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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

MT-ND6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 6
Gene namesi
Name:MT-ND6
Synonyms:MTND6, NADH6, ND6
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiHostDB:ENSG00000198695.2
HGNCiHGNC:7462 MT-ND6
MIMi516006 gene
neXtProtiNX_P03923

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Leber hereditary optic neuropathy (LHON)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00839536G → S in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs397515506Ensembl.1
Natural variantiVAR_00839659Y → C in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs869025186Ensembl.1
Natural variantiVAR_01439660L → S in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs199476106Ensembl.1
Natural variantiVAR_00851264M → I in LHON; possible rare primary mutation. Corresponds to variant dbSNP:rs199476108Ensembl.1
Natural variantiVAR_00476364M → V in LHON; primary mutation; low severity; up to 50% of vision recovery. 2 PublicationsCorresponds to variant dbSNP:rs199476104Ensembl.1
Leber hereditary optic neuropathy with dystonia (LDYT)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionPart of a spectrum of Leber hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with dystonia.
See also OMIM:500001
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00839426I → M in LDYT; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs387906424Ensembl.1
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionGenetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness.
See also OMIM:540000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01439774A → V in MELAS. 1 PublicationCorresponds to variant dbSNP:rs199476107Ensembl.1
Mitochondrial complex I deficiency (MT-C1D)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
See also OMIM:252010
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06456863M → V in MT-C1D. 2 PublicationsCorresponds to variant dbSNP:rs199476109Ensembl.1

Keywords - Diseasei

Disease mutation, Dystonia, Leber hereditary optic neuropathy, MELAS syndrome, Primary mitochondrial disease

Organism-specific databases

DisGeNETi4541
GeneReviewsiMT-ND6
MalaCardsiMT-ND6
MIMi252010 phenotype
500001 phenotype
535000 phenotype
540000 phenotype
OpenTargetsiENSG00000198695
Orphaneti104 Leber hereditary optic neuropathy
99718 Leber plus disease
255210 Maternally-inherited Leigh syndrome
550 MELAS
PharmGKBiPA31266

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

DMDMi6648060

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182911 – 174NADH-ubiquinone oxidoreductase chain 6Add BLAST174

Proteomic databases

EPDiP03923
PaxDbiP03923
PeptideAtlasiP03923
PRIDEiP03923
TopDownProteomicsiP03923

Expressioni

Gene expression databases

BgeeiENSG00000198695
ExpressionAtlasiP03923 baseline and differential
GenevisibleiP03923 HS

Interactioni

Protein-protein interaction databases

BioGridi110637, 6 interactors
CORUMiP03923
IntActiP03923, 4 interactors
MINTiP03923
STRINGi9606.ENSP00000354665

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70m1-174[»]
5XTDelectron microscopy3.70m1-174[»]
ProteinModelPortaliP03923
SMRiP03923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYM9 Eukaryota
ENOG410YP23 LUCA
GeneTreeiENSGT00390000003988
HOVERGENiHBG007487
InParanoidiP03923
KOiK03884
OMAiYLGGMMV
OrthoDBiEOG091G111J
PhylomeDBiP03923
TreeFamiTF343324

Family and domain databases

InterProiView protein in InterPro
IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6
PfamiView protein in Pfam
PF00499 Oxidored_q3, 1 hit

Sequencei

Sequence statusi: Complete.

P03923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY
60 70 80 90 100
MGLMVFLIYL GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV
110 120 130 140 150
GLVLWVKEYD GVVVVVNFNS VGSWMIYEGE GSGLIREDPI GAGALYDYGR
160 170
WLVVVTGWTL FVGVYIVIEI ARGN
Length:174
Mass (Da):18,622
Last modified:May 30, 2000 - v2
Checksum:iE50CD9F3FAFC600D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102L → F in CAA24037 (PubMed:7219534).Curated1
Sequence conflicti134L → F in CAA24037 (PubMed:7219534).Curated1
Sequence conflicti159T → P in CAA24037 (PubMed:7219534).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00839426I → M in LDYT; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs387906424Ensembl.1
Natural variantiVAR_01439331V → A1 PublicationCorresponds to variant dbSNP:rs41354845Ensembl.1
Natural variantiVAR_01439433I → V1 PublicationCorresponds to variant dbSNP:rs386829219Ensembl.1
Natural variantiVAR_00839536G → S in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs397515506Ensembl.1
Natural variantiVAR_01439558I → V1 PublicationCorresponds to variant dbSNP:rs201327354Ensembl.1
Natural variantiVAR_00839659Y → C in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs869025186Ensembl.1
Natural variantiVAR_01439660L → S in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs199476106Ensembl.1
Natural variantiVAR_06456863M → V in MT-C1D. 2 PublicationsCorresponds to variant dbSNP:rs199476109Ensembl.1
Natural variantiVAR_00851264M → I in LHON; possible rare primary mutation. Corresponds to variant dbSNP:rs199476108Ensembl.1
Natural variantiVAR_00476364M → V in LHON; primary mutation; low severity; up to 50% of vision recovery. 2 PublicationsCorresponds to variant dbSNP:rs199476104Ensembl.1
Natural variantiVAR_00476472A → V in MT-C1D and LDYT; most severe mutation with no vision recovery. 2 PublicationsCorresponds to variant dbSNP:rs199476105Ensembl.1
Natural variantiVAR_01439774A → V in MELAS. 1 PublicationCorresponds to variant dbSNP:rs199476107Ensembl.1
Natural variantiVAR_008604165Y → C1 PublicationCorresponds to variant dbSNP:rs200933339Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58954.1
V00662 Genomic DNA Translation: CAA24037.1
D38112 Genomic DNA Translation: BAA07298.1
AY063322 Genomic DNA Translation: AAL47640.1
AY339402 Genomic DNA Translation: AAP89047.1
AY339403 Genomic DNA Translation: AAP89060.1
AY339404 Genomic DNA Translation: AAP89073.1
AY339405 Genomic DNA Translation: AAP89086.1
AY339406 Genomic DNA Translation: AAP89099.1
AY339407 Genomic DNA Translation: AAP89112.1
AY339408 Genomic DNA Translation: AAP89125.1
AY339409 Genomic DNA Translation: AAP89138.1
AY339410 Genomic DNA Translation: AAP89151.1
AY339411 Genomic DNA Translation: AAP89164.1
AY339413 Genomic DNA Translation: AAP89190.1
AY339414 Genomic DNA Translation: AAP89203.1
AY339415 Genomic DNA Translation: AAP89216.1
AY339416 Genomic DNA Translation: AAP89229.1
AY339417 Genomic DNA Translation: AAP89242.1
AY339418 Genomic DNA Translation: AAP89255.1
AY339419 Genomic DNA Translation: AAP89268.1
AY339420 Genomic DNA Translation: AAP89281.1
AY339421 Genomic DNA Translation: AAP89294.1
AY339422 Genomic DNA Translation: AAP89307.1
AY339423 Genomic DNA Translation: AAP89320.1
AY339424 Genomic DNA Translation: AAP89333.1
AY339425 Genomic DNA Translation: AAP89346.1
AY339426 Genomic DNA Translation: AAP89359.1
AY339427 Genomic DNA Translation: AAP89372.1
AY339428 Genomic DNA Translation: AAP89385.1
AY339429 Genomic DNA Translation: AAP89398.1
AY339430 Genomic DNA Translation: AAP89411.1
AY339431 Genomic DNA Translation: AAP89424.1
AY339432 Genomic DNA Translation: AAP89437.1
AY339433 Genomic DNA Translation: AAP89450.1
AY339434 Genomic DNA Translation: AAP89463.1
AY339435 Genomic DNA Translation: AAP89476.1
AY339436 Genomic DNA Translation: AAP89489.1
AY339437 Genomic DNA Translation: AAP89502.1
AY339438 Genomic DNA Translation: AAP89515.1
AY339439 Genomic DNA Translation: AAP89528.1
AY339440 Genomic DNA Translation: AAP89541.1
AY339441 Genomic DNA Translation: AAP89554.1
AY339442 Genomic DNA Translation: AAP89567.1
AY339443 Genomic DNA Translation: AAP89580.1
AY339444 Genomic DNA Translation: AAP89593.1
AY339445 Genomic DNA Translation: AAP89606.1
AY339446 Genomic DNA Translation: AAP89619.1
AY339447 Genomic DNA Translation: AAP89632.1
AY339448 Genomic DNA Translation: AAP89645.1
AY339449 Genomic DNA Translation: AAP89658.1
AY339450 Genomic DNA Translation: AAP89671.1
AY339455 Genomic DNA Translation: AAP89736.1
AY339456 Genomic DNA Translation: AAP89749.1
AY339457 Genomic DNA Translation: AAP89762.1
AY339458 Genomic DNA Translation: AAP89775.1
AY339459 Genomic DNA Translation: AAP89788.1
AY339460 Genomic DNA Translation: AAP89801.1
AY339461 Genomic DNA Translation: AAP89814.1
AY339462 Genomic DNA Translation: AAP89827.1
AY339463 Genomic DNA Translation: AAP89840.1
AY339464 Genomic DNA Translation: AAP89853.1
AY339465 Genomic DNA Translation: AAP89866.1
AY339466 Genomic DNA Translation: AAP89879.1
AY339467 Genomic DNA Translation: AAP89892.1
AY339468 Genomic DNA Translation: AAP89905.1
AY339469 Genomic DNA Translation: AAP89918.1
AY339470 Genomic DNA Translation: AAP89931.1
AY339471 Genomic DNA Translation: AAP89944.1
AY339472 Genomic DNA Translation: AAP89957.1
AY339473 Genomic DNA Translation: AAP89970.1
AY339474 Genomic DNA Translation: AAP89983.1
AY339475 Genomic DNA Translation: AAP89996.1
AY339476 Genomic DNA Translation: AAP90009.1
AY339477 Genomic DNA Translation: AAP90022.1
AY339478 Genomic DNA Translation: AAP90035.1
AY339479 Genomic DNA Translation: AAP90048.1
AY339480 Genomic DNA Translation: AAP90061.1
AY339481 Genomic DNA Translation: AAP90074.1
AY339482 Genomic DNA Translation: AAP90087.1
AY339483 Genomic DNA Translation: AAP90100.1
AY339484 Genomic DNA Translation: AAP90113.1
AY339485 Genomic DNA Translation: AAP90126.1
AY339486 Genomic DNA Translation: AAP90139.1
AY339487 Genomic DNA Translation: AAP90152.1
AY339488 Genomic DNA Translation: AAP90165.1
AY339489 Genomic DNA Translation: AAP90178.1
AY339490 Genomic DNA Translation: AAP90191.1
AY339491 Genomic DNA Translation: AAP90204.1
AY339492 Genomic DNA Translation: AAP90217.1
AY339493 Genomic DNA Translation: AAP90230.1
AY339494 Genomic DNA Translation: AAP90243.1
AY339495 Genomic DNA Translation: AAP90256.1
AY339496 Genomic DNA Translation: AAP90269.1
AY339497 Genomic DNA Translation: AAP90282.1
AY339498 Genomic DNA Translation: AAP90295.1
AY339499 Genomic DNA Translation: AAP90308.1
AY339500 Genomic DNA Translation: AAP90321.1
AY339501 Genomic DNA Translation: AAP90334.1
AY339502 Genomic DNA Translation: AAP90347.1
AY339503 Genomic DNA Translation: AAP90360.1
AY339504 Genomic DNA Translation: AAP90373.1
AY339505 Genomic DNA Translation: AAP90386.1
AY339506 Genomic DNA Translation: AAP90399.1
AY339507 Genomic DNA Translation: AAP90412.1
AY339508 Genomic DNA Translation: AAP90425.1
AY339509 Genomic DNA Translation: AAP90438.1
AY339510 Genomic DNA Translation: AAP90451.1
AY339511 Genomic DNA Translation: AAP90464.1
AY339512 Genomic DNA Translation: AAP90477.1
AY339513 Genomic DNA Translation: AAP90490.1
AY339514 Genomic DNA Translation: AAP90503.1
