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P03911

- NU4M_MOUSE

UniProt

P03911 - NU4M_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

Mtnd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:Mtnd4
Synonyms:mt-Nd4, Nd4
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102498. mt-Nd4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex I Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117957Add
BLAST

Proteomic databases

MaxQBiP03911.
PaxDbiP03911.
PRIDEiP03911.

PTM databases

PhosphoSiteiP03911.

Expressioni

Gene expression databases

BgeeiP03911.
ExpressionAtlasiP03911. baseline and differential.
GenevestigatoriP03911.

Interactioni

Protein-protein interaction databases

BioGridi201550. 1 interaction.
IntActiP03911. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP03911.
SMRiP03911. Positions 59-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
HOVERGENiHBG093667.
InParanoidiP03911.
KOiK03881.
OMAiYSNNERA.
OrthoDBiEOG7DJSMN.
PhylomeDBiP03911.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

P03911-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIILPSLM LLPLTWLSSP KKTWTNVTSY SFLISLTSLT LLWQTDENYK
60 70 80 90 100
NFSNMFSSDP LSTPLIILTA WLLPLMLMAS QNHLKKDNNV LQKLYISMLI
110 120 130 140 150
SLQILLIMTF SATELIMFYI LFEATLIPTL IIITRWGNQT ERLNAGIYFL
160 170 180 190 200
FYTLIGSIPL LIALILIQNH VGTLNLMILS FTTHTLDASW SNNLLWLACM
210 220 230 240 250
MAFLIKMPLY GVHLWLPKAH VEAPIAGSMI LAAILLKLGS YGMIRISIIL
260 270 280 290 300
DPLTKYMAYP FILLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAS
310 320 330 340 350
IMIQTPWSFM GATMLMIAHG LTSSLLFCLA NSNYERIHSR TMIMARGLQM
360 370 380 390 400
VFPLMATWWL MASLANLALP PSINLMGELF ITMSLFSWSN FTIILMGINI
410 420 430 440 450
IITGMYSMYM IITTQRGKLT NHMINLQPSH TRELTLMALH MIPLILLTTS

PKLITGLTM
Length:459
Mass (Da):51,882
Last modified:July 21, 1986 - v1
Checksum:i62727CC11CCD137D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48653.1.
V00711 Genomic DNA. Translation: CAA24091.1. Sequence problems.
PIRiA00440. QXMS4M.
RefSeqiNP_904337.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363.
GeneIDi17719.
KEGGimmu:17719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48653.1 .
V00711 Genomic DNA. Translation: CAA24091.1 . Sequence problems.
PIRi A00440. QXMS4M.
RefSeqi NP_904337.1. NC_005089.1.

3D structure databases

ProteinModelPortali P03911.
SMRi P03911. Positions 59-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201550. 1 interaction.
IntActi P03911. 1 interaction.

PTM databases

PhosphoSitei P03911.

Proteomic databases

MaxQBi P03911.
PaxDbi P03911.
PRIDEi P03911.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082414 ; ENSMUSP00000081000 ; ENSMUSG00000064363 .
GeneIDi 17719.
KEGGi mmu:17719.

Organism-specific databases

CTDi 4538.
MGIi MGI:102498. mt-Nd4.

Phylogenomic databases

eggNOGi COG1008.
HOGENOMi HOG000100683.
HOVERGENi HBG093667.
InParanoidi P03911.
KOi K03881.
OMAi YSNNERA.
OrthoDBi EOG7DJSMN.
PhylomeDBi P03911.
TreeFami TF343520.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.

Miscellaneous databases

NextBioi 292341.
SOURCEi Search...

Gene expression databases

Bgeei P03911.
ExpressionAtlasi P03911. baseline and differential.
Genevestigatori P03911.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 246-255 AND 419-432, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNU4M_MOUSE
AccessioniPrimary (citable) accession number: P03911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3