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P03925

- NU6M_MOUSE

UniProt

P03925 - NU6M_MOUSE

Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

Mtnd6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 6 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 6
    Gene namesi
    Name:Mtnd6
    Synonyms:mt-Nd6, Nd6
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102495. mt-Nd6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172NADH-ubiquinone oxidoreductase chain 6PRO_0000118304Add
    BLAST

    PTM databases

    PhosphoSiteiP03925.

    Expressioni

    Gene expression databases

    BgeeiP03925.
    GenevestigatoriP03925.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 6 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70008.
    HOGENOMiHOG000113881.
    HOVERGENiHBG007487.
    InParanoidiP03925.
    KOiK03884.
    OMAiYLGGMMV.
    OrthoDBiEOG7HF1MX.
    PhylomeDBiP03925.
    TreeFamiTF343324.

    Family and domain databases

    InterProiIPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
    [Graphical view]
    PfamiPF00499. Oxidored_q3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P03925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF    50
    LGLMVFLIYL GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV 100
    FLICVLNYYD EVGVINLDGL GDWLMYEVDD VGVMLEGGIG VAAMYSCATW 150
    MMVVAGWSLF AGIFIIIEIT RD 172
    Length:172
    Mass (Da):18,626
    Last modified:July 21, 1986 - v1
    Checksum:i55DE2331AB0A1115
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48655.1.
    V00711 Genomic DNA. Translation: CAA24089.1.
    PIRiA00457. DEMSN6.
    RefSeqiNP_904339.1. NC_005089.1.

    Genome annotation databases

    EnsembliENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368.
    GeneIDi17722.
    KEGGimmu:17722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48655.1 .
    V00711 Genomic DNA. Translation: CAA24089.1 .
    PIRi A00457. DEMSN6.
    RefSeqi NP_904339.1. NC_005089.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P03925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082419 ; ENSMUSP00000081002 ; ENSMUSG00000064368 .
    GeneIDi 17722.
    KEGGi mmu:17722.

    Organism-specific databases

    CTDi 4541.
    MGIi MGI:102495. mt-Nd6.

    Phylogenomic databases

    eggNOGi NOG70008.
    HOGENOMi HOG000113881.
    HOVERGENi HBG007487.
    InParanoidi P03925.
    KOi K03884.
    OMAi YLGGMMV.
    OrthoDBi EOG7HF1MX.
    PhylomeDBi P03925.
    TreeFami TF343324.

    Miscellaneous databases

    NextBioi 292350.
    PROi P03925.
    SOURCEi Search...

    Gene expression databases

    Bgeei P03925.
    Genevestigatori P03925.

    Family and domain databases

    InterProi IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
    [Graphical view ]
    Pfami PF00499. Oxidored_q3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNU6M_MOUSE
    AccessioniPrimary (citable) accession number: P03925
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3