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P03911

- NU4M_MOUSE

UniProt

P03911 - NU4M_MOUSE

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

Mtnd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:Mtnd4
    Synonyms:mt-Nd4, Nd4
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102498. mt-Nd4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117957Add
    BLAST

    Proteomic databases

    MaxQBiP03911.
    PaxDbiP03911.
    PRIDEiP03911.

    PTM databases

    PhosphoSiteiP03911.

    Expressioni

    Gene expression databases

    BgeeiP03911.
    GenevestigatoriP03911.

    Interactioni

    Protein-protein interaction databases

    BioGridi201550. 1 interaction.
    IntActiP03911. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP03911.
    SMRiP03911. Positions 59-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1008.
    HOGENOMiHOG000100683.
    HOVERGENiHBG093667.
    InParanoidiP03911.
    KOiK03881.
    OMAiYSNNERA.
    OrthoDBiEOG7DJSMN.
    PhylomeDBiP03911.
    TreeFamiTF343520.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P03911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIILPSLM LLPLTWLSSP KKTWTNVTSY SFLISLTSLT LLWQTDENYK    50
    NFSNMFSSDP LSTPLIILTA WLLPLMLMAS QNHLKKDNNV LQKLYISMLI 100
    SLQILLIMTF SATELIMFYI LFEATLIPTL IIITRWGNQT ERLNAGIYFL 150
    FYTLIGSIPL LIALILIQNH VGTLNLMILS FTTHTLDASW SNNLLWLACM 200
    MAFLIKMPLY GVHLWLPKAH VEAPIAGSMI LAAILLKLGS YGMIRISIIL 250
    DPLTKYMAYP FILLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAS 300
    IMIQTPWSFM GATMLMIAHG LTSSLLFCLA NSNYERIHSR TMIMARGLQM 350
    VFPLMATWWL MASLANLALP PSINLMGELF ITMSLFSWSN FTIILMGINI 400
    IITGMYSMYM IITTQRGKLT NHMINLQPSH TRELTLMALH MIPLILLTTS 450
    PKLITGLTM 459
    Length:459
    Mass (Da):51,882
    Last modified:July 21, 1986 - v1
    Checksum:i62727CC11CCD137D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48653.1.
    V00711 Genomic DNA. Translation: CAA24091.1. Sequence problems.
    PIRiA00440. QXMS4M.
    RefSeqiNP_904337.1. NC_005089.1.

    Genome annotation databases

    EnsembliENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363.
    GeneIDi17719.
    KEGGimmu:17719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48653.1 .
    V00711 Genomic DNA. Translation: CAA24091.1 . Sequence problems.
    PIRi A00440. QXMS4M.
    RefSeqi NP_904337.1. NC_005089.1.

    3D structure databases

    ProteinModelPortali P03911.
    SMRi P03911. Positions 59-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201550. 1 interaction.
    IntActi P03911. 1 interaction.

    PTM databases

    PhosphoSitei P03911.

    Proteomic databases

    MaxQBi P03911.
    PaxDbi P03911.
    PRIDEi P03911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082414 ; ENSMUSP00000081000 ; ENSMUSG00000064363 .
    GeneIDi 17719.
    KEGGi mmu:17719.

    Organism-specific databases

    CTDi 4538.
    MGIi MGI:102498. mt-Nd4.

    Phylogenomic databases

    eggNOGi COG1008.
    HOGENOMi HOG000100683.
    HOVERGENi HBG093667.
    InParanoidi P03911.
    KOi K03881.
    OMAi YSNNERA.
    OrthoDBi EOG7DJSMN.
    PhylomeDBi P03911.
    TreeFami TF343520.

    Miscellaneous databases

    NextBioi 292341.
    SOURCEi Search...

    Gene expression databases

    Bgeei P03911.
    Genevestigatori P03911.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 246-255 AND 419-432, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNU4M_MOUSE
    AccessioniPrimary (citable) accession number: P03911
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3