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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

MT-ND6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 6
Gene namesi
Name:MT-ND6
Synonyms:MTND6, NADH6, ND6
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182481 – 175NADH-ubiquinone oxidoreductase chain 6Add BLAST175

Proteomic databases

PaxDbiP03924.
PRIDEiP03924.

Expressioni

Gene expression databases

BgeeiENSBTAG00000043546.
ExpressionAtlasiP03924. baseline.

Interactioni

Protein-protein interaction databases

CORUMiP03924.
DIPiDIP-62098N.
STRINGi9913.ENSBTAP00000053156.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35J2-172[»]
5LDWelectron microscopy4.27J1-175[»]
5LDXelectron microscopy5.60J1-175[»]
SMRiP03924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYM9. Eukaryota.
ENOG410YP23. LUCA.
GeneTreeiENSGT00390000003988.
HOGENOMiHOG000113881.
HOVERGENiHBG007487.
InParanoidiP03924.
KOiK03884.
OMAiYLGGMMV.
OrthoDBiEOG091G111J.
TreeFamiTF343324.

Family and domain databases

InterProiView protein in InterPro
IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
PfamiView protein in Pfam
PF00499. Oxidored_q3. 1 hit.

Sequencei

Sequence statusi: Complete.

P03924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLYIVFILS VIFVMGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS
60 70 80 90 100
FLGLMVFLIY LGGMMVVFGY TTAMATEQYP EIWLSNKAVL GAFVTGLLME
110 120 130 140 150
FFMVYYVLKD KEVEVVFEFN GLGDWVIYDT GDSGFFSEEA MGIAALYSYG
160 170
TWLVIVTGWS LLIGVVVIME ITRGN
Length:175
Mass (Da):19,078
Last modified:July 21, 1986 - v1
Checksum:i47E8F2BD497A84F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24006.1.
AF490528 Genomic DNA. Translation: AAM08328.1.
AF490529 Genomic DNA. Translation: AAM08341.1.
AF493541 Genomic DNA. Translation: AAM12800.1.
AF493542 Genomic DNA. Translation: AAM12813.1.
PIRiA00456. DEBON6.
RefSeqiYP_209216.1. NC_006853.1.

Genome annotation databases

EnsembliENSBTAT00000060562; ENSBTAP00000053156; ENSBTAG00000043546.
GeneIDi3283888.
KEGGibta:3283888.

Similar proteinsi

Entry informationi

Entry nameiNU6M_BOVIN
AccessioniPrimary (citable) accession number: P03924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families