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P03925

- NU6M_MOUSE

UniProt

P03925 - NU6M_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

Mtnd6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 6
Gene namesi
Name:Mtnd6
Synonyms:mt-Nd6, Nd6
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102495. mt-Nd6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172NADH-ubiquinone oxidoreductase chain 6PRO_0000118304Add
BLAST

PTM databases

PhosphoSiteiP03925.

Expressioni

Gene expression databases

BgeeiP03925.
ExpressionAtlasiP03925. baseline and differential.
GenevestigatoriP03925.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70008.
HOGENOMiHOG000113881.
HOVERGENiHBG007487.
InParanoidiP03925.
KOiK03884.
OMAiYLGGMMV.
OrthoDBiEOG7HF1MX.
PhylomeDBiP03925.
TreeFamiTF343324.

Family and domain databases

InterProiIPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
[Graphical view]
PfamiPF00499. Oxidored_q3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03925-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF
60 70 80 90 100
LGLMVFLIYL GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV
110 120 130 140 150
FLICVLNYYD EVGVINLDGL GDWLMYEVDD VGVMLEGGIG VAAMYSCATW
160 170
MMVVAGWSLF AGIFIIIEIT RD
Length:172
Mass (Da):18,626
Last modified:July 21, 1986 - v1
Checksum:i55DE2331AB0A1115
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48655.1.
V00711 Genomic DNA. Translation: CAA24089.1.
PIRiA00457. DEMSN6.
RefSeqiNP_904339.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368.
GeneIDi17722.
KEGGimmu:17722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48655.1 .
V00711 Genomic DNA. Translation: CAA24089.1 .
PIRi A00457. DEMSN6.
RefSeqi NP_904339.1. NC_005089.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P03925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082419 ; ENSMUSP00000081002 ; ENSMUSG00000064368 .
GeneIDi 17722.
KEGGi mmu:17722.

Organism-specific databases

CTDi 4541.
MGIi MGI:102495. mt-Nd6.

Phylogenomic databases

eggNOGi NOG70008.
HOGENOMi HOG000113881.
HOVERGENi HBG007487.
InParanoidi P03925.
KOi K03884.
OMAi YLGGMMV.
OrthoDBi EOG7HF1MX.
PhylomeDBi P03925.
TreeFami TF343324.

Miscellaneous databases

NextBioi 292350.
PROi P03925.
SOURCEi Search...

Gene expression databases

Bgeei P03925.
ExpressionAtlasi P03925. baseline and differential.
Genevestigatori P03925.

Family and domain databases

InterProi IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
[Graphical view ]
Pfami PF00499. Oxidored_q3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU6M_MOUSE
AccessioniPrimary (citable) accession number: P03925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3