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P03911 (NU4M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:Mtnd4
Synonyms:mt-Nd4, Nd4
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117957

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane434 – 45421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P03911 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 62727CC11CCD137D

FASTA45951,882
        10         20         30         40         50         60 
MLKIILPSLM LLPLTWLSSP KKTWTNVTSY SFLISLTSLT LLWQTDENYK NFSNMFSSDP 

        70         80         90        100        110        120 
LSTPLIILTA WLLPLMLMAS QNHLKKDNNV LQKLYISMLI SLQILLIMTF SATELIMFYI 

       130        140        150        160        170        180 
LFEATLIPTL IIITRWGNQT ERLNAGIYFL FYTLIGSIPL LIALILIQNH VGTLNLMILS 

       190        200        210        220        230        240 
FTTHTLDASW SNNLLWLACM MAFLIKMPLY GVHLWLPKAH VEAPIAGSMI LAAILLKLGS 

       250        260        270        280        290        300 
YGMIRISIIL DPLTKYMAYP FILLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAS 

       310        320        330        340        350        360 
IMIQTPWSFM GATMLMIAHG LTSSLLFCLA NSNYERIHSR TMIMARGLQM VFPLMATWWL 

       370        380        390        400        410        420 
MASLANLALP PSINLMGELF ITMSLFSWSN FTIILMGINI IITGMYSMYM IITTQRGKLT 

       430        440        450 
NHMINLQPSH TRELTLMALH MIPLILLTTS PKLITGLTM 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 246-255 AND 419-432, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48653.1.
V00711 Genomic DNA. Translation: CAA24091.1. Sequence problems.
PIRQXMS4M. A00440.
RefSeqNP_904337.1. NC_005089.1.

3D structure databases

ProteinModelPortalP03911.
SMRP03911. Positions 59-423.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201550. 1 interaction.
IntActP03911. 1 interaction.

PTM databases

PhosphoSiteP03911.

Proteomic databases

MaxQBP03911.
PaxDbP03911.
PRIDEP03911.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363.
GeneID17719.
KEGGmmu:17719.

Organism-specific databases

CTD4538.
MGIMGI:102498. mt-Nd4.

Phylogenomic databases

eggNOGCOG1008.
HOGENOMHOG000100683.
HOVERGENHBG093667.
InParanoidP03911.
KOK03881.
OMAYSNNERA.
OrthoDBEOG7DJSMN.
PhylomeDBP03911.
TreeFamTF343520.

Gene expression databases

BgeeP03911.
GenevestigatorP03911.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Other

NextBio292341.
SOURCESearch...

Entry information

Entry nameNU4M_MOUSE
AccessionPrimary (citable) accession number: P03911
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot