P03925 (NU6M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 6
EC=1.6.5.3

Alternative name(s):
NADH dehydrogenase subunit 6

Gene names

Name:	Mtnd6
Synonyms:	mt-Nd6, Nd6

Encoded on

Mitochondrion

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the complex I subunit 6 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	NADH-ubiquinone oxidoreductase chain 6		PRO_0000118304
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P03925 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 55DE2331AB0A1115	FASTA	172	18,626
	10 20 30 40 50 60 MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF LGLMVFLIYL 70 80 90 100 110 120 GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV FLICVLNYYD EVGVINLDGL 130 140 150 160 170 GDWLMYEVDD VGVMLEGGIG VAAMYSCATW MMVVAGWSLF AGIFIIIEIT RD

References

[1]	"Sequence and gene organization of mouse mitochondrial DNA." Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A. Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J01420 Genomic DNA. Translation: AAB48655.1. V00711 Genomic DNA. Translation: CAA24089.1.
IPI	IPI00116870.
PIR	DEMSN6. A00457.
RefSeq	NP_904339.1. NC_005089.1.
3D structure databases
ProteinModelPortal	P03925.
SMR	P03925. Positions 1-74.
ModBase	Search...
PTM databases
PhosphoSite	P03925.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368.
GeneID	17722.
KEGG	mmu:17722.
Organism-specific databases
CTD	4541.
MGI	MGI:102495. mt-Nd6.
Phylogenomic databases
eggNOG	NOG70008.
HOGENOM	HOG000113881.
HOVERGEN	HBG007487.
InParanoid	P03925.
KO	K03884.
OrthoDB	EOG48PMMJ.
ProtClustDB	MTH00109.
Gene expression databases
ArrayExpress	P03925.
Bgee	P03925.
Genevestigator	P03925.
Family and domain databases
InterPro	IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6. [Graphical view]
Pfam	PF00499. Oxidored_q3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	292350.
SOURCE	Search...

Entry information

Entry name

NU6M_MOUSE

Accession

Primary (citable) accession number: P03925

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program