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Protein

ATP synthase protein 8

Gene

Mtatp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
F-ATPase subunit 8
Gene namesi
Name:Mtatp8
Synonyms:Atp8, mt-Atp8
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:99926 mt-Atp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001955511 – 67ATP synthase protein 8Add BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysine; alternateCombined sources1
Modified residuei54N6-succinyllysine; alternateCombined sources1
Modified residuei57N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP03930
PaxDbiP03930
PeptideAtlasiP03930
PRIDEiP03930

PTM databases

iPTMnetiP03930
PhosphoSitePlusiP03930

Expressioni

Gene expression databases

BgeeiENSMUSG00000064356
ExpressionAtlasiP03930 baseline and differential

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201540, 1 interactor
STRINGi10090.ENSMUSP00000080995

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J587 Eukaryota
ENOG411154N LUCA
GeneTreeiENSGT00390000008771
HOGENOMiHOG000251628
HOVERGENiHBG017400
InParanoidiP03930
KOiK02125
OMAiLDTSTWF
OrthoDBiEOG091G1977
PhylomeDBiP03930
TreeFamiTF343854

Family and domain databases

InterProiView protein in InterPro
IPR001421 ATP8_metazoa
PfamiView protein in Pfam
PF00895 ATP-synt_8, 1 hit

Sequencei

Sequence statusi: Complete.

P03930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLDTSTWF ITIISSMITL FILFQLKVSS QTFPLAPSPK SLTTMKVKTP
60
WELKWTKIYL PHSLPQQ
Length:67
Mass (Da):7,766
Last modified:July 21, 1986 - v1
Checksum:i49C9BB34FF275349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48648.1
V00711 Genomic DNA Translation: CAA24084.1
AY172335 Genomic DNA Translation: AAN85126.1
PIRiA01064 PWMS8
RefSeqiNP_904332.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082407; ENSMUSP00000080995; ENSMUSG00000064356
GeneIDi17706
KEGGimmu:17706

Similar proteinsi

Entry informationi

Entry nameiATP8_MOUSE
AccessioniPrimary (citable) accession number: P03930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health