AY339515 Genomic DNA Translation: AAP90516.1
AY339516 Genomic DNA Translation: AAP90529.1
AY339517 Genomic DNA Translation: AAP90542.1
AY339518 Genomic DNA Translation: AAP90555.1
AY339519 Genomic DNA Translation: AAP90568.1
AY339520 Genomic DNA Translation: AAP90581.1
AY339521 Genomic DNA Translation: AAP90594.1
AY339522 Genomic DNA Translation: AAP90607.1
AY339523 Genomic DNA Translation: AAP90620.1
AY339524 Genomic DNA Translation: AAP90633.1
AY339525 Genomic DNA Translation: AAP90646.1
AY339526 Genomic DNA Translation: AAP90659.1
AY339528 Genomic DNA Translation: AAP90685.1
AY339529 Genomic DNA Translation: AAP90698.1
AY339530 Genomic DNA Translation: AAP90711.1
AY339531 Genomic DNA Translation: AAP90724.1
AY339532 Genomic DNA Translation: AAP90737.1
AY339533 Genomic DNA Translation: AAP90750.1
AY339534 Genomic DNA Translation: AAP90763.1
AY339535 Genomic DNA Translation: AAP90776.1
AY339536 Genomic DNA Translation: AAP90789.1
AY339537 Genomic DNA Translation: AAP90802.1
AY339538 Genomic DNA Translation: AAP90815.1
AY339539 Genomic DNA Translation: AAP90828.1
AY339540 Genomic DNA Translation: AAP90841.1
AY339541 Genomic DNA Translation: AAP90854.1
AY339542 Genomic DNA Translation: AAP90867.1
AY339543 Genomic DNA Translation: AAP90880.1
AY339544 Genomic DNA Translation: AAP90893.1
AY339545 Genomic DNA Translation: AAP90906.1
AY339546 Genomic DNA Translation: AAP90919.1
AY339547 Genomic DNA Translation: AAP90932.1
AY339548 Genomic DNA Translation: AAP90945.1
AY339549 Genomic DNA Translation: AAP90958.1
AY339550 Genomic DNA Translation: AAP90971.1
AY339551 Genomic DNA Translation: AAP90984.1
AY339552 Genomic DNA Translation: AAP90997.1
AY339553 Genomic DNA Translation: AAP91010.1
AY339554 Genomic DNA Translation: AAP91023.1
AY339555 Genomic DNA Translation: AAP91036.1
AY339556 Genomic DNA Translation: AAP91049.1
AY339557 Genomic DNA Translation: AAP91062.1
AY339558 Genomic DNA Translation: AAP91075.1
AY339559 Genomic DNA Translation: AAP91088.1
AY339560 Genomic DNA Translation: AAP91101.1
AY339561 Genomic DNA Translation: AAP91114.1
AY339562 Genomic DNA Translation: AAP91127.1
AY339563 Genomic DNA Translation: AAP91140.1
AY339564 Genomic DNA Translation: AAP91153.1
AY339565 Genomic DNA Translation: AAP91166.1
AY339566 Genomic DNA Translation: AAP91179.1
AY339567 Genomic DNA Translation: AAP91192.1
AY339568 Genomic DNA Translation: AAP91205.1
AY339569 Genomic DNA Translation: AAP91218.1
AY339570 Genomic DNA Translation: AAP91231.1
AY339571 Genomic DNA Translation: AAP91244.1
AY339572 Genomic DNA Translation: AAP91257.1
AY339573 Genomic DNA Translation: AAP91270.1
AY339574 Genomic DNA Translation: AAP91283.1
AY339575 Genomic DNA Translation: AAP91296.1
AY339576 Genomic DNA Translation: AAP91309.1
AY339577 Genomic DNA Translation: AAP91322.1
AY339578 Genomic DNA Translation: AAP91335.1
AY339579 Genomic DNA Translation: AAP91348.1
AY339580 Genomic DNA Translation: AAP91361.1
AY339581 Genomic DNA Translation: AAP91374.1
AY339582 Genomic DNA Translation: AAP91387.1
AY339583 Genomic DNA Translation: AAP91400.1
AY339584 Genomic DNA Translation: AAP91413.1
AY339585 Genomic DNA Translation: AAP91426.1
AY339586 Genomic DNA Translation: AAP91439.1
AY339587 Genomic DNA Translation: AAP91452.1
AY339588 Genomic DNA Translation: AAP91465.1
AY339589 Genomic DNA Translation: AAP91478.1
AY339590 Genomic DNA Translation: AAP91491.1
AY339591 Genomic DNA Translation: AAP91504.1
AY339592 Genomic DNA Translation: AAP91517.1
AY339593 Genomic DNA Translation: AAP91530.1
AF346964 Genomic DNA Translation: AAK17231.1
AF346965 Genomic DNA Translation: AAK17244.1
AF346966 Genomic DNA Translation: AAK17257.1
AF346967 Genomic DNA Translation: AAK17270.1
AF346971 Genomic DNA Translation: AAK17322.1
AF346972 Genomic DNA Translation: AAK17335.1
AF346973 Genomic DNA Translation: AAK17348.1
AF346974 Genomic DNA Translation: AAK17361.1
AF346975 Genomic DNA Translation: AAK17374.1
AF346976 Genomic DNA Translation: AAK17387.1
AF346977 Genomic DNA Translation: AAK17400.1
AF346978 Genomic DNA Translation: AAK17413.1
AF346981 Genomic DNA Translation: AAK17452.1
AF346982 Genomic DNA Translation: AAK17465.1
AF346983 Genomic DNA Translation: AAK17478.1
AF346984 Genomic DNA Translation: AAK17491.1
AF346985 Genomic DNA Translation: AAK17504.1
AF346988 Genomic DNA Translation: AAK17543.1
AF346989 Genomic DNA Translation: AAK17556.1
AF346990 Genomic DNA Translation: AAK17569.1
AF346993 Genomic DNA Translation: AAK17608.1
AF346994 Genomic DNA Translation: AAK17621.1
AF346995 Genomic DNA Translation: AAK17634.1
AF346998 Genomic DNA Translation: AAK17673.1
AF346999 Genomic DNA Translation: AAK17686.1
AF347000 Genomic DNA Translation: AAK17699.1
AF347001 Genomic DNA Translation: AAK17712.1
AF347002 Genomic DNA Translation: AAK17725.1
AF347003 Genomic DNA Translation: AAK17738.1
AF347004 Genomic DNA Translation: AAK17751.1
AF347005 Genomic DNA Translation: AAK17764.1
AF347006 Genomic DNA Translation: AAK17777.1
AF347007 Genomic DNA Translation: AAK17790.1
AF347008 Genomic DNA Translation: AAK17803.1
AF347009 Genomic DNA Translation: AAK17816.1
AF347010 Genomic DNA Translation: AAK17829.1
AF347014 Genomic DNA Translation: AAK17881.1
AF347015 Genomic DNA Translation: AAK17894.1
AY289052 Genomic DNA Translation: AAP47904.1
AY289053 Genomic DNA Translation: AAP47917.1
AY289056 Genomic DNA Translation: AAP47956.1
AY289057 Genomic DNA Translation: AAP47969.1
AY289058 Genomic DNA Translation: AAP47982.1
AY289059 Genomic DNA Translation: AAP47995.1
AY289060 Genomic DNA Translation: AAP48008.1
AY289062 Genomic DNA Translation: AAP48034.1
AY289063 Genomic DNA Translation: AAP48047.1
AY289064 Genomic DNA Translation: AAP48060.1
AY289065 Genomic DNA Translation: AAP48073.1
AY289066 Genomic DNA Translation: AAP48086.1
AY289067 Genomic DNA Translation: AAP48099.1
AY289068 Genomic DNA Translation: AAP48112.1
AY289069 Genomic DNA Translation: AAP48125.1
AY289070 Genomic DNA Translation: AAP48138.1
AY289071 Genomic DNA Translation: AAP48151.1
AY289072 Genomic DNA Translation: AAP48164.1
AY289073 Genomic DNA Translation: AAP48177.1
AY289074 Genomic DNA Translation: AAP48190.1
AY289075 Genomic DNA Translation: AAP48203.1
AY289076 Genomic DNA Translation: AAP48216.1
AY289077 Genomic DNA Translation: AAP48229.1
AY289078 Genomic DNA Translation: AAP48242.1
AY289079 Genomic DNA Translation: AAP48255.1
AY289080 Genomic DNA Translation: AAP48268.1
AY289081 Genomic DNA Translation: AAP48281.1
AY289082 Genomic DNA Translation: AAP48294.1
AY289083 Genomic DNA Translation: AAP48307.1
AY289084 Genomic DNA Translation: AAP48320.1
AY289085 Genomic DNA Translation: AAP48333.1
AY289086 Genomic DNA Translation: AAP48346.1
AY289088 Genomic DNA Translation: AAP48372.1
AY289089 Genomic DNA Translation: AAP48385.1
AY289090 Genomic DNA Translation: AAP48398.1
AY289091 Genomic DNA Translation: AAP48411.1
AY289092 Genomic DNA Translation: AAP48423.1
AY289093 Genomic DNA Translation: AAP48436.1
AY289094 Genomic DNA Translation: AAP48449.1
AY289095 Genomic DNA Translation: AAP48462.1
AY289096 Genomic DNA Translation: AAP48475.1
AY289097 Genomic DNA Translation: AAP48488.1
AY289098 Genomic DNA Translation: AAP48501.1
