Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase protein 8

Gene

MT-ATP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane (By similarity).By similarity

GO - Molecular functioni

  • proton transmembrane transporter activity Source: InterPro
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • ATP biosynthetic process Source: Reactome
  • cristae formation Source: Reactome
  • mitochondrial ATP synthesis coupled proton transport Source: UniProtKB

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase protein 8
Alternative name(s):
A6L
F-ATPase subunit 8
Gene namesi
Name:MT-ATP8
Synonyms:ATP8, ATPASE8, MTATP8
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiHostDB:ENSG00000228253.1
HGNCiHGNC:7415 MT-ATP8
MIMi516070 gene+phenotype
neXtProtiNX_P03928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disorder with heterogeneous clinical manifestations including neuropathy, ataxia, hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy can present with negligible to extreme hypertrophy, minimal to extensive fibrosis and myocyte disarray, absent to severe left ventricular outflow tract obstruction, and distinct septal contours/morphologies with extremely varying clinical course.
See also OMIM:516070
Cardiomyopathy, infantile hypertrophic (CMHI)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionAn infantile form of hypertrophic cardiomyopathy, a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:500006

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNETi4509
MalaCardsiMT-ATP8
MIMi500006 phenotype
516070 gene+phenotype
OpenTargetsiENSG00000228253
Orphaneti155 Familial isolated hypertrophic cardiomyopathy
480 Kearns-Sayre syndrome
397750 Periodic paralysis with later-onset distal motor neuropathy
PharmGKBiPA31222

Polymorphism and mutation databases

DMDMi114483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001955361 – 68ATP synthase protein 8Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysine; alternateBy similarity1
Modified residuei54N6-succinyllysine; alternateBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP03928
PaxDbiP03928
PeptideAtlasiP03928
PRIDEiP03928
TopDownProteomicsiP03928

PTM databases

iPTMnetiP03928
PhosphoSitePlusiP03928
SwissPalmiP03928

Expressioni

Gene expression databases

BgeeiENSG00000228253
ExpressionAtlasiP03928 baseline and differential
GenevisibleiP03928 HS

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi110613, 21 interactors
CORUMiP03928
IntActiP03928, 7 interactors
MINTiP03928
STRINGi9606.ENSP00000355265

Structurei

3D structure databases

ProteinModelPortaliP03928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase protein 8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J587 Eukaryota
ENOG411154N LUCA
GeneTreeiENSGT00390000008771
HOGENOMiHOG000251628
HOVERGENiHBG017400
InParanoidiP03928
KOiK02125
OMAiLDTSTWF
OrthoDBiEOG091G1977
PhylomeDBiP03928

Family and domain databases

InterProiView protein in InterPro
IPR001421 ATP8_metazoa
PfamiView protein in Pfam
PF00895 ATP-synt_8, 1 hit

Sequencei

Sequence statusi: Complete.

