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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

Mtnd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:Mtnd4
Synonyms:mt-Nd4, Nd4
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102498 mt-Nd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179571 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Proteomic databases

PaxDbiP03911
PeptideAtlasiP03911
PRIDEiP03911

PTM databases

PhosphoSitePlusiP03911
SwissPalmiP03911

Expressioni

Gene expression databases

BgeeiENSMUSG00000064363
ExpressionAtlasiP03911 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi201550, 2 interactors
CORUMiP03911
IntActiP03911, 2 interactors
STRINGi10090.ENSMUSP00000081000

Structurei

3D structure databases

ProteinModelPortaliP03911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845 Eukaryota
COG1008 LUCA
GeneTreeiENSGT00730000111316
HOGENOMiHOG000100683
HOVERGENiHBG093667
InParanoidiP03911
KOiK03881
OMAiTAPVHML
OrthoDBiEOG091G0T7G
PhylomeDBiP03911
TreeFamiTF343520

Family and domain databases

InterProiView protein in InterPro
IPR000260 NADH4_N
IPR010227 NADH_Q_OxRdtase_chainM/4
IPR003918 NADH_UbQ_OxRdtase
IPR001750 ND/Mrp_mem
PANTHERiPTHR43507 PTHR43507, 1 hit
PfamiView protein in Pfam
PF01059 Oxidored_q5_N, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01437 NUOXDRDTASE4
TIGRFAMsiTIGR01972 NDH_I_M, 1 hit

Sequencei

Sequence statusi: Complete.

P03911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIILPSLM LLPLTWLSSP KKTWTNVTSY SFLISLTSLT LLWQTDENYK
60 70 80 90 100
NFSNMFSSDP LSTPLIILTA WLLPLMLMAS QNHLKKDNNV LQKLYISMLI
110 120 130 140 150
SLQILLIMTF SATELIMFYI LFEATLIPTL IIITRWGNQT ERLNAGIYFL
160 170 180 190 200
FYTLIGSIPL LIALILIQNH VGTLNLMILS FTTHTLDASW SNNLLWLACM
210 220 230 240 250
MAFLIKMPLY GVHLWLPKAH VEAPIAGSMI LAAILLKLGS YGMIRISIIL
260 270 280 290 300
DPLTKYMAYP FILLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAS
310 320 330 340 350
IMIQTPWSFM GATMLMIAHG LTSSLLFCLA NSNYERIHSR TMIMARGLQM
360 370 380 390 400
VFPLMATWWL MASLANLALP PSINLMGELF ITMSLFSWSN FTIILMGINI
410 420 430 440 450
IITGMYSMYM IITTQRGKLT NHMINLQPSH TRELTLMALH MIPLILLTTS

PKLITGLTM
Length:459
Mass (Da):51,882
Last modified:July 21, 1986 - v1
Checksum:i62727CC11CCD137D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48653.1
V00711 Genomic DNA Translation: CAA24091.1 Sequence problems.
AY172335 Genomic DNA Translation: AAN85131.1
PIRiA00440 QXMS4M
RefSeqiNP_904337.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082414; ENSMUSP00000081000; ENSMUSG00000064363
GeneIDi17719
KEGGimmu:17719

Similar proteinsi

Entry informationi

Entry nameiNU4M_MOUSE
AccessioniPrimary (citable) accession number: P03911
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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