AY289099 Genomic DNA Translation: AAP48514.1
AY289100 Genomic DNA Translation: AAP48527.1
AY289101 Genomic DNA Translation: AAP48540.1
AY289102 Genomic DNA Translation: AAP48553.1
AY495090 Genomic DNA Translation: AAR92507.1
AY495091 Genomic DNA Translation: AAR92520.1
AY495092 Genomic DNA Translation: AAR92533.1
AY495093 Genomic DNA Translation: AAR92546.1
AY495094 Genomic DNA Translation: AAR92559.1
AY495096 Genomic DNA Translation: AAR92585.1
AY495097 Genomic DNA Translation: AAR92598.1
AY495098 Genomic DNA Translation: AAR92611.1
AY495099 Genomic DNA Translation: AAR92624.1
AY495100 Genomic DNA Translation: AAR92637.1
AY495101 Genomic DNA Translation: AAR92650.1
AY495102 Genomic DNA Translation: AAR92663.1
AY495103 Genomic DNA Translation: AAR92676.1
AY495104 Genomic DNA Translation: AAR92689.1
AY495105 Genomic DNA Translation: AAR92702.1
AY495106 Genomic DNA Translation: AAR92715.1
AY495107 Genomic DNA Translation: AAR92728.1
AY495109 Genomic DNA Translation: AAR92754.1
AY495110 Genomic DNA Translation: AAR92767.1
AY495112 Genomic DNA Translation: AAR92793.1
AY495113 Genomic DNA Translation: AAR92806.1
AY495114 Genomic DNA Translation: AAR92819.1
AY495115 Genomic DNA Translation: AAR92832.1
AY495116 Genomic DNA Translation: AAR92845.1
AY495117 Genomic DNA Translation: AAR92858.1
AY495118 Genomic DNA Translation: AAR92871.1
AY495119 Genomic DNA Translation: AAR92884.1
AY495120 Genomic DNA Translation: AAR92897.1
AY495121 Genomic DNA Translation: AAR92910.1
AY495122 Genomic DNA Translation: AAR92923.1
AY495124 Genomic DNA Translation: AAR92949.1
AY495125 Genomic DNA Translation: AAR92962.1
AY495126 Genomic DNA Translation: AAR92975.1
AY495128 Genomic DNA Translation: AAR93001.1
AY495129 Genomic DNA Translation: AAR93014.1
AY495130 Genomic DNA Translation: AAR93027.1
AY495131 Genomic DNA Translation: AAR93040.1
AY495132 Genomic DNA Translation: AAR93053.1
AY495133 Genomic DNA Translation: AAR93066.1
AY495134 Genomic DNA Translation: AAR93079.1
AY495135 Genomic DNA Translation: AAR93092.1
AY495136 Genomic DNA Translation: AAR93105.1
AY495137 Genomic DNA Translation: AAR93118.1
AY495138 Genomic DNA Translation: AAR93131.1
AY495139 Genomic DNA Translation: AAR93144.1
AY495140 Genomic DNA Translation: AAR93157.1
AY495141 Genomic DNA Translation: AAR93170.1
AY495142 Genomic DNA Translation: AAR93183.1
AY495143 Genomic DNA Translation: AAR93196.1
AY495144 Genomic DNA Translation: AAR93209.1
AY495145 Genomic DNA Translation: AAR93222.1
AY495146 Genomic DNA Translation: AAR93235.1
AY495147 Genomic DNA Translation: AAR93248.1
AY495148 Genomic DNA Translation: AAR93261.1
AY495149 Genomic DNA Translation: AAR93274.1
AY495150 Genomic DNA Translation: AAR93287.1
AY495151 Genomic DNA Translation: AAR93300.1
AY495152 Genomic DNA Translation: AAR93313.1
AY495153 Genomic DNA Translation: AAR93326.1
AY495154 Genomic DNA Translation: AAR93339.1
AY495155 Genomic DNA Translation: AAR93352.1
AY495156 Genomic DNA Translation: AAR93365.1
AY495157 Genomic DNA Translation: AAR93378.1
AY495158 Genomic DNA Translation: AAR93391.1
AY495159 Genomic DNA Translation: AAR93404.1
AY495160 Genomic DNA Translation: AAR93417.1
AY495161 Genomic DNA Translation: AAR93430.1
AY495162 Genomic DNA Translation: AAR93443.1
AY495163 Genomic DNA Translation: AAR93456.1
AY495164 Genomic DNA Translation: AAR93469.1
AY495165 Genomic DNA Translation: AAR93482.1
AY495166 Genomic DNA Translation: AAR93495.1
AY495167 Genomic DNA Translation: AAR93508.1
AY495168 Genomic DNA Translation: AAR93521.1
AY495169 Genomic DNA Translation: AAR93534.1