P03928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNTTVWP TMITPMLLTL FLITQLKMLN TNYHLPPSPK PMKMKNYNKP
60
WEPKWTKICS LHSLPPQS
Length:68
Mass (Da):7,992
Last modified:July 21, 1986 - v1
Checksum:i7D307E513AD76936
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → S in AAP90483 (PubMed:12949126).Curated1
Sequence conflicti32N → S in BAA07294 (PubMed:7530363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00856317L → P1 Publication1
Natural variantiVAR_00856421F → S1 Publication1
Natural variantiVAR_00856528M → T1 PublicationCorresponds to variant dbSNP:rs879056797Ensembl.1
Natural variantiVAR_06952755W → R in MC5DM2 and CMHI. 1 PublicationCorresponds to variant dbSNP:rs387906422Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58947.1
V00662 Genomic DNA Translation: CAA24030.1
D38112 Genomic DNA Translation: BAA07294.1
AY339402 Genomic DNA Translation: AAP89040.1
AY339403 Genomic DNA Translation: AAP89053.1
AY339404 Genomic DNA Translation: AAP89066.1
AY339405 Genomic DNA Translation: AAP89079.1
AY339406 Genomic DNA Translation: AAP89092.1
AY339407 Genomic DNA Translation: AAP89105.1
AY339408 Genomic DNA Translation: AAP89118.1
AY339409 Genomic DNA Translation: AAP89131.1
AY339410 Genomic DNA Translation: AAP89144.1
AY339411 Genomic DNA Translation: AAP89157.1
AY339412 Genomic DNA Translation: AAP89170.1
AY339413 Genomic DNA Translation: AAP89183.1
AY339414 Genomic DNA Translation: AAP89196.1
AY339415 Genomic DNA Translation: AAP89209.1
AY339416 Genomic DNA Translation: AAP89222.1
AY339417 Genomic DNA Translation: AAP89235.1
AY339418 Genomic DNA Translation: AAP89248.1
AY339419 Genomic DNA Translation: AAP89261.1
AY339420 Genomic DNA Translation: AAP89274.1
AY339421 Genomic DNA Translation: AAP89287.1
AY339422 Genomic DNA Translation: AAP89300.1
AY339423 Genomic DNA Translation: AAP89313.1
AY339424 Genomic DNA Translation: AAP89326.1
AY339425 Genomic DNA Translation: AAP89339.1
AY339426 Genomic DNA Translation: AAP89352.1
AY339427 Genomic DNA Translation: AAP89365.1
AY339428 Genomic DNA Translation: AAP89378.1
AY339429 Genomic DNA Translation: AAP89391.1
AY339430 Genomic DNA Translation: AAP89404.1
AY339431 Genomic DNA Translation: AAP89417.1
AY339432 Genomic DNA Translation: AAP89430.1
AY339433 Genomic DNA Translation: AAP89443.1
AY339434 Genomic DNA Translation: AAP89456.1
AY339435 Genomic DNA Translation: AAP89469.1
AY339436 Genomic DNA Translation: AAP89482.1
AY339437 Genomic DNA Translation: AAP89495.1
AY339438 Genomic DNA Translation: AAP89508.1
AY339439 Genomic DNA Translation: AAP89521.1
AY339440 Genomic DNA Translation: AAP89534.1
AY339441 Genomic DNA Translation: AAP89547.1
AY339442 Genomic DNA Translation: AAP89560.1
AY339443 Genomic DNA Translation: AAP89573.1
AY339444 Genomic DNA Translation: AAP89586.1
AY339445 Genomic DNA Translation: AAP89599.1
AY339446 Genomic DNA Translation: AAP89612.1
AY339447 Genomic DNA Translation: AAP89625.1
AY339448 Genomic DNA Translation: AAP89638.1
AY339449 Genomic DNA Translation: AAP89651.1
AY339450 Genomic DNA Translation: AAP89664.1
AY339451 Genomic DNA Translation: AAP89677.1
AY339452 Genomic DNA Translation: AAP89690.1
AY339453 Genomic DNA Translation: AAP89703.1
AY339454 Genomic DNA Translation: AAP89716.1
AY339455 Genomic DNA Translation: AAP89729.1
AY339456 Genomic DNA Translation: AAP89742.1
AY339457 Genomic DNA Translation: AAP89755.1
AY339458 Genomic DNA Translation: AAP89768.1
AY339459 Genomic DNA Translation: AAP89781.1
AY339460 Genomic DNA Translation: AAP89794.1
AY339461 Genomic DNA Translation: AAP89807.1
AY339462 Genomic DNA Translation: AAP89820.1
AY339463 Genomic DNA Translation: AAP89833.1
AY339464 Genomic DNA Translation: AAP89846.1
AY339465 Genomic DNA Translation: AAP89859.1
AY339466 Genomic DNA Translation: AAP89872.1
AY339467 Genomic DNA Translation: AAP89885.1
AY339468 Genomic DNA Translation: AAP89898.1
AY339469 Genomic DNA Translation: AAP89911.1
AY339470 Genomic DNA Translation: AAP89924.1
AY339471 Genomic DNA Translation: AAP89937.1
AY339472 Genomic DNA Translation: AAP89950.1
AY339473 Genomic DNA Translation: AAP89963.1
AY339474 Genomic DNA Translation: AAP89976.1
AY339475 Genomic DNA Translation: AAP89989.1
AY339476 Genomic DNA Translation: AAP90002.1
AY339477 Genomic DNA Translation: AAP90015.1
AY339478 Genomic DNA Translation: AAP90028.1
AY339479 Genomic DNA Translation: AAP90041.1
AY339480 Genomic DNA Translation: AAP90054.1
AY339481 Genomic DNA Translation: AAP90067.1
AY339482 Genomic DNA Translation: AAP90080.1
AY339483 Genomic DNA Translation: AAP90093.1
AY339484 Genomic DNA Translation: AAP90106.1
AY339485 Genomic DNA Translation: AAP90119.1
AY339486 Genomic DNA Translation: AAP90132.1
AY339487 Genomic DNA Translation: AAP90145.1
AY339488 Genomic DNA Translation: AAP90158.1
AY339489 Genomic DNA Translation: AAP90171.1
AY339490 Genomic DNA Translation: AAP90184.1
AY339491 Genomic DNA Translation: AAP90197.1
AY339492 Genomic DNA Translation: AAP90210.1
AY339493 Genomic DNA Translation: AAP90223.1
AY339494 Genomic DNA Translation: AAP90236.1
AY339495 Genomic DNA Translation: AAP90249.1
AY339496 Genomic DNA Translation: AAP90262.1
AY339497 Genomic DNA Translation: AAP90275.1
AY339498 Genomic DNA Translation: AAP90288.1
AY339499 Genomic DNA Translation: AAP90301.1
AY339500 Genomic DNA Translation: AAP90314.1
AY339501 Genomic DNA Translation: AAP90327.1
AY339502 Genomic DNA Translation: AAP90340.1
AY339503 Genomic DNA Translation: AAP90353.1
AY339504 Genomic DNA Translation: AAP90366.1
AY339505 Genomic DNA Translation: AAP90379.1
AY339506 Genomic DNA Translation: AAP90392.1
AY339507 Genomic DNA Translation: AAP90405.1
AY339508 Genomic DNA Translation: AAP90418.1
AY339509 Genomic DNA Translation: AAP90431.1
AY339510 Genomic DNA Translation: AAP90444.1
AY339511 Genomic DNA Translation: AAP90457.1
AY339512 Genomic DNA Translation: AAP90470.1
AY339513 Genomic DNA Translation: AAP90483.2
AY339515 Genomic DNA Translation: AAP90509.1
AY339516 Genomic DNA Translation: AAP90522.1
AY339517 Genomic DNA Translation: AAP90535.1
AY339518 Genomic DNA Translation: AAP90548.1
AY339519 Genomic DNA Translation: AAP90561.1
AY339520 Genomic DNA Translation: AAP90574.1
AY339521 Genomic DNA Translation: AAP90587.1
AY339522 Genomic DNA Translation: AAP90600.1
AY339523 Genomic DNA Translation: AAP90613.1
AY339524 Genomic DNA Translation: AAP90626.1
AY339525 Genomic DNA Translation: AAP90639.1
AY339526 Genomic DNA Translation: AAP90652.1
AY339527 Genomic DNA Translation: AAP90665.1
AY339528 Genomic DNA Translation: AAP90678.1
AY339529 Genomic DNA Translation: AAP90691.1
AY339530 Genomic DNA Translation: AAP90704.1
AY339531 Genomic DNA Translation: AAP90717.1
AY339532 Genomic DNA Translation: AAP90730.1
AY339533 Genomic DNA Translation: AAP90743.1
AY339534 Genomic DNA Translation: AAP90756.1
AY339535 Genomic DNA Translation: AAP90769.1
AY339536 Genomic DNA Translation: AAP90782.1
AY339537 Genomic DNA Translation: AAP90795.1
AY339538 Genomic DNA Translation: AAP90808.1
AY339539 Genomic DNA Translation: AAP90821.1
AY339540 Genomic DNA Translation: AAP90834.1
AY339541 Genomic DNA Translation: AAP90847.1
AY339542 Genomic DNA Translation: AAP90860.1
AY339543 Genomic DNA Translation: AAP90873.1
AY339544 Genomic DNA Translation: AAP90886.1
AY339545 Genomic DNA Translation: AAP90899.1
AY339546 Genomic DNA Translation: AAP90912.1
AY339547 Genomic DNA Translation: AAP90925.1
AY339548 Genomic DNA Translation: AAP90938.1
AY339549 Genomic DNA Translation: AAP90951.1
AY339550 Genomic DNA Translation: AAP90964.1
AY339551 Genomic DNA Translation: AAP90977.1
AY339552 Genomic DNA Translation: AAP90990.1
AY339553 Genomic DNA Translation: AAP91003.1
AY339554 Genomic DNA Translation: AAP91016.1
AY339555 Genomic DNA Translation: AAP91029.1
AY339556 Genomic DNA Translation: AAP91042.1
AY339557 Genomic DNA Translation: AAP91055.1
AY339558 Genomic DNA Translation: AAP91068.1
AY339559 Genomic DNA Translation: AAP91081.1
AY339560 Genomic DNA Translation: AAP91094.1
AY339561 Genomic DNA Translation: AAP91107.1
AY339562 Genomic DNA Translation: AAP91120.1
AY339563 Genomic DNA Translation: AAP91133.1
AY339564 Genomic DNA Translation: AAP91146.1
AY339565 Genomic DNA Translation: AAP91159.1
AY339566 Genomic DNA Translation: AAP91172.1
AY339567 Genomic DNA Translation: AAP91185.1
AY339568 Genomic DNA Translation: AAP91198.1
AY339569 Genomic DNA Translation: AAP91211.1
AY339570 Genomic DNA Translation: AAP91224.1
AY339571 Genomic DNA Translation: AAP91237.1
AY339572 Genomic DNA Translation: AAP91250.1
AY339573 Genomic DNA Translation: AAP91263.1
AY339574 Genomic DNA Translation: AAP91276.1
AY339575 Genomic DNA Translation: AAP91289.1
AY339576 Genomic DNA Translation: AAP91302.1
AY339577 Genomic DNA Translation: AAP91315.1
AY339578 Genomic DNA Translation: AAP91328.1
AY339579 Genomic DNA Translation: AAP91341.1
AY339580 Genomic DNA Translation: AAP91354.1
AY339581 Genomic DNA Translation: AAP91367.1
AY339582 Genomic DNA Translation: AAP91380.1
AY339583 Genomic DNA Translation: AAP91393.1
AY339584 Genomic DNA Translation: AAP91406.1
AY339585 Genomic DNA Translation: AAP91419.1
AY339586 Genomic DNA Translation: AAP91432.1
AY339587 Genomic DNA Translation: AAP91445.1
AY339588 Genomic DNA Translation: AAP91458.1
AY339589 Genomic DNA Translation: AAP91471.1
AY339590 Genomic DNA Translation: AAP91484.1
AY339591 Genomic DNA Translation: AAP91497.1
AY339592 Genomic DNA Translation: AAP91510.1
AY339593 Genomic DNA Translation: AAP91523.1
AF346963 Genomic DNA Translation: AAK17211.1
AF346964 Genomic DNA Translation: AAK17224.1
AF346965 Genomic DNA Translation: AAK17237.1
AF346966 Genomic DNA Translation: AAK17250.1
AF346967 Genomic DNA Translation: AAK17263.1
AF346968 Genomic DNA Translation: AAK17276.1
AF346969 Genomic DNA Translation: AAK17289.1
AF346970 Genomic DNA Translation: AAK17302.1
AF346971 Genomic DNA Translation: AAK17315.1
AF346972 Genomic DNA Translation: AAK17328.1
AF346973 Genomic DNA Translation: AAK17341.1
AF346974 Genomic DNA Translation: AAK17354.1
AF346975 Genomic DNA Translation: AAK17367.1
AF346976 Genomic DNA Translation: AAK17380.1
AF346977 Genomic DNA Translation: AAK17393.1
AF346978 Genomic DNA Translation: AAK17406.1
AF346979 Genomic DNA Translation: AAK17419.1
AF346980 Genomic DNA Translation: AAK17432.1
AF346981 Genomic DNA Translation: AAK17445.1
AF346982 Genomic DNA Translation: AAK17458.1
AF346983 Genomic DNA Translation: AAK17471.1
AF346985 Genomic DNA Translation: AAK17497.1
AF346986 Genomic DNA Translation: AAK17510.1
AF346987 Genomic DNA Translation: AAK17523.1
AF346988 Genomic DNA Translation: AAK17536.1
