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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

Mtnd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:Mtnd4
Synonyms:mt-Nd4, Nd4
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102498. mt-Nd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179571 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Proteomic databases

PaxDbiP03911.
PeptideAtlasiP03911.
PRIDEiP03911.

PTM databases

PhosphoSitePlusiP03911.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064363.
ExpressionAtlasiP03911. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi201550. 1 interactor.
IntActiP03911. 1 interactor.
STRINGi10090.ENSMUSP00000081000.

Structurei

3D structure databases

ProteinModelPortaliP03911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
GeneTreeiENSGT00730000111316.
HOGENOMiHOG000100683.
HOVERGENiHBG093667.
InParanoidiP03911.
KOiK03881.
OMAiHAWIKDF.
OrthoDBiEOG091G0T7G.
PhylomeDBiP03911.
TreeFamiTF343520.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

P03911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIILPSLM LLPLTWLSSP KKTWTNVTSY SFLISLTSLT LLWQTDENYK
60 70 80 90 100
NFSNMFSSDP LSTPLIILTA WLLPLMLMAS QNHLKKDNNV LQKLYISMLI
110 120 130 140 150
SLQILLIMTF SATELIMFYI LFEATLIPTL IIITRWGNQT ERLNAGIYFL
160 170 180 190 200
FYTLIGSIPL LIALILIQNH VGTLNLMILS FTTHTLDASW SNNLLWLACM
210 220 230 240 250
MAFLIKMPLY GVHLWLPKAH VEAPIAGSMI LAAILLKLGS YGMIRISIIL
260 270 280 290 300
DPLTKYMAYP FILLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAS
310 320 330 340 350
IMIQTPWSFM GATMLMIAHG LTSSLLFCLA NSNYERIHSR TMIMARGLQM
360 370 380 390 400
VFPLMATWWL MASLANLALP PSINLMGELF ITMSLFSWSN FTIILMGINI
410 420 430 440 450
IITGMYSMYM IITTQRGKLT NHMINLQPSH TRELTLMALH MIPLILLTTS

PKLITGLTM
Length:459
Mass (Da):51,882
Last modified:July 21, 1986 - v1
Checksum:i62727CC11CCD137D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48653.1.
V00711 Genomic DNA. Translation: CAA24091.1. Sequence problems.
AY172335 Genomic DNA. Translation: AAN85131.1.
PIRiA00440. QXMS4M.
RefSeqiNP_904337.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363.
GeneIDi17719.
KEGGimmu:17719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48653.1.
V00711 Genomic DNA. Translation: CAA24091.1. Sequence problems.
AY172335 Genomic DNA. Translation: AAN85131.1.
PIRiA00440. QXMS4M.
RefSeqiNP_904337.1. NC_005089.1.

3D structure databases

ProteinModelPortaliP03911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201550. 1 interactor.
IntActiP03911. 1 interactor.
STRINGi10090.ENSMUSP00000081000.

PTM databases

PhosphoSitePlusiP03911.

Proteomic databases

PaxDbiP03911.
PeptideAtlasiP03911.
PRIDEiP03911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363.
GeneIDi17719.
KEGGimmu:17719.

Organism-specific databases

CTDi4538.
MGIiMGI:102498. mt-Nd4.

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
GeneTreeiENSGT00730000111316.
HOGENOMiHOG000100683.
HOVERGENiHBG093667.
InParanoidiP03911.
KOiK03881.
OMAiHAWIKDF.
OrthoDBiEOG091G0T7G.
PhylomeDBiP03911.
TreeFamiTF343520.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiP03911.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064363.
ExpressionAtlasiP03911. baseline and differential.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_MOUSE
AccessioniPrimary (citable) accession number: P03911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.