AY495170 Genomic DNA Translation: AAR93547.1
AY495171 Genomic DNA Translation: AAR93560.1
AY495172 Genomic DNA Translation: AAR93573.1
AY495173 Genomic DNA Translation: AAR93586.1
AY495174 Genomic DNA Translation: AAR93599.1
AY495175 Genomic DNA Translation: AAR93612.1
AY495176 Genomic DNA Translation: AAR93625.1
AY495177 Genomic DNA Translation: AAR93638.1
AY495180 Genomic DNA Translation: AAR93677.1
AY495185 Genomic DNA Translation: AAR93742.1
AY495187 Genomic DNA Translation: AAR93768.1
AY495188 Genomic DNA Translation: AAR93781.1
AY495189 Genomic DNA Translation: AAR93794.1
AY495190 Genomic DNA Translation: AAR93807.1
AY495191 Genomic DNA Translation: AAR93820.1
AY495192 Genomic DNA Translation: AAR93833.1
AY495193 Genomic DNA Translation: AAR93846.1
AY495194 Genomic DNA Translation: AAR93859.1
AY495195 Genomic DNA Translation: AAR93872.1
AY495196 Genomic DNA Translation: AAR93885.1
AY495197 Genomic DNA Translation: AAR93898.1
AY495198 Genomic DNA Translation: AAR93911.1
AY495199 Genomic DNA Translation: AAR93924.1
AY495200 Genomic DNA Translation: AAR93937.1
AY495201 Genomic DNA Translation: AAR93950.1
AY495202 Genomic DNA Translation: AAR93963.1
AY495203 Genomic DNA Translation: AAR93976.1
AY495204 Genomic DNA Translation: AAR93989.1
AY495205 Genomic DNA Translation: AAR94002.1
AY495206 Genomic DNA Translation: AAR94015.1
AY495207 Genomic DNA Translation: AAR94028.1
AY495208 Genomic DNA Translation: AAR94041.1
AY495210 Genomic DNA Translation: AAR94067.1
AY495211 Genomic DNA Translation: AAR94080.1
AY495212 Genomic DNA Translation: AAR94093.1
AY495213 Genomic DNA Translation: AAR94106.1
AY495214 Genomic DNA Translation: AAR94119.1
AY495216 Genomic DNA Translation: AAR94145.1
AY495217 Genomic DNA Translation: AAR94158.1
AY495218 Genomic DNA Translation: AAR94171.1
AY495219 Genomic DNA Translation: AAR94184.1
AY495220 Genomic DNA Translation: AAR94197.1
AY495221 Genomic DNA Translation: AAR94210.1
AY495222 Genomic DNA Translation: AAR94223.1
AY495223 Genomic DNA Translation: AAR94236.1
AY495224 Genomic DNA Translation: AAR94249.1
AY495225 Genomic DNA Translation: AAR94262.1
AY495226 Genomic DNA Translation: AAR94275.1
AY495227 Genomic DNA Translation: AAR94288.1
AY495228 Genomic DNA Translation: AAR94301.1
AY495229 Genomic DNA Translation: AAR94314.1
AY495230 Genomic DNA Translation: AAR94327.1
AY495231 Genomic DNA Translation: AAR94340.1
AY495232 Genomic DNA Translation: AAR94353.1
AY495233 Genomic DNA Translation: AAR94366.1
AY495234 Genomic DNA Translation: AAR94379.1
AY495235 Genomic DNA Translation: AAR94392.1
AY495236 Genomic DNA Translation: AAR94405.1
AY495237 Genomic DNA Translation: AAR94418.1
AY495238 Genomic DNA Translation: AAR94431.1
AY495239 Genomic DNA Translation: AAR94444.1
AY495240 Genomic DNA Translation: AAR94457.1
AY495241 Genomic DNA Translation: AAR94470.1
AY495242 Genomic DNA Translation: AAR94483.1
AY495243 Genomic DNA Translation: AAR94496.1
AY495244 Genomic DNA Translation: AAR94509.1
AY495245 Genomic DNA Translation: AAR94522.1
AY495246 Genomic DNA Translation: AAR94535.1
AY495247 Genomic DNA Translation: AAR94548.1
AY495248 Genomic DNA Translation: AAR94561.1
AY495249 Genomic DNA Translation: AAR94574.1
AY495250 Genomic DNA Translation: AAR94587.1
AY495251 Genomic DNA Translation: AAR94600.1
AY495252 Genomic DNA Translation: AAR94613.1
AY495253 Genomic DNA Translation: AAR94626.1
AY495254 Genomic DNA Translation: AAR94639.1
AY495255 Genomic DNA Translation: AAR94652.1
AY495256 Genomic DNA Translation: AAR94665.1
AY495257 Genomic DNA Translation: AAR94678.1