AF346991 Genomic DNA Translation: AAK17575.1
AF346992 Genomic DNA Translation: AAK17588.1
AF346993 Genomic DNA Translation: AAK17601.1
AF346994 Genomic DNA Translation: AAK17614.1
AF346995 Genomic DNA Translation: AAK17627.1
AF346996 Genomic DNA Translation: AAK17640.1
AF346997 Genomic DNA Translation: AAK17653.1
AF347000 Genomic DNA Translation: AAK17692.1
AF347001 Genomic DNA Translation: AAK17705.1
AF347002 Genomic DNA Translation: AAK17718.1
AF347003 Genomic DNA Translation: AAK17731.1
AF347004 Genomic DNA Translation: AAK17744.1
AF347005 Genomic DNA Translation: AAK17757.1
AF347006 Genomic DNA Translation: AAK17770.1
AF347007 Genomic DNA Translation: AAK17783.1
AF347008 Genomic DNA Translation: AAK17796.1
AF347009 Genomic DNA Translation: AAK17809.1
AF347011 Genomic DNA Translation: AAK17835.1
AF347012 Genomic DNA Translation: AAK17848.1
AF347013 Genomic DNA Translation: AAK17861.1
AF347014 Genomic DNA Translation: AAK17874.1
AF347015 Genomic DNA Translation: AAK17887.1
AY289051 Genomic DNA Translation: AAP47884.1
AY289052 Genomic DNA Translation: AAP47897.1
AY289053 Genomic DNA Translation: AAP47910.1
AY289056 Genomic DNA Translation: AAP47949.1
AY289057 Genomic DNA Translation: AAP47962.1
AY289058 Genomic DNA Translation: AAP47975.1
AY289059 Genomic DNA Translation: AAP47988.1
AY289060 Genomic DNA Translation: AAP48001.1
AY289061 Genomic DNA Translation: AAP48014.1
AY289062 Genomic DNA Translation: AAP48027.1
AY289063 Genomic DNA Translation: AAP48040.1
AY289064 Genomic DNA Translation: AAP48053.1
AY289065 Genomic DNA Translation: AAP48066.1
AY289066 Genomic DNA Translation: AAP48079.1
AY289067 Genomic DNA Translation: AAP48092.1
AY289068 Genomic DNA Translation: AAP48105.1
AY289069 Genomic DNA Translation: AAP48118.1
AY289070 Genomic DNA Translation: AAP48131.1
AY289071 Genomic DNA Translation: AAP48144.1
AY289072 Genomic DNA Translation: AAP48157.1
AY289073 Genomic DNA Translation: AAP48170.1
AY289074 Genomic DNA Translation: AAP48183.1
AY289075 Genomic DNA Translation: AAP48196.1
AY289076 Genomic DNA Translation: AAP48209.1
AY289077 Genomic DNA Translation: AAP48222.1
AY289078 Genomic DNA Translation: AAP48235.1
AY289080 Genomic DNA Translation: AAP48261.1
AY289081 Genomic DNA Translation: AAP48274.1
AY289082 Genomic DNA Translation: AAP48287.1
AY289083 Genomic DNA Translation: AAP48300.1
AY289084 Genomic DNA Translation: AAP48313.1
AY289085 Genomic DNA Translation: AAP48326.1
AY289086 Genomic DNA Translation: AAP48339.1
AY289087 Genomic DNA Translation: AAP48352.1
AY289088 Genomic DNA Translation: AAP48365.1
AY289089 Genomic DNA Translation: AAP48378.1
AY289090 Genomic DNA Translation: AAP48391.1
AY289091 Genomic DNA Translation: AAP48404.1
AY289092 Genomic DNA Translation: AAP48417.1
AY289093 Genomic DNA Translation: AAP48429.1
AY289094 Genomic DNA Translation: AAP48442.1
AY289095 Genomic DNA Translation: AAP48455.1
AY289096 Genomic DNA Translation: AAP48468.1
AY289097 Genomic DNA Translation: AAP48481.1
AY289098 Genomic DNA Translation: AAP48494.1
AY289099 Genomic DNA Translation: AAP48507.1
AY289100 Genomic DNA Translation: AAP48520.1
AY289101 Genomic DNA Translation: AAP48533.1
AY289102 Genomic DNA Translation: AAP48546.1
AY495090 Genomic DNA Translation: AAR92500.1
AY495091 Genomic DNA Translation: AAR92513.1
AY495092 Genomic DNA Translation: AAR92526.1
AY495093 Genomic DNA Translation: AAR92539.1
AY495094 Genomic DNA Translation: AAR92552.1
AY495095 Genomic DNA Translation: AAR92565.1
AY495096 Genomic DNA Translation: AAR92578.1
AY495097 Genomic DNA Translation: AAR92591.1
AY495098 Genomic DNA Translation: AAR92604.1
AY495099 Genomic DNA Translation: AAR92617.1
AY495100 Genomic DNA Translation: AAR92630.1
AY495101 Genomic DNA Translation: AAR92643.1
AY495102 Genomic DNA Translation: AAR92656.1
AY495103 Genomic DNA Translation: AAR92669.1
AY495104 Genomic DNA Translation: AAR92682.1
AY495105 Genomic DNA Translation: AAR92695.1
AY495106 Genomic DNA Translation: AAR92708.1
AY495107 Genomic DNA Translation: AAR92721.1
AY495108 Genomic DNA Translation: AAR92734.1
AY495109 Genomic DNA Translation: AAR92747.1
AY495110 Genomic DNA Translation: AAR92760.1
AY495111 Genomic DNA Translation: AAR92773.1
AY495112 Genomic DNA Translation: AAR92786.1
AY495113 Genomic DNA Translation: AAR92799.1
AY495114 Genomic DNA Translation: AAR92812.1
AY495115 Genomic DNA Translation: AAR92825.1
AY495116 Genomic DNA Translation: AAR92838.1
AY495117 Genomic DNA Translation: AAR92851.1
AY495118 Genomic DNA Translation: AAR92864.1
AY495119 Genomic DNA Translation: AAR92877.1
AY495120 Genomic DNA Translation: AAR92890.1
AY495121 Genomic DNA Translation: AAR92903.1
AY495122 Genomic DNA Translation: AAR92916.1
AY495124 Genomic DNA Translation: AAR92942.1
AY495125 Genomic DNA Translation: AAR92955.1
AY495126 Genomic DNA Translation: AAR92968.1
AY495127 Genomic DNA Translation: AAR92981.1
AY495128 Genomic DNA Translation: AAR92994.1
AY495129 Genomic DNA Translation: AAR93007.1
AY495130 Genomic DNA Translation: AAR93020.1
AY495131 Genomic DNA Translation: AAR93033.1
AY495132 Genomic DNA Translation: AAR93046.1
AY495133 Genomic DNA Translation: AAR93059.1
AY495134 Genomic DNA Translation: AAR93072.1
AY495135 Genomic DNA Translation: AAR93085.1
AY495136 Genomic DNA Translation: AAR93098.1
AY495137 Genomic DNA Translation: AAR93111.1
AY495138 Genomic DNA Translation: AAR93124.1
AY495139 Genomic DNA Translation: AAR93137.1
AY495140 Genomic DNA Translation: AAR93150.1
AY495141 Genomic DNA Translation: AAR93163.1
AY495142 Genomic DNA Translation: AAR93176.1
AY495143 Genomic DNA Translation: AAR93189.1
AY495144 Genomic DNA Translation: AAR93202.1
AY495145 Genomic DNA Translation: AAR93215.1
AY495146 Genomic DNA Translation: AAR93228.1
AY495147 Genomic DNA Translation: AAR93241.1
AY495148 Genomic DNA Translation: AAR93254.1
AY495149 Genomic DNA Translation: AAR93267.1
AY495150 Genomic DNA Translation: AAR93280.1
AY495151 Genomic DNA Translation: AAR93293.1
AY495152 Genomic DNA Translation: AAR93306.1
AY495153 Genomic DNA Translation: AAR93319.1
AY495154 Genomic DNA Translation: AAR93332.1
AY495155 Genomic DNA Translation: AAR93345.1
AY495156 Genomic DNA Translation: AAR93358.1
AY495157 Genomic DNA Translation: AAR93371.1
AY495158 Genomic DNA Translation: AAR93384.1
AY495159 Genomic DNA Translation: AAR93397.1
AY495160 Genomic DNA Translation: AAR93410.1
AY495161 Genomic DNA Translation: AAR93423.1
AY495162 Genomic DNA Translation: AAR93436.1
AY495163 Genomic DNA Translation: AAR93449.1
AY495164 Genomic DNA Translation: AAR93462.1
AY495165 Genomic DNA Translation: AAR93475.1
AY495166 Genomic DNA Translation: AAR93488.1
AY495167 Genomic DNA Translation: AAR93501.1
AY495168 Genomic DNA Translation: AAR93514.1
AY495169 Genomic DNA Translation: AAR93527.1
AY495170 Genomic DNA Translation: AAR93540.1
AY495171 Genomic DNA Translation: AAR93553.1
AY495172 Genomic DNA Translation: AAR93566.1
AY495173 Genomic DNA Translation: AAR93579.1
AY495174 Genomic DNA Translation: AAR93592.1
AY495175 Genomic DNA Translation: AAR93605.1
