Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P03925 (NU6M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 6

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 6
Gene names
Name:Mtnd6
Synonyms:mt-Nd6, Nd6
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the complex I subunit 6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172NADH-ubiquinone oxidoreductase chain 6
PRO_0000118304

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane147 – 16721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P03925 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 55DE2331AB0A1115

FASTA17218,626
        10         20         30         40         50         60 
MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF LGLMVFLIYL 

        70         80         90        100        110        120 
GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV FLICVLNYYD EVGVINLDGL 

       130        140        150        160        170 
GDWLMYEVDD VGVMLEGGIG VAAMYSCATW MMVVAGWSLF AGIFIIIEIT RD 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48655.1.
V00711 Genomic DNA. Translation: CAA24089.1.
PIRDEMSN6. A00457.
RefSeqNP_904339.1. NC_005089.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP03925.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368.
GeneID17722.
KEGGmmu:17722.

Organism-specific databases

CTD4541.
MGIMGI:102495. mt-Nd6.

Phylogenomic databases

eggNOGNOG70008.
HOGENOMHOG000113881.
HOVERGENHBG007487.
InParanoidP03925.
KOK03884.
OMAVVFGYTT.
OrthoDBEOG7HF1MX.
ProtClustDBMTH00109.
TreeFamTF343324.

Gene expression databases

BgeeP03925.
GenevestigatorP03925.

Family and domain databases

InterProIPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
[Graphical view]
PfamPF00499. Oxidored_q3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292350.
PROP03925.
SOURCESearch...

Entry information

Entry nameNU6M_MOUSE
AccessionPrimary (citable) accession number: P03925
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot