTF343854.

Family and domain databases

InterProiIPR001421. ATP8_metazoa.
[Graphical view]
PfamiPF00895. ATP-synt_8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLDTSTWF ITIISSMITL FILFQLKVSS QTFPLAPSPK SLTTMKVKTP
60
WELKWTKIYL PHSLPQQ
Length:67
Mass (Da):7,766
Last modified:July 21, 1986 - v1
Checksum:i49C9BB34FF275349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48648.1.
V00711 Genomic DNA. Translation: CAA24084.1.
AY172335 Genomic DNA. Translation: AAN85126.1.
PIRiA01064. PWMS8.
RefSeqiNP_904332.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082407; ENSMUSP00000080995; ENSMUSG00000064356.
GeneIDi17706.
KEGGimmu:17706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48648.1.
V00711 Genomic DNA. Translation: CAA24084.1.
AY172335 Genomic DNA. Translation: AAN85126.1.
PIRiA01064. PWMS8.
RefSeqiNP_904332.1. NC_005089.1.

3D structure databases

ProteinModelPortaliP03930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201540. 1 interactor.
STRINGi10090.ENSMUSP00000080995.

PTM databases

iPTMnetiP03930.
PhosphoSitePlusiP03930.

Proteomic databases

EPDiP03930.
PaxDbiP03930.
PeptideAtlasiP03930.
PRIDEiP03930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082407; ENSMUSP00000080995; ENSMUSG00000064356.
GeneIDi17706.
KEGGimmu:17706.

Organism-specific databases

CTDi4509.
MGIiMGI:99926. mt-Atp8.

Phylogenomic databases

eggNOGiENOG410J587. Eukaryota.
ENOG411154N. LUCA.
GeneTreeiENSGT00390000008771.
HOGENOMiHOG000251628.
HOVERGENiHBG017400.
InParanoidiP03930.
KOiK02125.
OMAiLDTSTWF.
OrthoDBiEOG091G1977.
PhylomeDBiP03930.
TreeFamiTF343854.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiP03930.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064356.
ExpressionAtlasiP03930. baseline and differential.

Family and domain databases

InterProiIPR001421. ATP8_metazoa.
[Graphical view]
PfamiPF00895. ATP-synt_8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP8_MOUSE
AccessioniPrimary (citable) accession number: P03930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.