AY495176 Genomic DNA Translation: AAR93618.1
AY495177 Genomic DNA Translation: AAR93631.1
AY495178 Genomic DNA Translation: AAR93644.1
AY495179 Genomic DNA Translation: AAR93657.1
AY495180 Genomic DNA Translation: AAR93670.1
AY495181 Genomic DNA Translation: AAR93683.1
AY495182 Genomic DNA Translation: AAR93696.1
AY495183 Genomic DNA Translation: AAR93709.1
AY495184 Genomic DNA Translation: AAR93722.1
AY495185 Genomic DNA Translation: AAR93735.1
AY495186 Genomic DNA Translation: AAR93748.1
AY495187 Genomic DNA Translation: AAR93761.1
AY495188 Genomic DNA Translation: AAR93774.1
AY495189 Genomic DNA Translation: AAR93787.1
AY495190 Genomic DNA Translation: AAR93800.1
AY495191 Genomic DNA Translation: AAR93813.1
AY495192 Genomic DNA Translation: AAR93826.1
AY495193 Genomic DNA Translation: AAR93839.1
AY495194 Genomic DNA Translation: AAR93852.1
AY495195 Genomic DNA Translation: AAR93865.1
AY495196 Genomic DNA Translation: AAR93878.1
AY495197 Genomic DNA Translation: AAR93891.1
AY495198 Genomic DNA Translation: AAR93904.1
AY495199 Genomic DNA Translation: AAR93917.1
AY495200 Genomic DNA Translation: AAR93930.1
AY495201 Genomic DNA Translation: AAR93943.1
AY495202 Genomic DNA Translation: AAR93956.1
AY495203 Genomic DNA Translation: AAR93969.1
AY495204 Genomic DNA Translation: AAR93982.1
AY495205 Genomic DNA Translation: AAR93995.1
AY495206 Genomic DNA Translation: AAR94008.1
AY495207 Genomic DNA Translation: AAR94021.1
AY495208 Genomic DNA Translation: AAR94034.1
AY495209 Genomic DNA Translation: AAR94047.1
AY495210 Genomic DNA Translation: AAR94060.1
AY495211 Genomic DNA Translation: AAR94073.1
AY495212 Genomic DNA Translation: AAR94086.1
AY495213 Genomic DNA Translation: AAR94099.1
AY495214 Genomic DNA Translation: AAR94112.1
AY495215 Genomic DNA Translation: AAR94125.1
AY495216 Genomic DNA Translation: AAR94138.1
AY495217 Genomic DNA Translation: AAR94151.1
AY495218 Genomic DNA Translation: AAR94164.1
AY495219 Genomic DNA Translation: AAR94177.1
AY495220 Genomic DNA Translation: AAR94190.1
AY495221 Genomic DNA Translation: AAR94203.1
AY495222 Genomic DNA Translation: AAR94216.1
AY495223 Genomic DNA Translation: AAR94229.1
AY495224 Genomic DNA Translation: AAR94242.1
AY495225 Genomic DNA Translation: AAR94255.1
AY495227 Genomic DNA Translation: AAR94281.1
AY495228 Genomic DNA Translation: AAR94294.1
AY495229 Genomic DNA Translation: AAR94307.1
AY495230 Genomic DNA Translation: AAR94320.1
AY495231 Genomic DNA Translation: AAR94333.1
AY495232 Genomic DNA Translation: AAR94346.1
AY495233 Genomic DNA Translation: AAR94359.1
AY495234 Genomic DNA Translation: AAR94372.1
AY495235 Genomic DNA Translation: AAR94385.1
AY495236 Genomic DNA Translation: AAR94398.1
AY495237 Genomic DNA Translation: AAR94411.1
AY495238 Genomic DNA Translation: AAR94424.1
AY495239 Genomic DNA Translation: AAR94437.1
AY495240 Genomic DNA Translation: AAR94450.1
AY495241 Genomic DNA Translation: AAR94463.1
AY495242 Genomic DNA Translation: AAR94476.1
AY495243 Genomic DNA Translation: AAR94489.1
AY495244 Genomic DNA Translation: AAR94502.1
AY495245 Genomic DNA Translation: AAR94515.1
AY495246 Genomic DNA Translation: AAR94528.1
AY495247 Genomic DNA Translation: AAR94541.1
AY495248 Genomic DNA Translation: AAR94554.1
AY495249 Genomic DNA Translation: AAR94567.1
AY495250 Genomic DNA Translation: AAR94580.1
AY495251 Genomic DNA Translation: AAR94593.1
AY495252 Genomic DNA Translation: AAR94606.1
AY495253 Genomic DNA Translation: AAR94619.1
AY495254 Genomic DNA Translation: AAR94632.1