AY495258 Genomic DNA Translation: AAR94691.1
AY495259 Genomic DNA Translation: AAR94704.1
AY495261 Genomic DNA Translation: AAR94730.1
AY495262 Genomic DNA Translation: AAR94743.1
AY495263 Genomic DNA Translation: AAR94756.1
AY495264 Genomic DNA Translation: AAR94769.1
AY495266 Genomic DNA Translation: AAR94795.1
AY495267 Genomic DNA Translation: AAR94808.1
AY495268 Genomic DNA Translation: AAR94821.1
AY495269 Genomic DNA Translation: AAR94834.1
AY495270 Genomic DNA Translation: AAR94847.1
AY495271 Genomic DNA Translation: AAR94860.1
AY495272 Genomic DNA Translation: AAR94873.1
AY495273 Genomic DNA Translation: AAR94886.1
AY495274 Genomic DNA Translation: AAR94899.1
AY495275 Genomic DNA Translation: AAR94912.1
AY495276 Genomic DNA Translation: AAR94925.1
AY495277 Genomic DNA Translation: AAR94938.1
AY495278 Genomic DNA Translation: AAR94951.1
AY495279 Genomic DNA Translation: AAR94964.1
AY495280 Genomic DNA Translation: AAR94977.1
AY495281 Genomic DNA Translation: AAR94990.1
AY495282 Genomic DNA Translation: AAR95003.1
AY495283 Genomic DNA Translation: AAR95016.1
AY495284 Genomic DNA Translation: AAR95029.1
AY495285 Genomic DNA Translation: AAR95042.1
AY495286 Genomic DNA Translation: AAR95055.1
AY495287 Genomic DNA Translation: AAR95068.1
AY495288 Genomic DNA Translation: AAR95081.1
AY495289 Genomic DNA Translation: AAR95094.1
AY495290 Genomic DNA Translation: AAR95107.1
AY495291 Genomic DNA Translation: AAR95120.1
AY495292 Genomic DNA Translation: AAR95133.1
AY495293 Genomic DNA Translation: AAR95146.1
AY495294 Genomic DNA Translation: AAR95159.1
AY495295 Genomic DNA Translation: AAR95172.1
AY495296 Genomic DNA Translation: AAR95185.1
AY495297 Genomic DNA Translation: AAR95198.1
AY495298 Genomic DNA Translation: AAR95211.1
AY495299 Genomic DNA Translation: AAR95224.1
AY495300 Genomic DNA Translation: AAR95237.1
AY495301 Genomic DNA Translation: AAR95250.1
AY495302 Genomic DNA Translation: AAR95263.1
AY495303 Genomic DNA Translation: AAR95276.1
AY495304 Genomic DNA Translation: AAR95289.1
AY495305 Genomic DNA Translation: AAR95302.1
AY495306 Genomic DNA Translation: AAR95315.1
AY495307 Genomic DNA Translation: AAR95328.1
AY495308 Genomic DNA Translation: AAR95341.1
AY495310 Genomic DNA Translation: AAR95367.1
AY495311 Genomic DNA Translation: AAR95380.1
AY495312 Genomic DNA Translation: AAR95393.1
AY495313 Genomic DNA Translation: AAR95406.1
AY495314 Genomic DNA Translation: AAR95419.1
AY495315 Genomic DNA Translation: AAR95432.1
AY495316 Genomic DNA Translation: AAR95445.1
AY495317 Genomic DNA Translation: AAR95458.1
AY495318 Genomic DNA Translation: AAR95471.1
AY495319 Genomic DNA Translation: AAR95484.1
AY495320 Genomic DNA Translation: AAR95497.1
AY495321 Genomic DNA Translation: AAR95510.1
AY495322 Genomic DNA Translation: AAR95523.1
AY495323 Genomic DNA Translation: AAR95536.1
AY495324 Genomic DNA Translation: AAR95549.1
AY495325 Genomic DNA Translation: AAR95562.1
AY495326 Genomic DNA Translation: AAR95575.1
AY495327 Genomic DNA Translation: AAR95588.1
AY495328 Genomic DNA Translation: AAR95601.1
AY495329 Genomic DNA Translation: AAR95614.1
AY495330 Genomic DNA Translation: AAR95627.1
PIRiA00455 DEHUN6
RefSeqiYP_003024037.1, NC_012920.1

Genome annotation databases

EnsembliENST00000361681; ENSP00000354665; ENSG00000198695
GeneIDi4541
KEGGihsa:4541

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNU6M_HUMAN
AccessioniPrimary (citable) accession number: P03923
Secondary accession number(s): Q34774, Q8HG30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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