AY495255 Genomic DNA Translation: AAR94645.1
AY495256 Genomic DNA Translation: AAR94658.1
AY495257 Genomic DNA Translation: AAR94671.1
AY495259 Genomic DNA Translation: AAR94697.1
AY495260 Genomic DNA Translation: AAR94710.1
AY495261 Genomic DNA Translation: AAR94723.1
AY495262 Genomic DNA Translation: AAR94736.1
AY495263 Genomic DNA Translation: AAR94749.1
AY495264 Genomic DNA Translation: AAR94762.1
AY495265 Genomic DNA Translation: AAR94775.1
AY495266 Genomic DNA Translation: AAR94788.1
AY495267 Genomic DNA Translation: AAR94801.1
AY495268 Genomic DNA Translation: AAR94814.1
AY495269 Genomic DNA Translation: AAR94827.1
AY495270 Genomic DNA Translation: AAR94840.1
AY495271 Genomic DNA Translation: AAR94853.1
AY495272 Genomic DNA Translation: AAR94866.1
AY495273 Genomic DNA Translation: AAR94879.1
AY495274 Genomic DNA Translation: AAR94892.1
AY495275 Genomic DNA Translation: AAR94905.1
AY495277 Genomic DNA Translation: AAR94931.1
AY495278 Genomic DNA Translation: AAR94944.1
AY495279 Genomic DNA Translation: AAR94957.1
AY495280 Genomic DNA Translation: AAR94970.1
AY495281 Genomic DNA Translation: AAR94983.1
AY495282 Genomic DNA Translation: AAR94996.1
AY495284 Genomic DNA Translation: AAR95022.1
AY495285 Genomic DNA Translation: AAR95035.1
AY495286 Genomic DNA Translation: AAR95048.1
AY495287 Genomic DNA Translation: AAR95061.1
AY495288 Genomic DNA Translation: AAR95074.1
AY495289 Genomic DNA Translation: AAR95087.1
AY495290 Genomic DNA Translation: AAR95100.1
AY495291 Genomic DNA Translation: AAR95113.1
AY495292 Genomic DNA Translation: AAR95126.1
AY495293 Genomic DNA Translation: AAR95139.1
AY495294 Genomic DNA Translation: AAR95152.1
AY495295 Genomic DNA Translation: AAR95165.1
AY495296 Genomic DNA Translation: AAR95178.1
AY495297 Genomic DNA Translation: AAR95191.1
AY495298 Genomic DNA Translation: AAR95204.1
AY495299 Genomic DNA Translation: AAR95217.1
AY495301 Genomic DNA Translation: AAR95243.1
AY495302 Genomic DNA Translation: AAR95256.1
AY495304 Genomic DNA Translation: AAR95282.1
AY495305 Genomic DNA Translation: AAR95295.1
AY495306 Genomic DNA Translation: AAR95308.1
AY495307 Genomic DNA Translation: AAR95321.1
AY495308 Genomic DNA Translation: AAR95334.1
AY495309 Genomic DNA Translation: AAR95347.1
AY495310 Genomic DNA Translation: AAR95360.1
AY495311 Genomic DNA Translation: AAR95373.1
AY495312 Genomic DNA Translation: AAR95386.1
AY495313 Genomic DNA Translation: AAR95399.1
AY495314 Genomic DNA Translation: AAR95412.1
AY495315 Genomic DNA Translation: AAR95425.1
AY495316 Genomic DNA Translation: AAR95438.1
AY495317 Genomic DNA Translation: AAR95451.1
AY495318 Genomic DNA Translation: AAR95464.1
AY495319 Genomic DNA Translation: AAR95477.1
AY495320 Genomic DNA Translation: AAR95490.1
AY495322 Genomic DNA Translation: AAR95516.1
AY495323 Genomic DNA Translation: AAR95529.1
AY495324 Genomic DNA Translation: AAR95542.1
AY495325 Genomic DNA Translation: AAR95555.1
AY495326 Genomic DNA Translation: AAR95568.1
AY495327 Genomic DNA Translation: AAR95581.1
AY495328 Genomic DNA Translation: AAR95594.1
AY495329 Genomic DNA Translation: AAR95607.1
AY495330 Genomic DNA Translation: AAR95620.1
PIRiA01062 PWHU8
RefSeqiYP_003024030.1, NC_012920.1

Genome annotation databases

EnsembliENST00000361851; ENSP00000355265; ENSG00000228253
GeneIDi4509
KEGGihsa:4509

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATP8_HUMAN
AccessioniPrimary (citable) accession number: P03928
Secondary accession number(s): Q34771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health